{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:51:09Z","timestamp":1793087469404,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T00:00:00Z","timestamp":1437782400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Chang Gung Memorial Hospital Research Funding program","award":["CMRPD3D0181"],"award-info":[{"award-number":["CMRPD3D0181"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2320-182-MY3"],"award-info":[{"award-number":["104-2320-182-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13071-015-1000-5","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T01:36:32Z","timestamp":1437701792000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Nitric oxide maintains cell survival of Trichomonas vaginalis upon iron depletion"],"prefix":"10.1186","volume":"8","author":[{"given":"Wei-Hung","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Jung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Hsuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Kai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsun","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrus","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,25]]},"reference":[{"key":"1000_CR1","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1128\/CMR.17.4.794-803.2004","volume":"17","author":"JR Schwebke","year":"2004","unstructured":"Schwebke JR, Burgess D. Trichomoniasis. Clin Microbiol Rev. 2004;17:794\u2013803.","journal-title":"Clin Microbiol Rev"},{"key":"1000_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/mpat.1995.0049","volume":"19","author":"JF Alderete","year":"1995","unstructured":"Alderete JF, Provenzano D, Lehker MW. Iron mediates Trichomonas vaginalis resistance to complement lysis. Microb Pathog. 1995;19:93\u2013103.","journal-title":"Microb Pathog"},{"key":"1000_CR3","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/j.micinf.2007.09.011","volume":"9","author":"ME Alvarez-S\u00e1nchez","year":"2007","unstructured":"Alvarez-S\u00e1nchez ME, Solano-Gonz\u00e1lez E, Ya\u00f1ez-G\u00f3mez C, Arroyo R. Negative iron regulation of the CP65 cysteine proteinase cytotoxicity in Trichomonas vaginalis. Microbes Infect. 2007;9:1597\u2013605.","journal-title":"Microbes Infect"},{"key":"1000_CR4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1006\/mpat.2001.0455","volume":"31","author":"ML Crouch","year":"2001","unstructured":"Crouch ML, Benchimol M, Alderete JF. Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium. Microb Pathog. 2001;31:131\u201344.","journal-title":"Microb Pathog"},{"key":"1000_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/536037","volume":"2012","author":"R Sehgal","year":"2012","unstructured":"Sehgal R, Goyal K, Sehgal A. Trichomoniasis and lactoferrin: future prospects. Infect Dis Obstet Gynecol. 2012;2012:1\u20138.","journal-title":"Infect Dis Obstet Gynecol"},{"key":"1000_CR6","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.micinf.2012.09.004","volume":"14","author":"EE Figueroa-Angulo","year":"2012","unstructured":"Figueroa-Angulo EE, Rend\u00f3n-Gandarilla FJ, Puente-Rivera J, Calla-Choque JS, C\u00e1rdenas-Guerra RE, Ortega-L\u00f3pez J, et al. The effects of environmental factors on the virulence of Trichomonas vaginalis. Microb Infect. 2012;14:1411\u20137.","journal-title":"Microb Infect"},{"key":"1000_CR7","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.3390\/nu5082836","volume":"5","author":"JL Heath","year":"2013","unstructured":"Heath JL, Weiss JM, Lavau CP, Wechsler DS. Iron deprivation in cancer--potential therapeutic implications. Nutrients. 2013;5:2836\u201359.","journal-title":"Nutrients"},{"key":"1000_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002061","volume":"7","author":"S Vale-Costa","year":"2013","unstructured":"Vale-Costa S, Gomes-Pereira S, Teixeira CM, Rosa G, Rodrigues PN, Tom\u00e1s A, et al. Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen species. PLoS Negl Trop Dis. 2013;7, e2061.","journal-title":"PLoS Negl Trop Dis"},{"key":"1000_CR9","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1089\/ars.2012.4920","volume":"18","author":"SJ Storr","year":"2013","unstructured":"Storr SJ, Woolston CM, Zhang Y, Martin SG. Redox environment, free radical, and oxidative DNA damage. Antioxid Redox Sign. 2013;18:2399\u2013408.","journal-title":"Antioxid Redox Sign"},{"key":"1000_CR10","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ijpara.2013.04.002","volume":"43","author":"SB Gould","year":"2013","unstructured":"Gould SB, Woehle C, Kusdian G, Landan G, Tachezy J, Zimorski V, et al. Deep sequencing of Trichomonas vaginalis during the early infection of vaginal epithelial cells and amoeboid transition. Int J Parasitol. 2013;43:707\u201319.","journal-title":"Int J Parasitol"},{"key":"1000_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5051\/jpis.2014.44.2.57","volume":"44","author":"S Chakraborty","year":"2014","unstructured":"Chakraborty S, Tewari S, Sharma RK, Narula SC, Ghalaut PS, Ghalaut V. Impact of iron deficiency anemia on chronic periodontitis and superoxide dismutase activity: a cross-sectional study. J Periodontal Implant Sci. 2014;44:57\u201364.","journal-title":"J Periodontal Implant Sci"},{"key":"1000_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1152\/physrev.00014.2008","volume":"89","author":"N Bashan","year":"2009","unstructured":"Bashan N, Kovsan J, Kachko I, Ovadia H, Rudich A. Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species. Physiol Rev. 2009;89:27\u201371.","journal-title":"Physiol Rev"},{"key":"1000_CR13","first-page":"1","volume":"100","author":"T Makiuchi","year":"2013","unstructured":"Makiuchi T, Nozaki T. Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa. Biochimie. 2013;100:1\u201315.","journal-title":"Biochimie"},{"key":"1000_CR14","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.ijpara.2011.10.001","volume":"41","author":"RE Schneider","year":"2011","unstructured":"Schneider RE, Brown MT, Shiflett AM, Dyall SD, Hayes RD, Xie Y, et al. The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes. Int J Parasitol. 2011;41:1421\u201334.","journal-title":"Int J Parasitol"},{"key":"1000_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065148","volume":"8","author":"NC Beltr\u00e1n","year":"2013","unstructured":"Beltr\u00e1n NC, Horv\u00e1thov\u00e1 L, Jedelsk\u00fd PL, \u0160edinov\u00e1 M, Rada P, Marcin\u010dikov\u00e1 M, et al. Iron-induced changes in the proteome of Trichomonas vaginalis hydrogenosomes. PLoS One. 2013;8, e65148.","journal-title":"PLoS One"},{"key":"1000_CR16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3347\/kjp.2006.44.4.373","volume":"44","author":"Y-S Kim","year":"2006","unstructured":"Kim Y-S, Song H-O, Choi I-H, Park S-J, Ryu J-S. Hydrogenosomal activity of Trichomonas vaginalis cultivated under different iron conditions. Korean J Parasitol. 2006;44:373\u20138.","journal-title":"Korean J Parasitol"},{"key":"1000_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1006\/excr.2002.5496","volume":"276","author":"O Chose","year":"2002","unstructured":"Chose O, No\u00ebl C, Gerbod D, Brenner C, Viscogliosi E, Roseto A. A form of cell death with some features resembling apoptosis in the amitochondrial unicellular organism Trichomonas vaginalis. Exp Cell Res. 2002;276:32\u20139.","journal-title":"Exp Cell Res"},{"key":"1000_CR18","doi-asserted-by":"publisher","first-page":"403870","DOI":"10.1155\/2012\/403870","volume":"2012","author":"ED Yoboue","year":"2012","unstructured":"Yoboue ED, Devin A. Reactive oxygen species-mediated control of mitochondrial biogenesis. Int J Cell Biol. 2012;2012:403870.","journal-title":"Int J Cell Biol"},{"key":"1000_CR19","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1126\/science.1079368","volume":"299","author":"E Nisoli","year":"2003","unstructured":"Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science. 2003;299:896\u20139.","journal-title":"Science"},{"key":"1000_CR20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1550-7408.1995.tb01579.x","volume":"42","author":"LS Diamond","year":"1995","unstructured":"Diamond LS, Clark CG, Cunnick CC. YI-S, a casein-free medium for axenic cultivation of Entamoeba histolytica, related Entamoeba, Giardia intestinalis and Trichomonas vaginalis. J Eukaryot Microbiol. 1995;42:277\u20138.","journal-title":"J Eukaryot Microbiol"},{"key":"1000_CR21","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/gbe\/evs078","volume":"4","author":"L Horv\u00e1thov\u00e1","year":"2012","unstructured":"Horv\u00e1thov\u00e1 L, Safarikova L, Basler M, Hrd\u00fd I, Campo NB, Shin J-W, et al. Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome. Genome Biol Evol. 2012;4:905\u201317.","journal-title":"Genome Biol Evol"},{"key":"1000_CR22","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1128\/IAI.00611-12","volume":"80","author":"K-Y Huang","year":"2012","unstructured":"Huang K-Y, Huang P-J, Ku F-M, Lin R, Alderete JF, Tang P. Comparative transcriptomic and proteomic analyses of Trichomonas vaginalis following adherence to fibronectin. Infect Immun. 2012;80:3900\u201311.","journal-title":"Infect Immun"},{"key":"1000_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001831","volume":"6","author":"A Husain","year":"2012","unstructured":"Husain A, Sato D, Jeelani G, Soga T, Nozaki T. Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica. PLoS Negl Trop Dis. 2012;6, e1831.","journal-title":"PLoS Negl Trop Dis"},{"key":"1000_CR24","first-page":"53","volume":"2014","author":"K-Y Huang","year":"1840","unstructured":"Huang K-Y, Chen Y-YM, Fang Y-K, Cheng W-H, Cheng C-C, Chen Y-C, et al. Adaptive responses to glucose restriction enhance cell survival, antioxidant capability, and autophagy of the protozoan parasite Trichomonas vaginalis. Biochim Biophys Acta. 1840;2014:53\u201364.","journal-title":"Biochim Biophys Acta"},{"key":"1000_CR25","doi-asserted-by":"publisher","first-page":"D526","DOI":"10.1093\/nar\/gkn631","volume":"37","author":"C Aurrecoechea","year":"2009","unstructured":"Aurrecoechea C, Brestelli J, Brunk BP, Carlton JM, Dommer J, Fischer S, et al. GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res. 2009;37:D526\u201330.","journal-title":"Nucleic Acids Res"},{"key":"1000_CR26","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1128\/AAC.00009-13","volume":"57","author":"N Mallo","year":"2013","unstructured":"Mallo N, Lamas J, Leiro JM. Hydrogenosome metabolism is the key target for antiparasitic activity of resveratrol against Trichomonas vaginalis. Antimicrob Agents CH. 2013;57:2476\u201384.","journal-title":"Antimicrob Agents CH"},{"key":"1000_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1365-2958.1992.tb00844.x","volume":"6","author":"MW Lehker","year":"1992","unstructured":"Lehker MW, Alderete JF. Iron regulates growth of Trichomonas vaginalis and the expression of immunogenic trichomonad proteins. Mol Microbiol. 1992;6:123\u201332.","journal-title":"Mol Microbiol"},{"key":"1000_CR28","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/pmic.200600797","volume":"7","author":"JB De Jesus","year":"2007","unstructured":"De Jesus JB, Cuervo P, Junqueira M, Britto C, Silva-Filho FCE, Soares MJ, et al. A further proteomic study on the effect of iron in the human pathogen Trichomonas vaginalis. Proteomics. 2007;7:1961\u201372.","journal-title":"Proteomics"},{"key":"1000_CR29","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1128\/JB.06457-11","volume":"194","author":"M-C Boutrin","year":"2012","unstructured":"Boutrin M-C, Wang C, Aruni W, Li X, Fletcher HM. Nitric oxide stress resistance in Porphyromonas gingivalis is mediated by a putative hydroxylamine reductase. J Bacteriol. 2012;194:1582\u201392.","journal-title":"J Bacteriol"},{"key":"1000_CR30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10534-008-9191-2","volume":"22","author":"MC Justino","year":"2009","unstructured":"Justino MC, Baptista JM, Saraiva LM. Di-iron proteins of the Ric family are involved in iron-sulfur cluster repair. Biometals. 2009;22:99\u2013108.","journal-title":"Biometals"},{"key":"1000_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058028","volume":"8","author":"SN Yurgel","year":"2013","unstructured":"Yurgel SN, Rice J, Kahn ML. Transcriptome analysis of the role of GlnD\/GlnBK in nitrogen stress adaptation by Sinorhizobium meliloti Rm1021. PLoS One. 2013;8, e58028.","journal-title":"PLoS One"},{"key":"1000_CR32","doi-asserted-by":"publisher","first-page":"S182","DOI":"10.1111\/j.1550-7408.2006.00224.x","volume":"53","author":"KM Harris","year":"2006","unstructured":"Harris KM, Goldberg B, Biagini GA, Lloyd D. Trichomonas vaginalis and Giardia intestinalis produce nitric oxide and display NO-synthase activity. J Eukaryot Microbiol. 2006;53:S182\u20133.","journal-title":"J Eukaryot Microbiol"},{"key":"1000_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067707","volume":"8","author":"A Simon","year":"2013","unstructured":"Simon A, Karbach S, Habermeier A, Closs EI. Decoding the substrate supply to human neuronal nitric oxide synthase. PLoS One. 2013;8, e67707.","journal-title":"PLoS One"},{"key":"1000_CR34","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1242\/jcs.03062","volume":"119","author":"E Nisoli","year":"2006","unstructured":"Nisoli E, Carruba MO. Nitric oxide and mitochondrial biogenesis. J Cell Sci. 2006;119:2855\u201362.","journal-title":"J Cell Sci"},{"key":"1000_CR35","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1023\/A:1022945107762","volume":"8","author":"JD Ly","year":"2003","unstructured":"Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential (\u0394\u03c8m) in apoptosis; an update. Apoptosis. 2003;8:115\u201328.","journal-title":"Apoptosis"},{"key":"1000_CR36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1099\/00221287-147-1-53","volume":"147","author":"S Van\u00e1cov\u00e1","year":"2001","unstructured":"Van\u00e1cov\u00e1 S, Rasoloson D, R\u00e1zga J, Hrdy I, Kulda J, Tachezy J. Iron-induced changes in pyruvate metabolism of Tritrichomonas foetus and involvement of iron in expression of hydrogenosomal proteins. Microbiology. 2001;147:53\u201362.","journal-title":"Microbiology"},{"key":"1000_CR37","doi-asserted-by":"publisher","first-page":"324230","DOI":"10.1155\/2014\/324230","volume":"2014","author":"J Pacheco-Yepez","year":"2014","unstructured":"Pacheco-Yepez J, Jarillo-Luna RA, Gutierrez-Meza M, Abarca-Rojano E, Larsen BA, Campos-Rodriguez R. Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess. Biomed Res Int. 2014;2014:324230.","journal-title":"Biomed Res Int"},{"key":"1000_CR38","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1073\/pnas.92.5.1267","volume":"92","author":"K Pantopoulos","year":"1995","unstructured":"Pantopoulos K, Hentze MW. Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts. Proc Natl Acad Sci U S A. 1995;92:1267\u201371.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1000_CR39","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/j.1365-313X.2007.03283.x","volume":"52","author":"M Graziano","year":"2007","unstructured":"Graziano M, Lamattina L. Nitric oxide accumulation is required for molecular and physiological responses to iron deficiency in tomato roots. Plant J. 2007;52:949\u201360.","journal-title":"Plant J"},{"key":"1000_CR40","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.jplph.2006.02.011","volume":"164","author":"B Sun","year":"2007","unstructured":"Sun B, Jing Y, Chen K, Song L, Chen F, Zhang L. Protective effect of nitric oxide on iron deficiency-induced oxidative stress in maize (Zea mays). J Plant Physiol. 2007;164:536\u201343.","journal-title":"J Plant Physiol"},{"key":"1000_CR41","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/0003-9861(90)90680-W","volume":"283","author":"DW Reif","year":"1990","unstructured":"Reif DW, Simmons RD. Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys. 1990;283:537\u201341.","journal-title":"Arch Biochem Biophys"},{"key":"1000_CR42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrmicro2696","volume":"10","author":"J Maupin-Furlow","year":"2012","unstructured":"Maupin-Furlow J. Proteasomes and protein conjugation across domains of life. Nat Rev Microbiol. 2012;10:100\u201311.","journal-title":"Nat Rev Microbiol"},{"key":"1000_CR43","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.molcel.2012.08.003","volume":"48","author":"A Suraweera","year":"2012","unstructured":"Suraweera A, M\u00fcnch C, Hanssum A, Bertolotti A. Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell. 2012;48:242\u201353.","journal-title":"Mol Cell"},{"key":"1000_CR44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0166-6851(96)02616-3","volume":"78","author":"N Yarlett","year":"1996","unstructured":"Yarlett N, Martinez MP, Moharrami MA, Tachezy J. The contribution of the arginine dihydrolase pathway to energy metabolism by Trichomonas vaginalis. Mol Biochem Parasitol. 1996;78:117\u201325.","journal-title":"Mol Biochem Parasitol"},{"key":"1000_CR45","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0031-6997(24)01457-1","volume":"52","author":"KA Lucas","year":"2000","unstructured":"Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev. 2000;52:375\u2013414.","journal-title":"Pharmacol Rev"},{"key":"1000_CR46","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ni.2806","volume":"15","author":"AS Saini","year":"2014","unstructured":"Saini AS, Shenoy GN, Rath S, Bal V, George A. Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells. Nat Immunol. 2014;15:275\u201382.","journal-title":"Nat Immunol"},{"key":"1000_CR47","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.molbiopara.2005.10.020","volume":"146","author":"CA Diaz","year":"2006","unstructured":"Diaz CA, Allocco J, Powles MA, Yeung L, Donald RGK, Anderson JW, et al. Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor. Mol Biochem Parasitol. 2006;146:78\u201388.","journal-title":"Mol Biochem Parasitol"},{"key":"1000_CR48","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1128\/EC.1.3.317-328.2002","volume":"1","author":"RGK Donald","year":"2002","unstructured":"Donald RGK, Allocco J, Singh SB, Nare B, Salowe SP, Wiltsie J, et al. Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase. Eukaryot Cell. 2002;1:317\u201328.","journal-title":"Eukaryot Cell"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1000-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-015-1000-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1000-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1000-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T16:53:05Z","timestamp":1748537585000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-015-1000-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,25]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1000"],"URL":"https:\/\/doi.org\/10.1186\/s13071-015-1000-5","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,25]]},"assertion":[{"value":"16 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"393"}}