{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:58:51Z","timestamp":1782277131464,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31630078"],"award-info":[{"award-number":["31630078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31425025"],"award-info":[{"award-number":["31425025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-2889-2","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T07:29:28Z","timestamp":1527060568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characterization of MEDLE-1, a protein in early development of Cryptosporidium parvum"],"prefix":"10.1186","volume":"11","author":[{"given":"Jilan","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"2889_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","volume":"15","author":"W Checkley","year":"2015","unstructured":"Checkley W, White AC, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for Cryptosporidium. Lancet Infect Dis. 2015;15:85\u201394.","journal-title":"Lancet Infect Dis."},{"key":"2889_CR2","doi-asserted-by":"crossref","unstructured":"Chalmers RM, Davies AP. Minireview: clinical cryptosporidiosis. Exp Parasitol. 2010;124:138\u201346.","DOI":"10.1016\/j.exppara.2009.02.003"},{"key":"2889_CR3","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/S0020-7519(02)00197-2","volume":"32","author":"LH Xiao","year":"2002","unstructured":"Xiao LH, Sulaiman IM, Ryan UM, Zhou L, Atwill ER, Tischler ML, et al. Host adaptation and host-parasite co-evolution in Cryptosporidium: implications for taxonomy and public health. Int J Parasitol. 2002;32:1773\u201385.","journal-title":"Int J Parasitol."},{"key":"2889_CR4","doi-asserted-by":"crossref","unstructured":"Ryan U, Fayer R, Xiao LH. Cryptosporidium species in humans and animals: current understanding and research needs. Parasitology. 2014;141:1667\u201385.","DOI":"10.1017\/S0031182014001085"},{"key":"2889_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.exppara.2009.03.018","volume":"124","author":"LH Xiao","year":"2010","unstructured":"Xiao LH. Molecular epidemiology of cryptosporidiosis: an update. Exp Parasitol. 2010;124:80\u20139.","journal-title":"Exp Parasitol."},{"key":"2889_CR6","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1017\/S0031182014000237","volume":"141","author":"M Lendner","year":"2014","unstructured":"Lendner M, Daugschies A. Cryptosporidium infections: molecular advances. Parasitology. 2014;141:1511\u201332.","journal-title":"Parasitology"},{"key":"2889_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/CMR.00076-12","volume":"26","author":"M Bouzid","year":"2013","unstructured":"Bouzid M, Hunter PR, Chalmers RM, Tyler KM. Cryptosporidium pathogenicity and virulence. Clin Microbiol Rev. 2013;26:115\u201334.","journal-title":"Clin Microbiol Rev."},{"key":"2889_CR8","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1016\/j.micinf.2006.04.012","volume":"8","author":"V Jakobi","year":"2006","unstructured":"Jakobi V, Petry F. Differential expression of Cryptosporidium parvum genes encoding sporozoite surface antigens in infected HCT-8 host cells. Microbes Infect. 2006;8:2186\u201394.","journal-title":"Microbes Infect."},{"issue":"5669","key":"2889_CR9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1126\/science.1094786","volume":"304","author":"MS Abrahamsen","year":"2004","unstructured":"Abrahamsen MS, Templeton TJ, Enomoto S, Abrahante JE, Zhu G, Lancto CA, et al. Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science. 2004;304(5669):441\u20135.","journal-title":"Science."},{"key":"2889_CR10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12864-015-1517-1","volume":"16","author":"YQ Guo","year":"2015","unstructured":"Guo YQ, Tang K, Rowe LA, Li N, Roellig DM, Knipe K, et al. Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum. BMC Genomics. 2015;16:320.","journal-title":"BMC Genomics."},{"key":"2889_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ijpara.2016.12.002","volume":"47","author":"YY Feng","year":"2017","unstructured":"Feng YY, Li N, Roellig DM, Kelley A, Liu GY, Amer S, et al. Comparative genomic analysis of the IId subtype family of Cryptosporidium parvum. Int J Parasitol. 2017;47:281\u201390.","journal-title":"Int J Parasitol."},{"key":"2889_CR12","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1186\/s12864-016-3343-5","volume":"17","author":"SY Liu","year":"2016","unstructured":"Liu SY, Roellig DM, Guo YQ, Li N, Frace MA, Tang K, et al. Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium. BMC Genomics. 2016;17:1006.","journal-title":"BMC Genomics."},{"key":"2889_CR13","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.3389\/fmicb.2017.01647","volume":"8","author":"B Li","year":"2017","unstructured":"Li B, Wu HZ, Li N, Su JY, Jia RL, Jiang JL, et al. Preliminary characterization of MEDLE-2, a protein potentially involved in the invasion of Cryptosporidium parvum. Front Microbiol. 2017;8:1647.","journal-title":"Front Microbiol."},{"key":"2889_CR14","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","volume":"23","author":"MA Larkin","year":"2007","unstructured":"Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, et al. Clustal W and Clustal X version 2.0. Bioinformatics. 2007;23:2947\u20138.","journal-title":"Bioinformatics"},{"key":"2889_CR15","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2017","unstructured":"Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Molecular Biology and Evolution. 2017;33:1870\u20134.","journal-title":"Molecular Biology and Evolution."},{"key":"2889_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031715","volume":"7","author":"MJ Mauzy","year":"2012","unstructured":"Mauzy MJ, Enomoto S, Lancto CA, Abrahamsen MS, Rutherford MS. The Cryptosporidium parvum transcriptome during in vitro development. PLoS One. 2012;7:e31715.","journal-title":"PLoS One."},{"key":"2889_CR17","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402\u20138.","journal-title":"Methods."},{"key":"2889_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1017\/S0031182009990837","volume":"137","author":"H Borowski","year":"2010","unstructured":"Borowski H, Thompson RC, Armstrong T, Clode PL. Morphological characterization of Cryptosporidium parvum life-cycle stages in an in vitro model system. Parasitology. 2010;137:13\u201326.","journal-title":"Parasitology."},{"issue":"5668","key":"2889_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.1094717","volume":"304","author":"LD Sibley","year":"2004","unstructured":"Sibley LD. Intracellular parasite invasion strategies. Science. 2004;304(5668):248\u201353.","journal-title":"Science."},{"key":"2889_CR20","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.pt.2008.08.002","volume":"24","author":"H Borowski","year":"2008","unstructured":"Borowski H, Clode PL, Thompson RC. Active invasion and\/or encapsulation? A reappraisal of host-cell parasitism by Cryptosporidium. Trends Parasitol. 2008;24:509\u201316.","journal-title":"Trends Parasitol."},{"key":"2889_CR21","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1099\/00221287-144-12-3249","volume":"144","author":"L Tetley","year":"1998","unstructured":"Tetley L, Brown SM, McDonald V, Coombs GH. Ultrastructural analysis of the sporozoite of Cryptosporidium parvum. Microbiology. 1998;144:3249\u201355.","journal-title":"Microbiology."},{"key":"2889_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3347\/kjp.2015.53.5.583","volume":"53","author":"LA Marchat","year":"2015","unstructured":"Marchat LA, Arzola-Rodriguez SI, Hernandez-de la Cruz O, Lopez-Rosas I, Lopez-Camarillo C. DEAD\/DExH-Box RNA helicases in selected human parasites. Korean J Parasitol. 2015;53:583\u201395.","journal-title":"Korean J Parasitol."},{"key":"2889_CR23","doi-asserted-by":"crossref","unstructured":"Zhao YL, Yap GS. Toxoplasma\u2019s arms race with the host interferon response: a menage a trois of ROPs. Cell Host Microbe. 2014;15:517\u20138.","DOI":"10.1016\/j.chom.2014.05.002"},{"key":"2889_CR24","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1093\/infdis\/jix124","volume":"215","author":"Y Wang","year":"2017","unstructured":"Wang Y, Gong AY, Ma SB, Chen XQ, Li Y, Su CJ, et al. Delivery of parasite RNA transcripts into infected epithelial cells during Cryptosporidium infection and its potential impact on host gene transcription. J Infect Dis. 2017;215:636\u201343.","journal-title":"J Infect Dis."},{"key":"2889_CR25","doi-asserted-by":"publisher","unstructured":"Wang Y, Gong AY, Ma SB, Chen XQ, Strauss-Soukup JK, Chen XM. Delivery of parasite Cdg7_Flc_0990 RNA transcript into intestinal epithelial cells during Cryptosporidium parvum infection suppresses host cell gene transcription through epigenetic mechanisms. Cell Microbiol. 2017;19 \n                    https:\/\/doi.org\/10.1111\/cmi.12760\n                    \n                  .","DOI":"10.1111\/cmi.12760"},{"key":"2889_CR26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12862-016-0625-0","volume":"16","author":"FU Battistuzzi","year":"2016","unstructured":"Battistuzzi FU, Schneider KA, Spencer MK, Fisher D, Chaudhry S, Escalante AA. Profiles of low complexity regions in Apicomplexa. BMC Evol Biol. 2016;16:47.","journal-title":"BMC Evol Biol."},{"key":"2889_CR27","doi-asserted-by":"publisher","unstructured":"Widmer G. Diverse single-amino-acid repeat profiles in the genus Cryptosporidium. Parasitology. 2018:doi:\n                    https:\/\/doi.org\/10.1017\/S0031182018000112\n                    \n                  .","DOI":"10.1017\/S0031182018000112"},{"key":"2889_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1752-0509-4-43","volume":"4","author":"A Coletta","year":"2010","unstructured":"Coletta A, Pinney JW, Solis DYW, Marsh J, Pettifer SR, Attwood TK. Low-complexity regions within protein sequences have position-dependent roles. BMC Syst Biol. 2010;4:43.","journal-title":"BMC Syst Biol."},{"key":"2889_CR29","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1101\/gr.GR-1522R","volume":"11","author":"E Pizzi","year":"2001","unstructured":"Pizzi E, Frontali C. Low-complexity regions in Plasmodium falciparum proteins. Genome Res. 2001;11:218\u201329.","journal-title":"Genome Res."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2889-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-2889-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2889-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T19:08:37Z","timestamp":1558552117000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-2889-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,23]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2889"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-2889-2","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,23]]},"assertion":[{"value":"7 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of the East China University of Science and Technology.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"312"}}