{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:54:58Z","timestamp":1779245698300,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31230073"],"award-info":[{"award-number":["31230073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Fundamental Research Funds of Chinese Academy of Agricultural Sciences","award":["Y2016JC05"],"award-info":[{"award-number":["Y2016JC05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13071-017-2282-6","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T12:51:20Z","timestamp":1500382280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis"],"prefix":"10.1186","volume":"10","author":[{"given":"Xiao-Qing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany M.","family":"Elsheikha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Xue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"2282_CR1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","volume":"55","author":"JP Dubey","year":"2008","unstructured":"Dubey JP. The history of Toxoplasma gondii - the first 100 years. J Eukaryot Microbiol. 2008;55:467\u201375.","journal-title":"J Eukaryot Microbiol"},{"key":"2282_CR2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","volume":"39","author":"LM Weiss","year":"2009","unstructured":"Weiss LM, Dubey JP. Toxoplasmosis: a history of clinical observations. Int J Parasitol. 2009;39:895\u2013901.","journal-title":"Int J Parasitol"},{"key":"2282_CR3","doi-asserted-by":"crossref","unstructured":"Elsheikha HM. Congenital toxoplasmosis: priorities for further health promotion action. Public Health. 2008;122:335\u201353.","DOI":"10.1016\/j.puhe.2007.08.009"},{"key":"2282_CR4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00281-012-0339-3","volume":"34","author":"CD Dupont","year":"2012","unstructured":"Dupont CD, Christian DA, Hunter CA. Immune response and immunopathology during toxoplasmosis. Semin Immunopathol. 2012;34:793\u2013813.","journal-title":"Semin Immunopathol"},{"key":"2282_CR5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-065X.2010.00992.x","volume":"240","author":"M Munoz","year":"2011","unstructured":"Munoz M, Liesenfeld O, Heimesaat MM. Immunology of Toxoplasma gondii. Immunol Rev. 2011;240:269\u201385.","journal-title":"Immunol Rev"},{"key":"2282_CR6","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1128\/IAI.60.9.3719-3724.1992","volume":"60","author":"LL Johnson","year":"1992","unstructured":"Johnson LL. SCID mouse models of acute and relapsing chronic Toxoplasma gondii infections. Infect Immun. 1992;60:3719\u201324.","journal-title":"Infect Immun"},{"key":"2282_CR7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri3598","volume":"14","author":"F Yarovinsky","year":"2014","unstructured":"Yarovinsky F. Innate immunity to Toxoplasma gondii infection. Nat Rev Immunol. 2014;14:109\u201321.","journal-title":"Nat Rev Immunol"},{"key":"2282_CR8","doi-asserted-by":"crossref","unstructured":"Kang H, Remington JS, Suzuki Y. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J Immunol. 2000;164:2629\u201334.","DOI":"10.4049\/jimmunol.164.5.2629"},{"key":"2282_CR9","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/IAI.68.3.1026-1033.2000","volume":"68","author":"CS Peter","year":"2000","unstructured":"Peter CS, George WG, Lawrence LJ. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect Immun. 2000;68:1026\u201333.","journal-title":"Infect Immun"},{"key":"2282_CR10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S000711450769936X","volume":"98","author":"P Li","year":"2007","unstructured":"Li P, Yin YL, Li D, Kim SW, Wu G. Amino acids and immune function. Br J Nutr. 2007;98:237\u201352.","journal-title":"Br J Nutr"},{"key":"2282_CR11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/elps.201400450","volume":"36","author":"R Gonz\u00e1lezdom\u00ednguez","year":"2015","unstructured":"Gonz\u00e1lezdom\u00ednguez R, Garc\u00edabarrera T, Vitorica J, G\u00f3mezariza JL. Metabolomics reveals significant impairments in the immune system of the APP\/PS1 transgenic mice of Alzheimer's disease. Electrophoresis. 2015;36:577\u201387.","journal-title":"Electrophoresis"},{"key":"2282_CR12","doi-asserted-by":"crossref","first-page":"19557","DOI":"10.1038\/srep19557","volume":"6","author":"CX Zhou","year":"2016","unstructured":"Zhou CX, Zhou DH, Elsheikha HM, Zhao Y, Suo X, Zhu XQ. Metabolomic profiling of mice serum during toxoplasmosis progression using liquid chromatography-mass spectrometry. Sci Rep. 2016;6:19557.","journal-title":"Sci Rep"},{"key":"2282_CR13","doi-asserted-by":"crossref","first-page":"e0139635","DOI":"10.1371\/journal.pone.0139635","volume":"10","author":"CX Zhou","year":"2015","unstructured":"Zhou CX, Zhou DH, Elsheikha HM, Liu GX, Suo X, Zhu XQ. Global metabolomic profiling of mice brains following experimental infection with the cyst-forming Toxoplasma gondii. PLoS One. 2015;10:e0139635.","journal-title":"PLoS One"},{"key":"2282_CR14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/QCO.0000000000000265","volume":"29","author":"HM Elsheikha","year":"2016","unstructured":"Elsheikha HM, Zhu XQ. Toxoplasma gondii infection and schizophrenia: an inter-kingdom communication perspective. Curr Opin Infect Dis. 2016;29:311.","journal-title":"Curr Opin Infect Dis"},{"key":"2282_CR15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri1547","volume":"5","author":"J Aliberti","year":"2005","unstructured":"Aliberti J. Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma gondii. Nat Rev Immunol. 2005;5:162\u201370.","journal-title":"Nat Rev Immunol"},{"key":"2282_CR16","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1128\/IAI.00333-12","volume":"80","author":"AG Zaretsky","year":"2012","unstructured":"Zaretsky AG, Silver JS, Siwicki M, Durham A, Ware CF, Hunter CA. Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture. Infect Immun. 2012;80:3602\u201310.","journal-title":"Infect Immun"},{"key":"2282_CR17","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2008.08.026","volume":"134","author":"E Holmes","year":"2008","unstructured":"Holmes E, Wilson ID, Nicholson JK. Metabolic phenotyping in health and disease. Cell. 2008;134:714\u20137.","journal-title":"Cell"},{"key":"2282_CR18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2009.01.004","volume":"5","author":"KL Olszewski","year":"2011","unstructured":"Olszewski KL, Morrisey JM, Wilinski D, Burns JM, Vaidya AB, Rabinowitz JD, et al. Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe. 2011;5:191\u20139.","journal-title":"Cell Host Microbe"},{"key":"2282_CR19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1186\/1471-2164-15-806","volume":"15","author":"KJ Pittman","year":"2014","unstructured":"Pittman KJ, Aliota MT, Knoll LJ. Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection. BMC Genomics. 2014;15:806.","journal-title":"BMC Genomics"},{"key":"2282_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.vetpar.2006.05.008","volume":"141","author":"DE Hill","year":"2006","unstructured":"Hill DE, Chirukandoth S, Dubey JP, Lunney JK, Gamble HR. Comparison of detection methods for Toxoplasma gondii in naturally and experimentally infected swine. Vet Parasitol. 2006;141:9\u201317.","journal-title":"Vet Parasitol"},{"key":"2282_CR21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/1471-2105-9-470","volume":"9","author":"K Bryan","year":"2008","unstructured":"Bryan K, Brennan L, Cunningham P. Metafind: a feature analysis tool for metabolomics data. BMC Bioinformatics. 2008;9:470.","journal-title":"BMC Bioinformatics"},{"key":"2282_CR22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/pr3009572","volume":"12","author":"T Zhang","year":"2013","unstructured":"Zhang T, Wu X, Ke C, Yin M, Li Z, Fan L, et al. Identification of potential biomarkers for ovarian cancer by urinary metabolomic profiling. J Proteome Res. 2013;12:505\u201312.","journal-title":"J Proteome Res"},{"key":"2282_CR23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nprot.2011.319","volume":"6","author":"J Xia","year":"2011","unstructured":"Xia J, Wishart DS. Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst. Nat Protoc. 2011;6:743\u201360.","journal-title":"Nat Protoc"},{"key":"2282_CR24","unstructured":"Thorsten B, Peter E, Joachim K. Preparation of 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol useful as meiosis regulator for the promotion of fertility. 1999;German Patent DE19817520."},{"key":"2282_CR25","doi-asserted-by":"crossref","first-page":"16345","DOI":"10.1074\/jbc.M501523200","volume":"280","author":"N Gupta","year":"2005","unstructured":"Gupta N, Zahn MM, Coppens I, Joiner KA, Voelker DR. Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. J Biol Chem. 2005;280:16345\u201353.","journal-title":"J Biol Chem"},{"issue":"Suppl. 1","key":"2282_CR26","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1038\/jid.1995.4","volume":"105","author":"RA Daynes","year":"1995","unstructured":"Daynes RA, Araneo BA, Hennebold J, Enioutina E, Mu HH. Steroids as regulators of the mammalian immune response. J Invest Dermatol. 1995;105(Suppl. 1):14S\u20139S.","journal-title":"J Invest Dermatol"},{"key":"2282_CR27","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/ja00029a057","volume":"23","author":"H Nagai","year":"1992","unstructured":"Nagai H, Torigoe K, Satake M, Murata M, Yasumoto T, Hirota H. Gambieric acids: unprecedented potent antifungal substances isolated from cultures of a marine dinoflagellate Gambierdiscus toxicus. J Am Chem. 1992;23:1102\u20133.","journal-title":"J Am Chem"},{"key":"2282_CR28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1189\/jlb.0208104","volume":"84","author":"AS Tait","year":"2008","unstructured":"Tait AS, Butts CL, Sternberg EM. The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease. J Leukoc Biol. 2008;84:924\u201331.","journal-title":"J Leukoc Biol"},{"key":"2282_CR29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0929-7855(95)00029-P","volume":"12","author":"M Negishi","year":"1995","unstructured":"Negishi M, Koizumi T, Ichikawa A. Biological actions of delta 12-prostaglandin J2. J Lipid Mediat Cell Signal. 1995;12:443\u20138.","journal-title":"J Lipid Mediat Cell Signal"},{"key":"2282_CR30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/35154","volume":"391","author":"C Jiang","year":"1998","unstructured":"Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82\u20136.","journal-title":"Nature"},{"key":"2282_CR31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/156802607779941314","volume":"7","author":"SP Khanapure","year":"2007","unstructured":"Khanapure SP, Garvey DS, Janero DR, Letts LG. Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem. 2007;7:311\u201340.","journal-title":"Curr Top Med Chem"},{"key":"2282_CR32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.prostaglandins.2011.08.004","volume":"96","author":"ER Greene","year":"2011","unstructured":"Greene ER, Huang S, Serhan CN, Panigrahy D. Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat. 2011;96:27\u201336.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"2282_CR33","first-page":"5047","volume":"59","author":"MT Rizzo","year":"1999","unstructured":"Rizzo MT, Regazzi E, Garau D, Akard L, Dugan M, Boswell HS, et al. Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. Cancer Res. 1999;59:5047\u201353.","journal-title":"Cancer Res"},{"key":"2282_CR34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4049\/jimmunol.178.2.641","volume":"178","author":"SP Levick","year":"2007","unstructured":"Levick SP, Loch DC, Taylor SM, Janicki JS. Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation. J Immunol. 2007;178:641\u20136.","journal-title":"J Immunol"},{"key":"2282_CR35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.vetpar.2008.07.007","volume":"157","author":"L Li","year":"2008","unstructured":"Li L, Li X, Yan J. Alterations of concentrations of calcium and arachidonic acid and agglutinations of microfilaments in host cells during Toxoplasma gondii invasion. Vet Parasitol. 2008;157:21\u20133.","journal-title":"Vet Parasitol"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-017-2282-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T21:15:15Z","timestamp":1602537315000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-017-2282-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,18]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2282"],"URL":"https:\/\/doi.org\/10.1186\/s13071-017-2282-6","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,18]]},"article-number":"339"}}