{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:26:59Z","timestamp":1791354419164,"version":"4.3.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Natural Science Foundation of Gansu Province","award":["145RJZA234"],"award-info":[{"award-number":["145RJZA234"]}]},{"name":"NBCITS, MOA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13071-015-1001-4","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T01:36:54Z","timestamp":1437442614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Research advances in microneme protein 3 of Toxoplasma gondii"],"prefix":"10.1186","volume":"8","author":[{"given":"Yanhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"1001_CR1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jsb.2011.11.028","volume":"177","author":"TC Paredes-Santos","year":"2012","unstructured":"Paredes-Santos TC, de Souza W, Attias M. Dynamics and 3D organization of secretory organelles of Toxoplasma gondii. J Struct Biol. 2012;177:420\u201330.","journal-title":"J Struct Biol"},{"key":"1001_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/00006254-200105000-00025","volume":"56","author":"JL Jones","year":"2001","unstructured":"Jones JL, Lopez A, Wilson M, Schulkin J, Gibbs R. Congenital toxoplasmosis: a review. Obstet Gynecol Surv. 2001;56:296\u2013305.","journal-title":"Obstet Gynecol Surv"},{"key":"1001_CR3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/infdis\/132.1.44","volume":"132","author":"RE Raizman","year":"1975","unstructured":"Raizman RE, Neva FA. Detection of circulating antigen in acute experimental infections with Toxoplasma gondii. Infect Dis. 1975;132:44\u20138.","journal-title":"Infect Dis"},{"key":"1001_CR4","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/1756-3305-6-222","volume":"6","author":"B Mwambe","year":"2013","unstructured":"Mwambe B, Mshana SE, Kidenya BR, Massinde AN, Mazigo HD, Michael D, et al. Sero-prevalence and factors associated with Toxoplasma gondii infection among pregnant women attending antenatal care in Mwanza. Tanzania Parasites Vectors. 2013;6:222.","journal-title":"Tanzania. Parasites Vectors"},{"key":"1001_CR5","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1016\/j.vaccine.2005.04.025","volume":"23","author":"MN M\u00e9v\u00e9lec","year":"2005","unstructured":"M\u00e9v\u00e9lec MN, Bout D, Desolme B, Marchand H, Magn\u00e9 R, Bruneel O, et al. Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice. Vaccine. 2005;23:4489\u201399.","journal-title":"Vaccine"},{"key":"1001_CR6","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.mib.2004.06.013","volume":"7","author":"T Dowse","year":"2004","unstructured":"Dowse T, Soldati D. Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis. Curr Opin Microbiol. 2004;7:388\u201396.","journal-title":"Curr Opin Microbiol"},{"key":"1001_CR7","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0092-8674(00)81071-5","volume":"84","author":"JM Dobrowolski","year":"1996","unstructured":"Dobrowolski JM, Sibley LD. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell. 1996;84:933\u20139.","journal-title":"Cell"},{"key":"1001_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1046\/j.1365-2958.1997.5671913.x","volume":"26","author":"JM Dobrowolski","year":"1997","unstructured":"Dobrowolski JM, Carruthers VB, Sibley LD. Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii. Mol Microbiol. 1997;26:163\u201373.","journal-title":"Mol Microbiol"},{"key":"1001_CR9","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1126\/science.1074553","volume":"298","author":"M Meissner","year":"2002","unstructured":"Meissner M, Schl\u00fcter D, Soldati D. Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science. 2002;298:837\u201340.","journal-title":"Science"},{"key":"1001_CR10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S0966-842X(03)00205-1","volume":"11","author":"A Barragan","year":"2003","unstructured":"Barragan A, Sibley LD. Migration of Toxoplasma gondii across biological barriers. Trends Microbiol. 2003;11:426\u201330.","journal-title":"Trends Microbiol"},{"key":"1001_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ceb.2003.11.013","volume":"16","author":"D Soldati","year":"2004","unstructured":"Soldati D, Meissner M. Toxoplasma as a novel system for motility. Curt opion cell boil. 2004;16:32\u201340.","journal-title":"Curt opion cell boil"},{"key":"1001_CR12","first-page":"114","volume":"73","author":"VB Carruthers","year":"1997","unstructured":"Carruthers VB, Sibley LD. Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts. Eur J Cell Biol. 1997;73:114\u201323.","journal-title":"Eur J Cell Biol"},{"key":"1001_CR13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1242\/jcs.115.3.563","volume":"115","author":"M Meissner","year":"2002","unstructured":"Meissner M, Reiss M, Viebig N, Carruthers VB, Toursel C, Tomavo S, et al. A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters. J Cell Sci. 2002;115:563\u201374.","journal-title":"J Cell Sci"},{"key":"1001_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1084\/jem.20041672","volume":"201","author":"O C\u00e9r\u00e8de","year":"2005","unstructured":"C\u00e9r\u00e8de O, Dubremetz JF, So\u00eate M, Desl\u00e9e D, Vial H, Bout D, et al. Synergistic role of micronemal proteins in Toxoplasma gondii virulence. J Exp Med. 2005;201:453\u201363.","journal-title":"J Exp Med"},{"key":"1001_CR15","doi-asserted-by":"publisher","first-page":"38583","DOI":"10.1074\/jbc.C500365200","volume":"280","author":"S Saouros","year":"2005","unstructured":"Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, et al. A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assemblymand transport of a cell-adhesion complex. J Biol Chem. 2005;280:38583\u201391.","journal-title":"J Biol Chem"},{"key":"1001_CR16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0166-6851(96)02796-X","volume":"84","author":"KL Wan","year":"1997","unstructured":"Wan KL, Carruthers VB, Sibley LD, Ajioka JW. Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2. Mol Biochem Parasitol. 1997;84:203\u201314.","journal-title":"Mol Biochem Parasitol"},{"key":"1001_CR17","doi-asserted-by":"publisher","first-page":"9362","DOI":"10.1074\/jbc.M312590200","volume":"279","author":"TJ Jewett","year":"2004","unstructured":"Jewett TJ, Sibley LD. The Toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival. J Biol Chem. 2004;279:9362\u20139.","journal-title":"J Biol Chem"},{"key":"1001_CR18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1046\/j.1462-5822.2000.00064.x","volume":"2","author":"N Garcia-Reguet","year":"2000","unstructured":"Garcia-Reguet N, Lebrun M, Fourmaux MN, Mercereau-Puijalon O, Mann T, Beckers CJ, et al. The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesion that binds to both the surface of the host cells and the surface of the parasite. Cell Microbio. 2000;2:353\u201364.","journal-title":"Cell Microbio"},{"key":"1001_CR19","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1074\/jbc.M008294200","volume":"276","author":"S Brecht","year":"2001","unstructured":"Brecht S, Carruthers VB, Ferguson DJ, Giddings OK, Wang G, Jakle U, et al. The Toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. J Biol Chem. 2001;276:4119\u201327.","journal-title":"J Biol Chem"},{"key":"1001_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1083\/jcb.152.3.563","volume":"152","author":"M Reiss","year":"2001","unstructured":"Reiss M, Viebig N, Brecht S, Fourmaux MN, Soete M, Di Cristina M, et al. Identification and characterization of an escorter for two secretory adhesions in Toxoplasma gondii. J cell boil. 2001;152:563\u201378.","journal-title":"J cell boil"},{"key":"1001_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0166-6851(00)00296-6","volume":"111","author":"SD Brydges","year":"2000","unstructured":"Brydges SD, Sherman GD, Nockemann S, Loyens A, D\u00e4ubener W, Dubremetz JF, et al. Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii. Mol Biochem Parasitol. 2000;111:51\u201366.","journal-title":"Mol Biochem Parasitol"},{"key":"1001_CR22","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1006\/expr.2000.4585","volume":"97","author":"EF Hoff","year":"2001","unstructured":"Hoff EF, Cook SH, Sherman GD, Harper JM, Ferguson DJ, Dubremetz JF, et al. Toxoplasma gondii: molecular cloning and characterization of a novel 18-kDa secretory antigen, TgMIC10. Exp Parasitol. 2001;97:77\u201388.","journal-title":"Exp Parasitol"},{"key":"1001_CR23","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.ijpara.2004.05.006","volume":"34","author":"JM Harper","year":"2004","unstructured":"Harper JM, Zhou XW, Pszenny V, Kafsack BF, Carruthers VB. The novel coccidian micronemal protein MIC11 undergoes proteolytic maturation by sequential cleavage to remove an internal propeptide. Int J Parasitol. 2004;34:1047\u201358.","journal-title":"Int J Parasitol"},{"key":"1001_CR24","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1093\/emboj\/21.7.1577","volume":"21","author":"C Opitz","year":"2002","unstructured":"Opitz C, Di Cristina M, Reiss M, Ruppert T, Crisanti A, Soldati D. Intramembrane cleavage of microneme proteins at the surface of the apicom plexan parasite Toxoplasma gondii. EMBO J. 2002;21:1577\u201385.","journal-title":"EMBO J"},{"key":"1001_CR25","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1091\/mbc.E05-04-0281","volume":"16","author":"J Mital","year":"2005","unstructured":"Mital J, Meissner M, Soldati D, Ward GE. Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Mol Biol Cell. 2005;16:4341\u20139.","journal-title":"Mol Biol Cell"},{"key":"1001_CR26","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1046\/j.1365-2958.2001.02513.x","volume":"41","author":"KE Rabenau","year":"2001","unstructured":"Rabenau KE, Sohrabi A, Tripathy A, Reitter C, Ajioka JW, Tomley FM, et al. TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2. Mol Microbiol. 2001;41:537\u201347.","journal-title":"Mol Microbiol"},{"key":"1001_CR27","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1093\/emboj\/cdg217","volume":"22","author":"MH Huynh","year":"2003","unstructured":"Huynh MH, Rabenau KE, Harper JM, Beatty WL, Sibley LD, Carruthers VB. Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex. EMBO J. 2003;22:2082\u201390.","journal-title":"EMBO J"},{"key":"1001_CR28","doi-asserted-by":"publisher","first-page":"45341","DOI":"10.1074\/jbc.M106665200","volume":"276","author":"SA Miller","year":"2001","unstructured":"Miller SA, Binder EM, Blackman MJ, Carruthers VB, Kim K. A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii. J Biol Chem. 2001;276:45341\u20138.","journal-title":"J Biol Chem"},{"key":"1001_CR29","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1073\/pnas.0407918102","volume":"102","author":"F Brossier","year":"2005","unstructured":"Brossier F, Jewett TJ, Sibley LD, Urban S. Aspatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Proc Natl Acad Sci USA. 2005;102:4146\u201351.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1001_CR30","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.pt.2005.04.009","volume":"21","author":"TJ Dowse","year":"2005","unstructured":"Dowse TJ, Soldati D. Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature. Trends Parasitol. 2005;21:254\u20138.","journal-title":"Trends Parasitol"},{"key":"1001_CR31","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1128\/IAI.01877-14","volume":"82","author":"MH Huynh","year":"2014","unstructured":"Huynh MH, Boulanger MJ, Carruthers VB. A conserved apicomplexan microneme protein contributes to Toxoplasma gondii invasion and virulence. Infect Immun. 2014;82:4358\u201368.","journal-title":"Infect Immun"},{"key":"1001_CR32","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1126\/science.1165740","volume":"323","author":"BF Kafsack","year":"2009","unstructured":"Kafsack BF, Pena JD, Coppens I, Ravindran S, Boothroyd JC, Carruthers VB. Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science. 2009;323:530\u20133.","journal-title":"Science"},{"key":"1001_CR33","doi-asserted-by":"publisher","first-page":"8712","DOI":"10.1074\/jbc.M113.450932","volume":"288","author":"MS Roiko","year":"2013","unstructured":"Roiko MS, Carruthers VB. Functional dissection of Toxoplasma gondii perforin-like protein 1 reveals a dual domain mode of membrane binding for cytolysis and parasite egress. J Biol Chem. 2013;288:8712\u201325.","journal-title":"J Biol Chem"},{"key":"1001_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.molbiopara.2011.01.009","volume":"177","author":"J Lalibert\u00e9","year":"2011","unstructured":"Lalibert\u00e9 J, Carruthers VB. Toxoplasma gondii toxolysin 4 is an extensively processed putative metalloproteinase secreted from micronemes. Mol Biochem Parasitol. 2011;177:49\u201356.","journal-title":"Mol Biochem Parasitol"},{"key":"1001_CR35","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1093\/emboj\/21.11.2526","volume":"21","author":"O C\u00e8r\u00e8de","year":"2002","unstructured":"C\u00e8r\u00e8de O, Dubremetz JF, Bout D, Lebrun M. The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesion. EMBO J. 2002;21:2526\u201336.","journal-title":"EMBO J"},{"key":"1001_CR36","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/S0020-7519(01)00257-0","volume":"31","author":"D Soldati","year":"2001","unstructured":"Soldati D, Dubremetz JF, Lebrun M. Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii. Int J Parasitol. 2001;31:1293\u2013302.","journal-title":"Int J Parasitol"},{"key":"1001_CR37","doi-asserted-by":"publisher","first-page":"14346","DOI":"10.1074\/jbc.275.19.14346","volume":"275","author":"VB Carruthers","year":"2000","unstructured":"Carruthers VB, Sherman GD, Sibley LD. The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases. J Biol Chem. 2000;275:14346\u201353.","journal-title":"J Biol Chem"},{"key":"1001_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.actatropica.2003.11.016","volume":"91","author":"K Kim","year":"2004","unstructured":"Kim K. Role of proteases in host cell invasion by Toxoplasma gondii and other Apicomplexa. Acta Trop. 2004;91:69\u201381.","journal-title":"Acta Trop"},{"key":"1001_CR39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1046\/j.1462-5822.1999.00023.x","volume":"1","author":"VB Carruthers","year":"1999","unstructured":"Carruthers VB, Diggings OK, Sibley LD. Secretion of micronemal proteins is associated with Toxoplasma invasion of host cells. Cell Microbiol. 1999;1:225\u201335.","journal-title":"Cell Microbiol"},{"key":"1001_CR40","doi-asserted-by":"publisher","first-page":"41492","DOI":"10.1074\/jbc.M106154200","volume":"276","author":"R Moudy","year":"2001","unstructured":"Moudy R, Manning TJ, Beckers CJ. The loss of cytoplasmic potassium upon host cell breakdown triggers egress of Toxoplasma gondii. J Biol Chem. 2001;276:41492\u2013501.","journal-title":"J Biol Chem"},{"key":"1001_CR41","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1242\/jcs.00596","volume":"116","author":"JL Lovett","year":"2003","unstructured":"Lovett JL, Sibley LD. Intracellular calcium stores in Toxoplasma gondii govern invasion of host cell. Cell Sci. 2003;116:3009\u201316.","journal-title":"Cell Sci"},{"key":"1001_CR42","doi-asserted-by":"publisher","first-page":"7433","DOI":"10.1073\/pnas.0307769101","volume":"101","author":"KL Carey","year":"2004","unstructured":"Carey KL, Westwood NJ, Mitchison TJ, Ward GE. A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci USA. 2004;101:7433\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1001_CR43","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1091\/mbc.E06-01-0064","volume":"17","author":"JM Harper","year":"2006","unstructured":"Harper JM, Huynh MH, Coppens I, Parussini F, Moreno S, Carruthers VB. A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex. Mol Biol Cell. 2006;17:4551\u201363.","journal-title":"Mol Biol Cell"},{"key":"1001_CR44","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.1128\/IAI.68.7.4005-4011.2000","volume":"68","author":"VB Carruthers","year":"2000","unstructured":"Carruthers VB, H\u00e5kansson S, Giddings OK, Sibley LD. Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment. Infect Immun. 2000;68:4005\u201311.","journal-title":"Infect Immun"},{"key":"1001_CR45","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0166-6851(91)90182-6","volume":"47","author":"A Achbarou","year":"1991","unstructured":"Achbarou A, Mercereau-Puijalon O, Autheman JM, Fortier B, Camus D, Dubremetz JF. Characterization of microneme proteins of Toxoplasma gondii. Mol Biochem Parasitol. 1991;47:223\u201333.","journal-title":"Mol Biochem Parasitol"},{"key":"1001_CR46","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1128\/EC.00413-07","volume":"7","author":"H Hajj El","year":"2008","unstructured":"El Hajj H, Papoin J, C\u00e9r\u00e8de O, Garcia-R\u00e9guet N, So\u00eate M, Dubremetz JF, et al. Molecular signals in the trafficking of Toxoplasma gondii protein MIC3 to the micronemes. Eukaryot Cell. 2008;7:1019\u201328.","journal-title":"Eukaryot Cell"},{"key":"1001_CR47","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1046\/j.1462-5822.2003.00305.x","volume":"5","author":"SH Matthiesen","year":"2003","unstructured":"Matthiesen SH, Shenoy SM, Kim K, Singer RH, Satir BH. Role of the parafusion orthologue. PRP1. in microneme exocytosis and cell invasion in Toxoplasma gondii. Cell Microbiol. 2003;5:613\u201324.","journal-title":"Cell Microbiol"},{"key":"1001_CR48","doi-asserted-by":"publisher","first-page":"84l3","DOI":"10.1073\/pnas.93.16.8413","volume":"93","author":"E Suss-Toby","year":"1996","unstructured":"Suss-Toby E, Zimmerberg J, Ward GE. Toxoplasma invasion: the parasitophorous vacuole is formed from host cell plasma membrane and pinches of via a fission pore. Proc Natl Acad Sci USA. 1996;93:84l3\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1001_CR49","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1086\/507706","volume":"194","author":"AB Ismael","year":"2006","unstructured":"Ismael AB, Dimier-Poisson I, Lebrun M, Dubremetz JF, Bout D, Mevelec MN. Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in mice. J Infect Dis. 2006;194:1176\u201383.","journal-title":"J Infect Dis"},{"key":"1001_CR50","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1051\/vetres\/2010021","volume":"41","author":"MN M\u00e9v\u00e9lec","year":"2010","unstructured":"M\u00e9v\u00e9lec MN, Ducournau C, Bassuny Ismael A, Olivier M, S\u00e8che E, Lebrun M, et al. Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep. Vet Res. 2010;41:49.","journal-title":"Vet Res"},{"key":"1001_CR51","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.vetpar.2011.04.039","volume":"181","author":"H Nie","year":"2011","unstructured":"Nie H, Fang R, Xiong BQ, Wang LX, Hu M, Zhou YQ, et al. Immunogenicity and protective efficacy of two recombinant pseudorabies viruses expressing Toxoplasma gondii SAG1 and MIC3 proteins. Vet Parasitol. 2011;181:215\u201321.","journal-title":"Vet Parasitol"},{"key":"1001_CR52","doi-asserted-by":"publisher","first-page":"6222","DOI":"10.1128\/IAI.71.11.6222-6228.2003","volume":"71","author":"AB Ismael","year":"2003","unstructured":"Ismael AB, Sekkai D, Collin C, Bout D, M\u00e9v\u00e9lec MN. The MIC3 gene of toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis. Infect Immun. 2003;71:6222\u20138.","journal-title":"Infect Immun"},{"key":"1001_CR53","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.vetpar.2009.06.012","volume":"164","author":"R Fang","year":"2009","unstructured":"Fang R, Nie H, Wang Z, Tu P, Zhou D, Wang L, et al. Protective immune response in BALB\/c mice induced by a suicidal DNA vaccine of the MIC3 gene of Toxoplasma gondii. Vet Parasitol. 2009;164:134\u201340.","journal-title":"Vet Parasitol"},{"key":"1001_CR54","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1016\/j.vaccine.2009.02.107","volume":"27","author":"AB Ismael","year":"2009","unstructured":"Ismael AB, Hedhli D, C\u00e9r\u00e8de O, Lebrun M, Dimier-Poisson I, M\u00e9v\u00e9lec MN. Further analysis of protection induced by the MIC3 DNA vaccine against T. gondii: CD4 and CD8 T cells are the major effectors of the MIC3 DNA vaccine-induced protection, both Lectin-like and EGF-like domains of MIC3 conferred protection. Vaccine. 2009;27:2959\u201366.","journal-title":"Vaccine"},{"key":"1001_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetpar.2009.08.014","volume":"166","author":"X Wu","year":"2009","unstructured":"Wu X, Zhang Q, Liu LP, Tan K, Guan JW, Shu HP. The location of invasion-related protein MIC3 of Toxoplasma gondii and protective effect of its DNA vaccine in mice. Vet Parasitol. 2009;166:1\u20137.","journal-title":"Vet Parasitol"},{"key":"1001_CR56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/v10181-011-0107-7","volume":"15","author":"E Hiszczy\u0144ska-Sawicka","year":"2012","unstructured":"Hiszczy\u0144ska-Sawicka E, Li H, Boyu Xu J, Akhtar M, Holec-Gasior L, Kur J, et al. Induction of immune responses in sheep by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii MIC3 gene. Pol J Vet Sci. 2012;15:3\u20139.","journal-title":"Pol J Vet Sci"},{"key":"1001_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1479-0556-2-17","volume":"2","author":"C Ivory","year":"2004","unstructured":"Ivory C, Chadee K. DNA vaccines: designing strategies against parasitic infections. Genet Vaccines Ther. 2004;2:17\u201325.","journal-title":"Genet Vaccines Ther"},{"key":"1001_CR58","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/1756-3305-7-180","volume":"7","author":"YH Wang","year":"2014","unstructured":"Wang YH, Yin H. Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii. Parasites Vectors. 2014;7:180.","journal-title":"Parasites Vectors"},{"key":"1001_CR59","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.vetpar.2009.08.016","volume":"166","author":"D Qu","year":"2009","unstructured":"Qu D, Yu H, Wang S, Cai W, Du A. Induction of protective immunity by multiantigenic DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vet Parasitol. 2009;166:220\u20137.","journal-title":"Vet Parasitol"},{"key":"1001_CR60","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.vetpar.2011.12.007","volume":"187","author":"R Fang","year":"2012","unstructured":"Fang R, Feng H, Hu M, Khan MK, Wang L, Zhou Y, et al. Evaluation of immune responses induced by SAG1 and MIC3 vaccine cocktails against Toxoplasma gondii. Vet Parasitol. 2012;187:140\u20136.","journal-title":"Vet Parasitol"},{"key":"1001_CR61","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1007\/s00436-013-3425-0","volume":"112","author":"D Qu","year":"2013","unstructured":"Qu D, Han J, Du A. Evaluation of protective effect of multiantigenic DNA vaccine encoding MIC3 and ROP18 antigen segments of Toxoplasma gondii in mice. Parasitol Res. 2013;112:2593\u20139.","journal-title":"Parasitol Res"},{"key":"1001_CR62","doi-asserted-by":"publisher","first-page":"8619","DOI":"10.1016\/j.vaccine.2011.09.016","volume":"29","author":"YH Wang","year":"2011","unstructured":"Wang YH, Wang M, Wang GX, Pang AN, Fu BQ, Yin H, et al. Increased survival time in mice vaccinated with a branched lysine multiple antigenic peptide containing B- and T-cell epitopes from T. gondii antigens. Vaccine. 2011;29:8619\u201323.","journal-title":"Vaccine"},{"key":"1001_CR63","first-page":"519","volume":"26","author":"T Jiang","year":"2007","unstructured":"Jiang T, Zhou YQ, Nie H, Chen SG, Fang R, Yao BA, et al. Boost effect of interferon-gamma on immunoprotection of Toxoplasma gondii mic3 dna vaccine in mice. J Huazhong Agr Univ. 2007;26:519\u201323.","journal-title":"J Huazhong Agr Univ"},{"key":"1001_CR64","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0304-4017(03)00044-X","volume":"113","author":"A Daryani","year":"2003","unstructured":"Daryani A, Hosseine AZ, Dalimi A. Immune response against excreted\/secreted antigens of Toxoplasma gondii tachyzoites in the murine model. Vet Parasitol. 2003;113:123\u201334.","journal-title":"Vet Parasitol"},{"key":"1001_CR65","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1016\/S0264-410X(02)00054-3","volume":"20","author":"RM Hiramoto","year":"2002","unstructured":"Hiramoto RM, Galisteo AJ, do Nascimento N, de Andrade HF. 200Gy sterilized Toxoplasma gondii tachyzoites maintain metabolic functions and mammalian cell invasion, eliciting cellular immunity and cytokine response similar to natural infection in mice. Vaccine. 2002;20:2072\u201381.","journal-title":"Vaccine"},{"key":"1001_CR66","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.vetpar.2008.07.035","volume":"158","author":"T Jiang","year":"2008","unstructured":"Jiang T, Gong D, Ma LA, Nie H, Zhou Y, Yao B, et al. Evaluation of a recombinant MIC3 based latex agglutination test for the rapid serodiagnosis of Toxoplasma gondii infection in swines. Vet Parasitol. 2008;158:51\u20136.","journal-title":"Vet Parasitol"},{"key":"1001_CR67","doi-asserted-by":"publisher","first-page":"5414","DOI":"10.1128\/JCM.41.12.5414-5418.2003","volume":"4","author":"E Beghetto","year":"2003","unstructured":"Beghetto E, Buffolano W, Spadoni A, Del Pezzo M, Di Cristina M, Minenkova O, et al. Use of an immunoglobulin G avidity assay based on recombinant antigens for diagnosis of primary Toxoplasma gondii infection during pregnancy. J Clin Microbiol. 2003;4:5414\u20138.","journal-title":"J Clin Microbiol"},{"key":"1001_CR68","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1128\/CVI.00119-12","volume":"19","author":"P Maksimov","year":"2012","unstructured":"Maksimov P, Zerweck J, Maksimov A, Hotop A, Gross U, Pleyer U, et al. Peptide microarray analysis of in silico-predicted epitopes for serological diagnosis of Toxoplasma gondii infection in humans. Clin Vaccine Immunol. 2012;19:865\u201374.","journal-title":"Clin Vaccine Immunol"},{"key":"1001_CR69","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.vetpar.2011.08.025","volume":"184","author":"F Du","year":"2012","unstructured":"Du F, Feng HL, Nie H, Tu P, Zhang QL, Hu M, et al. Survey on the contamination of Toxoplasma gondii oocysts in the soil of public parks of Wuhan, China. Vet Parasitol. 2012;184:141\u20136.","journal-title":"Vet Parasitol"},{"key":"1001_CR70","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.vetpar.2011.12.036","volume":"187","author":"F Du","year":"2012","unstructured":"Du F, Zhang Q, Yu Q, Hu M, Zhou Y, Zhao J. Soil contamination of Toxoplasma gondii oocysts in pig farms in central China. Vet Parasitol. 2012;187:53\u20136.","journal-title":"Vet Parasitol"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1001-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-015-1001-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1001-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1001-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T16:31:33Z","timestamp":1652891493000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-015-1001-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,22]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1001"],"URL":"https:\/\/doi.org\/10.1186\/s13071-015-1001-4","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,22]]},"assertion":[{"value":"7 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"384"}}