{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:53:01Z","timestamp":1790603581488,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","award":["TC00685704"],"award-info":[{"award-number":["TC00685704"]}],"id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13071-017-2049-0","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T11:10:35Z","timestamp":1489489835000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy, safety and tolerance of imidocarb dipropionate versus atovaquone or buparvaquone plus azithromycin used to treat sick dogs naturally infected with the Babesia microti-like piroplasm"],"prefix":"10.1186","volume":"10","author":[{"given":"Roc\u00edo","family":"Checa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Gonz\u00e1lez-Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Bartolom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"2049_CR1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s13071-016-1596-0","volume":"9","author":"L Solano-Gallego","year":"2016","unstructured":"Solano-Gallego L, Sainz \u00c1, Roura X, Estrada-Pe\u00f1a A, Mir\u00f3 G. A review of canine babesiosis: the European perspective. Parasit Vectors. 2016;9:336.","journal-title":"Parasit Vectors"},{"key":"2049_CR2","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.cvsm.2010.08.001","volume":"40","author":"PJ Irwin","year":"2010","unstructured":"Irwin PJ. Canine babesiosis. Vet Clin North Am Small Anim Pract. 2010;40:1141\u201356.","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2049_CR3","doi-asserted-by":"publisher","unstructured":"Baneth G, Florin-Christensen M, Cardoso L, Schnittger L. Reclassification of Theileria annae as Babesia vulpes sp. nov. Parasit Vectors. 2015;8:207.","DOI":"10.1186\/s13071-015-0830-5"},{"key":"2049_CR4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1136\/vr.149.18.552","volume":"149","author":"AT Camacho","year":"2001","unstructured":"Camacho AT, Pallas E, Gestal JJ, Guiti\u00e1n FJ, Olmeda AS, Goethert HK, et al. Infection of dogs in north-west Spain with a Babesia microti-like agent. Vet Rec. 2001;149:552\u20135.","journal-title":"Vet Rec"},{"key":"2049_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s13071-015-0825-2","volume":"8","author":"G Mir\u00f3","year":"2015","unstructured":"Mir\u00f3 G, Checa R, Paparini A, Ortega N, Gonz\u00e1lez-Fraga JL, Gofton A, et al. Theileria annae (syn. Babesia microti-like) infection in dogs in NW Spain detected using direct and indirect diagnostic techniques: clinical report of 75 cases. Parasit Vectors. 2015;8:217.","journal-title":"Parasit Vectors"},{"key":"2049_CR6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.vetpar.2006.01.048","volume":"138","author":"HJ Vial","year":"2006","unstructured":"Vial HJ, Gorenflot A. Chemotherapy against babesiosis. Vet Parasitol. 2006;138:147\u201360.","journal-title":"Vet Parasitol"},{"key":"2049_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.2307\/3284461","volume":"83","author":"M Pudney","year":"1997","unstructured":"Pudney M, Gray JS. Therapeutic efficacy of atovaquone against the bovine intraerythrocytic parasite, Babesia divergens. J Parasitol. 1997;83:307\u201310.","journal-title":"J Parasitol"},{"key":"2049_CR8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4269\/ajtmh.1996.55.219","volume":"55","author":"M Wittner","year":"1996","unstructured":"Wittner M, Lederman J, Tanowitz HB, Rosenbaum GS, Weiss LM. Atovaquone in the treatment of Babesia microti infections in hamsters. Am J Trop Med Hyg. 1996;55:219\u201322.","journal-title":"Am J Trop Med Hyg"},{"key":"2049_CR9","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1056\/NEJM200011163432004","volume":"343","author":"PJ Krause","year":"2000","unstructured":"Krause PJ, Lepore T, Sikand VK, Gadbaw J, Burke G, Telford SR, et al. Atovaquone and azithromycin for the treatment of babesiosis. N Engl J Med. 2000;343:1454\u20138.","journal-title":"N Engl J Med"},{"key":"2049_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1939-1676.2010.0646.x","volume":"25","author":"LA Cohn","year":"2011","unstructured":"Cohn LA, Birkenheuer AJ, Brunker JD, Ratcliff ER, Craig AW. Efficacy of atovaquone and azithromycin or imidocarb dipropionate in cats with acute cytauxzoonosis. J Vet Intern Med. 2011;25:55\u201360.","journal-title":"J Vet Intern Med"},{"key":"2049_CR11","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1939-1676.2004.tb02573.x","volume":"18","author":"AJ Birkenheuer","year":"2004","unstructured":"Birkenheuer AJ, Levy MG, Breitschwerdt EB. Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs. J Vet Intern Med. 2004;18:494\u20138.","journal-title":"J Vet Intern Med"},{"key":"2049_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.vetpar.2012.01.006","volume":"187","author":"MF Cicco Di","year":"2012","unstructured":"Di Cicco MF, Downey ME, Beeler E, Marr H, Cyrog P, Kidd L, et al. Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin. Vet Parasitol. 2012;187:23\u20137.","journal-title":"Vet Parasitol"},{"key":"2049_CR13","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1128\/AAC.46.5.1163-1173.2002","volume":"46","author":"AL Baggish","year":"2002","unstructured":"Baggish AL, Hill DR. Antiparasitic agent atovaquone. Antimicrob Agents Chemother. 2002;46:1163\u201373.","journal-title":"Antimicrob Agents Chemother"},{"key":"2049_CR14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0034-5288(18)31765-X","volume":"39","author":"N McHardy","year":"1985","unstructured":"McHardy N, Wekesa LS, Hudson AT, Randall AW. Antitheilerial activity of BW720C (buparvaquone): a comparison with parvaquone. Res Vet Sci. 1985;39:29\u201333.","journal-title":"Res Vet Sci"},{"key":"2049_CR15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s12639-014-0457-z","volume":"40","author":"AK Verma","year":"2016","unstructured":"Verma AK, Singh SK. Control and therapeutic management of bovine tropical theileriosis in crossbred cattle. J Parasit Dis. 2016;40:208\u201310.","journal-title":"J Parasit Dis"},{"key":"2049_CR16","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2460\/ajvr.1992.53.08.1396","volume":"53","author":"JL Zaugg","year":"1992","unstructured":"Zaugg JL, Lane VM. Efficacy of buparvaquone as a therapeutic and clearing agent of Babesia equi of European origin in horses. Am J Vet Res. 1992;53:1396\u20139.","journal-title":"Am J Vet Res"},{"key":"2049_CR17","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1292\/jvms.65.1171","volume":"65","author":"S Kumar","year":"2003","unstructured":"Kumar S, Gupta AK, Pal Y, Dwivedi SK. In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys. J Vet Med Sci. 2003;65:1171\u20137.","journal-title":"J Vet Med Sci"},{"issue":"Pt 1","key":"2049_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1017\/S0031182000049003","volume":"90","author":"AT Hudson","year":"1985","unstructured":"Hudson AT, Randall AW, Fry M, Ginger CD, Hill B, Latter VS, et al. Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. Parasitology. 1985;90(Pt 1):45\u201355.","journal-title":"Parasitology"},{"key":"2049_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.exppara.2015.04.017","volume":"154","author":"Q Jamal","year":"2015","unstructured":"Jamal Q, Khan NH, Wahid S, Awan MM, Sutherland C, Shah A. In vitro sensitivity of Pakistani Leishmania tropica field isolate against buparvaquone in comparison to standard anti-leishmanial drugs. Exp Parasitol. 2015;154:93\u20137.","journal-title":"Exp Parasitol"},{"key":"2049_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13567-016-0317-1","volume":"47","author":"J M\u00fcller","year":"2016","unstructured":"M\u00fcller J, Aguado-Mart\u00ednez A, Manser V, Wong HN, Haynes RK, Hemphill A. Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Vet Res. 2016;47:32.","journal-title":"Vet Res"},{"key":"2049_CR21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijpddr.2015.02.001","volume":"5","author":"J M\u00fcller","year":"2015","unstructured":"M\u00fcller J, Aguado-Martinez A, Manser V, Balmer V, Winzer P, Ritler D, et al. Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. Int J Parasitol Drugs Drug Resist. 2015;5:16\u201325.","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"2049_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1756-3305-6-117","volume":"6","author":"G Mir\u00f3","year":"2013","unstructured":"Mir\u00f3 G, Montoya A, Roura X, G\u00e1lvez R, Sainz A. Seropositivity rates for agents of canine vector-borne diseases in Spain: a multicentre study. Parasit Vectors. 2013;6:117.","journal-title":"Parasit Vectors"},{"key":"2049_CR23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1365-3164.2009.00824.x","volume":"20","author":"G Mir\u00f3","year":"2009","unstructured":"Mir\u00f3 G, Oliva G, Cruz I, Ca\u00f1avate C, Mortarino M, Vischer C, et al. Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis. Vet Dermatol. 2009;20:397\u2013404.","journal-title":"Vet Dermatol"},{"key":"2049_CR24","doi-asserted-by":"publisher","unstructured":"Hern\u00e1ndez L, Fern\u00e1ndez F, Montoya A, et al. Unresponsiveness of experimental canine leishmaniosis to a new amphotericin B formulation. Adv Pharm. 2015;2015:1\u201313.","DOI":"10.1155\/2015\/160208"},{"key":"2049_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.vetpar.2006.09.022","volume":"144","author":"R Jefferies","year":"2007","unstructured":"Jefferies R, Ryan UM, Irwin PJ. PCR-RFLP for the detection and differentiation of the canine piroplasm species and its use with filter paper-based technologies. Vet Parasitol. 2007;144:20\u20137.","journal-title":"Vet Parasitol"},{"key":"2049_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0304-4017(03)00078-5","volume":"113","author":"A Criado-Fornelio","year":"2003","unstructured":"Criado-Fornelio A, Martinez-Marcos A, Buling-Sara\u00f1a A, Barba-Carretero JC. Molecular studies on Babesia, Theileria and Hepatozoon in southern Europe. Part I. Epizootiological aspects. Vet Parasitol. 2003;113:189\u2013201.","journal-title":"Vet Parasitol"},{"key":"2049_CR27","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13071-016-1364-1","volume":"9","author":"PM Bartley","year":"2016","unstructured":"Bartley PM, Hamilton C, Wilson C, Innes EA, Katzer F. Detection of Babesia annae DNA in lung exudate samples from Red foxes (Vulpes vulpes) in Great Britain. Parasit Vectors. 2016;9:84.","journal-title":"Parasit Vectors"},{"key":"2049_CR28","doi-asserted-by":"publisher","unstructured":"Guiti\u00e1n FJ, Camacho AT, Telford SR. Case-control study of canine infection by a newly recognised Babesia microti-like piroplasm. Prev Vet Med. 2003;61:137\u201345.","DOI":"10.1016\/S0167-5877(03)00164-8"},{"key":"2049_CR29","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.vetpar.2006.01.043","volume":"138","author":"AT Garc\u00eda","year":"2006","unstructured":"Garc\u00eda AT. Piroplasma infection in dogs in northern Spain. Vet Parasitol. 2006;138:97\u2013102.","journal-title":"Vet Parasitol"},{"key":"2049_CR30","first-page":"141","volume":"18","author":"AT Camacho","year":"2004","unstructured":"Camacho AT, Guitian EJ, Pallas E, Gestal JJ, Olmeda AS, Goethert HK, et al. Azotemia and mortality among Babesia microti-like infected dogs. J Vet Intern Med. 2004;18:141\u20136.","journal-title":"J Vet Intern Med"},{"key":"2049_CR31","doi-asserted-by":"publisher","first-page":"e138","DOI":"10.5326\/JAAHA-MS-5576","volume":"47","author":"DJ Slade","year":"2011","unstructured":"Slade DJ, Lees GE, Berridge BR, Clubb FJ, Kuczynski LA, Littman MP. Resolution of a proteinuric nephropathy associated with Babesia gibsoni infection in a dog. J Am Anim Hosp Assoc. 2011;47:e138\u201344.","journal-title":"J Am Anim Hosp Assoc"},{"key":"2049_CR32","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1292\/jvms.63.977","volume":"63","author":"S Fukumoto","year":"2001","unstructured":"Fukumoto S, Xuan X, Shigeno S, Kimbita E, Igarashi I, Nagasawa H, et al. Development of a polymerase chain reaction method for diagnosing Babesia gibsoni infection in dogs. J Vet Med Sci. 2001;63:977\u201381.","journal-title":"J Vet Med Sci"},{"key":"2049_CR33","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1046\/j.1365-2958.1999.01515.x","volume":"33","author":"IK Srivastava","year":"1999","unstructured":"Srivastava IK, Morrisey JM, Darrouzet E, Daldal F, Vaidya AB. Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol Microbiol. 1999;33:704\u201311.","journal-title":"Mol Microbiol"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-017-2049-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T23:38:47Z","timestamp":1719099527000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-017-2049-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2049"],"URL":"https:\/\/doi.org\/10.1186\/s13071-017-2049-0","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,13]]},"article-number":"145"}}