{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:22:07Z","timestamp":1769520127801,"version":"3.49.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#31472058"],"award-info":[{"award-number":["#31472058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13071-017-2009-8","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T05:11:30Z","timestamp":1487221890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Recombinant \u03b1-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis"],"prefix":"10.1186","volume":"10","author":[{"given":"Yi-Ting","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petrus","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Hide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Hua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Rong","family":"Lun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"2009_CR1","first-page":"2012","volume-title":"Global incidence and prevalence of selected curable sexually transmitted infections","author":"World Health Organization","year":"2008","unstructured":"World Health Organization. Global incidence and prevalence of selected curable sexually transmitted infections. Geneva: WHO; 2008. p. 2012."},{"key":"2009_CR2","volume-title":"Prevalence and incidence of selected sexually transmitted infections. Methods and results used by WHO to generate 2005 estimates","author":"World Health Organization","year":"2011","unstructured":"World Health Organization. Prevalence and incidence of selected sexually transmitted infections. Methods and results used by WHO to generate 2005 estimates. Geneva: WHO; 2011."},{"key":"2009_CR3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/JCM.30.2.465-472.1992","volume":"30","author":"DE Riley","year":"1992","unstructured":"Riley DE, Roberts MC, Takayama T, Krieger JN. Development of a polymerase chain reaction-based diagnosis of Trichomonas vaginalis. J Clin Microbiol. 1992;30:465\u201372.","journal-title":"J Clin Microbiol"},{"key":"2009_CR4","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1128\/JCM.37.12.4127-4130.1999","volume":"37","author":"C Schee van Der","year":"1999","unstructured":"van Der Schee C, van Belkum A, Zwijgers L, van Der Brugge E, O\u2019Neill EL, Luijendijk A, et al. Improved diagnosis of Trichomonas vaginalis infection by PCR using vaginal swabs and urine specimens compared to diagnosis by wet mount microscopy, culture, and fluorescent staining. J Clin Microbiol. 1999;37:4127\u201330.","journal-title":"J Clin Microbiol"},{"key":"2009_CR5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1128\/JCM.35.1.132-138.1997","volume":"35","author":"MF Shaio","year":"1997","unstructured":"Shaio MF, Lin PR, Liu JY. Colorimetric one-tube nested PCR for detection of Trichomonas vaginalis in vaginal discharge. J Clin Microbiol. 1997;35:132\u20138.","journal-title":"J Clin Microbiol"},{"key":"2009_CR6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00003081-199303000-00019","volume":"36","author":"P Heine","year":"1993","unstructured":"Heine P, Macgregor JA. Trichomonas vaginalis: a re-emerging pathogen. Clin Obstet Gynecol. 1993;36:137\u201344.","journal-title":"Clin Obstet Gynecol"},{"key":"2009_CR7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/CMR.17.4.783-793.2004","volume":"17","author":"SL Cudmore","year":"2004","unstructured":"Cudmore SL, Delgaty KL, Hayward-McClelland SF, Petrin DP, Garber GE. Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis. Clin Microbiol Rev. 2004;17:783\u201393.","journal-title":"Clin Microbiol Rev"},{"key":"2009_CR8","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.clinbiochem.2014.02.008","volume":"47","author":"R Bardan","year":"2014","unstructured":"Bardan R, Dumache R, Dema A, Cumpanasa A, Bucurasa V. The role of prostatic inflammation biomarkers in the diagnosis of prostate diseases. Clin Biochem. 2014;47:909\u201315.","journal-title":"Clin Biochem"},{"key":"2009_CR9","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/1055-9965.EPI-05-0781","volume":"15","author":"S Sutcliffe","year":"2006","unstructured":"Sutcliffe S, Giovannucci E, Alderete JF, Chang TH, Gaydos CA, Zenilman JM, et al. Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:939\u201345.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2009_CR10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0897.2010.00902.x","volume":"65","author":"AR Thurman","year":"2011","unstructured":"Thurman AR, Doncel GF. Innate immunity and inflammatory response to Trichomonas vaginalis and bacterial vaginosis: relationship to HIV acquisition. Am J Reprod Immunol. 2011;65:89\u201398.","journal-title":"Am J Reprod Immunol"},{"key":"2009_CR11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00007435-199703000-00001","volume":"24","author":"B Jacobs","year":"1997","unstructured":"Jacobs B, Mayaud P, Changalucha J, Todd J, Ka-Gina G, Grosskurth H, et al. Sexual transmission of hepatitis B in Mwanza, Tanzania. Sex Transm Dis. 1997;24:121\u20136.","journal-title":"Sex Transm Dis"},{"key":"2009_CR12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00436-012-2848-3","volume":"111","author":"MY Afzan","year":"2012","unstructured":"Afzan MY, Suresh K. Pseudocyst forms of Trichomonas vaginalis from cervical neoplasia. Parasitol Res. 2012;111:371\u201381.","journal-title":"Parasitol Res"},{"key":"2009_CR13","first-page":"629","volume":"37","author":"TH Connor","year":"1977","unstructured":"Connor TH, Stoeckel M, Evrard J, Legator MS. The contribution of metronidazole and two metabolites to the mutagenic activity detected in urine of treated humans and mice. Cancer Res. 1977;37:629\u201333.","journal-title":"Cancer Res"},{"key":"2009_CR14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1128\/AAC.10.3.476","volume":"10","author":"DG Lindmark","year":"1976","unstructured":"Lindmark DG, M\u00fcller M. Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles. Antimicrob Agents Chemother. 1976;10:476\u201382.","journal-title":"Antimicrob Agents Chemother"},{"key":"2009_CR15","first-page":"13","volume":"7","author":"E Aburel","year":"1963","unstructured":"Aburel E, Zervos G, Titea V, Pana S. Immunological and therapeutic investigations into vaginal trichomoniasis. Rom Med Rev. 1963;7:13\u20139.","journal-title":"Rom Med Rev"},{"key":"2009_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jiph.2010.01.003","volume":"3","author":"SL Cudmore","year":"2010","unstructured":"Cudmore SL, Garber GE. Prevention or treatment: the benefits of Trichomonas vaginalis vaccine. J Infect Public Health. 2010;3:47\u201353.","journal-title":"J Infect Public Health"},{"key":"2009_CR17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/infdis\/jiv036","volume":"212","author":"JD Smith","year":"2015","unstructured":"Smith JD, Garber GE. Trichomonas vaginalis infection induces vaginal CD4+ T-Cell infiltration in a mouse model: A vaccine strategy to reduce vaginal infection and HIV transmission. J Infect Dis. 2015;212:285\u201393.","journal-title":"J Infect Dis"},{"key":"2009_CR18","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/IAI.64.9.3571-3575.1996","volume":"64","author":"MC Abraham","year":"1996","unstructured":"Abraham MC, Desjardins M, Filion LG, Garber GE. Inducible immunity to Trichomonas vaginalis in a mouse model of vaginal infection. Infect Immun. 1996;64:3571\u20135.","journal-title":"Infect Immun"},{"key":"2009_CR19","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez HM, Figueredo M, Garrido N, S\u00e1nchez L, Sarracent J. Intranasal immunisation with a 62 kDa proteinase combined with cholera toxin or CpG adjuvant protects against Trichomonas vaginalis genital tract infections in mice. Int J Parasitol. 2005;35:1333\u20137.","DOI":"10.1016\/j.ijpara.2005.08.010"},{"key":"2009_CR20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.1132894","volume":"315","author":"JM Carlton","year":"2007","unstructured":"Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, et al. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007;315:207\u201312.","journal-title":"Science"},{"key":"2009_CR21","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1128\/IAI.66.10.4924-4931.1998","volume":"66","author":"MF Addis","year":"1998","unstructured":"Addis MF, Rappelli P, Delogu G, Carta F, Cappuccinelli P, Fiori PL. Cloning and molecular characterization of a cDNA clone coding for Trichomonas vaginalis alpha-actinin and intracellular localization of the protein. Infect Immun. 1998;66:4924\u201331.","journal-title":"Infect Immun"},{"key":"2009_CR22","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.micinf.2012.09.004","volume":"14","author":"EE Figueroa-Angulo","year":"2012","unstructured":"Figueroa-Angulo EE, Rend\u00f3n-Gandarilla FJ, Puente-Rivera J, Calla-Choquea JS, C\u00e1rdenas-Guerrab RE, Ortega-L\u00f3pezb J, et al. The effects of environmental factors on the virulence of Trichomonas vaginalis. Microbes Infect. 2012;14:1411\u201327.","journal-title":"Microbes Infect"},{"key":"2009_CR23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/BC20060084","volume":"99","author":"A Pereira-Neves","year":"2007","unstructured":"Pereira-Neves A, Benchimol M. Phagocytosis by Trichomonas vaginalis: new insights. Biol Cell. 2007;99:87\u2013101.","journal-title":"Biol Cell"},{"key":"2009_CR24","doi-asserted-by":"crossref","unstructured":"Addis MF, Rappelli P, de Andrade Amp P, Rita FM, Colombo MM, Cappuccinelli P, et al. Identification of Trichomonas vaginalis \u03b1-actinin as the most common immunogen recognized by sera of women exposed to the parasite. J Infect Dis. 1999;180:1727\u201330.","DOI":"10.1086\/315095"},{"key":"2009_CR25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/IAI.51.1.250-253.1986","volume":"51","author":"GE Garber","year":"1986","unstructured":"Garber GE, Proctor EM, Bowie WR. Immunogenic proteins of Trichomonas vaginalis as demonstrated by the immunoblot technique. Infect Immun. 1986;51:253\u201363.","journal-title":"Infect Immun"},{"key":"2009_CR26","doi-asserted-by":"crossref","unstructured":"Yadava A, Sattabongkot J, Washington MA, Ware LA, Majam V, Zheng H, et al. A novel chimeric Plasmodium vivax circumsporozoite protein induces biologically functional antibodies that recognize both VK210 and VK247 sporozoites. Infect Immun. 2007;75:1177\u201385.","DOI":"10.1128\/IAI.01667-06"},{"key":"2009_CR27","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/j.vaccine.2013.05.082","volume":"31","author":"N C\u00e9spedes","year":"2013","unstructured":"C\u00e9spedes N, Ar\u00e9valo-Herrera M, Felger I, Reed S, Kajava AV, Corradin G, et al. Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the P. vivax circumsporozoite protein. Vaccine. 2013;31:4923\u201330.","journal-title":"Vaccine"},{"key":"2009_CR28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00436-006-0215-y","volume":"100","author":"JC Xiao","year":"2006","unstructured":"Xiao JC, Xie LF, Fang SL, Gao MY, Zhu Y, Song LY, et al. Symbiosis of Mycoplasma hominis in Trichomonas vaginalis may link metronidazole resistance in vitro. Parasitol Res. 2006;100:123\u201330.","journal-title":"Parasitol Res"},{"key":"2009_CR29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2307\/3274682","volume":"43","author":"LS Diamond","year":"1957","unstructured":"Diamond LS. The establishment of various trichomonads of animals and man in axenic cultures. J Parasitol. 1957;43:488\u201390.","journal-title":"J Parasitol"},{"key":"2009_CR30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/abbs\/gmq033","volume":"42","author":"Z Wang","year":"2010","unstructured":"Wang Z, Feng S, Huang Y, Qiao M, Zhang B, Xu H. Prokaryotic expression, purification, and polyclonal antibody production of a hydrophobin from Grifola frondosa. Acta Biochim Biophys Sin. 2010;42:388\u201395.","journal-title":"Acta Biochim Biophys Sin"},{"key":"2009_CR31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1084\/jem.178.3.1041","volume":"178","author":"A D\u2019Andrea","year":"1993","unstructured":"D\u2019Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor\/IL-12 synthesis in accessory cells. J Exp Med. 1993;178:1041\u20138.","journal-title":"J Exp Med"},{"key":"2009_CR32","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1586\/14760584.2015.1074043","volume":"14","author":"P Riese","year":"2015","unstructured":"Riese P, Trittel S, Schulze K, Guzm\u00e1na CA. Rodents as pre-clinical models for predicting vaccine performance in humans. Expert Rev Vaccines. 2015;14:1213\u201325.","journal-title":"Expert Rev Vaccines"},{"key":"2009_CR33","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/jnci\/djp306","volume":"101","author":"JR Stark","year":"2009","unstructured":"Stark JR, Judson G, Alderete JF, Mundodi V, Kucknoor AS, Giovannucci EL, et al. Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians\u2019 Health Study. J Natl Cancer Inst. 2009;101:1406\u201311.","journal-title":"J Natl Cancer Inst"},{"key":"2009_CR34","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1128\/JCM.00582-13","volume":"51","author":"CJ Neace","year":"2013","unstructured":"Neace CJ, Alderete JF. Epitopes of the highly immunogenic Trichomonas vaginalis \u03b1-actinin are serodiagnostic targets for both women and men. J Clin Microbiol. 2013;51:2483\u201390.","journal-title":"J Clin Microbiol"},{"key":"2009_CR35","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/AAC.15.2.254","volume":"15","author":"JG Meingassner","year":"1979","unstructured":"Meingassner JG, Thurner J. Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles. Antimicrob Agents Chemother. 1979;15:254\u20137.","journal-title":"Antimicrob Agents Chemother"},{"key":"2009_CR36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/978-1-4612-3224-7_8","volume-title":"Trichomonads Parasitic in Humans","author":"J Kulda","year":"1990","unstructured":"Kulda J. Employment of experimental animals in studies of Trichomonas vaginalis infection. In: Honigberg BM, editor. Trichomonads Parasitic in Humans. New York: Springer; 1990. p. 112\u201354."},{"key":"2009_CR37","first-page":"179","volume":"35","author":"TL Hammond","year":"1990","unstructured":"Hammond TL, Hankins GD, Snyder RR. Transvaginal-peritoneal migration of Trichomonas vaginalis as a cause of ascites. A report of two cases. J Reprod Med. 1990;35:179\u201381.","journal-title":"J Reprod Med"},{"key":"2009_CR38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/978-1-4612-3224-7_19","volume-title":"Trichomonads Parasitic in Humans","author":"BM Honigberg","year":"1990","unstructured":"Honigberg BM. Trichomonads found outside the urogenital tract of humans. In: Honigberg BM, editor. Trichomonads Parasitic in Humans. New York: Springer; 1990. p. 342\u201393."},{"key":"2009_CR39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0141-9838.2004.00690.x","volume":"26","author":"H Hern\u00e1ndez","year":"2004","unstructured":"Hern\u00e1ndez H, Sariego I, Garber G, Delgado R, L\u00f3pez O, Sarracent J. Monoclonal antibodies against a 62kDa proteinase of Trichomonas vaginalis decrease parasite cytoadherence to epithelial cells and confer protection in mice. Parasite Immunol. 2004;26:119\u201325.","journal-title":"Parasite Immunol"},{"key":"2009_CR40","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/IAI.60.6.2375-2379.1992","volume":"60","author":"T Mcgrory","year":"1992","unstructured":"Mcgrory T, Garber GE. Mouse intravaginal infection with Trichomonas vaginalis and role of Lactobacillus acidophilus in sustaining infection. Infect Immun. 1992;60:2375\u20139.","journal-title":"Infect Immun"},{"key":"2009_CR41","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/JCM.24.5.790-795.1986","volume":"24","author":"SM Wos","year":"1986","unstructured":"Wos SM, Watt RM. Immunoglobulin isotypes of anti-Trichomonas vaginalis antibodies in patients with vaginal trichomoniasis. J Clin Microbiol. 1986;24:790\u20135.","journal-title":"J Clin Microbiol"},{"key":"2009_CR42","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1128\/JCM.21.4.588-592.1985","volume":"21","author":"M Cogne","year":"1985","unstructured":"Cogne M, Brasseur P, Ballet JJ. Detection and characterization of serum antitrichomonal antibodies in urogenital trichomoniasis. J Clin Microbiol. 1985;21:588\u201392.","journal-title":"J Clin Microbiol"},{"key":"2009_CR43","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s004360100396","volume":"88","author":"M Paintlia","year":"2002","unstructured":"Paintlia M, Kaur S, Gupta I, Ganguly N, Mahajan R, Malla N. Specific IgA response, T cell subtype and cytokine profile in experimental intravaginal trichomoniasis. Parasitol Res. 2002;88:338\u201343.","journal-title":"Parasitol Res"},{"key":"2009_CR44","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3347\/kjp.1991.29.4.381","volume":"29","author":"K Yoon","year":"1991","unstructured":"Yoon K, Ryu JS, Min DY. Cytotoxicity of lymphokine activated peritoneal macrophages against Trichomonas vaginalis. Korean J Parasitol. 1991;29:381\u20133.","journal-title":"Korean J Parasitol"},{"key":"2009_CR45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3347\/kjp.1997.35.3.189","volume":"35","author":"GC Park","year":"1997","unstructured":"Park GC, Ryu JS, Min DY. The role of nitric oxide as an effector of macrophage-mediated cytotoxicity against Trichomonas vaginalis. Korean J Parasitol. 1997;35:189\u201395.","journal-title":"Korean J Parasitol"},{"key":"2009_CR46","first-page":"391","volume":"46","author":"A Mantovani","year":"1981","unstructured":"Mantovani A, Polentarutti N, Peri G, Martinotti G, Landolfo S. Cytotoxicity of human peripheral blood monocytes against Trichomonas vaginalis. Clin Exp Immunol. 1981;46:391.","journal-title":"Clin Exp Immunol"},{"key":"2009_CR47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/aji.12100","volume":"70","author":"HM Makinde","year":"2013","unstructured":"Makinde HM, Zariffard R, Mirmonsef P, Novak RM, Jarrett O, Landay AL, et al. IL-22 Levels are Associated with Trichomonas vaginalis Infection in the Lower Genital Tract. Am J Reprod Immunol. 2013;70:38\u201344.","journal-title":"Am J Reprod Immunol"},{"key":"2009_CR48","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.vaccine.2010.11.013","volume":"29","author":"X Guo","year":"2011","unstructured":"Guo X, Barroso L, Lyerly DM, Petri Jr WA, Houpt ER. CD4+ and CD8+ T cell-and IL-17-mediated protection against Entamoeba histolytica induced by a recombinant vaccine. Vaccine. 2011;29:772\u20137.","journal-title":"Vaccine"},{"key":"2009_CR49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","volume":"8","author":"SA Khader","year":"2007","unstructured":"Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007;8:369\u201377.","journal-title":"Nat Immunol"},{"key":"2009_CR50","doi-asserted-by":"crossref","first-page":"e1000159","DOI":"10.1371\/journal.ppat.1000159","volume":"4","author":"YJ Lu","year":"2008","unstructured":"Lu YJ, Gross J, Bogaert D, Finn A, Bagrade L, Zhang Q, et al. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog. 2008;4:e1000159.","journal-title":"PLoS Pathog"},{"key":"2009_CR51","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.0901584","volume":"183","author":"H Bai","year":"2009","unstructured":"Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, et al. IL-17\/Th17 promotes type 1T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J Immunol. 2009;183:5886\u201395.","journal-title":"J Immunol"},{"key":"2009_CR52","first-page":"63","volume":"63","author":"N Moav","year":"1988","unstructured":"Moav N, Draghi E, David A, Gold D. Anti-Trichomonas vaginalis monoclonal antibodies inducing complement-dependent cytotoxicity. Immunology. 1988;63:63.","journal-title":"Immunology"},{"key":"2009_CR53","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-3024.1991.tb00279.x","volume":"13","author":"MF Shaio","year":"1991","unstructured":"Shaio MF, Chang FY, Hou SC, Lee CS, Lin PR. The role of immunoglobulin and complement in enhancing the respiratory burst of neutrophils against Trichomonas vaginalis. Parasite Immunol. 1991;13:241\u201350.","journal-title":"Parasite Immunol"},{"key":"2009_CR54","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3347\/kjp.2013.51.4.479","volume":"51","author":"HO Song","year":"2013","unstructured":"Song HO, Ryu JS. Superoxide anion production by human neutrophils activated by Trichomonas vaginalis. Korean J Parasitol. 2013;51:479.","journal-title":"Korean J Parasitol"},{"key":"2009_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.71.1.1","volume":"71","author":"S Aggarwal","year":"2002","unstructured":"Aggarwal S, Gurney AL. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol. 2002;71:1\u20138.","journal-title":"J Leukoc Biol"},{"key":"2009_CR56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1359-6101(03)00002-9","volume":"14","author":"TA Moseley","year":"2003","unstructured":"Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003;14:155\u201374.","journal-title":"Cytokine Growth Factor Rev"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-017-2009-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T11:51:50Z","timestamp":1749988310000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-017-2009-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2009"],"URL":"https:\/\/doi.org\/10.1186\/s13071-017-2009-8","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]},"article-number":"83"}}