{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:06:11Z","timestamp":1794445571999,"version":"4.9.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Foundation for Research Levy on Agricultural Products\/Agricultural Agreement Research Fund","award":["244162"],"award-info":[{"award-number":["244162"]}]},{"name":"Norwegian Meat and Poultry Research Centre"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-2976-4","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T10:10:10Z","timestamp":1530785410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Controlled efficacy trial confirming toltrazuril resistance in a field isolate of ovine Eimeria spp."],"prefix":"10.1186","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-1700","authenticated-orcid":false,"given":"Ane","family":"Odden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi L.","family":"Enemark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy J.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Ersdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silje K.","family":"Nes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"T\u00f8mmerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snorre","family":"Stuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"2976_CR1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/03079459708419208","volume":"26","author":"HD Chapman","year":"1997","unstructured":"Chapman HD. Biochemical, genetic and applied aspects of drug resistance in Eimeria parasites of the fowl. Avian Pathol. 1997;26:221\u201344.","journal-title":"Avian Pathol."},{"key":"2976_CR2","doi-asserted-by":"crossref","unstructured":"Lan LH, Sun BB, Zuo BXZ, Chen XQ, Du AF. Prevalence and drug resistance of avian Eimeria species in broiler chicken farms of Zhejiang Province, China. Poult Sci. 2017;96:2104\u20139.","DOI":"10.3382\/ps\/pew499"},{"key":"2976_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0304-4017(96)01096-5","volume":"69","author":"B Stephan","year":"1997","unstructured":"Stephan B, Rommel M, Daugschies A, Haberkorn A. Studies of resistance to anticoccidials in Eimeria field isolates and pure Eimeria strains. Vet Parasitol. 1997;69:19\u201329.","journal-title":"Vet Parasitol."},{"key":"2976_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/s13071-017-2257-7","volume":"10","author":"A Shrestha","year":"2017","unstructured":"Shrestha A, Freudenschuss B, Jansen R, Hinney B, Ruttkowski B, Joachim A. Experimentally confirmed toltrazuril resistance in a field isolate of Cystoisospora suis. Parasit Vectors. 2017;10:317.","journal-title":"Parasit Vectors."},{"key":"2976_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/01652176.2011.605247","volume":"31","author":"HW Peek","year":"2011","unstructured":"Peek HW, Landman WJM. Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies. Vet Quart. 2011;31:143\u201361.","journal-title":"Vet Quart."},{"key":"2976_CR6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.ijpddr.2018.05.002","volume":"8","author":"A Odden","year":"2018","unstructured":"Odden A, Denwood MJ, Stuen S, Robertson LJ, Ruiz A, Hamnes IS, et al. Field evaluation of anticoccidial efficacy: a novel approach demonstrates reduced efficacy of toltrazuril against ovine Eimeria spp. in Norway. Int J Parasitol Drugs Drug Resist. 2018;8:304\u201311.","journal-title":"Int J Parasitol Drugs Drug Resist."},{"key":"2976_CR7","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0749-0720(15)30838-0","volume":"6","author":"WJ Foreyt","year":"1990","unstructured":"Foreyt WJ. Coccidiosis and cryptosporidiosis in sheep and goats. Vet Clin North Am Food Anim Pract. 1990;6:655\u201370.","journal-title":"Vet Clin North Am Food Anim Pract."},{"key":"2976_CR8","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1136\/vr.144.16.442","volume":"144","author":"JP Alzieu","year":"1999","unstructured":"Alzieu JP, Mage C, Maes L, de M\u00fbelenaere C. Economic benefits of prophylaxis with diclazuril against subclinical coccidiosis in lambs reared indoors. Vet Rec. 1999;144:442\u20134.","journal-title":"Vet Rec."},{"key":"2976_CR9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.smallrumres.2011.10.022","volume":"103","author":"C Chartier","year":"2012","unstructured":"Chartier C, Paraud C. Coccidiosis due to Eimeria in sheep and goat, a review. Small Ruminant Res. 2012;103:84\u201392.","journal-title":"Small Ruminant Res."},{"key":"2976_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1439-0450.2005.00894.x","volume":"52","author":"A Daugschies","year":"2005","unstructured":"Daugschies A, Najdrowski M. Eimeriosis in cattle: current understanding. J Vet Med B Infect Dis Vet Public Health. 2005;52:417\u201327.","journal-title":"J Vet Med B Infect Dis Vet Public Health."},{"key":"2976_CR11","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1136\/inpract.22.10.604","volume":"22","author":"M Taylor","year":"2000","unstructured":"Taylor M. Protozoal disease in cattle and sheep. In Pract. 2000;22:604\u201317.","journal-title":"In Pract."},{"key":"2976_CR12","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00436-017-5400-7","volume":"116","author":"A Odden","year":"2017","unstructured":"Odden A, Enemark HL, Robertson LJ, Ruiz A, Hektoen L, Stuen S. Treatment against coccidiosis in Norwegian lambs and potential risk factors for development of anticoccidial resistance - a questionnaire-based study. Parasitol Res. 2017;116:1237\u201345.","journal-title":"Parasitol Res."},{"key":"2976_CR13","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.vetpar.2013.01.020","volume":"196","author":"A Saratsis","year":"2013","unstructured":"Saratsis A, Karagiannis I, Brozos C, Kiossis E, Tzanidakis N, Joachim A, et al. Lamb eimeriosis: applied treatment protocols in dairy sheep production systems. Vet Parasitol. 2013;196:56\u201363.","journal-title":"Vet Parasitol."},{"key":"2976_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetpar.2004.11.031","volume":"129","author":"B Platzer","year":"2005","unstructured":"Platzer B, Prosl H, Cieslicki M, Joachim A. Epidemiology of Eimeria infections in an Austrian milking sheep flock and control with diclazuril. Vet Parasitol. 2005;129:1\u20139.","journal-title":"Vet Parasitol."},{"key":"2976_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1136\/vr.123.22.573","volume":"123","author":"SM Taylor","year":"1988","unstructured":"Taylor SM, Kenny J. Coccidiocidal efficacy of a single treatment of toltrazuril in naturally infected lambs. Vet Rec. 1988;123:573.","journal-title":"Vet Rec."},{"key":"2976_CR16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/BF03548565","volume":"27","author":"B Gjerde","year":"1986","unstructured":"Gjerde B, Helle O. Efficacy of toltrazuril in the prevention of coccidiosis in naturally infected lambs on pasture. Acta Vet Scand. 1986;27:124\u201337.","journal-title":"Acta Vet Scand."},{"key":"2976_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0304-4017(91)90120-K","volume":"38","author":"B Gjerde","year":"1991","unstructured":"Gjerde B, Helle O. Chemoprophylaxis of coccidiosis in lambs with a single oral dose of toltrazuril. Vet Parasitol. 1991;38:97\u2013107.","journal-title":"Vet Parasitol."},{"key":"2976_CR18","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00436-008-1305-9","volume":"104","author":"C Le Sueur","year":"2009","unstructured":"Le Sueur C, Mage C, Mundt HC. Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with pathogenic Eimeria spp. in housed lambs. Parasitol Res. 2009;104:1157\u201362.","journal-title":"Parasitol Res."},{"key":"2976_CR19","first-page":"355","volume":"116","author":"K Dittmar","year":"2009","unstructured":"Dittmar K, Mundt HC, Grzonka E, Daugschies A, Bangoura B. Multicentric study on the efficacy of toltrazuril as metaphylactical treatment against naturally acquired coccidiosis in housed lambs. Dtsch Tieraerztl Wochenschr. 2009;116:355\u201362.","journal-title":"Dtsch Tieraerztl Wochenschr."},{"key":"2976_CR20","doi-asserted-by":"publisher","first-page":"S166","DOI":"10.1007\/s00436-003-0929-z","volume":"90","author":"HC Mundt","year":"2003","unstructured":"Mundt HC, Daugschies A, Uebe F, Rinke M. Efficacy of toltrazuril against artificial infections with Eimeria bovis in calves. Parasitol Res. 2003;90:S166\u2013S7.","journal-title":"Parasitol Res."},{"key":"2976_CR21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0304-4017(03)00256-5","volume":"116","author":"MA Taylor","year":"2003","unstructured":"Taylor MA, Catchpole J, Marshall J, Marshall RN, Hoeben D. Histopathological observations on the activity of diclazuril (Vecoxan\u00ae) against the endogenous stages of Eimeria crandallis in sheep. Vet Parasitol. 2003;116:305\u201314.","journal-title":"Vet Parasitol."},{"key":"2976_CR22","unstructured":"L\u00e4kemedelsverket. QP51AJ - Antiprotozoal drugs. 2017. https:\/\/lakemedelsverket.se\/LMF\/ . Accessed 30 Nov 2017"},{"key":"2976_CR23","unstructured":"Felleskatalogen (2017) ATC-register: QP51A Antiprotozoal drugs. https:\/\/www.felleskatalogen.no\/medisin-vet\/atc-register\/QP51A . Accessed 30 Aug 2017"},{"key":"2976_CR24","unstructured":"Veterin\u00e6rmedicinsk Industriforening (2017) Anticoccidials for sheep. http:\/\/www.medicintildyr.dk\/produkt.aspx?soeg=dyr&dyr=5&i=0,414&t=0 . Accessed 30 Nov 2017"},{"key":"2976_CR25","doi-asserted-by":"crossref","unstructured":"Joachim A, Altreuther G, Bangoura B, Charles S, Daugschies A, Hinney B, et al. W.A.A.V.P. Guideline for evaluating the efficacy of anticoccidials in mammals (pigs, dogs, cattle, sheep). Vet Parasitol. 2018;253:102\u201319.","DOI":"10.1016\/j.vetpar.2018.02.029"},{"key":"2976_CR26","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","volume":"44","author":"GC Coles","year":"1992","unstructured":"Coles GC, Bauer C, Borgsteede FH, Geerts S, Klei TR, Taylor MA, et al. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol. 1992;44:35\u201344.","journal-title":"Vet Parasitol."},{"key":"2976_CR27","unstructured":"EMA (2014) Europen Medicines Agency: Reflection paper on anthelmintic resistance. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2014\/04\/WC500165561.pdf . Accessed 12 Nov 2017"},{"key":"2976_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0304-4017(95)00806-2","volume":"58","author":"IB Wood","year":"1995","unstructured":"Wood IB, Amaral NK, Bairden K, Duncan JL, Kassai T, Malone JB, et al. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet Parasitol. 1995;58:181\u2013213.","journal-title":"Vet Parasitol."},{"key":"2976_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1017\/S0031182000074369","volume":"54","author":"AR Jackson","year":"1964","unstructured":"Jackson AR. The isolation of viable coccidial sporozoites. Parasitology. 1964;54:87\u201393.","journal-title":"Parasitology."},{"key":"2976_CR30","first-page":"103","volume-title":"Guidelines on techniques in coccidiosis research. Luxembourg: European Commission","author":"J Eckert","year":"1995","unstructured":"Eckert J, Taylor MA, Catchpole J, Licois D, Coudert P, Bucklar H. Morphological characteristics of oocysts. In: Guidelines on techniques in coccidiosis research. Luxembourg: European Commission; 1995. p. 103\u201319."},{"key":"2976_CR31","first-page":"836","volume-title":"Schalm\u2019s Veterinary Hematology","author":"SR Byers","year":"2010","unstructured":"Byers SR, Kramer JW. Normal hematology of sheep and goats. In: Weiss DJ, Wardrop KJ, editors. Schalm\u2019s Veterinary Hematology. 6th ed. Ames: Wiley-Blackwell; 2010. p. 836\u201342.","edition":"6"},{"key":"2976_CR32","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1051\/parasite\/2014038","volume":"21","author":"SA Holm","year":"2014","unstructured":"Holm SA, Sorensen CR, Thamsborg SM, Enemark HL. Gastrointestinal nematodes and anthelmintic resistance in Danish goat herds. Parasite. 2014;21:37.","journal-title":"Parasite."},{"key":"2976_CR33","volume-title":"Handbook of microbiological media","author":"RM Atlas","year":"1997","unstructured":"Atlas RM, Parks LC. Handbook of microbiological media. 2nd ed. Boca Raton: CRC Press; 1997.","edition":"2"},{"key":"2976_CR34","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2017","unstructured":"R Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2017."},{"key":"2976_CR35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1017\/S0031182000048447","volume":"72","author":"J Catchpole","year":"1976","unstructured":"Catchpole J, Norton CC, Joyner LP. Experiments with defined multispecific coccidial infections in lambs. Parasitology. 1976;72:137\u201347.","journal-title":"Parasitology."},{"key":"2976_CR36","doi-asserted-by":"crossref","unstructured":"Catchpole J, Gregory MW. Pathogenicity of the coccidium Eimeria crandallis in laboratory lambs. Parasitology. 1985;91:45\u201352.","DOI":"10.1017\/S003118200005650X"},{"key":"2976_CR37","doi-asserted-by":"crossref","unstructured":"Catchpole J, Norton CC, Gregory MW. Immunisation of lambs against coccidiosis. Vet Rec. 1993;132:56\u20139.","DOI":"10.1136\/vr.132.3.56"},{"key":"2976_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0034-5288(18)33765-2","volume":"16","author":"HD Chapman","year":"1974","unstructured":"Chapman HD. The effects of natural and artificially acquired infections of coccidia in lambs. Res Vet Sci. 1974;16:1\u20136.","journal-title":"Res Vet Sci."},{"key":"2976_CR39","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.smallrumres.2004.02.001","volume":"55","author":"M Gauly","year":"2004","unstructured":"Gauly M, Reeg J, Bauer C, Erhardt G. Influence of production systems in lambs on the Eimeria oocyst output and weight gain. Small Ruminant Res. 2004;55:159\u201367.","journal-title":"Small Ruminant Res."},{"key":"2976_CR40","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1080\/0307945031000121149","volume":"32","author":"HW Peek","year":"2003","unstructured":"Peek HW, Landman WJM. Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001. Avian Pathol. 2003;32:391\u2013401.","journal-title":"Avian Pathol."},{"key":"2976_CR41","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3920\/978-90-8686-274-0","volume-title":"Parasitology in Veterinary Medicine","author":"P Deplazes","year":"2016","unstructured":"Deplazes P, Eckert J, Mathis A, von Samson-Himmelstjerna G, Zahner H. 5.1.2 Order Eimeriida. In: Parasitology in Veterinary Medicine. Wageningen: Wageningen Academic Publishers; 2016. p. 82\u2013122."},{"key":"2976_CR42","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/0020-7519(87)90162-7","volume":"17","author":"MW Gregory","year":"1987","unstructured":"Gregory MW, Catchpole J. Ovine coccidiosis: pathology of Eimeria ovinoidalis infection. Int J Parasitol. 1987;17:1099\u2013111.","journal-title":"Int J Parasitol."},{"key":"2976_CR43","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.2307\/3284354","volume":"83","author":"LS Vieira","year":"1997","unstructured":"Vieira LS, Lima JD, Rosa JS. Development of Eimeria ninakohlyakimovae Yakimoff & Rastegaieff, 1930 Emend. Levine, 1961 in experimentally infected goats (Capra hircus). J Parasitol. 1997;83:1015\u20138.","journal-title":"J Parasitol."},{"key":"2976_CR44","first-page":"25","volume-title":"Guidelines on Techniques in Coccidiosis Research. Luxembourg: European Commision","author":"M Taylor","year":"1995","unstructured":"Taylor M, Catchpole J, Marshall R, Norton CC, Green J. Eimeria species of sheep. In: Eckert J, editor. Guidelines on Techniques in Coccidiosis Research. Luxembourg: European Commision; 1995. p. 25\u201339."},{"key":"2976_CR45","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1136\/inpract.8.1.33","volume":"8","author":"M Gregory","year":"1986","unstructured":"Gregory M, Norton C. Anticoccidials. In Pract. 1986;8:33\u20135.","journal-title":"In Pract."},{"key":"2976_CR46","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1136\/inpract.17.4.172","volume":"17","author":"M Taylor","year":"1995","unstructured":"Taylor M. Diagnosis and control of coccidiosis in sheep. In Pract. 1995;17:172\u20137.","journal-title":"In Pract."},{"key":"2976_CR47","unstructured":"The National Office of Animal Health (NOAH). Datasheep search results: sulfadiazine [Sulphadiazine]. 2018. http:\/\/www.noahcompendium.co.uk\/?id=-454043&fromsearch=true#iosfirsthighlight . Accessed 25 May 2018."},{"key":"2976_CR48","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13568-017-0378-1","volume":"7","author":"Y Zeng","year":"2017","unstructured":"Zeng Y, Zeng D, Ni X, Zhu H, Jian P, Zhou Y, et al. Microbial community compositions in the gastrointestinal tract of Chinese Mongolian sheep using Illumina MiSeq sequencing revealed high microbial diversity. AMB Express. 2017;7:75.","journal-title":"AMB Express."},{"key":"2976_CR49","first-page":"264","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","author":"CC Brown","year":"2007","unstructured":"Brown CC, Baker DC, Barker IK. Coccidiosis in sheep and goats. In: Maxie MG, editor. Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals, vol. 2. 5th ed. Edinburgh: Saunders Elsevier; 2007. p. 264\u20137.","edition":"5"},{"key":"2976_CR50","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/0020-7519(89)90118-5","volume":"19","author":"MW Gregory","year":"1989","unstructured":"Gregory MW, Catchpole J, Norton CC. Observations on the endogenous stages of Eimeria crandallis in domestic lambs (Ovis aries). Int J Parasitol. 1989;19:907\u201314.","journal-title":"Int J Parasitol."},{"key":"2976_CR51","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0020-7519(90)90022-F","volume":"20","author":"MW Gregory","year":"1990","unstructured":"Gregory MW, Catchpole J. Ovine coccidiosis: the pathology of Eimeria crandallis infection. Int J Parasitol. 1990;20:849\u201360.","journal-title":"Int J Parasitol."},{"key":"2976_CR52","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1007\/s00436-017-5597-5","volume":"116","author":"F de Souza Rodrigues","year":"2017","unstructured":"de Souza Rodrigues F, Cezar AS, de Menezes FR, Sangioni LA, Vogel FSF, de Avila Botton S. Efficacy and economic analysis of two treatment regimens using toltrazuril in lambs naturally infected with Eimeria spp. on pasture. Parasitol Res. 2017;116:2911\u20139.","journal-title":"Parasitol Res."},{"key":"2976_CR53","unstructured":"Diaferia M, Veronesi F, Morganti G, Nisoli L, Fioretti D. Efficacy of toltrazuril 5% suspension (Baycox\u00ae, Bayer) and diclazuril (Vecoxan\u00ae, Janssen-Cilag) in the control of Eimeria spp. in lambs. Parasitol Res. 2013;112:1638."},{"key":"2976_CR54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00436-009-1505-y","volume":"105","author":"H-C Mundt","year":"2009","unstructured":"Mundt H-C, Dittmar K, Daugschies A, Grzonka E, Bangoura B. Study of the comparative efficacy of toltrazuril and diclazuril against ovine coccidiosis in housed lambs. Parasitol Res. 2009;105:141\u201350.","journal-title":"Parasitol Res."},{"key":"2976_CR55","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.vetpar.2016.11.009","volume":"232","author":"A P\u00e9rez-Fonseca","year":"2016","unstructured":"P\u00e9rez-Fonseca A, Alcala-Canto Y, Salem AZM, Alberti-Navarro AB. Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp. Vet Parasitol. 2016;232:58\u201365.","journal-title":"Vet Parasitol."},{"key":"2976_CR56","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1590\/S1984-29612016048","volume":"25","author":"F de Souza Rodrigues","year":"2016","unstructured":"de Souza Rodrigues F, Tavares LER, Paiva F. Efficacy of treatments with toltrazuril 7.5% and lasalocid sodium in sheep naturally infected with Eimeria spp. Rev Bras Parasitol Vet. 2016;25:293\u20138.","journal-title":"Rev Bras Parasitol Vet."},{"key":"2976_CR57","unstructured":"Norwegian Institute of Public Health. Wholesaler-based drug statistics report of 2015 for ATC codes QP51AJ01 and QP51AJ03. 2015; Oslo, Norway."},{"key":"2976_CR58","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0169-4758(93)90137-5","volume":"9","author":"HD Chapman","year":"1993","unstructured":"Chapman HD. Resistance to anticoccidial drugs in fowl. Parasitol Today. 1993;9:159\u201362.","journal-title":"Parasitol Today."},{"key":"2976_CR59","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/S0020-7519(98)00024-1","volume":"28","author":"HD Chapman","year":"1998","unstructured":"Chapman HD. Evaluation of the efficacy of anticoccidial drugs against Eimeria species in the fowl. Int J Parasitol. 1998;28:1141\u20134.","journal-title":"Int J Parasitol."},{"key":"2976_CR60","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.3382\/ps.2008-00077","volume":"87","author":"ML Wang","year":"2008","unstructured":"Wang ML, Suo X, Gu JH, Zhang WW, Fang Q, Wang X. Influence of grape seed proanthocyanidin extract in broiler chickens: effect on chicken coccidiosis and antioxidant status. Poult Sci. 2008;87:2273\u201380.","journal-title":"Poult Sci."},{"key":"2976_CR61","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1007\/s00436-013-3430-3","volume":"112","author":"MA Dkhil","year":"2013","unstructured":"Dkhil MA. Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract. Parasitol Res. 2013;112:2639\u201346.","journal-title":"Parasitol Res."},{"key":"2976_CR62","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/S0020-7519(98)00029-0","volume":"28","author":"PC Allen","year":"1998","unstructured":"Allen PC, Danforth HD, Augustine PC. Dietary modulation of avian coccidiosis. Int J Parasitol. 1998;28:1131\u201340.","journal-title":"Int J Parasitol."},{"key":"2976_CR63","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.vetpar.2008.02.013","volume":"153","author":"V Naidoo","year":"2008","unstructured":"Naidoo V, McGaw LJ, Bisschop SPR, Duncan N, Eloff JN. The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens. Vet Parasitol. 2008;153:214\u20139.","journal-title":"Vet Parasitol."},{"key":"2976_CR64","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1007\/s00436-016-4966-9","volume":"115","author":"A Saratsis","year":"2016","unstructured":"Saratsis A, Voutzourakis N, Theodosiou T, Stefanakis A, Sotiraki S. The effect of sainfoin (Onobrychis viciifolia) and carob pods (Ceratonia siliqua) feeding regimes on the control of lamb coccidiosis. Parasitol Res. 2016;115:2233\u201342.","journal-title":"Parasitol Res."},{"key":"2976_CR65","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pt.2013.10.003","volume":"30","author":"DP Blake","year":"2014","unstructured":"Blake DP, Tomley FM. Securing poultry production from the ever-present Eimeria challenge. Trends Parasitol. 2014;30:12\u20139.","journal-title":"Trends Parasitol."},{"key":"2976_CR66","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3382\/ps.2013-03634","volume":"93","author":"HD Chapman","year":"2014","unstructured":"Chapman HD. Milestones in avian coccidiosis research: A review. Poult Sci. 2014;93:501\u201311.","journal-title":"Poult Sci."},{"key":"2976_CR67","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.vetpar.2013.09.032","volume":"199","author":"A Ruiz","year":"2014","unstructured":"Ruiz A, Munoz MC, Molina JM, Hermosilla C, Andrada M, Lara P, et al. Immunization with Eimeria ninakohlyakimovae-live attenuated oocysts protect goat kids from clinical coccidiosis. Vet Parasitol. 2014;199:8\u201317.","journal-title":"Vet Parasitol."}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2976-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-2976-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-2976-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T20:41:26Z","timestamp":1661546486000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-2976-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2976"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-2976-4","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]},"assertion":[{"value":"3 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal experiment was performed in compliance with ethical guidelines and approved by the Norwegian Animal Research Authority (ID 11657) with reference to the Norwegian regulation on animal experimentation (FOR-2015-06-18-761).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"394"}}