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The study design as well as different protocols was approved by the REFOTDE Institutional Animal Ethics Committee (RIAEC), with an ethical clearance obtained from this board, and the Cameroon National Ethics Committee (Ministry of Public Health). Handling of the animals and the investigations carried out were done strictly according to the international guidelines of rearing animals and using them in medical research under the official authorisation of the Ministry of Scientific Research in Cameroon (Research permit N\u00b0 028\/MINRESI\/B00\/C00\/\/C10\/C12\/2007). The manipulations of the animals were done strictly according to the Animal Welfare Legislation and Policies, complied with the Animals (Scientific Procedures) Act 1986 (ASPA) and its associated codes of practice on animal housing and care []. Informed consent was obtained the human participant. Previous works that used the same procedures are found here [, ].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"275"}}