{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:52:16Z","timestamp":1791942736601,"version":"4.3.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13071-016-1345-4","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T19:44:44Z","timestamp":1454355884000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs"],"prefix":"10.1186","volume":"9","author":[{"given":"L\u00e9na\u00efg","family":"Halos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephus J.","family":"Fourie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Fankhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Beugnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"1345_CR1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pt.2005.03.010","volume":"21","author":"MK Rust","year":"2005","unstructured":"Rust MK. Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs. Trends Parasitol. 2005;21:232\u20136.","journal-title":"Trends Parasitol"},{"key":"1345_CR2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-3164.2012.01092.x","volume":"23","author":"V Bruet","year":"2012","unstructured":"Bruet V, Bourdeau PJ, Roussel A, Imparato L, Desfontis JC. Characterization of pruritus in canine atopic dermatitis, flea bite hypersensitivity and flea infestation and its role in diagnosis. Vet Dermatol. 2012;23:487\u201393.","journal-title":"Vet Dermatol"},{"key":"1345_CR3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0195-5616(88)50105-5","volume":"18","author":"VJ Scheidt","year":"1988","unstructured":"Scheidt VJ. Flea allergy dermatitis. Vet Clin North Am Small Anim Pract. 1988;18:1023\u201342.","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"1345_CR4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/1756-3305-7-353","volume":"7","author":"F Segura","year":"2014","unstructured":"Segura F, Pons I, Miret J, Pla J, Ortu\u00f1o A, Nogueras MM. The role of cats in the eco-epidemiology of spotted fever group diseases. Parasit Vectors. 2014;7:353.","journal-title":"Parasit Vectors"},{"key":"1345_CR5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pt.2010.01.001","volume":"26","author":"KM McElroy","year":"2010","unstructured":"McElroy KM, Blagburn BL, Breitschwerdt EB, Mead PS, McQuiston JH. Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plague. Trends Parasitol. 2010;26:197\u2013204.","journal-title":"Trends Parasitol"},{"key":"1345_CR6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.vetpar.2009.03.028","volume":"163","author":"F Beugnet","year":"2009","unstructured":"Beugnet F, Mari\u00e9 JL. Emerging arthropod-borne diseases of companion animals in Europe. Vet Parasitol. 2009;163:298\u2013305.","journal-title":"Vet Parasitol"},{"key":"1345_CR7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1603\/0022-2585-37.4.634","volume":"37","author":"MC Cadiergues","year":"2000","unstructured":"Cadiergues MC, Hourcq P, Cantaloube B, Franc M. First bloodmeal of Ctenocephalides felis felis (Siphonaptera: Pulicidae) on cats: time to initiation and duration of feeding. J Med Entomol. 2000;37:634\u20136.","journal-title":"J Med Entomol"},{"key":"1345_CR8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1645\/0022-3395(2001)087[0214:FBMOCC]2.0.CO;2","volume":"87","author":"MC Cadiergues","year":"2001","unstructured":"Cadiergues MC, Santamarta D, Mallet X, Franc M. First blood meal of Ctenocephalides canis (Siphonaptera: Pulicidae) on dogs: time to initiation of feeding and duration. J Parasitol. 2001;87:214\u20135.","journal-title":"J Parasitol"},{"key":"1345_CR9","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s00436-015-4470-7","volume":"114","author":"M Varloud","year":"2015","unstructured":"Varloud M, Fourie JJ, Blagburn BL, Deflandre A. Expellency, anti-feeding and speed of kill of a dinotefuran-permethrin-pyriproxyfen spot-on (Vectra\u00ae3D) in dogs weekly challenged with adult fleas (Ctenocephalides felis) for 1\u00a0month-comparison to a spinosad tablet (Comfortis\u00ae). Parasitol Res. 2015;114:2649\u201357.","journal-title":"Parasitol Res"},{"key":"1345_CR10","doi-asserted-by":"crossref","unstructured":"Fankhauser B, Dumont P, Halos L, Hunter 3rd JS, Kunkle B, Everett WR, et al. Efficacy of a new combination of fipronil and permethrin against Ctenocephalides felis flea infestation in dogs. Parasit Vectors. 2015;8:62.","DOI":"10.1186\/s13071-015-0687-7"},{"key":"1345_CR11","unstructured":"EMEA. Guideline for the testing and evaluation of the efficacy of antiparasitic substances for the treatment and prevention of tick and flea infestation in dogs and cats. EMEA\/CVMP\/EWP\/005\/2000-Rev.2. 2007. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/10\/WC500004596.pdf . Accessed 28 Sept 2015."},{"key":"1345_CR12","doi-asserted-by":"crossref","unstructured":"Marchiondo AA, Holdsworth PA, Fourie LJ, Rugg D, Hellmann K, Snyder DE, et al. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Vet Parasitol. 2013;194:84\u201397.","DOI":"10.1016\/j.vetpar.2013.02.003"},{"key":"1345_CR13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pt.2012.04.004","volume":"28","author":"F Beugnet","year":"2012","unstructured":"Beugnet F, Franc M. Insecticide and acaricide molecules and\/or combinations to prevent pet infestation by ectoparasites. Trends Parasitol. 2012;28:267\u201379.","journal-title":"Trends Parasitol"},{"key":"1345_CR14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13071-015-0680-1","volume":"8","author":"F Beugnet","year":"2015","unstructured":"Beugnet F, Soll MD, Bouhsira E, Franc M. Sustained speed of kill and repellency of a novel combination of fipronil and permethrin against Ctenocephalides canis flea infestations in dogs. Parasit Vectors. 2015;8:52.","journal-title":"Parasit Vectors"},{"key":"1345_CR15","unstructured":"EMEA. Vectra3D Product information EPAR- European Medicines Agency. 2013. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/veterinary\/002555\/WC500163785.pdfAccessed 28 Sept 2015."},{"key":"1345_CR16","unstructured":"EMEA. VICH Topic GL9 (GCP). Guideline on Good Clinical Practices. The European Agency for the Evaluation of Medicinal Products. (EMWA\/CVMP\/VICH\/595\/98-Final). 2000. http:\/\/www.ema.europa.eu\/docs\/enGB\/documentlibrary\/Scientificguideline\/2009\/10\/WC500004343.pdf . Accessed 28 Sept 2015."},{"key":"1345_CR17","unstructured":"Beugnet F, Halos L, Liebenberg J, Fourie J. Assessment of the prophylactic speed of kill of Frontline Tri-Act\u00ae against ticks (Ixodes ricinus and Rhipicephalus sanguineus) on dogs (in press in Parasites)."},{"key":"1345_CR18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s13071-015-1207-5","volume":"8","author":"F Jongejan","year":"2015","unstructured":"Jongejan F, de Vos C, Fourie J, Beugnet F. A novel combination of fipronil and permethrin (Frontline Tri-Act\u00ae\/Frontect\u00ae) reduces risk of transmission of Babesia canis by Dermacentor reticulatus and of Ehrlichia canis by Rhipicephalus sanguineus ticks to dogs. Parasit Vectors. 2015;8:602.","journal-title":"Parasit Vectors"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-016-1345-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T00:59:20Z","timestamp":1498265960000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.parasitesandvectors.com\/content\/9\/1\/57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1345"],"URL":"https:\/\/doi.org\/10.1186\/s13071-016-1345-4","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]},"article-number":"57"}}