{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:47:07Z","timestamp":1792788427700,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Zoetis Brazil"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13071-016-1697-9","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T09:16:11Z","timestamp":1469178971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Selamectin for the prevention of canine Dirofilaria immitis infection: field efficacy in client-owned dogs in a high risk area"],"prefix":"10.1186","volume":"9","author":[{"given":"Maria de F\u00e1tima Chicarino Varaj\u00e3o","family":"Moraes-da-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavya","family":"Mendes-de-Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonimar Pereira","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Vollmer","family":"Labarthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"1697_CR1","first-page":"13","volume-title":"Proceedings of the Heartworm Symposium \u201889","author":"J Guerrero","year":"1989","unstructured":"Guerrero J, Vezzoni A, Ducos De Lahitte J, Bussieras J, Rojo FA, Ortega LM, et al. Distribution of Dirofilaria immitis in selected areas of Europe and South America. In: Otto GH, editor. Proceedings of the Heartworm Symposium \u201889. Washington DC: American Heartworm Society; 1989. p. 13\u20138."},{"key":"1697_CR2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1590\/S0074-02761997000100010","volume":"92","author":"N Labarthe","year":"1997","unstructured":"Labarthe N, Almosny N, Guerrero J, Duque-Araujo AM. Description of the occurrence of canine dirofilariasis in the State of Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 1997;92:47\u201351.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"1697_CR3","volume-title":"Reavalia\u00e7\u00e3o de filariose canina no Rio de Janeiro. MSc thesis, Faculdade de Veterin\u00e1ria","author":"GLG Almeida","year":"1981","unstructured":"Almeida GLG. Reavalia\u00e7\u00e3o de filariose canina no Rio de Janeiro. MSc thesis, Faculdade de Veterin\u00e1ria. Rio de Janeiro: Universidade Federal Rural do Rio de Janeiro; 1981."},{"key":"1697_CR4","first-page":"111","volume-title":"Hemoparasitoses em Pequenos Dom\u00e9sticos e como Zoonoses","author":"NV Labarthe","year":"2002","unstructured":"Labarthe NV, Alves LC, Serrao ML. Dirofilariose em pequenos animais domesticos e como zoonose. In: Almosny NRP, editor. Hemoparasitoses em Pequenos Dom\u00e9sticos e como Zoonoses. Rio de Janeiro: LF Livros de Veterinaria Ltda; 2002. p. 111\u201335."},{"key":"1697_CR5","first-page":"67","volume":"4","author":"N Labarthe","year":"2003","unstructured":"Labarthe N, de Campos PM, Barbarini O, McKee W, Coimbra CA, Hoskins J. Serologic prevalence of Dirofilaria immitis, Ehrlichia canis, and Borrelia burgdorferi infections in Brazil. Vet Ther. 2003;4:67\u201375.","journal-title":"Vet Ther"},{"key":"1697_CR6","first-page":"23","volume":"13","author":"RC Costa","year":"2004","unstructured":"Costa RC, Couto-Lima D, Serrao ML, Labarthe N. An update survey of the prevalence of canine dirofilariasis in a focus area of the city of Rio de Janeiro. Brazil Rev Bras Parasitol Vet. 2004;13:23\u20138.","journal-title":"Brazil Rev Bras Parasitol Vet"},{"key":"1697_CR7","first-page":"678","volume":"35","author":"AJR Bendas","year":"2007","unstructured":"Bendas AJR, Paiva JP, Doria MI, Mendes-de-Almeida F, Branco AS, Silvano DRB, et al. Ocorr\u00eancia de Dirofilaria immitis no entorno de um caso diagnosticado na Zona Sul do Rio de Janeiro\/RJ, Brasil. Acta Sci Vet. 2007;35:678\u20139.","journal-title":"Acta Sci Vet"},{"key":"1697_CR8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s13071-014-0493-7","volume":"7","author":"NV Labarthe","year":"2014","unstructured":"Labarthe NV, Paiva JP, Reifur L, Mendes-de-Almeida F, Merlo A, Carvalho Pinto CJ, et al. Updated canine infection rates for Dirofilaria immitis in areas of Brazil previously identified as having a high incidence of heartworm-infected dogs. Parasit Vectors. 2014;7:493.","journal-title":"Parasit Vectors"},{"key":"1697_CR9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/j.tcam.2011.09.004","volume":"26","author":"TG Geary","year":"2011","unstructured":"Geary TG, Bourguinat C, Prichard RK. Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis. Top Companion Anim Med. 2011;26:186\u201392.","journal-title":"Top Companion Anim Med"},{"key":"1697_CR10","unstructured":"Nelson CT, McCall J, Carithers D, Jones S, Graham W, von Simson C, et al. Current canine guidelines for the prevention, diagnosis, and management of heartworm (Dirofilaria immitis) infection in dogs (Revised July 2014). https:\/\/heartwormsociety.org . Accessed 14 February 2016"},{"key":"1697_CR11","volume-title":"Resistance and heartworm preventives: historical perspectives and overview of research","author":"B Blagburn","year":"2013","unstructured":"Blagburn B, Carmichael C, Kaminsky R, Schenker R, Kaplan R, Moorhead A, et al. Resistance and heartworm preventives: historical perspectives and overview of research. New Orleans: LA: Triennial Heartworm Symposia; 2013."},{"key":"1697_CR12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vetpar.2010.12.049","volume":"176","author":"BL Blagburn","year":"2011","unstructured":"Blagburn BL, Dillon AR, Arther RG, Butler JM, Newton JC. Comparative efficacy of four commercially available heartworm preventive products against the MP3 laboratory strain of Dirofilaria immitis. Vet Parasitol. 2011;176:189\u201394.","journal-title":"Vet Parasitol"},{"key":"1697_CR13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vetpar.2011.01.024","volume":"176","author":"C Bourguinat","year":"2011","unstructured":"Bourguinat C, Keller K, Blagburn B, Schenker R, Geary TG, Prichard RK. Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype. Vet Parasitol. 2011;176:374\u201381.","journal-title":"Vet Parasitol"},{"key":"1697_CR14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.vetpar.2011.01.023","volume":"176","author":"C Bourguinat","year":"2011","unstructured":"Bourguinat C, Keller K, Prichard RK, Geary TG. Genetic polymorphism in Dirofilaria immitis. Vet Parasitol. 2011;176:368\u201373.","journal-title":"Vet Parasitol"},{"key":"1697_CR15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vetpar.2015.04.002","volume":"210","author":"C Bourguinat","year":"2015","unstructured":"Bourguinat C, Lee AC, Lizundia R, Blagburn BL, Liotta JL, Kraus MS, et al. Macrocyclic lactone resistance in Dirofilaria immitis: failure of heartworm preventives and investigation of genetic markers for resistance. Vet Parasitol. 2015;210:167\u201378.","journal-title":"Vet Parasitol"},{"key":"1697_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.vetpar.2005.04.004","volume":"133","author":"VA Hampshire","year":"2005","unstructured":"Hampshire VA. Evaluation of efficacy of heartworm preventive products at the FDA. Vet Parasitol. 2005;133:191\u20135.","journal-title":"Vet Parasitol"},{"key":"1697_CR17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s13071-014-0494-6","volume":"7","author":"CN Pulaski","year":"2014","unstructured":"Pulaski CN, Malone JB, Bourguinat C, Prichard R, Geary T, Ward D, et al. Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs. Parasit Vectors. 2014;7:494.","journal-title":"Parasit Vectors"},{"key":"1697_CR18","unstructured":"Willi LMV, Valle TZ, D\u2019Escoffier LN, Paiva JP, Alves LC, Labarthe N, et al. Search for genetic polymorphism in canine Dirofilaria immitis. Liverpool: ENG: International Conference of the World Association for the Advancement of Veterinary Parasitologyl; 2015."},{"key":"1697_CR19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-4017(00)00295-8","volume":"91","author":"MG Boy","year":"2000","unstructured":"Boy MG, Six RH, Thomas CA, Novotny MJ, Smothers CD, Rowan TG, et al. Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Vet Parasitol. 2000;91:233\u201350.","journal-title":"Vet Parasitol"},{"key":"1697_CR20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0304-4017(00)00296-X","volume":"91","author":"RG Clemence","year":"2000","unstructured":"Clemence RG, Sarasola P, Genchi C, Smith DG, Shanks DJ, Jernigan AD, Rowan TG. Efficacy of selamectin in the prevention of adult heartworm (Dirofilaria immitis) infection in dogs in northern Italy. Vet Parasitol. 2000;91:251\u20138.","journal-title":"Vet Parasitol"},{"key":"1697_CR21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1186\/s13071-015-1141-6","volume":"8","author":"NV Labarthe","year":"2015","unstructured":"Labarthe NV, Willi LM, Paiva JP, Miranda MG, Zoreck K, Almeida FM. Chemoprophylaxis of Dirofilaria immitis (Leidy 1856) infection at a high challenge environment. Parasit Vectors. 2015;8:523.","journal-title":"Parasit Vectors"},{"key":"1697_CR22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2307\/3274849","volume":"42","author":"WL Newton","year":"1956","unstructured":"Newton WL, Wright WH. The occurrence of a dog filariid other than Dirofilaria immitis in the United States. J Parasitol. 1956;42:246\u201358.","journal-title":"J Parasitol"},{"key":"1697_CR23","first-page":"16","volume-title":"Heartworms Today. Search for Solutions","author":"MT Long","year":"2013","unstructured":"Long MT, Beachboard SE, Wenzlow N, Stoop K, Walden HS. Comparison of five commercial antigen kits for detection of Dirofilaria immitis infections in necropsy-confirmed canines. In: Heartworms Today. Search for Solutions. New Orleans: Triennial Symposium, American Heartworm Society; 2013. p. 16\u20137."},{"key":"1697_CR24","unstructured":"IPP - Pereira Passos Institution. Sistema de Assentamentos de Baixa Renda, Rio de Janeiro 2007. Mapa das favelas cariocas. http:\/\/portalgeo.rio.rj.gov.br\/ . Accessed 2 December 2013."},{"key":"1697_CR25","unstructured":"Forattini OP, Gomes A, Santos JLF, Kakitani I, Marrucci D. Culicidologia M\u00e9dica. S\u00e3o Paulo. S\u00e3o Paulo: \u2018EDUSP; 2002."},{"key":"1697_CR26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1590\/S0034-89101990000200004","volume":"24","author":"OP Forattini","year":"1990","unstructured":"Forattini OP, Gomes Ade C, Santos JL, Kakitani I, Marucci D. Frequency in human environment and dispersion of Culicidae mosquitoes in an area adjacent to a primitive Atlantic plain forest. Rev Saude Publica. 1990;24:101\u20137.","journal-title":"Rev Saude Publica"},{"key":"1697_CR27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1590\/S0074-02762003000200005","volume":"98","author":"NA Honorio","year":"2003","unstructured":"Honorio NA, Silva Wda C, Leite PJ, Goncalves JM, Lounibos LP, Lourenco-de-Oliveira R. Dispersal of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in an urban endemic dengue area in the State of Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 2003;98:191\u20138.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"1697_CR28","unstructured":"IBGE, Brazilian Institute of Geography and Statistics. Censo demogr\u00e1fico 2010: aglomerados subnormais: informa\u00e7\u00f5es territoriais. http:\/\/bibliotecca.ibge.gov.br\/visualizacao\/periodicos\/552\/cd_2010_agsn_if.pdf . Accessed 21 January 2013."},{"key":"1697_CR29","unstructured":"Center for Disease Control and Prevention. Epi Info, 2010. http:\/\/www.cdc.gov\/epiinfo\/downloads.htm . Accessed 21 January 2013."},{"key":"1697_CR30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2460\/ajvr.1986.47.02.329","volume":"47","author":"RB Grieve","year":"1986","unstructured":"Grieve RB, Glickman LT, Bater AK, Mika-Grieve M, Thomas CB, Patronek GJ. Canine Dirofilaria immitis infection in a hyperenzootic area: examination by parasitologic findings at necropsy and by two serodiagnostic methods. Am J Vet Res. 1986;47:329\u201332.","journal-title":"Am J Vet Res"},{"key":"1697_CR31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1756-3305-5-138","volume":"5","author":"DD Bowman","year":"2012","unstructured":"Bowman DD. Heartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States. Parasit Vectors. 2012;5:138.","journal-title":"Parasit Vectors"},{"key":"1697_CR32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vetpar.2014.08.013","volume":"206","author":"CE Atkins","year":"2014","unstructured":"Atkins CE, Murray MJ, Olavessen LJ, Burton KW, Marshall JW, Brooks CC. Heartworm \u2018lack of effectiveness\u2019 claims in the Mississippi delta: computerized analysis of owner compliance--2004\u20132011. Vet Parasitol. 2014;206:106\u201313.","journal-title":"Vet Parasitol"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-016-1697-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:57:31Z","timestamp":1748995051000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-016-1697-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1697"],"URL":"https:\/\/doi.org\/10.1186\/s13071-016-1697-9","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,22]]},"article-number":"407"}}