{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:28:36Z","timestamp":1762298916720,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"crossref","award":["n\u00ba 642609\u201d"],"award-info":[{"award-number":["n\u00ba 642609\u201d"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-3231-8","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T06:56:42Z","timestamp":1543993002000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A randomized, blinded, controlled trial to assess sand fly mortality of fluralaner administered orally in dogs"],"prefix":"10.1186","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-1473","authenticated-orcid":false,"given":"Sonia Ares","family":"Gomez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Lucientes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paz","family":"Peris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Delacour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald-Vladimir","family":"Oropeza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Picado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"3231_CR1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/1756-3305-7-275","volume":"7","author":"H Williams","year":"2014","unstructured":"Williams H, Young DR, Qureshi T, Zoller H, Heckeroth AR. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment. Parasit Vectors. 2014;7:275.","journal-title":"Parasit Vectors."},{"key":"3231_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ibmb.2013.11.009","volume":"45","author":"M Gassel","year":"2014","unstructured":"Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod \u03b3-aminobutyric acid- and l-glutamate-gated chloride channels and insecticidal\/acaricidal activity. Insect Biochem Mol Biol. 2014;45:111\u201324.","journal-title":"Insect Biochem Mol Biol."},{"key":"3231_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1756-3305-7-85","volume":"7","author":"S Kilp","year":"2014","unstructured":"Kilp S, Ramirez D, Allan MJ, Roepke RK, Nuernberger MC. Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration. Parasit Vectors. 2014;7:85.","journal-title":"Parasit Vectors."},{"key":"3231_CR4","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/tmi.12870","volume":"22","author":"SA Gomez","year":"2017","unstructured":"Gomez SA, Picado A. Systemic insecticides used in dogs: potential candidates for phlebotomine vector control? Trop Med Int Health. 2017;22:755\u201364.","journal-title":"Trop Med Int Health."},{"key":"3231_CR5","doi-asserted-by":"publisher","first-page":"E6920","DOI":"10.1073\/pnas.1801338115","volume":"115","author":"M Miglianico","year":"2018","unstructured":"Miglianico M, Eldering M, Slater H, Ferguson N, Ambrose P, Lees RS, et al. Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases. Proc Natl Acad Sci USA. 2018;115:E6920\u20136.","journal-title":"Proc Natl Acad Sci USA."},{"key":"3231_CR6","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s13071-018-2820-x","volume":"11","author":"SA Gomez","year":"2018","unstructured":"Gomez SA, Curdi JL, Hernandez JAC, Peris PP, Gil AE, Velasquez RVO, et al. Phlebotomine mortality effect of systemic insecticides administered to dogs. Parasit Vectors. 2018;11:230.","journal-title":"Parasit Vectors."},{"key":"3231_CR7","first-page":"1","volume-title":"Manual de Vigil\u00e2ncia e Controle da Leishmaniose Visceral","author":"Ministry of Health of Brazil","year":"2014","unstructured":"Ministry of Health of Brazil. Manual de Vigil\u00e2ncia e Controle da Leishmaniose Visceral. 1st ed. Brazil: (Brasilia -DF): Minist\u00e9rio da Sa\u00fade; 2014. p. 1\u2013114.","edition":"1"},{"key":"3231_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.vetpar.2008.01.005","volume":"153","author":"CM Nunes","year":"2008","unstructured":"Nunes CM, de LVMF, de PHB, Perri SHV, de AAM, Dias FEF, et al. Dog culling and replacement in an area endemic for visceral leishmaniasis in Brazil. Vet Parasitol. 2008;153:19\u201323.","journal-title":"Vet Parasitol."},{"key":"3231_CR9","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1086\/344312","volume":"186","author":"O Courtenay","year":"2002","unstructured":"Courtenay O, Quinnell RJ, Garcez LM, Shaw JJ, Dye C. Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. J Infect Dis. 2002;186:1314\u201320.","journal-title":"J Infect Dis."},{"key":"3231_CR10","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/S0140-6736(11)60202-X","volume":"377","author":"ML Barreto","year":"2011","unstructured":"Barreto ML, Teixeira MG, Bastos FI, Ximenes RA, Barata RB, Rodrigues LC. Successes and failures in the control of infectious diseases in Brazil: social and environmental context, policies, interventions, and research needs. Lancet. 2011;377:1877\u201389.","journal-title":"Lancet."},{"key":"3231_CR11","first-page":"e170377","volume":"113","author":"S RA e","year":"2018","unstructured":"RA e S, de AAJ, Quint BB, Raffoul GES, Werneck GL, Rangel EF, et al. Effectiveness of dog collars impregnated with 4% deltamethrin in controlling visceral leishmaniasis in Lutzomyia longipalpis (Diptera: Psychodidade: Phlebotominae) populations. Mem Inst Oswaldo Cruz. 2018;113:e170377.","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"3231_CR12","doi-asserted-by":"publisher","first-page":"e0006496","DOI":"10.1371\/journal.pntd.0006496","volume":"12","author":"BMM Leite","year":"2018","unstructured":"Leite BMM, Solc\u00e0 M d S, Santos LCS, Coelho LB, Amorim LDAF, Donato LE, et al. The mass use of deltamethrin collars to control and prevent canine visceral leishmaniasis: a field effectiveness study in a highly endemic area. PLoS Negl Trop Dis. 2018;12:e0006496.","journal-title":"PLoS Negl Trop Dis."},{"key":"3231_CR13","unstructured":"Camargo-Neves V, Rodas L, Calemes E. Cost effectiveness of deltamethrin impregnated collars (Scalibor) for the control of visceral leishmaniasis in human and canine populations in Brazil. Proceedings of the Second International Congress on Canine Leishmaniasis; 2010. p. 118\u201320."},{"issue":"9330","key":"3231_CR14","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/S0140-6736(02)09609-5","volume":"360","author":"A S Mazloumi Gavgani","year":"2002","unstructured":"Gavgani ASM, Hodjati MH, Mohite H, Davies CR. Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial. Lancet. 2002;360:374\u20139.","journal-title":"The Lancet"},{"key":"3231_CR15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ijpara.2003.09.006","volume":"34","author":"R Reithinger","year":"2004","unstructured":"Reithinger R, Coleman PG, Alexander B, Vieira EP, Assis G, Davies CR. Are insecticide-impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniasis in Brazil? Int J Parasitol. 2004;34:55\u201362.","journal-title":"Int J Parasitol."},{"key":"3231_CR16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2915.2009.00815.x","volume":"23","author":"O Courtenay","year":"2009","unstructured":"Courtenay O, Kovacic V, Gomes PA, Garcez LM, Quinnell RJ. A long-lasting topical deltamethrin treatment to protect dogs against visceral leishmaniasis. Med Vet Entomol. 2009;23:245\u201356.","journal-title":"Med Vet Entomol."},{"key":"3231_CR17","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3201\/eid0705.017516","volume":"7","author":"R Reithinger","year":"2001","unstructured":"Reithinger R, Teodoro U, Davies CR. Topical insecticide treatments to protect dogs from sand fly vectors of leishmaniasis. Emerg Infect Dis. 2001;7:872\u20136.","journal-title":"Emerg Infect Dis."},{"issue":"9","key":"3231_CR18","doi-asserted-by":"publisher","first-page":"e0006797","DOI":"10.1371\/journal.pntd.0006797","volume":"12","author":"Sonia A. Gomez","year":"2018","unstructured":"Gomez SA, Chapman LAC, Dilger E, Courtenay O, Picado A. Estimating the efficacy of community-wide use of systemic insecticides in dogs to control zoonotic visceral leishmaniasis: a modelling study in a Brazilian scenario. PLoS Negl Trop Dis. 2018;12:e0006797.","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"3231_CR19","unstructured":"R Development Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2015."},{"key":"3231_CR20","unstructured":"Molina R, Jimenez M, Alvar J. Methods in Sand Fly Research. 1st ed. Madrid, Spain: Servicio de Publicaciones Universidad de Alcal\u00e1 de Henares; 2017."},{"key":"3231_CR21","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s13071-017-2278-2","volume":"10","author":"A Loza","year":"2017","unstructured":"Loza A, Talaga A, Herbas G, Canaviri RJ, Cahuasiri T, Luck L, et al. Systemic insecticide treatment of the canine reservoir of Trypanosoma cruzi induces high levels of lethality in Triatoma infestans, a principal vector of Chagas disease. Parasit Vectors. 2017;10:344.","journal-title":"Parasit Vectors."},{"key":"3231_CR22","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/jmedent\/50.2.833","volume":"50","author":"RM Poch\u00e9","year":"2013","unstructured":"Poch\u00e9 RM, Garlapati R, Singh MI, Poch\u00e9 DM. Evaluation of fipronil oral dosing to cattle for control of adult and larval sand flies under controlled conditions. J Med Entomol. 2013;50:833\u20137.","journal-title":"J Med Entomol."},{"key":"3231_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1017\/S0007485309990356","volume":"100","author":"ZS Ma","year":"2010","unstructured":"Ma ZS. Survival analysis approach to insect life table analysis and hypothesis testing: with particular reference to Russian wheat aphid (Diuraphis noxia (Mordvilko)) populations. Bull Entomol Res. 2010;100:315\u201324.","journal-title":"Bull Entomol Res."},{"key":"3231_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/jee\/48.2.157","volume":"48","author":"CF Henderson","year":"1955","unstructured":"Henderson CF, Tilton EW. Tests with acaricides against the brown wheat mite. J Econ Entomol. 1955;48:157\u201361.","journal-title":"J Econ Entomol."},{"key":"3231_CR25","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/j.1365-3156.2012.02987.x","volume":"17","author":"N Alexander","year":"2012","unstructured":"Alexander N. Analysis of parasite and other skewed counts. Trop Med Int Health. 2012;17:684\u201393.","journal-title":"Trop Med Int Health."},{"key":"3231_CR26","volume-title":"Guideline on statistical principles for clinical trials for veterinary medicinal products (pharmaceuticals). EMA\/CVMP\/EWP\/81976\/2010","author":"Committee for Medicinal Products for Veterinary use (CVMP)","year":"2012","unstructured":"Committee for Medicinal Products for Veterinary use (CVMP). Guideline on statistical principles for clinical trials for veterinary medicinal products (pharmaceuticals). EMA\/CVMP\/EWP\/81976\/2010. London: European Medicine Agency; 2012."},{"key":"3231_CR27","unstructured":"Guideline for the testing and evaluation of the efficacy of antiparasitic substances for the treatment and prevention of tick and flea infestation in dogs and cats. 14 July 2016 EMEA\/CVMP\/EWP\/005\/2000-Rev.3 Committee for Medicinal Products for Veterinary Use (CVMP). \n                    https:\/\/www.ema.europa.eu\/documents\/scientific-guideline\/guideline-testing-evaluation-efficacy-antiparasitic-substances-treatment-prevention-tick-flea_en-0.pdf\n                    \n                  ."},{"key":"3231_CR28","unstructured":"Ripley B, Venables B, Bates DM, Hornik K, Gebhardt A, Firth D. MASS: Support Functions and Datasets for Venables and Ripley\u2019s MASS; 2017. \n                    https:\/\/cran.r-project.org\/web\/packages\/MASS\/index.html\n                    \n                  ."},{"key":"3231_CR29","unstructured":"Therneau TM. Lumley T. survival: Survival analysis; 2017. \n                    https:\/\/cran.r-project.org\/web\/packages\/survival\/index.html\n                    \n                  ."},{"key":"3231_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.11613\/BM.2013.009","volume":"23","author":"S Cuhadar","year":"2013","unstructured":"Cuhadar S, Koseoglu M, Atay A, Dirican A. The effect of storage time and freeze-thaw cycles on the stability of serum samples. Biochem Medica. 2013;23:70\u20137.","journal-title":"Biochem Medica."},{"key":"3231_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1756-3305-7-84","volume":"7","author":"FM Walther","year":"2014","unstructured":"Walther FM, Allan MJ, Roepke RK, Nuernberger MC. The effect of food on the pharmacokinetics of oral fluralaner in dogs. Parasit Vectors. 2014;7:84.","journal-title":"Parasit Vectors."},{"key":"3231_CR32","first-page":"419","volume":"38","author":"M Maroli","year":"2002","unstructured":"Maroli M, Cianchi T, Bianchi R, Khoury C. Testing insecticide susceptibility of Phlebotomus perniciosus and P. papatasi (Diptera: Psychodidae) in Italy. Ann Ist Super Sanita. 2002;38:419\u201323.","journal-title":"Ann Ist Super Sanita."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-3231-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-3231-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-3231-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T19:15:27Z","timestamp":1575486927000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-3231-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3231"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-3231-8","relation":{},"ISSN":["1756-3305"],"issn-type":[{"type":"electronic","value":"1756-3305"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"17 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted at the Faculty of Veterinary Medicine at the University of Zaragoza (Spain). Approvals for the animal experiments were obtained from the Universidad de Zaragoza (UNIZAR), Zaragoza, Espa\u00f1a (Comisi\u00f3n \u00c9tica asesora para la experimentaci\u00f3n animal, ref. PI44\/17) and the University of Barcelona, Espa\u00f1a, Comite Etic d\u2019Experimentaci\u00f3n Animal (CEEA no. 9\/18). All animal handling and bioassay procedures, and the maintenance of the <i>P. papatasi<\/i> colony followed protocols approved by the ethical committee of the University of Zaragoza, Spain.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"627"}}