{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:11:09Z","timestamp":1785510669619,"version":"3.56.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81572029"],"award-info":[{"award-number":["81572029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Commonweal Technology Application Project of Zhejiang Province","award":["2015C33101"],"award-info":[{"award-number":["2015C33101"]}]},{"name":"the Natural Science Foundation of Zhejiang Province","award":["LY13C080001"],"award-info":[{"award-number":["LY13C080001"]}]},{"name":"the Technology Application Project of Wenzhou City","award":["Y20170022"],"award-info":[{"award-number":["Y20170022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-2697-8","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T13:35:15Z","timestamp":1520861715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Microarray analysis of long non-coding RNA expression profiles uncovers a Toxoplasma-induced negative regulation of host immune signaling"],"prefix":"10.1186","volume":"11","author":[{"given":"Wenquan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"issue":"9425","key":"2697_CR1","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"JG Montoya","year":"2004","unstructured":"Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet. 2004;363(9425):1965\u201376.","journal-title":"Lancet"},{"key":"2697_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1756-3305-4-165","volume":"4","author":"P Zhou","year":"2011","unstructured":"Zhou P, Chen Z, Li HL, Zheng H, He S, Lin RQ, Zhu XQ. Toxoplasma gondii infection in humans in China. Parasit Vectors. 2011;4:165.","journal-title":"Parasit Vectors"},{"issue":"8","key":"2697_CR3","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","volume":"39","author":"LM Weiss","year":"2009","unstructured":"Weiss LM, Dubey JP. Toxoplasmosis: a history of clinical observations. Int J Parasitol. 2009;39(8):895\u2013901.","journal-title":"Int J Parasitol"},{"issue":"5806","key":"2697_CR4","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1126\/science.1133690","volume":"314","author":"JP Saeij","year":"2006","unstructured":"Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, et al. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006;314(5806):1780\u20133.","journal-title":"Science"},{"key":"2697_CR5","doi-asserted-by":"crossref","unstructured":"Balder IJ, Manger ID, Boothroyd JC. Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. J Biol Chem. 2001;276(26):24223\u201331.","DOI":"10.1074\/jbc.M100951200"},{"issue":"2","key":"2697_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0001-706X(01)00201-7","volume":"81","author":"VB Carruthers","year":"2002","unstructured":"Carruthers VB. Host cell invasion by the opportunistic pathogen Toxoplasma gondii. Acta Trop. 2002;81(2):111\u201322.","journal-title":"Acta Trop"},{"key":"2697_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1756-3305-6-96","volume":"6","author":"DH Zhou","year":"2013","unstructured":"Zhou DH, Zhao FR, Huang SY, Xu MJ, Song HQ, Su C, Zhu XQ. Changes in the proteomic profiles of mouse brain after infection with cyst-forming Toxoplasma gondii. Parasit Vectors. 2013;6:96.","journal-title":"Parasit Vectors"},{"issue":"4","key":"2697_CR8","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/j.1462-5822.2007.00909.x","volume":"9","author":"JF Dubremetz","year":"2007","unstructured":"Dubremetz JF. Rhoptries are major players in Toxoplasma gondii invasion and host cell interaction. Cell Microbiol. 2007;9(4):841\u20138.","journal-title":"Cell Microbiol"},{"key":"2697_CR9","doi-asserted-by":"crossref","unstructured":"Hakansson S, Charron AJ, Sibley LD. Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole. EMBO J. 2001;20(12):3132\u201344.","DOI":"10.1093\/emboj\/20.12.3132"},{"issue":"2","key":"2697_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000288","volume":"5","author":"YO Zhao","year":"2009","unstructured":"Zhao YO, Khaminets A, Hunn JP, Howard JC. Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog. 2009;5(2):e1000288.","journal-title":"PLoS Pathog"},{"issue":"4","key":"2697_CR11","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.4049\/jimmunol.160.4.1824","volume":"160","author":"PB Nash","year":"1998","unstructured":"Nash PB, Purner MB, Leon RP, Clarke P, Duke RC, Curiel TJ. Toxoplasma gondii-infected cells are resistant to multiple inducers of apoptosis. J Immunol. 1998;160(4):1824\u201330.","journal-title":"J Immunol"},{"issue":"Pt 19","key":"2697_CR12","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1242\/jcs.114.19.3495","volume":"114","author":"S Goebel","year":"2001","unstructured":"Goebel S, Gross U, Inhibition LCG. Of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression. J Cell Sci. 2001;114(Pt 19):3495\u2013505.","journal-title":"J Cell Sci"},{"issue":"3","key":"2697_CR13","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1074\/jbc.M807890200","volume":"284","author":"Y Wang","year":"2009","unstructured":"Wang Y, Weiss LM, Orlofsky A. Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J Biol Chem. 2009;284(3):1694\u2013701.","journal-title":"J Biol Chem"},{"issue":"5","key":"2697_CR14","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1462-5822.2008.01117.x","volume":"10","author":"RE Molestina","year":"2008","unstructured":"Molestina RE, El-Guendy N, Sinai AP. Infection with Toxoplasma gondii results in dysregulation of the host cell cycle. Cell Microbiol. 2008;10(5):1153\u201365.","journal-title":"Cell Microbiol"},{"issue":"3","key":"2697_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0928-8244(03)00279-7","volume":"39","author":"EY Denkers","year":"2003","unstructured":"Denkers EY. From cells to signaling cascades. Manipulation of innate immunity by Toxoplasma gondii. FEMS Immunol Med Microbiol. 2003;39(3):193\u2013203.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2697_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3389\/fgene.2015.00165","volume":"6","author":"PO Angrand","year":"2015","unstructured":"Angrand PO, Vennin C, Le Bourhis X, Adriaenssens E. The role of long non-coding RNAs in genome formatting and expression. Front Genet. 2015;6:165.","journal-title":"Front Genet"},{"issue":"12","key":"2697_CR17","doi-asserted-by":"publisher","first-page":"e114917","DOI":"10.1371\/journal.pone.0114917","volume":"9","author":"L Peng","year":"2014","unstructured":"Peng L, Paulson A, Li H, Piekos S, He X, Li L, Zhong XB. Developmental programming of long non-coding RNAs during postnatal liver maturation in mice. PLoS One. 2014;9(12):e114917.","journal-title":"PLoS One"},{"key":"2697_CR18","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3389\/fimmu.2014.00573","volume":"5","author":"K Imamura","year":"2014","unstructured":"Imamura K, Akimitsu N. Long non-coding RNAs involved in immune responses. Front Immunol. 2014;5:573.","journal-title":"Front Immunol"},{"key":"2697_CR19","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3389\/fimmu.2014.00513","volume":"5","author":"A Stachurska","year":"2014","unstructured":"Stachurska A, Zorro MM, van der Sijde MR, Withoff S. Small and long regulatory RNAs in the immune system and immune diseases. Front Immunol. 2014;5:513.","journal-title":"Front Immunol"},{"issue":"12","key":"2697_CR20","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nrm.2016.126","volume":"17","author":"JM Engreitz","year":"2016","unstructured":"Engreitz JM, Ollikainen N, Guttman M. Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression. Nat Rev Mol Cell Biol. 2016;17(12):756\u201370.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"2697_CR21","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.devcel.2012.12.012","volume":"24","author":"P Grote","year":"2013","unstructured":"Grote P, Wittler L, Hendrix D, Koch F, Wahrisch S, Beisaw A, et al. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell. 2013;24(2):206\u201314.","journal-title":"Dev Cell"},{"issue":"38","key":"2697_CR22","doi-asserted-by":"publisher","first-page":"5392","DOI":"10.1038\/onc.2017.133","volume":"36","author":"C Lin","year":"2017","unstructured":"Lin C, Wang Y, Wang Y, Zhang S, Yu L, Guo C, Xu H. Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells. Oncogene. 2017;36(38):5392\u2013406.","journal-title":"Oncogene"},{"issue":"5","key":"2697_CR23","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.immuni.2015.05.004","volume":"42","author":"T Satpathy Ansuman","year":"2015","unstructured":"Satpathy Ansuman T, Chang Howard Y. Long noncoding RNA in hematopoiesis and immunity. Immunity. 2015;42(5):792\u2013804.","journal-title":"Immunity"},{"issue":"1","key":"2697_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010039","volume":"18","author":"Y Ma","year":"2016","unstructured":"Ma Y, Ouyang J, Wei J, Maarouf M, Chen JL. Involvement of host non-coding RNAs in the pathogenesis of the influenza virus. Int J Mol Sci. 2016;18(1):e39.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2697_CR25","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bbrc.2012.11.101","volume":"430","author":"Z Yin","year":"2013","unstructured":"Yin Z, Guan D, Fan Q, Su J, Zheng W, Ma W, Ke C. lncRNA expression signatures in response to enterovirus 71 infection. Biochem Biophys Res Commun. 2013;430(2):629\u201333.","journal-title":"Biochem Biophys Res Commun"},{"key":"2697_CR26","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fgene.2012.00308","volume":"3","author":"V Scaria","year":"2013","unstructured":"Scaria V, Pasha A. Long non-coding RNAs in infection biology. Front Genet. 2013;3:308.","journal-title":"Front Genet"},{"issue":"5","key":"2697_CR27","doi-asserted-by":"publisher","first-page":"00206","DOI":"10.1128\/mBio.00206-10","volume":"1","author":"X Peng","year":"2010","unstructured":"Peng X, Gralinski L, Armour CD, Ferris MT, Thomas MJ, Proll S, et al. Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. MBio. 2010;1(5):00206\u201310.","journal-title":"MBio"},{"issue":"2","key":"2697_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12417","volume":"39","author":"Y Cai","year":"2017","unstructured":"Cai Y, Shen J. Modulation of host immune responses to Toxoplasma gondii by microRNAs. Parasite Immunol. 2017;39(2):12417.","journal-title":"Parasite Immunol"},{"issue":"1","key":"2697_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008742","volume":"5","author":"GM Zeiner","year":"2010","unstructured":"Zeiner GM, Norman KL, Thomson JM, Hammond SM, Boothroyd JC. Toxoplasma gondii infection specifically increases the levels of key host microRNAs. PLoS One. 2010;5(1):e8742.","journal-title":"PLoS One"},{"key":"2697_CR30","doi-asserted-by":"crossref","unstructured":"He JJ, Ma J, Wang JL, Xu MJ, Zhu XQ. Analysis of miRNA expression profiling in mouse spleen affected by acute toxoplasma gondii infection. Infect Genet Evol. 2016; 37:137\u2013142.","DOI":"10.1016\/j.meegid.2015.11.005"},{"key":"2697_CR31","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1756-3305-6-154","volume":"6","author":"M-J Xu","year":"2013","unstructured":"Xu M-J, Zhou D-H, Nisbet AJ, Huang S-Y, Fan Y-F, Zhu X-Q. Characterization of mouse brain microRNAs after infection with cyst-forming Toxoplasma gondii. Parasit Vectors. 2013;6:154.","journal-title":"Parasit Vectors"},{"issue":"4","key":"2697_CR32","doi-asserted-by":"publisher","first-page":"00255","DOI":"10.1128\/mBio.00255-13","volume":"4","author":"L Gov","year":"2013","unstructured":"Gov L, Karimzadeh A, Ueno N, Lodoen MB. Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. MBio. 2013;4(4):00255\u201313.","journal-title":"MBio"},{"issue":"12","key":"2697_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003779","volume":"9","author":"MB Melo","year":"2013","unstructured":"Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, et al. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog. 2013;9(12):e1003779.","journal-title":"PLoS Pathog"},{"issue":"2","key":"2697_CR34","first-page":"1","volume":"15","author":"XG Chen","year":"2016","unstructured":"Chen XG, Lv QX, Construction ZXQ. Of recombinant adenovirus ad-rat PLCg2-shRNA and successful suppression of PLCg2 expression in BRL-3A cells. Genet Mol Res. 2016;15(2):1\u201310.","journal-title":"Genet Mol Res"},{"issue":"8","key":"2697_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001071","volume":"6","author":"MB Melo","year":"2010","unstructured":"Melo MB, Kasperkovitz P, Cerny A, Konen-Waisman S, Kurt-Jones EA, Lien E, et al. UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog. 2010;6(8):e1001071.","journal-title":"PLoS Pathog"},{"issue":"5","key":"2697_CR36","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1074\/jbc.M110.171025","volume":"286","author":"R Pifer","year":"2011","unstructured":"Pifer R, Benson A, Sturge CR, Yarovinsky F. UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem. 2011;286(5):3307\u201314.","journal-title":"J Biol Chem"},{"issue":"3","key":"2697_CR37","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ijpara.2003.12.009","volume":"34","author":"K Kim","year":"2004","unstructured":"Kim K, Weiss LM. Toxoplasma gondii: the model apicomplexan. Int J Parasitol. 2004;34(3):423\u201332.","journal-title":"Int J Parasitol"},{"issue":"3","key":"2697_CR38","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1574-6976.2011.00305.x","volume":"36","author":"WJ Sullivan Jr","year":"2012","unstructured":"Sullivan WJ Jr, Jeffers V. Mechanisms of Toxoplasma gondii persistence and latency. FEMS Microbiol Rev. 2012;36(3):717\u201333.","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"2697_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152022","volume":"11","author":"JJ He","year":"2016","unstructured":"He JJ, Ma J, Elsheikha HM, Song HQ, Zhou DH, Zhu XQ. Proteomic profiling of mouse liver following acute Toxoplasma gondii infection. PLoS One. 2016;11(3):e0152022.","journal-title":"PLoS One"},{"issue":"7125","key":"2697_CR40","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature05395","volume":"445","author":"JP Saeij","year":"2007","unstructured":"Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007;445(7125):324\u20137.","journal-title":"Nature"},{"issue":"1","key":"2697_CR41","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.molbiopara.2005.02.013","volume":"142","author":"X Xu","year":"2005","unstructured":"Xu X, Dong Y, Abraham EG, Kocan A, Srinivasan P, Ghosh AK, et al. Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. Mol Biochem Parasitol. 2005;142(1):76\u201387.","journal-title":"Mol Biochem Parasitol"},{"key":"2697_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/srep38963","volume":"6","author":"X Yang","year":"2016","unstructured":"Yang X, Yang J, Wang J, Wen Q, Wang H, He J, et al. Microarray analysis of long noncoding RNA and mRNA expression profiles in human macrophages infected with Mycobacterium tuberculosis. Sci Rep. 2016;6:38963.","journal-title":"Sci Rep"},{"issue":"2","key":"2697_CR43","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1645\/GE-404R","volume":"91","author":"SM Guk","year":"2005","unstructured":"Guk SM, Kook J, Jeon YH, Choi JH, Han ET, Shin EH, Chai JY. Suppressed cytokine and immunoglobulin secretions by murine splenic lymphocytes infected in vitro with Toxoplasma gondii tachyzoites. J Parasitol. 2005;91(2):467\u201370.","journal-title":"J Parasitol"},{"issue":"3","key":"2697_CR44","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.4049\/jimmunol.176.3.1840","volume":"176","author":"S Zimmermann","year":"2006","unstructured":"Zimmermann S, Murray PJ, Heeg K, Dalpke AH. Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol. 2006;176(3):1840\u20137.","journal-title":"J Immunol"},{"issue":"Suppl 1","key":"2697_CR45","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1086\/338000","volume":"185","author":"S Shapira","year":"2002","unstructured":"Shapira S, Speirs K, Gerstein A, Caamano J, Hunter CA. Suppression of NF-kappaB activation by infection with Toxoplasma gondii. J Infect Dis. 2002;185(Suppl 1):S66\u201372.","journal-title":"J Infect Dis"},{"issue":"1","key":"2697_CR46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.4049\/jimmunol.182.1.489","volume":"182","author":"J Leng","year":"2009","unstructured":"Leng J, Butcher BA, Egan CE, Abi Abdallah DS, Denkers EY. Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation. J Immunol. 2009;182(1):489\u201397.","journal-title":"J Immunol"},{"issue":"1","key":"2697_CR47","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.immuni.2012.09.016","volume":"38","author":"AA Koblansky","year":"2013","unstructured":"Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, et al. Recognition of profilin by toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity. 2013;38(1):119\u201330.","journal-title":"Immunity"},{"issue":"9","key":"2697_CR48","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.4049\/jimmunol.1301301","volume":"191","author":"M Raetz","year":"2013","unstructured":"Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, et al. Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin. J Immunol. 2013;191(9):4818\u201327.","journal-title":"J Immunol"},{"issue":"19","key":"2697_CR49","doi-asserted-by":"publisher","first-page":"7072","DOI":"10.1073\/pnas.1322838111","volume":"11","author":"JW Huh","year":"2014","unstructured":"Huh JW, Shibata T, Hwang M, Kwon EH, Jang MS, Fukui R, et al. UNC93B1 is essential for the plasma membrane localization and signaling of toll-like receptor 5. Proc Natl Acad Sci USA. 2014;11(19):7072\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2697_CR50","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.immuni.2011.05.010","volume":"35","author":"R Fukui","year":"2011","unstructured":"Fukui R, Saitoh S, Kanno A, Onji M, Shibata T, Ito A, et al. Unc93B1 restricts systemic lethal inflammation by orchestrating toll-like receptor 7 and 9 trafficking. Immunity. 2011;35(1):69\u201381.","journal-title":"Immunity"},{"issue":"7184","key":"2697_CR51","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nature06726","volume":"452","author":"YM Kim","year":"2008","unstructured":"Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008;452(7184):234\u20138.","journal-title":"Nature"},{"issue":"2","key":"2697_CR52","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1083\/jcb.200612056","volume":"177","author":"MM Brinkmann","year":"2007","unstructured":"Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007;177(2):265\u201375.","journal-title":"J Cell Biol"},{"issue":"6","key":"2697_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039161","volume":"7","author":"MJ Crane","year":"2012","unstructured":"Crane MJ, Gaddi PJ, Salazar-Mather TP. UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection. PLoS One. 2012;7(6):e39161.","journal-title":"PLoS One"},{"issue":"4","key":"2697_CR54","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.4049\/jimmunol.1003911","volume":"187","author":"BC Caetano","year":"2011","unstructured":"Caetano BC, Carmo BB, Melo MB, Cerny A, dos Santos SL, Bartholomeu DC, et al. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol. 2011;187(4):1903\u201311.","journal-title":"J Immunol"},{"issue":"3","key":"2697_CR55","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1128\/IAI.72.3.1257-1264.2004","volume":"72","author":"LC Gavrilescu","year":"2004","unstructured":"Gavrilescu LC, Butcher BA, Del Rio L, Taylor GA, Denkers EY. STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect Immun. 2004;72(3):1257\u201364.","journal-title":"Infect Immun"},{"issue":"6147","key":"2697_CR56","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/science.1240925","volume":"341","author":"S Carpenter","year":"2013","unstructured":"Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013;341(6147):789\u201392.","journal-title":"Science"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2697-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-2697-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2697-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:24:37Z","timestamp":1693581877000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-2697-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2697"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-2697-8","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]},"assertion":[{"value":"25 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"174"}}