{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:41:27Z","timestamp":1778715687642,"version":"3.51.4"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"National Key Basic Research Program (973 Program) of China","award":["2015CB150300"],"award-info":[{"award-number":["2015CB150300"]}]},{"name":"the Fundamental Research Funds for Central Research Institutes of Public Interests","award":["1610312017022"],"award-info":[{"award-number":["1610312017022"]}]},{"name":"the Fundamental Research Funds of Chinese Academy of Agricultural Sciences","award":["Y2016JC05"],"award-info":[{"award-number":["Y2016JC05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13071-017-1990-2","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T02:58:58Z","timestamp":1485917938000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica"],"prefix":"10.1186","volume":"10","author":[{"given":"Fu-Kai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany M.","family":"Elsheikha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-An","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Gang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-Jiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"1990_CR1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1051\/vetres:2002030","volume":"33","author":"C Mage","year":"2002","unstructured":"Mage C, Bourgne H, Toullieu JM, Rondelaud D, Dreyfuss G. Fasciola hepatica and Paramphistomum daubneyi: changes in prevalences of natural infections in cattle and in Lymnaea truncatula from central France over the past 12\u00a0years. Vet Res. 2002;33:439\u201347.","journal-title":"Vet Res"},{"key":"1990_CR2","first-page":"342","volume":"7","author":"JA Kuchai","year":"2011","unstructured":"Kuchai JA, Chishti MZ, Zaki MM, Rasool SAM, Ahmad J, Tak H. Some epidemiological aspects of fascioliasis among cattle of Ladakh. Global Vet. 2011;7:342\u201346.","journal-title":"Global Vet"},{"key":"1990_CR3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0169-4758(98)01245-9","volume":"14","author":"TW Spithill","year":"1998","unstructured":"Spithill TW, Dalton JP. Progress in development of liver fluke vaccines. Parasitol Today. 1998;14:224\u20138.","journal-title":"Parasitol Today"},{"key":"1990_CR4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.actatropica.2010.09.003","volume":"117","author":"TG Nguyen","year":"2011","unstructured":"Nguyen TG, Le TH, Dao TH, Tran TL, Praet N, Speybroeck N, et al. Bovine fasciolosis in the human fasciolosis hyperendemic Binh Dinh province in Central Vietnam. Acta Trop. 2011;117:19\u201322.","journal-title":"Acta Trop"},{"key":"1990_CR5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004962","volume":"10","author":"C Machicado","year":"2016","unstructured":"Machicado C, Machicado JD, Maco V, Terashima A, Marcos LA. Association of Fasciola hepatica infection with liver fibrosis, cirrhosis, and cancer: a systematic review. PLoS Negl Trop Dis. 2016;10, e0004962.","journal-title":"PLoS Negl Trop Dis"},{"key":"1990_CR6","volume":"8","author":"JX Chen","year":"2013","unstructured":"Chen JX, Chen MX, Ai L, Xu XN, Jiao JM, Zhu TJ, et al. An outbreak of human Fascioliasis gigantica in southwest China. PLoS One. 2013;8, e71520.","journal-title":"PLoS One"},{"key":"1990_CR7","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00436-006-0370-1","volume":"100","author":"K Inoue","year":"2007","unstructured":"Inoue K, Kanemasa H, Inoue K, Matsumoto M, Kajita Y, Mitsufuji S, et al. A case of human fasciolosis: discrepancy between egg size and genotype of Fasciola sp. Parasitol Res. 2007;100:665\u20137.","journal-title":"Parasitol Res"},{"key":"1990_CR8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.tmaid.2014.09.006","volume":"12","author":"K Ashrafi","year":"2014","unstructured":"Ashrafi K, Bargues MD, O'Neill S, Mas-Coma S. Fascioliasis: a worldwide parasitic disease of importance in travel medicine. Travel Med Infect Dis. 2014;12:636\u201349.","journal-title":"Travel Med Infect Dis"},{"key":"1990_CR9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0304-4017(99)00005-9","volume":"82","author":"SC Yadav","year":"1999","unstructured":"Yadav SC, Sharma RL, Kalicharan A, Mehra UR, Dass RS, Verma AK. Primary experimental infection of riverine buffaloes with Fasciola gigantica. Vet Parasitol. 1999;82:285\u201396.","journal-title":"Vet Parasitol"},{"key":"1990_CR10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/tvjl.1999.0377","volume":"158","author":"I Fairweather","year":"1999","unstructured":"Fairweather I, Boray JC. Fasciolicides: efficacy, actions, resistance and its management. Vet J. 1999;158:81\u2013112.","journal-title":"Vet J."},{"key":"1990_CR11","first-page":"283","volume":"61","author":"VM Venturina","year":"2015","unstructured":"Venturina VM, Alejandro MA, Baltazar CP, Abes NS, Mingala CN. Evidence of Fasciola spp. resistance to albendazole, triclabendazole and bromofenofos in water buffaloes (Bubalus bubalis). Ann Parasitol. 2015;61:283\u20139.","journal-title":"Ann Parasitol"},{"key":"1990_CR12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0378-8741(00)00172-0","volume":"71","author":"WS Koko","year":"2000","unstructured":"Koko WS, Galal M, Khalid HS. Fasciolicidal efficacy of Albizia anthelmintica and Balanites aegyptiaca compared with albendazole. J Ethnopharmacol. 2000;71:247\u201352.","journal-title":"J Ethnopharmacol"},{"key":"1990_CR13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exppara.2013.06.016","volume":"135","author":"E Hossain","year":"2013","unstructured":"Hossain E, Chandra G, Nandy AP, Gupta JK, Mandal SC. Possible fasciocidal activity of methanol extract of Dregea volubilis leaves. Exp Parasitol. 2013;135:183\u20137.","journal-title":"Exp Parasitol"},{"key":"1990_CR14","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.4269\/ajtmh.1985.34.1127","volume":"34","author":"GV Hillyer","year":"1985","unstructured":"Hillyer GV. Induction of immunity in mice to Fasciola hepatica with a Fasciola\/Schistosoma cross-reactive defined immunity antigen. Am J Trop Med Hyg. 1985;34:1127\u201331.","journal-title":"Am J Trop Med Hyg"},{"key":"1990_CR15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0304-4017(96)01131-4","volume":"69","author":"A Muro","year":"1997","unstructured":"Muro A, Ramajo V, Lopez J, Simon F, Hillyer GV. Fasciola hepatica: vaccination of rabbits with native and recombinant antigens related to fatty acid binding proteins. Vet Parasitol. 1997;69:219\u201329.","journal-title":"Vet Parasitol"},{"key":"1990_CR16","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.4049\/jimmunol.145.11.3905","volume":"145","author":"JL Sexton","year":"1990","unstructured":"Sexton JL, Milner AR, Panaccio M, Waddington J, Wijffels G, Chandler D, et al. Glutathione S-transferase. Novel vaccine against Fasciola hepatica infection in sheep. J Immunol. 1990;145:3905\u201310.","journal-title":"J Immunol"},{"key":"1990_CR17","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.4049\/jimmunol.152.4.1861","volume":"152","author":"JL Sexton","year":"1994","unstructured":"Sexton JL, Wilce MC, Colin T, Wijffels GL, Salvatore L, Feil S, et al. Vaccination of sheep against Fasciola hepatica with glutathione S-transferase. Identification and mapping of antibody epitopes on a three-dimensional model of the antigen. J Immunol. 1994;152:1861\u201372.","journal-title":"J Immunol"},{"key":"1990_CR18","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1016\/j.vaccine.2010.01.055","volume":"28","author":"RE Mendes","year":"2010","unstructured":"Mendes RE, Perez-Ecija RA, Zafra R, Buffoni L, Martinez-Moreno A, Dalton JP, et al. Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica. Vaccine. 2010;28:2832\u201340.","journal-title":"Vaccine"},{"key":"1990_CR19","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0264-410X(96)00147-8","volume":"14","author":"CA Morrison","year":"1996","unstructured":"Morrison CA, Colin T, Sexton JL, Bowen F, Wicker J, Friedel T, et al. Protection of cattle against Fasciola hepatica infection by vaccination with glutathione S-transferase. Vaccine. 1996;14:1603\u201312.","journal-title":"Vaccine"},{"key":"1990_CR20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.vetpar.2008.01.023","volume":"153","author":"J Lopez-Aban","year":"2008","unstructured":"Lopez-Aban J, Nogal-Ruiz JJ, Vicente B, Morrondo P, Diez-Banos P, Hillyer GV, et al. The addition of a new immunomodulator with the adjuvant adaptation ADAD system using fatty acid binding proteins increases the protection against Fasciola hepatica. Vet Parasitol. 2008;153:176\u201381.","journal-title":"Vet Parasitol"},{"key":"1990_CR21","volume":"10","author":"Y Fu","year":"2016","unstructured":"Fu Y, Chryssafidis AL, Browne JA, O'Sullivan J, McGettigan PA, Mulcahy G. Transcriptomic study on ovine immune responses to Fasciola hepatica infection. PLoS Negl Trop Dis. 2016;10, e0005015.","journal-title":"PLoS Negl Trop Dis"},{"key":"1990_CR22","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.ijpara.2008.05.008","volume":"38","author":"R Flynn","year":"2008","unstructured":"Flynn R, Mulcahy G. The roles of IL-10 and TGF-beta in controlling IL-4 and IFN-gamma production during experimental Fasciola hepatica infection. Int J Parasitol. 2008;38:1673\u201380.","journal-title":"Int J Parasitol"},{"key":"1990_CR23","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4049\/jimmunol.0803803","volume":"183","author":"KP Walsh","year":"2009","unstructured":"Walsh KP, Brady MT, Finlay CM, Boon L, Mills KH. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol. 2009;183:1577\u201386.","journal-title":"J Immunol"},{"key":"1990_CR24","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1128\/IAI.00919-08","volume":"6","author":"C Hamilton","year":"2009","unstructured":"Hamilton C, Dowling D, Loscher C, Morphew R, Brophy P, O'Neill S. Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function. Infect Immun. 2009;6:2488\u201398.","journal-title":"Infect Immun"},{"issue":"12","key":"1990_CR25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004234","volume":"9","author":"E Rodr\u00edguez","year":"2015","unstructured":"Rodr\u00edguez E, Noya V, Cervi L, Chiribao ML, Brossard N, Chiale C, et al. Glycans from Fasciola hepatica modulate the host immune response and TLR-induced maturation of dendritic cells. PLoS Negl Trop Dis. 2015;9(12), e0004234.","journal-title":"PLoS Negl Trop Dis"},{"key":"1990_CR26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4142\/jvs.2005.6.2.135","volume":"6","author":"EC Molina","year":"2005","unstructured":"Molina EC. Serum interferon-gamma and interleukins-6 and -8 during infection with Fasciola gigantica in cattle and buffaloes. J Vet Sci. 2005;6:135\u20139.","journal-title":"J Vet Sci"},{"issue":"1","key":"1990_CR27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.exppara.2013.06.010","volume":"135","author":"P Chantree","year":"2013","unstructured":"Chantree P, Phatsara M, Meemon K, Chaichanasak P, Changklungmoa N, Kueakhai P, et al. Vaccine potential of recombinant cathepsin B against Fasciola gigantica. Exp Parasitol. 2013;135(1):102\u20139.","journal-title":"Exp Parasitol"},{"key":"1990_CR28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13071-015-0715-7","volume":"8","author":"CA Alvarez Rojas","year":"2015","unstructured":"Alvarez Rojas CA, Ansell BR, Hall RS, Gasser RB, Young ND, Jex AR, et al. Transcriptional analysis identifies key genes involved in metabolism, fibrosis\/tissue repair and the immune response against Fasciola hepatica in sheep liver. Parasit Vectors. 2015;8:124.","journal-title":"Parasit Vectors"},{"key":"1990_CR29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159194","volume":"11","author":"CA Alvarez Rojas","year":"2016","unstructured":"Alvarez Rojas CA, Scheerlinck JP, Ansell BR, Hall RS, Gasser RB, Jex AR. Time-course study of the transcriptome of peripheral blood mononuclear cells (PBMCs) from sheep infected with Fasciola hepatica. PLoS One. 2016;11, e0159194.","journal-title":"PLoS One"},{"key":"1990_CR30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12864-015-1539-8","volume":"16","author":"O Hacariz","year":"2015","unstructured":"Hacariz O, Akgun M, Kavak P, Yuksel B, Sagiroglu MS. Comparative transcriptome profiling approach to glean virulence and immunomodulation-related genes of Fasciola hepatica. BMC Genomics. 2015;16:366.","journal-title":"BMC Genomics"},{"key":"1990_CR31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetpar.2005.04.028","volume":"131","author":"EC Molina","year":"2005","unstructured":"Molina EC, Skerratt LF. Cellular and humoral responses in liver of cattle and buffaloes infected with a single dose of Fasciola gigantica. Vet Parasitol. 2005;131:157\u201363.","journal-title":"Vet Parasitol"},{"key":"1990_CR32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11250-005-4301-4","volume":"37","author":"EC Molina","year":"2005","unstructured":"Molina EC, Gonzaga EA, Sinolinding EO, Lumbao LA, Peralta AA, Barraca AP. Differences in susceptibility between cattle and swamp buffaloes to infection with Fasciola gigantica. Trop Anim Health Prod. 2005;37:611\u20136.","journal-title":"Trop Anim Health Prod"},{"key":"1990_CR33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3347\/kjp.2015.53.1.59","volume":"53","author":"A Phalee","year":"2015","unstructured":"Phalee A, Wongsawad C, Rojanapaibul A, Chai JY. Experimental life history and biological characteristics of Fasciola gigantica (Digenea: Fasciolidae). Korean J Parasitol. 2015;53:59\u201364.","journal-title":"Korean J Parasitol"},{"key":"1990_CR34","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0020-7519(95)00039-5","volume":"25","author":"A Chauvin","year":"1995","unstructured":"Chauvin A, Bouvet G, Boulard C. Humoral and cellular immune responses to Fasciola hepatica experimental primary and secondary infection in sheep. Int J Parasitol. 1995;25:1227\u201341.","journal-title":"Int J Parasitol"},{"key":"1990_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000366100","volume":"165","author":"S Sipka","year":"2014","unstructured":"Sipka S, Bruckner G. The immunomodulatory role of bile acids. Int Arch Allergy Immunol. 2014;165:1\u20138.","journal-title":"Int Arch Allergy Immunol"},{"key":"1990_CR36","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25:1105\u201311.","journal-title":"Bioinformatics"},{"key":"1990_CR37","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol. 2010;11:R106.","journal-title":"Genome Biol"},{"key":"1990_CR38","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","volume":"11","author":"MD Young","year":"2010","unstructured":"Young MD, Wakefield MJ, Smyth GK, Oshlack A. Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol. 2010;11:R14.","journal-title":"Genome Biol"},{"key":"1990_CR39","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","volume":"36","author":"M Kanehisa","year":"2008","unstructured":"Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, et al. KEGG for linking genomes to life and the environment. Nucleic Acids Res. 2008;36:D480\u20134.","journal-title":"Nucleic Acids Res"},{"key":"1990_CR40","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","volume":"21","author":"X Mao","year":"2005","unstructured":"Mao X, Cai T, Olyarchuk JG, Wei L. Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics. 2005;21:3787\u201393.","journal-title":"Bioinformatics"},{"key":"1990_CR41","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1128\/IAI.01445-06","volume":"75","author":"RJ Flynn","year":"2007","unstructured":"Flynn RJ, Mannion C, Golden O, Hacariz O, Mulcahy G. Experimental Fasciola hepatica infection alters responses to tests used for diagnosis of bovine tuberculosis. Infect Immun. 2007;75:1373\u201381.","journal-title":"Infect Immun"},{"key":"1990_CR42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.vetpar.2016.07.009","volume":"226","author":"N Changklungmoa","year":"2016","unstructured":"Changklungmoa N, Phoinok N, Yencham C, Sobhon P, Kueakhai P. Vaccine potential of recombinant cathepsinL1G against Fasciola gigantica in mice. Vet Parasitol. 2016;226:124\u201331.","journal-title":"Vet Parasitol"},{"key":"1990_CR43","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1007\/s00436-013-3540-y","volume":"112","author":"N Kumar","year":"2013","unstructured":"Kumar N, Raina OK, Nagar G, Prakash V, Jacob SS. Th1 and Th2 cytokine gene expression in primary infection and vaccination against Fasciola gigantica in buffaloes by real-time PCR. Parasitol Res. 2013;112:3561\u20138.","journal-title":"Parasitol Res"},{"key":"1990_CR44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00436-011-2507-0","volume":"110","author":"N Kumar","year":"2012","unstructured":"Kumar N, Anju V, Gaurav N, Chandra D, Samanta S, Gupta SC, et al. Vaccination of buffaloes with Fasciola gigantica recombinant glutathione S-transferase and fatty acid binding protein. Parasitol Res. 2012;110:419\u201326.","journal-title":"Parasitol Res"},{"key":"1990_CR45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.vetpar.2010.02.015","volume":"169","author":"RJ Flynn","year":"2010","unstructured":"Flynn RJ, Mulcahy G, Elsheikha HM. Coordinating innate and adaptive immunity in Fasciola hepatica infection: implications for control. Vet Parasitol. 2010;169:235\u201340.","journal-title":"Vet Parasitol"},{"key":"1990_CR46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri2368","volume":"8","author":"JM Vyas","year":"2008","unstructured":"Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008;8:607\u201318.","journal-title":"Nat Rev Immunol"},{"key":"1990_CR47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000163569","volume":"58","author":"G Ramadori","year":"1990","unstructured":"Ramadori G, Buschenfelde KH M z, Tobias PS, Mathison JC, Ulevitch RJ. Biosynthesis of lipopolysaccharide-binding protein in rabbit hepatocytes. Pathobiology. 1990;58:89\u201394.","journal-title":"Pathobiology"},{"key":"1990_CR48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1179\/096805104225006273","volume":"10","author":"RW Finberg","year":"2004","unstructured":"Finberg RW, Re F, Popova L, Golenbock DT, Kurt-Jones EA. Cell activation by Toll-like receptors: role of LBP and CD14. J Endotoxin Res. 2004;10:413\u20138.","journal-title":"J Endotoxin Res"},{"key":"1990_CR49","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.4049\/jimmunol.1401182","volume":"194","author":"I Martin","year":"2015","unstructured":"Martin I, Caban-Hernandez K, Figueroa-Santiago O, Espino AM. Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo. J Immunol. 2015;194:3924\u201336.","journal-title":"J Immunol"},{"key":"1990_CR50","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1128\/IAI.67.10.5372-5378.1999","volume":"67","author":"MT Brady","year":"1999","unstructured":"Brady MT, O'Neill SM, Dalton JP, Mills KHG. Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis. Infect Immun. 1999;67:5372\u20138.","journal-title":"Infect Immun"},{"key":"1990_CR51","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0264-410X(97)00289-2","volume":"16","author":"G Mulcahy","year":"1998","unstructured":"Mulcahy G, O'Connor F, McGonigle S, Dowd A, Clery DG, Andrews SJ, Dalton JP. Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica. Vaccine. 1998;16:932\u20139.","journal-title":"Vaccine"},{"key":"1990_CR52","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0065-2776(08)60623-9","volume":"58","author":"BA Imhof","year":"1995","unstructured":"Imhof BA, Dunon D. Leukocyte migration and adhesion. Adv Immunol. 1995;58:345\u2013416.","journal-title":"Adv Immunol"},{"key":"1990_CR53","doi-asserted-by":"crossref","first-page":"S460","DOI":"10.1067\/mai.2003.108","volume":"111","author":"LC Borish","year":"2003","unstructured":"Borish LC, Steinke JW. 2. Cytokines and chemokines. J Allergy Clin Immunol. 2003;111:S460\u201375.","journal-title":"J Allergy Clin Immunol"},{"key":"1990_CR54","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1128\/IAI.71.4.1643-1649.2003","volume":"71","author":"GB Mitchell","year":"2003","unstructured":"Mitchell GB, Albright BN, Caswell JL. Effect of interleukin-8 and granulocyte colony-stimulating factor on priming and activation of bovine neutrophils. Infect Immun. 2003;71:1643\u20139.","journal-title":"Infect Immun"},{"key":"1990_CR55","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/icb.1995.38","volume":"73","author":"E Reali","year":"1995","unstructured":"Reali E, Spisani S, Gavioli R, Lanza F, Moretti S, Traniello S. IL-8 enhances antibody-dependent cellular cytotoxicity in human neutrophils. Immunol Cell Biol. 1995;73:234\u20138.","journal-title":"Immunol Cell Biol"},{"issue":"10","key":"1990_CR56","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","volume":"2","author":"C Bogdan","year":"2001","unstructured":"Bogdan C. Nitric oxide and the immune response. Nat Immunol. 2001;2(10):907\u201316.","journal-title":"Nat Immunol"},{"key":"1990_CR57","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1128\/IAI.02541-14","volume":"82","author":"O Figueroa-Santiago","year":"2014","unstructured":"Figueroa-Santiago O, Espino AM. Fasciola hepatica fatty acid binding protein induces the alternative activation of human macrophages. Infect Immun. 2014;82:5005\u201312.","journal-title":"Infect Immun"},{"issue":"9","key":"1990_CR58","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1365-3024.2001.00404.x","volume":"23","author":"D Piedrafita","year":"2001","unstructured":"Piedrafita D, Parsons JC, Sandeman RM, Wood PR, Estuningsih SE, Partoutomo S, et al. Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates. Parasite Immunol. 2001;23(9):473\u201382.","journal-title":"Parasite Immunol"},{"key":"1990_CR59","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.4049\/jimmunol.1103246","volume":"188","author":"MA Kroenke","year":"2012","unstructured":"Kroenke MA, Eto D, Locci M, Cho M, Davidson T, Haddad EK, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 2012;188:3734\u201344.","journal-title":"J Immunol"},{"key":"1990_CR60","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.1300675","volume":"192","author":"S Nakayamada","year":"2014","unstructured":"Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, et al. Type I Interferon induces binding of STAT1 to Bcl6: Divergent Roles of STAT-family transcription factors in the TFH cell genetic program. J Immunol. 2014;192:2156\u201366.","journal-title":"J Immunol"},{"key":"1990_CR61","volume":"6","author":"D Eto","year":"2011","unstructured":"Eto D, Lao C, DiToro D, Barnett B, Escobar TC, Kageyama R, et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One. 2011;6, e17739.","journal-title":"PLoS One"},{"key":"1990_CR62","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","volume":"192","author":"D Breitfeld","year":"2000","unstructured":"Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med. 2000;192:1545\u201352.","journal-title":"J Exp Med"},{"key":"1990_CR63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.tibs.2015.03.012","volume":"40","author":"MJ Macias","year":"2015","unstructured":"Macias MJ, Martin-Malpartida P, Massague J. Structural determinants of SMAD function in TGF-\u03b2 signaling. Trends Biochem Sci. 2015;40:296\u2013308.","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"1990_CR64","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-3024.2009.01135.x","volume":"31","author":"O Hacariz","year":"2009","unstructured":"Hacariz O, Sayers G, Flynn RJ, Lejeune A, Mulcahy G. IL-10 and TGF-beta1 are associated with variations in fluke burdens following experimental fasciolosis in sheep. Parasite immunol. 2009;31(10):613\u201322.","journal-title":"Parasite immunol"},{"key":"1990_CR65","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jcp.24488","volume":"229","author":"ZY Ding","year":"2014","unstructured":"Ding ZY, Liang HF, Jin GN, Chen WX, Wang W, Datta PK, et al. Smad6 suppresses the growth and self-renewal of hepatic progenitor cells. J Cell Physiol. 2014;229:651\u201360.","journal-title":"J Cell Physiol"},{"key":"1990_CR66","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","volume":"138","author":"UM Zanger","year":"2013","unstructured":"Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138:103\u201341.","journal-title":"Pharmacol Ther"},{"key":"1990_CR67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0034-5288(91)90056-T","volume":"50","author":"AE Tufenkji","year":"1991","unstructured":"Tufenkji AE, Alvinerie M, Larrieu G, Houin G, Galtier P. Pharmacokinetics of ampicillin and pentobarbital in the course of subclinical fascioliasis in sheep. Res Vet Sci. 1991;50:75\u201380.","journal-title":"Res Vet Sci"},{"key":"1990_CR68","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1365-2885.2001.00341.x","volume":"24","author":"M Giorgi","year":"2001","unstructured":"Giorgi M, Salvatori AP, Soldani G, Giusiani M, Longo V, Gervasi PG, et al. Pharmacokinetics and microsomal oxidation of praziquantel and its effects on the P450 system in three-month-old lambs infested by Fasciola hepatica. J Vet Pharmacol Ther. 2001;24:251\u20139.","journal-title":"J Vet Pharmacol Ther"},{"key":"1990_CR69","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/expr.1994.1042","volume":"78","author":"P Lopez","year":"1994","unstructured":"Lopez P, Gonzalez P, Tunon MJ, Gonzalez-Gallego J. The effects of experimental fasciolosis on bilirubin metabolism in the rat. Exp Parasitol. 1994;78:386\u201393.","journal-title":"Exp Parasitol"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-017-1990-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:49:12Z","timestamp":1692665352000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-017-1990-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1990"],"URL":"https:\/\/doi.org\/10.1186\/s13071-017-1990-2","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,1]]},"article-number":"56"}}