{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:40:57Z","timestamp":1788482457248,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012752","name":"Elanco","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-2968-4","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T08:29:03Z","timestamp":1531384143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Laboratory evaluation of the efficacy and speed of kill of lotilaner (CredelioTM) against Ixodes ricinus ticks on cats"],"prefix":"10.1186","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-2146","authenticated-orcid":false,"given":"Daniela","family":"Cavalleri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Seewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Drake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Nanchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"2968_CR1","volume-title":"Credelio Summary of opinion. EMA\/CVMP\/49053\/2017","author":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use","year":"2017","unstructured":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use. Credelio Summary of opinion. EMA\/CVMP\/49053\/2017. London: European Medicines Agency; 2017."},{"key":"2968_CR2","unstructured":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use, Credelio European Product Information. 2017. \n                    http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/veterinary\/004247\/WC500227518.pdf\n                    \n                  . Accessed 11 Apr 2018."},{"key":"2968_CR3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1186\/s13071-017-2471-3","volume":"10","author":"SE Little","year":"2017","unstructured":"Little SE. Lotilaner - a novel systemic tick and flea control product for dogs. Parasit Vectors. 2017;10:539.","journal-title":"Parasit Vectors."},{"key":"2968_CR4","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1021\/tx400055p","volume":"26","author":"P Garcia-Reynaga","year":"2013","unstructured":"Garcia-Reynaga P, Zhao C, Sarpong R, Casida JE. New GABA\/glutamate receptor target for [(3)H]isoxazoline insecticide. Chem Res Toxicol. 2013;26:514\u20136.","journal-title":"Chem Res Toxicol."},{"key":"2968_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1186\/s13071-017-2470-4","volume":"10","author":"L Rufener","year":"2017","unstructured":"Rufener L, Danelli V, Bertrand D, Sager H. The novel isoxazoline ectoparasiticide lotilaner (Credelio\u2122): a non-competitive antagonist specific to invertebrates \u03b3-aminobutyric acid-gated chloride channels (GABACls). Parasit Vectors. 2017;10:530.","journal-title":"Parasit Vectors."},{"key":"2968_CR6","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/cmdc.201500516","volume":"11","author":"T Weber","year":"2016","unstructured":"Weber T, Selzer PM. Isoxazolines: a novel chemotype highly effective on ectoparasites. ChemMedChem. 2016;11:270\u20136.","journal-title":"ChemMedChem."},{"key":"2968_CR7","doi-asserted-by":"crossref","unstructured":"Cavalleri D, Murphy M, Seewald W, Nanchen S. Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio\u2122) against Ctenocephalides felis on cats. Parasit Vectors. 2018. In press.","DOI":"10.1186\/s13071-018-2972-8"},{"key":"2968_CR8","doi-asserted-by":"crossref","unstructured":"Cavalleri D, Murphy M, Seewald W, Nanchen S. A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio\u2122) in controlling fleas in client-owned cats in Europe. Parasit Vectors. 2018. In press.","DOI":"10.1186\/s13071-018-2971-9"},{"key":"2968_CR9","doi-asserted-by":"crossref","unstructured":"Cavalleri D, Murphy M, Seewald W, Nanchen S. A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio\u2122) in controlling ticks in client-owned cats in Europe. Parasit Vectors. 2018. In press.","DOI":"10.1186\/s13071-018-2967-5"},{"key":"2968_CR10","doi-asserted-by":"crossref","unstructured":"Kuntz EA, Kammanadiminti S. Safety of lotilaner flavoured chewable tablets Credelio\u2122 after oral administration in cats. Parasit Vectors. 2018. In press.","DOI":"10.1186\/s13071-018-2969-3"},{"key":"2968_CR11","volume-title":"VICH GL9, Good Clinical Practice","author":"International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products","year":"2000","unstructured":"International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products. VICH GL9, Good Clinical Practice. London: European Medicines Agency; 2000."},{"key":"2968_CR12","unstructured":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use, EMEA\/CVMP\/EWP\/005\/2000-Rev.2: Guideline for the testing and evaluation of the efficacy of antiparasitic substances for the treatment and prevention of tick and flea infestation in dogs and cats, 12 November 2007. London: European Medicines Agency; 2007."},{"key":"2968_CR13","unstructured":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use, EMEA\/CVMP\/EWP\/005\/2000-Rev.3: Guideline for the testing and evaluation of the efficacy of antiparasitic substances for the treatment and prevention of tick and flea infestation in dogs and cats \n                    http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2016\/07\/WC500210927.pdf\n                    \n                  . Accessed 11 Apr 2018."},{"key":"2968_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.vetpar.2013.02.003","volume":"194","author":"AA Marchiondo","year":"2013","unstructured":"Marchiondo AA, Holdsworth PA, Fourie LJ, Rugg D, Hellmann K, Snyder DE, Dryden MW. World Association for the Advancement of Veterinary Parasitology. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Vet Parasitol. 2013;194:84\u201397.","journal-title":"Vet Parasitol."},{"key":"2968_CR15","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev.ento.46.1.167","volume":"46","author":"AE Kiszewski","year":"2001","unstructured":"Kiszewski AE, Matuschka F, Spielman A. Mating strategies and spermiogenesis in ixodid ticks. Annu Rev Entolmol. 2001;46:167\u201382.","journal-title":"Annu Rev Entolmol."},{"key":"2968_CR16","doi-asserted-by":"crossref","unstructured":"Toutain CE, Seewald W, Jung M. Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats. Parasit Vectors. 2018. In press.","DOI":"10.1186\/s13071-018-2966-6"},{"key":"2968_CR17","unstructured":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use, Stronghold\u00ae Plus, European Product Information. \n                    http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/veterinary\/004194\/WC500222781.pdf\n                    \n                  . Accessed 11 Apr 2018."},{"key":"2968_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1086\/318818","volume":"183","author":"F des Vignes","year":"2001","unstructured":"des Vignes F, Piesman J, Heffernan R, Schulze TL, Stafford IIIKC, Fish D. Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs. J Inf Dis. 2001;183:773\u20138.","journal-title":"J Inf Dis."},{"key":"2968_CR19","first-page":"584","volume":"88","author":"C Heile","year":"2007","unstructured":"Heile C, Hoffmann-K\u00f6hler P, Wiemann A, Schein E. Transmission time of tick-borne disease agents in dogs: Borrelia, Anaplasma \/ Ehrlichia and Babesia. Der Praktische Tierarzt. 2007;88:584\u201390.","journal-title":"Der Praktische Tierarzt."},{"key":"2968_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0934-8840(98)80142-4","volume":"287","author":"O Khal","year":"1998","unstructured":"Khal O, Janetzki-Mittmann C, Gray JS, Jonas R, Stein J, de Boer R. Risk of infection with Borrelia burgdorferi sensu lato for a host in relation to the duration of nymphal Ixodes ricinus feeding and the method of tick removal. Zentralbl Bakteriol. 1998;287:41\u201352.","journal-title":"Zentralbl Bakteriol."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2968-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-2968-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2968-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T19:18:00Z","timestamp":1562959080000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-2968-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2968"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-2968-4","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]},"assertion":[{"value":"13 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The studies were approved by the laboratories Institutional Animal Care and Use Committee (IACUC).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors are employees of Elanco Animal Health.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"413"}}