{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:41:07Z","timestamp":1793475667563,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T00:00:00Z","timestamp":1427500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13071-015-0775-8","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T20:38:19Z","timestamp":1427488699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Efficacy of orally administered fluralaner (BravectoTM) or topically applied imidacloprid\/moxidectin (Advocate\u00ae) against generalized demodicosis in dogs"],"prefix":"10.1186","volume":"8","author":[{"given":"Josephus J","family":"Fourie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian E","family":"Liebenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan G","family":"Horak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Taenzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja R","family":"Heckeroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis","family":"Fr\u00e9nais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,28]]},"reference":[{"key":"775_CR1","volume-title":"The arthropod parasites of vertebrates in Africa south of the Sahara (Ethiopian region)","author":"F Zumpt","year":"1961","unstructured":"Zumpt F. The arthropod parasites of vertebrates in Africa south of the Sahara (Ethiopian region), vol. 1. Johannesburg: Chelicerata. South African Institute for Medical Research; 1961."},{"key":"775_CR2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1603\/0022-2585-40.2.146","volume":"40","author":"CE Desch","year":"2003","unstructured":"Desch CE, Hillier A. Demodex injai: a new species of hair follicle mite (Acari: Demodecidae) from the domestic dog (Canidae). J Med Entomol. 2003;40:146\u20139.","journal-title":"J Med Entomol"},{"key":"775_CR3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.0959-4493.2001.00258.x","volume":"12","author":"Y Tamura","year":"2001","unstructured":"Tamura Y, Kawamura Y, Inoue I, Ishino S. Scanning electron microscopy description of a new species of Demodex canis spp. Vet Dermatol. 2001;12:275\u20138.","journal-title":"Vet Dermatol"},{"key":"775_CR4","first-page":"565","volume":"3","author":"JN Izdebska","year":"2011","unstructured":"Izdebska JN, Fryderyk S. Diversity of three species of the genus Demodex (Acari, Demodecidae) parasitizing dogs in Poland. Pol J of Environ Stud. 2011;3:565\u20139.","journal-title":"Pol J of Environ Stud"},{"key":"775_CR5","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00436-012-3067-7","volume":"111","author":"M Rojas De","year":"2012","unstructured":"De Rojas M, Riazzo C, Callej\u00f3n R, Guevara D, Cutillas C. Molecular study on three morphotypes of Demodex Mites (Acarina: Demodicidae) from dogs. Parasitol Res. 2012;111:2165\u201372.","journal-title":"Parasitol Res"},{"key":"775_CR6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/vde.12001","volume":"23","author":"N Sastre","year":"2012","unstructured":"Sastre N, Ravera I, Villanueva S, Altet L, Bardagit M, S\u00e1nchez A, et al. Phylogenetic relationships in three species of canine Demodex mite based on partial sequences of mitochondrial 16\u00a0s rDNA. Vet Dermatol. 2012;23:509\u2013e101.","journal-title":"Vet Dermatol"},{"key":"775_CR7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/vde.12010","volume":"24","author":"MA Milosevic","year":"2013","unstructured":"Milosevic MA, Frank LA, Brahmbhatt RA, Kania SA. PCR amplification and DNA sequencing of Demodex injai from otic secretions of a dog. Vet Dermatol. 2013;24:286\u2013e66.","journal-title":"Vet Dermatol"},{"key":"775_CR8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0195-5616(99)50136-8","volume":"29","author":"M Paradis","year":"1999","unstructured":"Paradis M. New approaches to the treatment of canine demodicosis. Vet Clin North Am Small Anim Pract. 1999;29:1425\u201336.","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"775_CR9","first-page":"417","volume-title":"Muller and Kirk\u2019s Small Animal Dermatology","author":"DW Scott","year":"1995","unstructured":"Scott DW, Miller WH, Griffin CE. Parasitic skin diseases. In: Scott DW, Miller WH, Griffin CE, editors. Muller and Kirk\u2019s Small Animal Dermatology. 5th ed. Philadelphia: W B Saunders; 1995. p. 417\u201332.","edition":"5"},{"key":"775_CR10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-3164.1998.00072.x","volume":"9","author":"M Paradis","year":"1998","unstructured":"Paradis M, Pag\u00e9 N. Topical (pour-on) ivermectin in the treatment of chronic generalized demodicosis in dogs. Vet Dermatol. 1998;9:55\u20139.","journal-title":"Vet Dermatol"},{"key":"775_CR11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1751-0813.2000.tb11741.x","volume":"78","author":"M Shipstone","year":"2000","unstructured":"Shipstone M. Generalized demodicosis in dogs, clinical perspective. Aust Vet J. 2000;78:240\u20132.","journal-title":"Aust Vet J"},{"key":"775_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2014.03.008","volume":"203","author":"KS Singh","year":"2014","unstructured":"Singh KS, Dimri U. The immuno-pathological conversions of canine demodicosis. Vet Parasitol. 2014;203:1\u20135.","journal-title":"Vet Parasitol"},{"key":"775_CR13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-3164.2009.00755.x","volume":"20","author":"L Ordeix","year":"2009","unstructured":"Ordeix L, Mar Bardag\u00ed M, Scarampella F, Ferrer L, Fondati F. Demodex injai infestation and dorsal greasy skin and hair in eight wirehaired fox terrier dogs. Vet Dermatol. 2009;20:267\u201372.","journal-title":"Vet Dermatol"},{"key":"775_CR14","first-page":"775","volume":"89","author":"L Medleau","year":"1994","unstructured":"Medleau L, Ristic Z. Treating chronic refractory demodicosis in dogs. Vet Med. 1994;89:775\u20137.","journal-title":"Vet Med"},{"key":"775_CR15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1751-0813.2000.tb11743.x","volume":"78","author":"AK Burrows","year":"2000","unstructured":"Burrows AK. Generalised demodicosis in the dog: the unresponsive or recurrent case. Aust Vet J. 2000;78:244\u20136.","journal-title":"Aust Vet J"},{"key":"775_CR16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-3164.2004.00344.x","volume":"15","author":"RS Mueller","year":"2004","unstructured":"Mueller RS. Treatment protocols for demodicosis:an evidence-based review. Vet Dermatol. 2004;15:75\u201389.","journal-title":"Vet Dermatol"},{"key":"775_CR17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00436-009-1502-1","volume":"105","author":"JJ Fourie","year":"2009","unstructured":"Fourie JJ, Delport PC, Fourie LJ, Heine J, Horak IG, Krieger KJ. Comparative efficacy and safety of two treatment regimens with a topically applied combination of imidacloprid and moxidectin (Advocate\u00ae) against generalised demodicosis in dogs. Parasitol Res. 2009;105:115\u201324.","journal-title":"Parasitol Res"},{"key":"775_CR18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.vetpar.2014.08.021","volume":"205","author":"TE Paterson","year":"2014","unstructured":"Paterson TE, Halliwell RE, Fields PJ, Louw ML, Ball G, Louw J, et al. Canine generalized demodicosis treated with varying doses of a 2.5% moxidectin\u2009+\u200910% imidacloprid spot-on and oral ivermectin: Parasiticidal effects and long-term treatment outcomes. Vet Parasitol. 2014;205:687\u201396.","journal-title":"Vet Parasitol"},{"key":"775_CR19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2013.11.009","volume":"45","author":"M Gassel","year":"2014","unstructured":"Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod \u03b3-aminobutyric acid- and L-glutamategated chloride channels and insecticidal\/acaricidal activity. Insect Biochem Mol Biol. 2014;45:111\u201324.","journal-title":"Insect Biochem Mol Biol"},{"key":"775_CR20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1756-3305-7-83","volume":"7","author":"N Rohdich","year":"2014","unstructured":"Rohdich N, Roepke RKA, Zschiesche E. A randomized, blinded controlled and multi-centered field study comparing the efficacy and safety of Bravecto\u2122 (fluralaner) against Frontline\u2122 (fipronil) in flea- and tick-infested dogs. Parasit Vectors. 2014;7:83.","journal-title":"Parasit Vectors"},{"key":"775_CR21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1756-3305-7-275","volume":"7","author":"H Williams","year":"2014","unstructured":"Williams H, Young DR, Qureshi T, Zoller H, Heckeroth AR. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment. Parasit Vectors. 2014;7:275.","journal-title":"Parasit Vectors"},{"key":"775_CR22","first-page":"525","volume":"7","author":"C Wengenmayer","year":"2014","unstructured":"Wengenmayer C, Williams H, Zschiesche E, Moritz A, Langenstein J, Roepke RKA, et al. The speed of kill of fluralaner (Bravecto\u2122) against Ixodes ricinus ticks on dogs. Parasit Vectors. 2014;7:525.","journal-title":"Parasit Vectors"},{"key":"775_CR23","first-page":"567","volume":"7","author":"J Taenzler","year":"2014","unstructured":"Taenzler J, Wengenmayer C, Williams H, Fourie J, Zschiesche E, Roepke RKA, et al. Onset of activity of fluralaner (BRAVECTO\u2122) against Ctenocephalides felis on dogs. Parasit Vectors. 2014;7:567.","journal-title":"Parasit Vectors"},{"key":"775_CR24","volume-title":"Code of Federal Regulations Title 21, Part 58: Good Laboratory Practice For Nonclinical Laboratory Studies. US Department of Health and Human Services","author":"US FDA","year":"2009","unstructured":"FDA US. Code of Federal Regulations Title 21, Part 58: Good Laboratory Practice For Nonclinical Laboratory Studies. US Department of Health and Human Services. MD, USA: US FDA. Center for Drug Evaluation and Research; 2009."},{"key":"775_CR25","unstructured":"SANS 10386: 2008. \u201cThe care and use of animals for scientific purposes\u201d"},{"key":"775_CR26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1756-3305-7-87","volume":"7","author":"FM Walther","year":"2014","unstructured":"Walther FM, Allan MJ, Roepke RKA, Nuernberger MC. Safety of fluralaner chewable tablets (Bravecto\u2122), a novel systemic antiparasitic drug, in dogs after oral administration. Parasit Vectors. 2014;7:87.","journal-title":"Parasit Vectors"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-0775-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-015-0775-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-0775-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T22:52:08Z","timestamp":1553640728000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.parasitesandvectors.com\/content\/8\/1\/187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,28]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["775"],"URL":"https:\/\/doi.org\/10.1186\/s13071-015-0775-8","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,28]]},"article-number":"187"}}