{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:49:47Z","timestamp":1779889787536,"version":"3.53.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["3020-32000-010"],"award-info":[{"award-number":["3020-32000-010"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["3020-32000-007"],"award-info":[{"award-number":["3020-32000-007"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-2935-0","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T11:20:45Z","timestamp":1529493645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Physiological and immunological responses to Culicoides sonorensis blood-feeding: a murine model"],"prefix":"10.1186","volume":"11","author":[{"given":"Christopher J.","family":"Lehiy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey M.","family":"Reister-Hendricks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Ruder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Scott","family":"McVey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-4512","authenticated-orcid":false,"given":"Barbara S.","family":"Drolet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"2935_CR1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1603\/ME13239","volume":"51","author":"TJ Lysyk","year":"2014","unstructured":"Lysyk TJ, Dergousoff SJ. Distribution of Culicoides sonorensis (Diptera: Ceratopogonidae) in Alberta, Canada. J Med Entomol. 2014;51:560\u201371.","journal-title":"J Med Entomol."},{"key":"2935_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1603\/0022-2585-37.1.65","volume":"37","author":"FR Holbrook","year":"2000","unstructured":"Holbrook FR, Tabachnick WJ, Schmidtmann ET, McKinnon CN, Bobian RJ, Grogan WL. Sympatry in the Culicoides variipennis complex (Diptera: Ceratopogonidae): a taxonomic reassessment. J Med Entomol. 2000;37:65\u201376.","journal-title":"J Med Entomol."},{"key":"2935_CR3","doi-asserted-by":"publisher","first-page":"476","DOI":"10.7589\/0090-3558-28.3.476","volume":"28","author":"BA Mullens","year":"1992","unstructured":"Mullens BA, Dada CE. Insects feeding on desert bighorn sheep, domestic rabbits, and Japanese-quail in the Santa-Rosa mountains of Southern California. J Wildl Dis. 1992;28:476\u201380.","journal-title":"J Wildl Dis."},{"key":"2935_CR4","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1093\/jmedent\/8.5.532","volume":"8","author":"CH Tempelis","year":"1971","unstructured":"Tempelis CH, Nelson RL. Blood-feeding patterns of midges of Culicoides variipennis complex in Kern-County. California. J Med Entomol. 1971;8:532\u20134.","journal-title":"California. J Med Entomol."},{"key":"2935_CR5","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1603\/033.046.0329","volume":"46","author":"AC Gerry","year":"2009","unstructured":"Gerry AC, Sarto i, Monteys V, Moreno Vidal JO, Francino O, Mullens BA. Biting rates of Culicoides midges (Diptera: Ceratopogonidae) on sheep in northeastern Spain in relation to midge capture using UV light and carbon dioxide-baited traps. J Med Entomol. 2009;46:615\u201324.","journal-title":"J Med Entomol."},{"key":"2935_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/jmedent\/35.3.245","volume":"35","author":"BA Mullens","year":"1998","unstructured":"Mullens BA, Gerry AC. Comparison of bait cattle and carbon dioxide-baited suction traps for collecting Culicoides variipennis sonorensis (Diptera: Ceratopogonidae) and Culex quinquefasciatus (Diptera: Culicidae). J Med Entomol. 1998;35:245\u201350.","journal-title":"J Med Entomol."},{"key":"2935_CR7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/1756-3305-4-187","volume":"4","author":"A Fontaine","year":"2011","unstructured":"Fontaine A, Diouf I, Bakkali N, Misse D, Pages F, Fusai T, et al. Implication of haematophagous arthropod salivary proteins in host-vector interactions. Parasit Vectors. 2011;4:187.","journal-title":"Parasit Vectors."},{"key":"2935_CR8","doi-asserted-by":"publisher","first-page":"e426","DOI":"10.7717\/peerj.426","volume":"2","author":"CJ Lehiy","year":"2014","unstructured":"Lehiy CJ, Drolet BS. The salivary secretome of the biting midge, Culicoides sonorensis. PeerJ. 2014;2:e426.","journal-title":"PeerJ."},{"key":"2935_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2583.2004.00537.x","volume":"14","author":"CL Campbell","year":"2005","unstructured":"Campbell CL, Vandyke KA, Letchworth GJ, Drolet BS, Hanekamp T, Wilson WC. Midgut and salivary gland transcriptomes of the arbovirus vector Culicoides sonorensis (Diptera: Ceratopogonidae). Insect Mol Biol. 2005;14:121\u201336.","journal-title":"Insect Mol Biol."},{"key":"2935_CR10","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1365-2583.2009.00882.x","volume":"18","author":"CL Russell","year":"2009","unstructured":"Russell CL, Heesom KJ, Arthur CJ, Helps CR, Mellor PS, Day MJ, et al. Identification and isolation of cDNA clones encoding the abundant secreted proteins in the saliva proteome of Culicoides nubeculosus. Insect Mol Biol. 2009;18:383\u201393.","journal-title":"Insect Mol Biol."},{"key":"2935_CR11","first-page":"255","volume":"124","author":"DA Price","year":"1954","unstructured":"Price DA, Hardy WT. Isolation of the bluetongue virus from Texas sheep - Culicoides shown to be a vector. J Am Vet Med Assoc. 1954;124:255\u20138.","journal-title":"J Am Vet Med Assoc"},{"key":"2935_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7589\/0090-3558-13.1.9","volume":"13","author":"NM Foster","year":"1977","unstructured":"Foster NM, Breckon RD, Luedke AJ, Jones RH. Transmission of two strains of epizootic hemorrhagic disease virus in deer by Culicoides variipennis. J Wildl Dis. 1977;13:9\u201316.","journal-title":"J Wildl Dis"},{"key":"2935_CR13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/1756-3305-5-236","volume":"5","author":"MG Ruder","year":"2012","unstructured":"Ruder MG, Howerth EW, Stallknecht DE, Allison AB, Carter DL, Drolet BS, et al. Vector competence of Culicoides sonorensis (Diptera: Ceratopogonidae) to epizootic hemorrhagic disease virus serotype 7. Parasit Vectors. 2012;5:236.","journal-title":"Parasit Vectors"},{"key":"2935_CR14","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1177\/0300985815610387","volume":"53","author":"MG Ruder","year":"2016","unstructured":"Ruder MG, Stallknecht DE, Allison AB, Mead DG, Carter DL, Howerth EW. Host and potential vector susceptibility to an emerging orbivirus in the United States: epizootic hemorrhagic disease virus serotype 6. Vet Pathol. 2016;53:574\u201384.","journal-title":"Vet Pathol"},{"key":"2935_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.ento.45.1.307","volume":"45","author":"PS Mellor","year":"2000","unstructured":"Mellor PS, Boorman J, Baylis M. Culicoides biting midges: their role as arbovirus vectors. Annu Rev Entomol. 2000;45:307\u201340.","journal-title":"Annu Rev Entomol"},{"key":"2935_CR16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/jmedent\/42.3.409","volume":"42","author":"BS Drolet","year":"2005","unstructured":"Drolet BS, Campbell CL, Stuart MA, Wilson WC. Vector competence of Culicoides sonorensis (Diptera: Ceratopogonidae) for vesicular stomatitis virus. J Med Entomol. 2005;42:409\u201318.","journal-title":"J Med Entomol"},{"key":"2935_CR17","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1603\/0022-2585(2006)43[568:IOGPWV]2.0.CO;2","volume":"43","author":"AA Perez de Leon","year":"2006","unstructured":"Perez de Leon AA, O'Toole D, Tabachnick WJ. Infection of guinea pigs with vesicular stomatitis New Jersey virus transmitted by Culicoides sonorensis (Diptera: Ceratopogonidae). J Med Entomol. 2006;43:568\u201373.","journal-title":"J Med Entomol"},{"key":"2935_CR18","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1603\/0022-2585(2006)043[0323:TOVSNJ]2.0.CO;2","volume":"43","author":"AA Perez de Leon","year":"2006","unstructured":"Perez de Leon AA, Tabachnick WJ. Transmission of vesicular stomatitis New Jersey virus to cattle by the biting midge Culicoides sonorensis (Diptera: Ceratopogonidae). J Med Entomol. 2006;43:323\u20139.","journal-title":"J Med Entomol"},{"key":"2935_CR19","doi-asserted-by":"crossref","unstructured":"Nandi S, Negi BS. Bovine ephemeral fever: a review. Comp Immunol Microbiol Infect Dis. 1999;22:81\u201391.","DOI":"10.1016\/S0147-9571(98)00027-7"},{"key":"2935_CR20","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1126\/science.6800036","volume":"215","author":"FP Pinheiro","year":"1982","unstructured":"Pinheiro FP, Travassos Da Rosa APA, Gomes MLC, Leduc JW, Hoch AL. Transmission of oropouche virus from man to hamster by the midge Culicoides paraensis. Science. 1982;215:1251\u20133.","journal-title":"Science"},{"key":"2935_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/1756-3305-5-213","volume":"5","author":"K Lehmann","year":"2012","unstructured":"Lehmann K, Werner D, Hoffmann B, Kampen H. PCR identification of culicoid biting midges (Diptera, Ceratopogonidae) of the Obsoletus complex including putative vectors of bluetongue and Schmallenberg viruses. Parasit Vectors. 2012;5:213.","journal-title":"Parasit Vectors"},{"key":"2935_CR22","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1365-2915.2008.00732.x","volume":"22","author":"M Baylis","year":"2008","unstructured":"Baylis M, O'Connell L, Mellor PS. Rates of bluetongue virus transmission between Culicoides sonorensis and sheep. Med Vet Entomol. 2008;22:228\u201337.","journal-title":"Med Vet Entomol"},{"key":"2935_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0378-1135(85)90019-7","volume":"10","author":"HW Ghalib","year":"1985","unstructured":"Ghalib HW, Cherrington JM, Osburn BI. Virological, clinical and serological responses of sheep infected with tissue culture adapted bluetongue virus serotypes 10, 11, 13 and 17. Vet Microbiol. 1985;10:179\u201388.","journal-title":"Vet Microbiol"},{"key":"2935_CR24","doi-asserted-by":"publisher","first-page":"e83683","DOI":"10.1371\/journal.pone.0083683","volume":"9","author":"N Pages","year":"2014","unstructured":"Pages N, Breard E, Urien C, Talavera S, Viarouge C, Lorca-Oro C, et al. Culicoides midge bites modulate the host response and impact on bluetongue virus infection in sheep. PLoS One. 2014;9:e83683.","journal-title":"PLoS One"},{"key":"2935_CR25","first-page":"379","volume":"51","author":"BS Drolet","year":"2015","unstructured":"Drolet BS, Reister LM, Lehiy CJ, Van Rijn PA, Bowen RA. Effect of Culicoides sonorensis salivary proteins on clinical disease outcome in experimental bluetongue virus serotype 8 infection of Dorset sheep. Vet Ital. 2015;51:379\u201384.","journal-title":"Vet Ital"},{"key":"2935_CR26","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/jmedent\/28.5.685","volume":"28","author":"GS Anderson","year":"1991","unstructured":"Anderson GS, Belton P, Kleider N. Culicoides-Obsoletus (Diptera, Ceratopogonidae) as a causal agent of Culicoides hypersensitivity (sweet itch) in British-Columbia. J Med Entomol. 1991;28:685\u201393.","journal-title":"J Med Entomol"},{"key":"2935_CR27","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1136\/vr.147.13.360","volume":"147","author":"I Yeruham","year":"2000","unstructured":"Yeruham I, Braverman Y, Perl S. Study of apparent hypersensitivity to Culicoides species in sheep in Israel. Veterinary Record. 2000;147:360\u20133.","journal-title":"Veterinary Record"},{"key":"2935_CR28","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0034-5288(18)31247-5","volume":"47","author":"S Halldorsdottir","year":"1989","unstructured":"Halldorsdottir S, Larsen HJ, Mehl R. Intradermal challenge of Icelandic horses with extracts of 4 species of the genus Culicoides. Res Vet Sci. 1989;47:283\u20137.","journal-title":"Res Vet Sci"},{"key":"2935_CR29","doi-asserted-by":"publisher","first-page":"707","DOI":"10.2746\/042516401776249363","volume":"33","author":"AD Wilson","year":"2001","unstructured":"Wilson AD, Harwood LJ, Bjornsdottir S, Marti E, Day MJ. Detection of IgG and IgE serum antibodies to Culicoides salivary gland antigens in horses with insect dermal hypersensitivity (sweet itch). Equine Vet J. 2001;33:707\u201313.","journal-title":"Equine Vet J"},{"key":"2935_CR30","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1159\/000106459","volume":"144","author":"E Hamza","year":"2007","unstructured":"Hamza E, Doherr MG, Bertoni G, Jungi TW, Marti E. Modulation of allergy incidence in Icelandic horses is associated with a change in IL-4-producing T cells. Int Arch Allergy Imm. 2007;144:325\u201337.","journal-title":"Int Arch Allergy Imm"},{"key":"2935_CR31","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ijpara.2008.06.008","volume":"39","author":"KFA Langner","year":"2009","unstructured":"Langner KFA, Jarvis DL, Nimtz M, Heselhaus JE, McHolland LE, Leibold W, et al. Identification, expression and characterisation of a major salivary allergen (Cul s 1) of the biting midge Culicoides sonorensis relevant for summer eczema in horses. Int J Parasitol. 2009;39:243\u201350.","journal-title":"Int J Parasitol"},{"key":"2935_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.vetimm.2006.04.009","volume":"113","author":"W Hellberg","year":"2006","unstructured":"Hellberg W, Wilson AD, Mellor P, Doherr MG, Torsteinsdottir S, Zurbriggen A, et al. Equine insect bite hypersensitivity: immunoblot analysis of IgE and IgG subclass responses to Culicoides nubeculosus salivary gland extract. Vet Immunol Immunop. 2006;113:99\u2013112.","journal-title":"Vet Immunol Immunop"},{"key":"2935_CR33","doi-asserted-by":"publisher","first-page":"8789","DOI":"10.1128\/JVI.00626-09","volume":"83","author":"B Hemati","year":"2009","unstructured":"Hemati B, Contreras V, Urien C, Bonneau M, Takamatsu HH, Mertens PP, et al. Bluetongue virus targets conventional dendritic cells in skin lymph. J Virol. 2009;83:8789\u201399.","journal-title":"J Virol"},{"key":"2935_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1297-9716-43-40","volume":"43","author":"KE Darpel","year":"2012","unstructured":"Darpel KE, Monaghan P, Simpson J, Anthony SJ, Veronesi E, Brooks HW, et al. Involvement of the skin during bluetongue virus infection and replication in the ruminant host. Vet Res. 2012;43:40.","journal-title":"Vet Res"},{"key":"2935_CR35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0147-9571(94)90043-4","volume":"17","author":"NJ MacLachlan","year":"1994","unstructured":"MacLachlan NJ. The pathogenesis and immunology of bluetongue virus infection of ruminants. Comp Immunol Microbiol Infect Dis. 1994;17:197\u2013206.","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"2935_CR36","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/jee\/53.5.731","volume":"53","author":"RH Jones","year":"1960","unstructured":"Jones RH. Mass-production methods for the colonization of Culicoides variipennis sonorensis. J Econ Entomol. 1960;53:731\u20135.","journal-title":"J Econ Entomol"},{"key":"2935_CR37","doi-asserted-by":"crossref","unstructured":"Razin E, Cordoncardo C, Good RA. Growth of a pure population of mouse mast-cells in vitro with conditioned medium derived from concanavalin A - stimulated splenocytes. Proc Natl Acad Sci USA. 1981;78:2559\u201361.","DOI":"10.1073\/pnas.78.4.2559"},{"key":"2935_CR38","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.4049\/jimmunol.157.4.1720","volume":"157","author":"C Tkaczyk","year":"1996","unstructured":"Tkaczyk C, Frandji P, Botros HG, Poncet P, Lapeyre J, Peronet R, et al. Mouse bone marrow-derived mast cells and mast cell lines constitutively produce B cell growth and differentiation activities. J Immunol. 1996;157:1720\u20138.","journal-title":"J Immunol"},{"key":"2935_CR39","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4049\/jimmunol.158.1.393","volume":"158","author":"T Ogasawara","year":"1997","unstructured":"Ogasawara T, Murakami M, SuzukiNishimura T, Uchida MK, Kudo I. Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. J Immunol. 1997;158:393\u2013404.","journal-title":"J Immunol"},{"key":"2935_CR40","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/jmedent\/44.2.238","volume":"44","author":"KFA Langner","year":"2007","unstructured":"Langner KFA, Darpel KE, Denison E, Drolet BS, Leibold W, Mellor PS, et al. Collection and analysis of salivary proteins from the biting midge Culicoides nubeculosus (Diptera: Ceratopogonidae). J Med Entomol. 2007;44:238\u201348.","journal-title":"J Med Entomol"},{"key":"2935_CR41","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/biomet\/93.3.491","volume":"93","author":"Y Benjamini","year":"2006","unstructured":"Benjamini Y, Krieger AM, Yekutieli D. Adaptive linear step-up procedures that control the false discovery rate. Biometrika. 2006;93:491\u201350.","journal-title":"Biometrika"},{"key":"2935_CR42","doi-asserted-by":"publisher","first-page":"3.25.1","DOI":"10.1002\/0471142735.im0325s106","volume":"106","author":"TY Halim","year":"2014","unstructured":"Halim TY, Takei F. Isolation and characterization of mouse innate lymphoid cells. Curr Protoc Immunol. 2014;106:3.25.1\u201313.","journal-title":"Curr Protoc Immunol"},{"key":"2935_CR43","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402\u20138.","journal-title":"Methods"},{"key":"2935_CR44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/scrt114","volume":"3","author":"GR Barclay","year":"2012","unstructured":"Barclay GR, Tura O, Samuel K, Hadoke PW, Mills NL, Newby DE, et al. Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularization. Stem Cell Res Ther. 2012;3:23.","journal-title":"Stem Cell Res Ther"},{"key":"2935_CR45","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jim.2007.11.012","volume":"332","author":"MI Harrell","year":"2008","unstructured":"Harrell MI, Iritani BM, Ruddell A. Lymph node mapping in the mouse. J Immunol Methods. 2008;332:170\u20134.","journal-title":"J Immunol Methods"},{"key":"2935_CR46","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/104063870301500116","volume":"15","author":"D O'Toole","year":"2003","unstructured":"O'Toole D, Perez de Leon AA, Hearne C, McHolland L, Yun L, Tabachnick W. Papular dermatitis induced in guinea pigs by the biting midge Culicoides sonorensis (Diptera: Ceratopogonidae). J Vet Diagn Invest. 2003;15:67\u201371.","journal-title":"J Vet Diagn Invest"},{"key":"2935_CR47","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","volume":"106","author":"K Amin","year":"2012","unstructured":"Amin K. The role of mast cells in allergic inflammation. Respir Med. 2012;106:9\u201314.","journal-title":"Respir Med"},{"key":"2935_CR48","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.4049\/jimmunol.174.7.3932","volume":"174","author":"CE Demeure","year":"2005","unstructured":"Demeure CE, Brahimi K, Hacini F, Marchand F, Peronet R, Huerre M, et al. Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia. J Immunol. 2005;174:3932\u201340.","journal-title":"J Immunol"},{"key":"2935_CR49","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00018-010-0587-0","volume":"68","author":"A Lundequist","year":"2011","unstructured":"Lundequist A, Pejler G. Biological implications of preformed mast cell mediators. Cell Mol Life Sci. 2011;68:965\u201375.","journal-title":"Cell Mol Life Sci"},{"key":"2935_CR50","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1369\/0022155414545334","volume":"62","author":"EZ da Silva","year":"2014","unstructured":"da Silva EZ, Jamur MC, Oliver C. Mast cell function: a new vision of an old cell. J Histochem Cytochem. 2014;62:698\u2013738.","journal-title":"J Histochem Cytochem"},{"key":"2935_CR51","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.4049\/jimmunol.176.4.2238","volume":"176","author":"S Nakae","year":"2006","unstructured":"Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, et al. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol. 2006;176:2238\u201348.","journal-title":"J Immunol"},{"key":"2935_CR52","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/0167-5699(91)90109-7","volume":"12","author":"WR Hein","year":"1991","unstructured":"Hein WR, Mackay CR. Prominence of gamma delta T cells in the ruminant immune system. Immunol Today. 1991;12:30\u20134.","journal-title":"Immunol Today"},{"key":"2935_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcpa.2009.04.003","volume":"141","author":"NJ MacLachlan","year":"2009","unstructured":"MacLachlan NJ, Drew CP, Darpel KE, Worwa G. The pathology and pathogenesis of bluetongue. J Comp Pathol. 2009;141:1\u201316.","journal-title":"J Comp Pathol"},{"key":"2935_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rvsc.2011.05.004","volume":"91","author":"G Savini","year":"2011","unstructured":"Savini G, Afonso A, Mellor P, Aradaib I, Yadin H, Sanaa M, et al. Epizootic heamorragic disease. Res Vet Sci. 2011;91:1\u201317.","journal-title":"Res Vet Sci"},{"key":"2935_CR55","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0147-9571(94)90047-7","volume":"17","author":"TG Burrage","year":"1994","unstructured":"Burrage TG, Laegreid WW. African horsesickness: pathogenesis and immunity. Comp Immunol Microbiol Infect Dis. 1994;17:275\u201385.","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"2935_CR56","doi-asserted-by":"publisher","first-page":"E6238","DOI":"10.1073\/pnas.1610012113","volume":"113","author":"E Melzi","year":"2016","unstructured":"Melzi E, Caporale M, Rocchi M, Martin V, Gamino V, di Provvido A, et al. Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression. Proc Natl Acad Sci USA. 2016;113:E6238\u2013E47.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2935-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-2935-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2935-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:56:44Z","timestamp":1693727804000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-2935-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,20]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2935"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-2935-0","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,20]]},"assertion":[{"value":"19 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal work was performed at USDA, ARS, in compliance with Kansas State University\u2019s Institutional Animal Care and Use Committee (IACUC) guidelines (Protocol #3659).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"358"}}