{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:08:42Z","timestamp":1791248922712,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"The National Key Research and Development Program of China","award":["2016YFC1202003"],"award-info":[{"award-number":["2016YFC1202003"]}]},{"name":"The National Key Research and Development Program of China","award":["2016YFC1202005"],"award-info":[{"award-number":["2016YFC1202005"]}]},{"name":"National Natural Science Foundation of China (CN)","award":["81641094"],"award-info":[{"award-number":["81641094"]}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"crossref","award":["S2012010008504"],"award-info":[{"award-number":["S2012010008504"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The National Key Basic Research Program of China","award":["2010CB530000"],"award-info":[{"award-number":["2010CB530000"]}]},{"name":"The Guangdong Natural Science Fund","award":["S2012010008504"],"award-info":[{"award-number":["S2012010008504"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171602"],"award-info":[{"award-number":["81171602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101270"],"award-info":[{"award-number":["81101270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13071-017-2179-4","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T11:48:52Z","timestamp":1495712932000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma"],"prefix":"10.1186","volume":"10","author":[{"given":"Caiqin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"2179_CR1","first-page":"800","volume":"10020","author":"MB Qian","year":"2016","unstructured":"Qian MB, Utzinger J, Keiser J, Zhou XN. Clonorchiasis. Lancet Infect Dis. 2016;10020:800\u201310.","journal-title":"Lancet Infect Dis"},{"key":"2179_CR2","doi-asserted-by":"crossref","unstructured":"Wu Y, Li Y, Shang M, Jian Y, Wang C, Bardeesi ASA, et al. Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling. Parasit Vectors. 2017;10:147.","DOI":"10.1186\/s13071-017-2082-z"},{"key":"2179_CR3","doi-asserted-by":"crossref","unstructured":"Huang Y, Chen W, Wang X, Liu H, Guo L, Luo F, et al. The carcinogenic liver fluke, Clonorchis sinensis: new assembly, reannotation and analysis of the genome and characterization of tissue transcriptomes. PLoS One.2013;8:e54732.","DOI":"10.1371\/journal.pone.0054732"},{"issue":"2","key":"2179_CR4","first-page":"114","volume":"16","author":"SK Tan","year":"2008","unstructured":"Tan SK, Qiu XQ, Yu HP, Zeng XY, Zhao YN, Hu L. Evaluation of the risk of clonorchiasis inducing primary hepatocellular carcinoma. Zhonghua Gan Zang Bing Za Zhi. 2008;16(2):114\u20136.","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"1","key":"2179_CR5","first-page":"16","volume":"4","author":"X Xiao","year":"1985","unstructured":"Xiao X, Liang X, Zhu S. Studies on primary hepatoma cases and non-hepatoma cases infested by clonorchiasis. Journal of Jinan University. 1985;4(1):16\u20138.","journal-title":"Journal of Jinan University"},{"issue":"9b","key":"2179_CR6","first-page":"1121","volume":"34","author":"YI Kim","year":"1984","unstructured":"Kim YI. Liver carcinoma and liver fluke infection. Arzneimittelforsch. 1984;34(9b):1121\u20136.","journal-title":"Arzneimittelforsch"},{"issue":"10","key":"2179_CR7","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2011-12-10-r107","volume":"12","author":"X Wang","year":"2011","unstructured":"Wang X, Chen W, Huang Y, Sun J, Men J, Liu H, et al. The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biol. 2011;12(10):R107.","journal-title":"Genome Biol"},{"issue":"6","key":"2179_CR8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000719","volume":"4","author":"ND Young","year":"2010","unstructured":"Young ND, Campbell BE, Hall RS, Jex AR, Cantacessi C, Laha T, et al. Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. PLoS Negl Trop Dis. 2010;4(6), e719.","journal-title":"PLoS Negl Trop Dis"},{"key":"2179_CR9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/bies.200900086","volume":"31","author":"A Bateman","year":"2009","unstructured":"Bateman A, Bennett HP. The granulin gene family: from cancer to dementia. Bioessays. 2009;31:1245\u201354.","journal-title":"Bioessays"},{"key":"2179_CR10","first-page":"1275","volume":"1","author":"CH Ong","year":"2003","unstructured":"Ong CH, Bateman A. Progranulin (Granulin-epithelin precursor, PC-cell derived growth factor, Acrogranin) in proliferation and tumorigenesis. Histol Histopathol. 2003;1:1275\u201388.","journal-title":"Histol Histopathol"},{"key":"2179_CR11","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/carcin\/bgu164","volume":"35","author":"CW Yip","year":"2014","unstructured":"Yip CW, Cheunq PF, Leung IC, Wong NC, Cheng CK, Fan ST, et al. Granulin-epithelin precursor interacts with heparan sulfate on liver cancer cells. Carcinogenesis. 2014;35:2485\u201394.","journal-title":"Carcinogenesis"},{"key":"2179_CR12","doi-asserted-by":"crossref","unstructured":"Smout MJ, Laha T, Mulvenna J, Sripa B, Suttiprapa S, Jones A, et al. A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells. PLoS Pathog.2009;5(10):e1000611.","DOI":"10.1371\/journal.ppat.1000611"},{"key":"2179_CR13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exppara.2014.11.004","volume":"148","author":"A Papatpremsiri","year":"2015","unstructured":"Papatpremsiri A, Smout MJ, Loukas A, Brindley PJ, Sripa B, Laha T. Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells. Exp Parasitol. 2015;148:17\u201323.","journal-title":"Exp Parasitol"},{"issue":"1","key":"2179_CR14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1186\/s40064-016-2443-7","volume":"5","author":"C Machicado","year":"2016","unstructured":"Machicado C, Marcos LA, Zimic M. Hypothetical granulin-like molecule from Fasciola hepatica identified by bioinformati analysis. Springerplus. 2016;5(1):773.","journal-title":"Springerplus"},{"key":"2179_CR15","doi-asserted-by":"crossref","unstructured":"Zheng S, Zhu Y, Zhao Z, Wu Z, Okanurak K, Lv Z. Liver fluke infection and cholangiocarcinoma: a review. Parasitol Res. 2016;116:11\u201319.","DOI":"10.1007\/s00436-016-5276-y"},{"issue":"12","key":"2179_CR16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002606","volume":"7","author":"X Chen","year":"2013","unstructured":"Chen X, Li S, He L, Wang X, Liang P, Chen W, et al. Molecular characterization of severin from Clonorchis sinensis excretory\/secretory products and its potential anti-apoptotic role in hepatocarcinoma PLC cells. PLoS Negl Trop Dis. 2013;7(12):e2606.","journal-title":"PLoS Negl Trop Dis"},{"key":"2179_CR17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1186\/s13071-015-1248-9","volume":"8","author":"W Chen","year":"2015","unstructured":"Chen W, Ning D, Wang X, Chen T, Lv X, Sun J, et al. Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. Parasit Vectors. 2015;8:647.","journal-title":"Parasit Vectors"},{"issue":"2","key":"2179_CR18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.exppara.2007.04.003","volume":"117","author":"F Hu","year":"2007","unstructured":"Hu F, Yu X, Ma C, Zhou H, Zhou Z, Li Y, et al. Clonorchis sinensis: expression, characterization, immunolocalization and serological reactivity of one excretory\/secretory antigen-LPAP homologue. Exp Parasitol. 2007;117(2):157\u201364.","journal-title":"Exp Parasitol"},{"issue":"12","key":"2179_CR19","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","volume":"30","author":"K Tamura","year":"2013","unstructured":"Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30(12):2725\u20139.","journal-title":"Mol Biol Evol"},{"issue":"5","key":"2179_CR20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/cam.36224","volume":"8","author":"JE Jonkman","year":"2014","unstructured":"Jonkman JE, Cathcart JA, Xu F, Bartolini ME, Amon JE, Stevens KM, et al. An introduction to the wound healing assay using live-cell microscopy. Cell Adh Migr. 2014;8(5):440\u201351.","journal-title":"Cell Adh Migr"},{"key":"2179_CR21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-61779-207-6_8","volume":"769","author":"J Marshall","year":"2011","unstructured":"Marshall J. Transwell (\u00ae) invasion assays. Methods Mol Biol. 2011;769:97\u2013110.","journal-title":"Methods Mol Biol"},{"issue":"10020","key":"2179_CR22","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0140-6736(15)60313-0","volume":"387","author":"MB Qian","year":"2016","unstructured":"Qian MB, Utzinger J, Keiser J, Zhou XN. Clonorchiasis. Lancet. 2016;387(10020):800\u201310.","journal-title":"Lancet"},{"key":"2179_CR23","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00436-008-1286-8","volume":"5","author":"JH Pak","year":"2009","unstructured":"Pak JH, Kim DW, Moon JH, Nam JH, Kim JH. Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products. Parasitol Res. 2009;5:1035\u201346.","journal-title":"Parasitol Res"},{"key":"2179_CR24","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1007\/s00436-014-3972-z","volume":"113","author":"X Wang","year":"2014","unstructured":"Wang X, Hu F, Hu X, Chen W, Huang Y. Proteomic identification of potential Clonorchis sinensis excretory\/secretory products capable of binding and activating human hepatic stellate cells. Parasitol Res. 2014;113:3063\u201371.","journal-title":"Parasitol Res"},{"key":"2179_CR25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12885-015-1294-x","volume":"2","author":"MK Yung","year":"2015","unstructured":"Yung MK, Lo KW, Yip CW, Chung GT, Tong CY. Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer. BMC Cancer. 2015;2:264.","journal-title":"BMC Cancer"},{"key":"2179_CR26","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1158\/0008-5472.CAN-15-3332","volume":"10","author":"T Marsh","year":"2016","unstructured":"Marsh T, Wong I, Sceneay J, Barakat A, Qin Y, Sjodin A, et al. Hematopoietic age at onset of triple-negative breast cancer dictates disease aggressiveness and progression. Cancer Res. 2016;10:2932\u201343.","journal-title":"Cancer Res"},{"issue":"3","key":"2179_CR27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/cr.2010.19","volume":"20","author":"S Kumari","year":"2010","unstructured":"Kumari S, Mg S, Mayor S. Endocytosis unplugged: multiple ways to enter the cell. Cell Res. 2010;20(3):256\u201375.","journal-title":"Cell Res"},{"key":"2179_CR28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biocel.2015.05.014","volume":"65","author":"P Matchimakul","year":"2015","unstructured":"Matchimakul P, Rinaldi G, Suttiprapa S, Mann VH, Popratiloff A, Laha T, et al. Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke. Int J Biochem Cell Biol. 2015;65:72\u201380.","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"2179_CR29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.molbiopara.2008.04.010","volume":"160","author":"S Suttiprapa","year":"2008","unstructured":"Suttiprapa S, Loukas A, Laha T, Wongkham S, Kaewkes S, Gaze S, et al. Characterization of the antioxidant enzyme, thioredoxin peroxidase, from the carcinogenic human liver fluke, Opisthorchis viverrini. Mol Biochem Parasit. 2008;160(2):116\u201322.","journal-title":"Mol Biochem Parasit"},{"key":"2179_CR30","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3109\/07357900903346455","volume":"5","author":"R Cuevas-Antonio","year":"2010","unstructured":"Cuevas-Antonio R, Cancino C, Arechavaleta-Velasco F, Andrade A, Barron L, Estrada I, et al. Expression of progranulin (Acrogranin\/PCDGF\/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line. Cancer Invest. 2010;5:452\u20138.","journal-title":"Cancer Invest"},{"issue":"Suppl 2","key":"2179_CR31","first-page":"71","volume":"9","author":"WE Kim","year":"2015","unstructured":"Kim WE, Yue B, Serrero G. Signaling pathway of GP88 (Progranulin) in breast cancer cells: upregulation and phosphorylation of c-myc by GP88\/Progranulin in Her2-overexpressing breast cancer cells. Breast Cancer (Auckl). 2015;9 Suppl 2:71\u20137.","journal-title":"Breast Cancer (Auckl)"},{"issue":"4","key":"2179_CR32","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s12032-011-0131-6","volume":"29","author":"M Wang","year":"2012","unstructured":"Wang M, Li G, Yin J, Lin T, Zhang J. Progranulin overexpression predicts overall survival in patients with glioblastoma. Med Oncol. 2012;29(4):2423\u201331.","journal-title":"Med Oncol"},{"issue":"1","key":"2179_CR33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1574-695X.2011.00833.x","volume":"63","author":"H Wang","year":"2011","unstructured":"Wang H, Sun Y, Liu S, Yu H, Li W, Zeng J, et al. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1\/2 signaling pathway: role in epithelial cell proliferation and migration. FEMS Immunol Med Mic. 2011;63(1):82\u201392.","journal-title":"FEMS Immunol Med Mic"},{"key":"2179_CR34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00438-015-1118-3","volume":"1","author":"M Zhao","year":"2016","unstructured":"Zhao M, He M, Huang X, Wang Q, Shi Y. Functional characterization and molecular mechanism exploration of three granulin epithelin precursor splice variants in biomineralization of the pearl oyster Pinctada fucata. Mol Genet Genomi. 2016;1:399\u2013409.","journal-title":"Mol Genet Genomi"},{"key":"2179_CR35","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/carcin\/bgh171","volume":"9","author":"W Tangkeangsirisin","year":"2004","unstructured":"Tangkeangsirisin W, Seeerro G. PC cell-derived growth factor (PCDGF\/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells. Carcinogenesis. 2004;9:1587\u201392.","journal-title":"Carcinogenesis"},{"issue":"10","key":"2179_CR36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005209","volume":"11","author":"MJ Smout","year":"2015","unstructured":"Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, et al. Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia. PLoS Pathog. 2015;11(10), e1005209.","journal-title":"PLoS Pathog"},{"issue":"7","key":"2179_CR37","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1007\/s00436-016-5090-6","volume":"115","author":"MC Botelho","year":"2016","unstructured":"Botelho MC, Alves H, Richter J. Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma. Parasitol Res. 2016;115(7):2913\u20134.","journal-title":"Parasitol Res"},{"issue":"7142","key":"2179_CR38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature05765","volume":"447","author":"I Saadat","year":"2007","unstructured":"Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, et al. Helicobacter pylori CagA targets PAR1\/MARK kinase to disrupt epithelial cell polarity. Nature. 2007;447(7142):330\u20133.","journal-title":"Nature"},{"issue":"18","key":"2179_CR39","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/j.ejca.2014.09.014","volume":"50","author":"M Rios","year":"2014","unstructured":"Rios M, Foretz M, Viollet B, Prieto A, Fraga M, Garcia-Caballero T, et al. Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth. Eur J Cancer. 2014;50(18):3187\u201397.","journal-title":"Eur J Cancer"},{"issue":"6159","key":"2179_CR40","doi-asserted-by":"crossref","first-page":"1234850","DOI":"10.1126\/science.1234850","volume":"342","author":"MA Nieto","year":"2013","unstructured":"Nieto MA. Epithelial plasticity: a common theme in embryonic and cancer cells. Science. 2013;342(6159):1234850.","journal-title":"Science"},{"issue":"6","key":"2179_CR41","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ceb.2003.10.006","volume":"15","author":"JP Thiery","year":"2003","unstructured":"Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol. 2003;15(6):740\u20136.","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"2179_CR42","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","volume":"119","author":"M Zeisberg","year":"2009","unstructured":"Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009;119(6):1429\u201337.","journal-title":"J Clin Invest"},{"issue":"6672","key":"2179_CR43","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/32433","volume":"392","author":"AK Perl","year":"1998","unstructured":"Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998;392(6672):190\u20133.","journal-title":"Nature"},{"issue":"3","key":"2179_CR44","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.147.3.631","volume":"147","author":"MT Nieman","year":"1999","unstructured":"Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-Cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 1999;147(3):631\u201343.","journal-title":"J Cell Biol"},{"issue":"4","key":"2179_CR45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.148.4.779","volume":"148","author":"RB Hazan","year":"2000","unstructured":"Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 2000;148(4):779\u201390.","journal-title":"J Cell Biol"},{"key":"2179_CR46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.cellbio.19.011102.111135","volume":"19","author":"MJ Wheelock","year":"2003","unstructured":"Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol. 2003;19:207\u201335.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"24","key":"2179_CR47","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1242\/jcs.00154","volume":"115","author":"S Bek","year":"2002","unstructured":"Bek S, Kemler R. Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci. 2002;115(24):4743\u201353.","journal-title":"J Cell Sci"},{"issue":"3","key":"2179_CR48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)81478-6","volume":"94","author":"J Kim","year":"1998","unstructured":"Kim J, Yu W, Kovalski K, Ossowski L. Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell. 1998;94(3):353\u201362.","journal-title":"Cell"},{"issue":"5307","key":"2179_CR49","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1126\/science.275.5307.1790","volume":"275","author":"B Rubinfeld","year":"1997","unstructured":"Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science. 1997;275(5307):1790\u20132.","journal-title":"Science"},{"key":"2179_CR50","unstructured":"Chaiyadet S, Smout M, Laha T, Sripa B, Loukas A, Sotillo J. Proteomic characterization of the internalization of Opisthorchis viverrini excretory\/secretory products in human cells. Parasitol Int. 2016;S1383-5769(16)30007-1."}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-017-2179-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T22:04:14Z","timestamp":1569362654000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-017-2179-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2179"],"URL":"https:\/\/doi.org\/10.1186\/s13071-017-2179-4","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]},"article-number":"262"}}