{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:03:46Z","timestamp":1775671426179,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["H2020-635408"],"award-info":[{"award-number":["H2020-635408"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["AGL2015-67023-C2-1-R"],"award-info":[{"award-number":["AGL2015-67023-C2-1-R"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13071-018-3250-5","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T08:05:28Z","timestamp":1544774728000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis"],"prefix":"10.1186","volume":"11","author":[{"given":"Ra\u00fal","family":"P\u00e9rez-Caballero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Javier Mart\u00ednez-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Zafra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Molina-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel L.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Teresa Ruiz-Campillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Escamilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Mart\u00ednez-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Buffoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"3250_CR1","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.ijpara.2005.07.010","volume":"35","author":"S Mas-Coma","year":"2005","unstructured":"Mas-Coma S, Bargues MD, Valero MA. Fascioliasis and other plant-borne trematode zoonoses. Int J Parasitol. 2005;35:1255\u201378.","journal-title":"Int J Parasitol."},{"key":"3250_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.vetpar.2015.01.004","volume":"208","author":"V Molina-Hern\u00e1ndez","year":"2015","unstructured":"Molina-Hern\u00e1ndez V, Mulcahy G, P\u00e9rez J, Mart\u00ednez-Moreno \u00c1, Donnelly S, O\u2019Neill SM, et al. Fasciola hepatica vaccine: we may not be there yet but we\u2019re on the right road. Vet Parasitol. 2015;208:101\u201311.","journal-title":"Vet Parasitol."},{"key":"3250_CR3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0304-4017(01)00430-7","volume":"98","author":"JP Dalton","year":"2001","unstructured":"Dalton JP, Mulcahy G. Parasite vaccines - a reality? Vet Parasitol. 2001;98:149\u201367.","journal-title":"Vet Parasitol."},{"key":"3250_CR4","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1007\/s00216-012-6310-2","volume":"404","author":"KM Cooper","year":"2012","unstructured":"Cooper KM, Kennedy DG, Danaher M. ProSafeBeef and anthelmintic drug residues - a case study in collaborative application of multi-analyte mass spectrometry to enhance consumer safety. Anal Bioanal Chem. 2012;404:1623\u201330.","journal-title":"Anal Bioanal Chem."},{"key":"3250_CR5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.vetpar.2013.01.001","volume":"195","author":"P Ortiz","year":"2013","unstructured":"Ortiz P, Scarcella S, Cerna C, Rosales C, Cabrera M, Guzm\u00e1n M, et al. Resistance of Fasciola hepatica against triclabendazole in cattle in Cajamarca (Peru): a clinical trial and in vivo efficacy test in sheep. Vet Parasitol. 2013;195:118\u201321.","journal-title":"Vet Parasitol."},{"key":"3250_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ijpddr.2013.11.005","volume":"4","author":"YM Brockwell","year":"2014","unstructured":"Brockwell YM, Elliott TP, Anderson GR, Stanton R, Spithill TW, Sangster NC. Confirmation of Fasciola hepatica resistant to triclabendazole in naturally infected Australian beef and dairy cattle. Int J Parasitol Drugs Drug Res. 2014;4:48\u201354.","journal-title":"Int J Parasitol Drugs Drug Res."},{"key":"3250_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.vetpar.2011.05.034","volume":"180","author":"I Fairweather","year":"2011","unstructured":"Fairweather I. Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy? Vet Parasitol. 2011;180:133\u201343.","journal-title":"Vet Parasitol."},{"key":"3250_CR8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1136\/vr.159.13.424","volume":"159","author":"MA \u00c1lvarez-S\u00e1nchez","year":"2006","unstructured":"\u00c1lvarez-S\u00e1nchez MA, Mainar-Jaime RC, P\u00e9rez-Garc\u00eda J, Rojo-V\u00e1zquez FA. Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain. Vet Rec. 2006;159:424\u20135.","journal-title":"Vet Rec."},{"key":"3250_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.exppara.2016.07.010","volume":"169","author":"M Moazeni","year":"2016","unstructured":"Moazeni M, Ahmadi A. Controversial aspects of the life cycle of Fasciola hepatica. Exp Parasitol. 2016;169:81\u20139.","journal-title":"Exp Parasitol."},{"key":"3250_CR10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.vetpar.2013.04.008","volume":"195","author":"JP Dalton","year":"2013","unstructured":"Dalton JP, Robinson MW, Mulcahy G, O\u2019Neill SM, Donelly S. Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development. Vet Parasitol. 2013;195:272\u20135.","journal-title":"Vet Parasitol."},{"key":"3250_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1096\/fj.201500093R","volume":"31","author":"R Alvarado","year":"2016","unstructured":"Alvarado R, To J, Lund ME, Pinar A, Mansell A, Robinson MW, et al. The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages. FASEB J. 2016;31:85\u201395.","journal-title":"FASEB J."},{"key":"3250_CR12","doi-asserted-by":"publisher","unstructured":"Finlay CM, Stefanska AM, Coleman MM, Jahns H, Cassidy JP, McLoughlin RM, et al. Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy. Parasite Immunol. 2017;39. \n                    https:\/\/doi.org\/10.1111\/pim.12460\n                    \n                  .","DOI":"10.1111\/pim.12460"},{"key":"3250_CR13","first-page":"264","volume":"8","author":"E Rodr\u00edguez","year":"2017","unstructured":"Rodr\u00edguez E, Carasi P, Frigerio S, da Costa V, van Vliet S, Noya V, et al. Fasciola hepatica immunoregulates CD11c+ cells by interacting with the macrophage gal\/GalNAc lectin. Front Immunol. 2017;8:264.","journal-title":"Front Immunol."},{"key":"3250_CR14","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s00436-015-4834-z","volume":"115","author":"V Noya","year":"2016","unstructured":"Noya V, Brossard N, Berasa\u00edn P, Rodr\u00edguez E, Chiale C, Mazal D, et al. A mucin-like peptide from Fasciola hepatica induces parasite-specific Th1-type cell immunity. Parasitol Res. 2016;115:1053\u201363.","journal-title":"Parasitol Res."},{"key":"3250_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.molbiopara.2010.04.003","volume":"172","author":"A Hern\u00e1ndez-Gonz\u00e1lez","year":"2010","unstructured":"Hern\u00e1ndez-Gonz\u00e1lez A, Valero ML, del PMS, Oleaga A, Siles-Lucas M. Proteomic analysis of in vitro newly excysted juveniles from Fasciola hepatica. Mol Biochem Parasitol. 2010;172:121\u20138.","journal-title":"Mol Biochem Parasitol."},{"key":"3250_CR16","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1074\/mcp.M115.053934","volume":"14","author":"K Cwiklinski","year":"2015","unstructured":"Cwiklinski K, de la Torre-Escudero E, Trelis M, Bernal D, Dufresne PJ, Brennan GP, et al. The extracellular vesicles of the helminth patogen, Fasciola hepatica: biogenesis pathways and cargo mollecules involved in parasite pathogenesis. Moll Cell Proteomics. 2015;14:3258\u201373.","journal-title":"Moll Cell Proteomics"},{"key":"3250_CR17","doi-asserted-by":"publisher","first-page":"e0004688","DOI":"10.1371\/journal.pntd.0004688","volume":"10","author":"A Garc\u00eda-Campos","year":"2016","unstructured":"Garc\u00eda-Campos A, Ravid\u00e0 A, Nguyen DL, Cwiklinski K, Dalton JP, Hokke CH, et al. Tegument glycoproteins and cathepsins of newly excysted juvenile Fasciola hepatica carry mannosidic and paucimannosidic N-glycans. PLoS Negl Trop Dis. 2016;10:e0004688.","journal-title":"PLoS Negl Trop Dis."},{"key":"3250_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.vetpar.2018.05.019","volume":"257","author":"MT Ruiz-Campillo","year":"2018","unstructured":"Ruiz-Campillo MT, Molina-Hern\u00e1ndez V, P\u00e9rez J, Pacheco IL, P\u00e9rez R, Escamilla A, et al. Study of peritoneal macrophage immunophenotype in sheep experimentally infected with Fasciola hepatica. Vet Parasitol. 2018;257:34\u20139.","journal-title":"Vet Parasitol."},{"key":"3250_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-3024.1981.tb00387.x","volume":"3","author":"C Davies","year":"1981","unstructured":"Davies C, Goose J. Killing of newly excysted juveniles of Fasciola hepatica in sensitized rats. Parasite Immunol. 1981;3:81\u201396.","journal-title":"Parasite Immunol."},{"key":"3250_CR20","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1046\/j.1365-3024.2001.00404.x","volume":"23","author":"D Piedrafita","year":"2001","unstructured":"Piedrafita D, Parsons JC, Sandeman RM, Wood PR, Estuningsih SE, Partoutomo S, et al. Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates. Parasite Immunol. 2001;23:473\u201382.","journal-title":"Parasite Immunol."},{"key":"3250_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.vetpar.2017.03.015","volume":"238","author":"A Escamilla","year":"2017","unstructured":"Escamilla A, P\u00e9rez-Caballero R, Zafra R, Bautista MJ, Pacheco IL, Ruiz MT, et al. Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep. Vet Parasitol. 2017;238:49\u201353.","journal-title":"Vet Parasitol."},{"key":"3250_CR22","volume-title":"Manual of Veterinary Parasitological Laboratory Techniques. Reference Book 418 (Third edition)","author":"Ministry of Agriculture, Fisheries and Food","year":"1986","unstructured":"Ministry of Agriculture, Fisheries and Food. Manual of Veterinary Parasitological Laboratory Techniques. Reference Book 418 (Third edition). London: Her Majesty\u2019s Stationery Office; 1986."},{"key":"3250_CR23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0165-2427(95)05497-9","volume":"51","author":"JA Navarro","year":"1996","unstructured":"Navarro JA, Caro MR, Seva J, Rosillo MC, Gomez MA, Gallego MC. Study of lymphocyte subpopulations in peripheral blood and secondary lymphoid organs in the goat using monoclonal antibodies to surface markers of bovine lymphocytes. Vet Immunol Immunopathol. 1996;51:147\u201356.","journal-title":"Vet Immunol Immunopathol."},{"key":"3250_CR24","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1046\/j.1365-2567.2002.01515.x","volume":"107","author":"SSM Chan","year":"2002","unstructured":"Chan SSM, McConnell I, Blacklaws BA. Generation and characterization of ovine dendritic cells derived from peripheral blood monocytes. Immunology. 2002;107:366\u201372.","journal-title":"Immunology."},{"key":"3250_CR25","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez E, Noya V, Cervi L, Chiribao ML, Brossard N, Chiale C, et al. Glycans from Fasciola hepatica modulate the host immune response and TLR-induced maturation of dendritic cells. PLoS Negl Trop Dis. 2015;9:e0004234.","DOI":"10.1371\/journal.pntd.0004234"},{"key":"3250_CR26","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1128\/IAI.00573-09","volume":"78","author":"DJ Dowling","year":"2010","unstructured":"Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, et al. Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses. Infect Immun. 2010;78:793\u2013801.","journal-title":"Infect Immun."},{"key":"3250_CR27","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1128\/IAI.00919-08","volume":"77","author":"CM Hamilton","year":"2009","unstructured":"Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O\u2019Neill SM. The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function. Infect Immun. 2009;77:2488\u201398.","journal-title":"Infect Immun."},{"key":"3250_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.exppara.2011.02.004","volume":"128","author":"L Jedlina","year":"2011","unstructured":"Jedlina L, Kozak-Ljunggren M, Wedrychowicz H. In vivo studies of the early, peritoneal, cellular and free radical response in rats infected with Fasciola hepatica by flow cytometric analysis. Exp Parasitol. 2011;128:291\u20137.","journal-title":"Exp Parasitol."},{"key":"3250_CR29","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.4049\/jimmunol.1203011","volume":"190","author":"KV Vukman","year":"2013","unstructured":"Vukman KV, Adams PN, Metz M, Maurer M, O\u2019Neill SM. Fasciola hepatica tegumental coat impairs mast cells\u2019 ability to drive Th1 immune responses. J Immunol. 2013;190:2873\u20139.","journal-title":"J Immunol."},{"key":"3250_CR30","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1002\/eji.201545905","volume":"46","author":"A Aldridge","year":"2016","unstructured":"Aldridge A, O\u2019Neill SM. Fasciola hepatica tegumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner. Europ J Immunol. 2016;46:1180\u201392.","journal-title":"Europ J Immunol."},{"key":"3250_CR31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.vetimm.2013.06.006","volume":"155","author":"R Zafra","year":"2013","unstructured":"Zafra R, P\u00e9rez J, Buffoni L, Mart\u00ednez-Moreno FJ, Acosta I, Mozos E, et al. Peripheral blood lymphocyte subsets in Fasciola hepatica infected and immunised goats. Vet Immunol Immunopathol. 2013;155:135\u20138.","journal-title":"Vet Immunol Immunopathol."},{"key":"3250_CR32","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/eji.201646575","volume":"47","author":"S Steinfelder","year":"2017","unstructured":"Steinfelder S, Rausch S, Michael D, K\u00fchl AA, Hartmann S. Intestinal helminth infection induces highly functional resident memory CD4 + T cells in mice. Eur J Immunol. 2017;47:353\u201363.","journal-title":"Eur J Immunol."},{"key":"3250_CR33","first-page":"43","volume":"78","author":"HS Gill","year":"1993","unstructured":"Gill HS, Watson DL, Brandon MR. Monoclonal antibody to CD4+ T-cells abrogates genetic resistance to Haemonchus contortus in sheep. Immunol. 1993;78:43\u20139.","journal-title":"Immunol."},{"key":"3250_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0165-2427(00)00189-6","volume":"75","author":"A Balic","year":"2000","unstructured":"Balic A, Bowles VM, Meeusen ENT. Cellular profiles in the abomasal mucosa and lymph node during primary infection with Haemonchus contortus in sheep. Vet Immunol Immunopathol. 2000;75:109\u201320.","journal-title":"Vet Immunol Immunopathol."},{"key":"3250_CR35","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1096\/fj.04-1855fje","volume":"18","author":"R Mitra","year":"2004","unstructured":"Mitra R, Dharajiya N, Kumari L, Varalakshmi C, Khar A. Migration of antigen presenting cells from periphery to the peritoneum during an inflammatory response: role of chemokines and cytokines. FASEB J. 2004;18:1764\u20136.","journal-title":"FASEB J."},{"key":"3250_CR36","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.4049\/jimmunol.1402021","volume":"194","author":"H Hsu","year":"2015","unstructured":"Hsu H, Chen C, Nenninger A, Holz L, Baldwin CL, Telfer JC. WC1 is a hybrid \u03b3\u03b4 TCR coreceptor and pattern recognition receptor for pathogenic bacteria. J Immunol. 2015;194:2280\u20138.","journal-title":"J Immunol."},{"key":"3250_CR37","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1189\/jlb.0804482","volume":"77","author":"KK Lahmers","year":"2005","unstructured":"Lahmers KK, Norimine J, Abrahamsen MS, Palmer GH, Brown WC. The CD4+ T cell immunodominant Anaplasma marginale major surface protein 2 stimulates \u03b3\u03b4 T cell clones that express unique T cell receptors. J Leukoc Biol. 2005;77:199\u2013208.","journal-title":"J Leukoc Biol."},{"key":"3250_CR38","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1002\/eji.200636216","volume":"37","author":"SL Blumerman","year":"2007","unstructured":"Blumerman SL, Herzig CT, Baldwin CL. WC1+ \u03b3\u03b4 T cell memory population is inducen by killed bacterial vaccine. Eur J Immunol. 2007;37:1204\u201316.","journal-title":"Eur J Immunol."},{"key":"3250_CR39","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1600-065X.2006.00470.x","volume":"215","author":"YH Chien","year":"2007","unstructured":"Chien YH, Konigshofer Y. Antigen recognition by \u03b3\u03b4 T cells. Immunol Rev. 2007;215:46\u201358.","journal-title":"Immunol Rev."},{"issue":"Supplement 1","key":"3250_CR40","first-page":"68","volume":"198","author":"C Ruiz-Jimenez","year":"2017","unstructured":"Ruiz-Jimenez C, Celias D, Silvane L, Cervi L, Espino AM. Fasciola hepatica fatty acid binding protein (Fh12) inhibits the activation of murine dendritic cells. J Immunol. 2017;198(Supplement 1):68 15.","journal-title":"J Immunol."},{"key":"3250_CR41","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/s13071-018-3072-5","volume":"11","author":"R P\u00e9rez-Caballero","year":"2018","unstructured":"P\u00e9rez-Caballero R, Buffoni L, Mart\u00ednez-Moreno FJ, Zafra R, Molina-Hern\u00e1ndez V. Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection. Parasit Vectors. 2018;11:500.","journal-title":"Parasit Vectors."},{"key":"3250_CR42","doi-asserted-by":"crossref","unstructured":"Rojas CAA, Scheerlinck JP, Ansell BRE, Hall RS, Gasser RB, Jex AR. Time-course study of the transcriptome of peripheral blood mononuclear cells (PBMCs) from sheep infected with Fasciola hepatica. PLoS One. 2016;11:e0159194.","DOI":"10.1371\/journal.pone.0159194"},{"key":"3250_CR43","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3389\/fimmu.2017.00485","volume":"8","author":"Y Fu","year":"2017","unstructured":"Fu Y, Browne JA, Killick K, Mulcahy G. Network analysis of the systemic response to Fasciola hepatica infection in sheep reveals changes in fibrosis, apoptosis, toll-like receptors 3\/4, and B cell function. Front Immunol. 2017;8:485.","journal-title":"Front Immunol."},{"key":"3250_CR44","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.3389\/fimmu.2017.01002","volume":"8","author":"D Sachdev","year":"2017","unstructured":"Sachdev D, Gough KC, Flynn RJ. The chronic stages of bovine Fasciola hepatica are dominated by CD4 T-cell exhaustion. Front Immunol. 2017;8:1002.","journal-title":"Front Immunol."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-3250-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-018-3250-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-018-3250-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T19:09:56Z","timestamp":1576264196000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-018-3250-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3250"],"URL":"https:\/\/doi.org\/10.1186\/s13071-018-3250-5","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"24 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This experiment was performed in accordance with the University of C\u00f3rdoba Bioethics Committee (code no. 1118) and European (2010\/63\/UE) and Spanish Directives (RD 1201\/2005) on animal experimentation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"640"}}