{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:04:57Z","timestamp":1760709897084,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Basic Research Program (973 Program) of China","award":["2015CB150300"],"award-info":[{"award-number":["2015CB150300"]}]},{"name":"the National Key Research and Development Program of China","award":["2017YFD0501201"],"award-info":[{"award-number":["2017YFD0501201"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772729"],"award-info":[{"award-number":["31772729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2017CFA020"],"award-info":[{"award-number":["2017CFA020"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13071-019-3457-0","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T15:04:30Z","timestamp":1556895870000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of a novel thrombospondin-related anonymous protein (BoTRAP2) from Babesia orientalis"],"prefix":"10.1186","volume":"12","author":[{"given":"Xueyan","family":"Zhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangnan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-9767","authenticated-orcid":false,"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"key":"3457_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.vetpar.2005.03.021","volume":"130","author":"Q Liu","year":"2005","unstructured":"Liu Q, Zhao J, Zhou Y, Liu E, Yao B, Fu Y. Study on some molecular characterization of Babesia orientalis. Vet Parasitol. 2005;130:191\u20138.","journal-title":"Vet Parasitol"},{"key":"3457_CR2","first-page":"84","volume":"28","author":"Z Liu","year":"1997","unstructured":"Liu Z, Zhao J, Ma L, Yao B. Babesia orientalis sp. nov parasitized in buffalo Bubalus bubalis in China (Piroplasmida: Babesiidae). Acta Vet Zootech Sin. 1997;28:84\u20139.","journal-title":"Acta Vet Zootech Sin"},{"key":"3457_CR3","doi-asserted-by":"publisher","first-page":"33S","DOI":"10.1007\/BF02632914","volume":"29","author":"Z Liu","year":"1997","unstructured":"Liu Z, Zhao J, Ma L, Yao B. Studies on buffalo babesiosis in Hubei Province, China. Trop Anim Health Prod. 1997;29:33S\u20136S.","journal-title":"Trop Anim Health Prod"},{"key":"3457_CR4","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1007\/s00436-001-0561-8","volume":"88","author":"B Yao","year":"2002","unstructured":"Yao B, Zhao J, Liu E, Ding S, Shi J, Liu Z. Serological investigations on Babesia orientalis infection. Status of water buffaloes in Hubei Province. Parasitol Res. 2002;88:S11\u20132.","journal-title":"Parasitol Res"},{"key":"3457_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.vetpar.2006.01.037","volume":"138","author":"N Yokoyama","year":"2006","unstructured":"Yokoyama N, Okamura M, Igarashi I. Erythrocyte invasion by Babesia parasites: current advances in the elucidation of the molecular interactions between the protozoan ligands and host receptors in the invasion stage. Vet Parasitol. 2006;138:22\u201332.","journal-title":"Vet Parasitol"},{"key":"3457_CR6","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1242\/jcs.00596","volume":"116","author":"JL Lovett","year":"2003","unstructured":"Lovett JL, Sibley LD. Intracellular calcium stores in Toxoplasma gondii govern invasion of host cells. J Cell Sci. 2003;116:3009\u201316.","journal-title":"J Cell Sci"},{"key":"3457_CR7","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.1074\/jbc.M509807200","volume":"281","author":"J Baum","year":"2006","unstructured":"Baum J, Richard D, Healer J, Rug M, Krnajski Z, Gilberger TW, et al. A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem. 2006;281:5197\u2013208.","journal-title":"J Biol Chem"},{"key":"3457_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0092-8674(00)80511-5","volume":"90","author":"AA Sultan","year":"1997","unstructured":"Sultan AA, Thathy V, Frevert U, Robson KJ, Crisanti A, Nussenzweig V, et al. TRAP is necessary for gliding motility and infectivity of Plasmodium sporozoites. Cell. 1997;90:511\u201322.","journal-title":"Cell"},{"key":"3457_CR9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.pt.2008.08.006","volume":"24","author":"J Baum","year":"2008","unstructured":"Baum J, Gilberger TW, Frischknecht F, Meissner M. Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma. Trends Parasitol. 2008;24:557\u201363.","journal-title":"Trends Parasitol"},{"key":"3457_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.pt.2008.11.004","volume":"25","author":"BJ Morahan","year":"2009","unstructured":"Morahan BJ, Wang L, Coppel RL. No TRAP, no invasion. Trends Parasitol. 2009;25:77\u201384.","journal-title":"Trends Parasitol"},{"key":"3457_CR11","doi-asserted-by":"publisher","first-page":"e1005734","DOI":"10.1371\/journal.ppat.1005734","volume":"12","author":"J Kehrer","year":"2016","unstructured":"Kehrer J, Singer M, Lemgruber L, Silva PA, Frischknecht F, Mair GRM. A putative small solute transporter is responsible for the secretion of G377 and TRAP-containing secretory vesicles during Plasmodium gamete egress and sporozoite motility. PLoS Pathog. 2016;12:e1005734.","journal-title":"PLoS Pathog"},{"key":"3457_CR12","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1042\/BJ20121058","volume":"450","author":"T Pihlajamaa","year":"2013","unstructured":"Pihlajamaa T, Kajander T, Knuuti J, Horkka K, Sharma A, Permi P. Structure of Plasmodium falciparum TRAP (thrombospondin-related anonymous protein) a domain highlights distinct features in apicomplexan von Willebrand factor A homologues. Biochem J. 2013;450:469\u201376.","journal-title":"Biochem J"},{"key":"3457_CR13","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1016\/j.biocel.2005.06.006","volume":"37","author":"F Brossier","year":"2005","unstructured":"Brossier F, David Sibley L. Toxoplasma gondii: microneme protein MIC2. Int J Biochem Cell Biol. 2005;37:2266\u201372.","journal-title":"Int J Biochem Cell Biol"},{"key":"3457_CR14","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/S0020-7519(01)00255-7","volume":"31","author":"FM Tomley","year":"2001","unstructured":"Tomley FM, Billington KJ, Bumstead JM, Clark JD, Monaghan P. EtMIC4: a microneme protein from Eimeria tenella that contains tandem arrays of epidermal growth factor-like repeats and thrombospondin type-I repeats. Int J Parasitol. 2001;31:1303\u201310.","journal-title":"Int J Parasitol"},{"key":"3457_CR15","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0020-7519(03)00086-9","volume":"33","author":"DM Witcombe","year":"2003","unstructured":"Witcombe DM, Belli SI, Wallach MG, Smith NC. Molecular characterisation of EmTFP250: a novel member of the TRAP protein family in Eimeria maxima. Int J Parasitol. 2003;33:691\u2013702.","journal-title":"Int J Parasitol"},{"key":"3457_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0166-6851(99)00228-5","volume":"107","author":"JL Lovett","year":"2000","unstructured":"Lovett JL, Howe DK, Sibley LD. Molecular characterization of a thrombospondin-related anonymous protein homologue in Neospora caninum. Mol Biochem Parasitol. 2000;107:33\u201343.","journal-title":"Mol Biochem Parasitol"},{"key":"3457_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1017\/S0031182010001290","volume":"138","author":"LM Pereira","year":"2011","unstructured":"Pereira LM, Candido-Silva JA, De Vries E, Yatsuda AP. A new thrombospondin-related anonymous protein homologue in Neospora caninum (NcMIC2-like1). Parasitology. 2011;138:287\u201397.","journal-title":"Parasitology"},{"key":"3457_CR18","doi-asserted-by":"publisher","first-page":"e83305","DOI":"10.1371\/journal.pone.0083305","volume":"8","author":"MA Terkawi","year":"2013","unstructured":"Terkawi MA, Ratthanophart J, Salama A, AbouLaila M, Asada M, Ueno A, et al. Molecular characterization of a new Babesia bovis thrombospondin-related anonymous protein (BbTRAP2). PLoS ONE. 2013;8:e83305.","journal-title":"PLoS ONE"},{"key":"3457_CR19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.vetpar.2009.02.025","volume":"162","author":"H Jia","year":"2009","unstructured":"Jia H, Aboge GO, Terkawi MA, Goo YK, Nishikawa Y, Kuriki K, et al. Genetic diversity of two selected antigen loci in Babesia gibsoni Asian genotype obtained from Japan and Jeju island of South Korea. Vet Parasitol. 2009;162:142\u20136.","journal-title":"Vet Parasitol"},{"key":"3457_CR20","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1371\/journal.ppat.0030148","volume":"3","author":"KA Brayton","year":"2007","unstructured":"Brayton KA, Lau AOT, Herndon DR, Hannick L, Kappmeyer LS, Berens SJ, et al. Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa. PLoS Pathog. 2007;3:1401\u201313.","journal-title":"PLoS Pathog"},{"key":"3457_CR21","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1186\/s13071-018-3245-2","volume":"11","author":"L Yu","year":"2018","unstructured":"Yu L, Liu Q, Zhan X, Huang Y, Sun Y, Nie Z, et al. Identification and molecular characterization of a novel Babesia orientalis thrombospondin-related anonymous protein (BoTRAP1). Parasites Vectors. 2018;11:667.","journal-title":"Parasites Vectors"},{"key":"3457_CR22","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12864-018-4701-2","volume":"19","author":"DR Bogema","year":"2018","unstructured":"Bogema DR, Micallef ML, Liu M, Padula MP, Djordjevic SP, Darling AE, et al. Analysis of Theileria orientalis draft genome sequences reveals potential species-level divergence of the Ikeda, Chitose and Buffeli genotypes. BMC Genom. 2018;19:298.","journal-title":"BMC Genom"},{"key":"3457_CR23","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1016\/S0264-410X(99)00146-2","volume":"17","author":"WO Rogers","year":"1999","unstructured":"Rogers WO, Gowda K, Hoffman SL. Construction and immunogenicity of DNA vaccine plasmids encoding four Plasmodium vivax candidate vaccine antigens. Vaccine. 1999;17:3136\u201344.","journal-title":"Vaccine"},{"key":"3457_CR24","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1126\/science.275.5305.1485","volume":"275","author":"S K\u00f6hler","year":"1997","unstructured":"K\u00f6hler S, Delwiche CF, Denny PW, Tilney LG, Webster P, Wilson RJM, et al. A plastid of probable green algal origin in apicomplexan parasites. Science. 1997;275:1485\u20139.","journal-title":"Science"},{"key":"3457_CR25","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/molbev\/msm092","volume":"24","author":"K Tamura","year":"2007","unstructured":"Tamura K, Dudley J, Nei M, Kumar S. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol Biol Evol. 2007;24:1596\u20139.","journal-title":"Mol Biol Evol"},{"key":"3457_CR26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1756-3305-7-293","volume":"7","author":"MK Khan","year":"2014","unstructured":"Khan MK, He L, Zhang W, Wang Y, Tao Q, Song Q, et al. Identification of two novel HSP90 proteins in Babesia orientalis: molecular characterization, and computational analyses of their structure, function, antigenicity and inhibitor interaction. Parasites Vectors. 2014;7:293.","journal-title":"Parasites Vectors"},{"key":"3457_CR27","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.vetpar.2011.11.021","volume":"186","author":"L He","year":"2012","unstructured":"He L, Feng HH, Zhang WJ, Zhang QL, Fang R, Wang LX, et al. Occurrence of Theileria and Babesia species in water buffalo (Bubalus babalis Linnaeus, 1758) in the Hubei Province, South China. Vet Parasitol. 2012;186:490\u20136.","journal-title":"Vet Parasitol"},{"key":"3457_CR28","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.chom.2016.10.015","volume":"20","author":"DY Bargieri","year":"2016","unstructured":"Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, et al. Plasmodium merozoite TRAP family protein is essential for vacuole membrane disruption and gamete egress from erythrocytes. Cell Host Microbe. 2016;20:618\u201330.","journal-title":"Cell Host Microbe"},{"key":"3457_CR29","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1091\/mbc.e03-06-0355","volume":"14","author":"CA Buscaglia","year":"2003","unstructured":"Buscaglia CA, Coppens I, Hol WG, Nussenzweig V. Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium. Mol Biol Cell. 2003;14:4947.","journal-title":"Mol Biol Cell"},{"key":"3457_CR30","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/385336a0","volume":"385","author":"R Menard","year":"1997","unstructured":"Menard R, Sultan AA, Cortes C, Altszuler R, van Dijk MR, Janse CJ, et al. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature. 1997;385:336\u201340.","journal-title":"Nature"},{"key":"3457_CR31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1475-2875-7-63","volume":"7","author":"RR Akhouri","year":"2008","unstructured":"Akhouri RR, Sharma A, Malhotra P, Sharma A. Role of Plasmodium falciparum thrombospondin-related anonymous protein in host\u2013cell interactions. Malar J. 2008;7:63.","journal-title":"Malar J"},{"key":"3457_CR32","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.molbiopara.2006.03.015","volume":"148","author":"J Zhou","year":"2006","unstructured":"Zhou J, Fukumoto S, Jia H, Yokoyama N, Zhang G, Fujisaki K, et al. Characterization of the Babesia gibsoni P18 as a homologue of thrombospondin related adhesive protein. Mol Biochem Parasitol. 2006;148:190\u20138.","journal-title":"Mol Biochem Parasitol"},{"key":"3457_CR33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.exppara.2013.06.002","volume":"135","author":"YK Goo","year":"2013","unstructured":"Goo YK, Ueno A, Terkawi MA, Aboge GO, Junya Y, Igarashi M, et al. Actin polymerization mediated by Babesia gibsoni aldolase is required for parasite invasion. Exp Parasitol. 2013;135:42\u20139.","journal-title":"Exp Parasitol"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-019-3457-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-019-3457-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-019-3457-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T23:10:01Z","timestamp":1588374601000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-019-3457-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,3]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3457"],"URL":"https:\/\/doi.org\/10.1186\/s13071-019-3457-0","relation":{},"ISSN":["1756-3305"],"issn-type":[{"type":"electronic","value":"1756-3305"}],"subject":[],"published":{"date-parts":[[2019,5,3]]},"assertion":[{"value":"30 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"200"}}