{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:41:56Z","timestamp":1773859316558,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13071-015-1195-5","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T11:47:02Z","timestamp":1447069622000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Speed of flea knockdown of spinosad compared to afoxolaner, and of spinosad through 28\u00a0days post-treatment in controlled laboratory studies"],"prefix":"10.1186","volume":"8","author":[{"given":"Daniel E.","family":"Snyder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Rumschlag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa Marie","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"issue":"3, Summer","key":"1195_CR1","first-page":"208","volume":"2","author":"MS Dryden","year":"2001","unstructured":"Dryden MS, Magid-Denenberg T, Bunch S, Boyer J, Schenker R. Control of fleas on dogs and cats and in homes with the combination of oral lufenuron and nitenpyram. Vet Ther. 2001;2(3, Summer):208\u201314.","journal-title":"Vet Ther"},{"issue":"3A","key":"1195_CR2","first-page":"24","volume":"23","author":"MW Dryden","year":"2001","unstructured":"Dryden MW, McCoy CM, Payne PA. Speed of flea kill with nitenpyram tablets compared to imidacloprid spot on and fipronil spot on in dogs. SupplCompendContinEducPract Vet. 2001;23(3A):24\u20137.","journal-title":"SupplCompendContinEducPract Vet"},{"key":"1195_CR3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.vetpar.2008.04.028","volume":"156","author":"C McCoy","year":"2008","unstructured":"McCoy C, Broce AB, Dryden MW. Flea blood feeding patterns in cats treated with oral nitenpyram and the topical insecticides imidacloprid, fipronil and selamectin. Vet Parasitol. 2008;156:293\u2013301.","journal-title":"Vet Parasitol"},{"key":"1195_CR4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.vetpar.2009.11.023","volume":"168","author":"BL Blagburn","year":"2010","unstructured":"Blagburn BL, Young DR, Moran C, Meyer JA, Leigh-Heffron A, Paarlberg T, et al. Effects of orally administered spinosad (Comfortis) in dogs on adult and immature stages of the cat flea (Ctenocephalidesfelis). Vet Parasitol. 2010;168:312\u20137.","journal-title":"Vet Parasitol"},{"key":"1195_CR5","first-page":"26","volume":"9","author":"C Robertson-Plouch","year":"2008","unstructured":"Robertson-Plouch C, Baker KA, Hozak RR, Zimmermann AG, Parks SC, Herr C, et al. Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs. Vet Ther. 2008;9:26\u201336.","journal-title":"Vet Ther"},{"key":"1195_CR6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/vr.100211","volume":"170","author":"S Wolken","year":"2012","unstructured":"Wolken S, Franc M, Bouhsira E, Wiseman S, Hayes B, Schnitzler B, et al. Evaluation of spinosad for the oral treatment and control of flea infestations on dogs in Europe. Vet Rec. 2012;170:99\u2013103.","journal-title":"Vet Rec"},{"key":"1195_CR7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.vetpar.2012.09.003","volume":"191","author":"MW Dryden","year":"2013","unstructured":"Dryden MW, Ryan WG, Bell M, Rumschlag AJ, Young LM, Snyder DE. Assessment of owner-administered monthly treatments with oral spinosad or topical spot-on fipronil\/(S)-methoprene in controlling fleas and associated pruritus in dogs. Vet Parasitol. 2013;191:340\u20136.","journal-title":"Vet Parasitol"},{"key":"1195_CR8","unstructured":"Freedom of Information Summary. Original New Animal Drug Application (NADA 141-406). NEXGARD Afoxolaner Chewable Tablet Dogs. Date of Approval: September 14, 2013."},{"key":"1195_CR9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/1756-3305-7-375","volume":"7","author":"C Meadows","year":"2014","unstructured":"Meadows C, Guerino F, Sun F. A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling canine flea infestations. Parasit Vectors. 2014;7:375.","journal-title":"Parasit Vectors"},{"key":"1195_CR10","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13071-015-0945-8","volume":"8","author":"MN Saridomichelakis","year":"2015","unstructured":"Saridomichelakis MN, Chatzis MK, Petanides T, Papadopoulos E. A field trial of spinosad for the treatment and prevention of flea infestation in shepherd dogs living in close proximity to flea-infested sheep. Parasit Vectors. 2015;8:324.","journal-title":"Parasit Vectors"},{"issue":"2","key":"1195_CR11","first-page":"123","volume":"9","author":"MW Dryden","year":"2011","unstructured":"Dryden MW, Payne PA, Vicki S, Kobuszewki D. Efficacy of topically applied dinotefuran formulations and orally administered spinosad tablets against the KS1 flea strain infesting dogs. J Appl Res Vet Med. 2011;9(2):123\u201328.","journal-title":"J Appl Res Vet Med"},{"key":"1195_CR12","doi-asserted-by":"crossref","unstructured":"Dryden MW, Payne PA, Smith V, Berg TC, Lane M. Efficacy of selamectin, spinosad, and spinosad\/milbemycin oxime against the KS1 Ctenocephalidesfelisflea strain infesting dogs. Parasit Vectors. 2013. doi: 10.1186\/1756-3305-6-80 .","DOI":"10.1186\/1756-3305-6-80"},{"key":"1195_CR13","doi-asserted-by":"crossref","unstructured":"Ross DH, Arther RG, von Simson C, Doyle V, Dryden MW. Evaluation of the efficacy of topically administered imidacloprid\u2009+\u2009pyriproxyfen and orally administered spinosad against cat fleas (Ctenocephalidesfelis): impact of treated dogs on flea life stages in a simulated home environment. Parasit Vectors. 2012. doi: 10.1186\/1756-3305-5-192 .","DOI":"10.1186\/1756-3305-5-192"},{"key":"1195_CR14","doi-asserted-by":"crossref","unstructured":"Varloud M, Fourie JJ, Blagburn BL, Deflandre A. Expellency, anti-feeding and speed of kill of a dinotefuran-permethrin-pyriproxyfen spot-on (Vectra\u00ae3D) in dogs weekly challenged with adult fleas (Ctenocephalidesfelis) for 1 month-comparison to a spinosad tablet (Comfortis\u00ae). Parasitol Res. 2015. doi: 10.1007\/s00436-015-4470-7 .","DOI":"10.1007\/s00436-015-4470-7"},{"key":"1195_CR15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1051\/parasite\/2011184325","volume":"18","author":"F Beugnet","year":"2011","unstructured":"Beugnet F, Doyle V, Murray M, Chalvet-Monfray K. Comparative efficacy on dogs of a single topical treatment with the pioneer fipronil\/(S)-methoprene and an oral treatment with spinosad against Ctenocephalidesfelis. Parasite. 2011;18:325\u201331.","journal-title":"Parasite"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-1195-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T23:12:32Z","timestamp":1498259552000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.parasitesandvectors.com\/content\/8\/1\/578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,9]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1195"],"URL":"https:\/\/doi.org\/10.1186\/s13071-015-1195-5","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,9]]},"article-number":"578"}}