{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:57:14Z","timestamp":1789545434203,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Boehringer Ingelheim","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13071-019-3475-y","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T15:04:43Z","timestamp":1557846283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["LONGRANGE\u00ae (eprinomectin 5% w\/v extended-release injection) efficacy against Hypoderma lineatum in an endemic area in southern Italy"],"prefix":"10.1186","volume":"12","author":[{"given":"Riccardo Paolo","family":"Lia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Rehbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Giannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Fankhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Otranto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"3475_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0169-4758(86)90041-4","volume":"2","author":"DW Tarry","year":"1986","unstructured":"Tarry DW. Progress in warble fly eradication. Parasitol Today. 1986;2:111\u20136.","journal-title":"Parasitol Today"},{"key":"3475_CR2","volume-title":"Control of arthropod pests of livestock: a review of technology","author":"RO Drummond","year":"1988","unstructured":"Drummond RO, George JE, Kunz SE. Control of arthropod pests of livestock: a review of technology. Boca Raton: CRC Press Inc; 1988."},{"key":"3475_CR3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/jee\/77.2.402","volume":"77","author":"RO Drummond","year":"1984","unstructured":"Drummond RO. Control of larvae of the common cattle grub (Diptera: Oestridae) with animal systemic insecticides. J Econ Entomol. 1984;77:402\u20136.","journal-title":"J Econ Entomol"},{"key":"3475_CR4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1079\/9780851996844.0210","volume-title":"The Oestrid flies: biology, host-parasite relationships, impact and management","author":"PJ Scholl","year":"2006","unstructured":"Scholl PJ. Management and control of oestrid flies. In: Colwell DD, Hall MJR, Scholl PJ, editors. The Oestrid flies: biology, host-parasite relationships, impact and management. Wallingford: CABI; 2006. p. 210\u20139."},{"key":"3475_CR5","first-page":"335","volume":"16","author":"C Boulard","year":"1985","unstructured":"Boulard C. Avantages de l\u2019immunodiagnostic de l\u2019hypodermose bovine \u00e9tabli par h\u00e9magglutination passive et par ELISA, \u00e0 partir du s\u00e9rum et du lactos\u00e9rum, sur la num\u00e9ration des varons. Ann Rech V\u00e9t. 1985;16:335\u201343.","journal-title":"Ann Rech V\u00e9t."},{"key":"3475_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.vetpar.2013.07.009","volume":"197","author":"DD Colwell","year":"2013","unstructured":"Colwell DD. Out of sight but not gone: sero-surveillance for cattle grubs, Hypoderma spp., in western Canada between 2008 and 2010. Vet Parasitol. 2013;197:297\u2013303.","journal-title":"Vet Parasitol"},{"key":"3475_CR7","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1186\/s13071-016-1823-8","volume":"9","author":"D Otranto","year":"2016","unstructured":"Otranto D, Johnson G, Syvrud K, Yoon S, Hunter JS, Rehbein S. Treatment and control of bovine hypodermosis with ivermectin long-acting injection (IVOMEC\u00ae GOLD). Parasit Vectors. 2016;9:551.","journal-title":"Parasit Vectors"},{"key":"3475_CR8","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1645\/GE-232R","volume":"90","author":"D Otranto","year":"2004","unstructured":"Otranto D, Traversa D, Colwell DD, Guan G, Giangaspero A, Boulard C, Yin H. A third species of Hypoderma (Diptera: Oestridae) affecting cattle and yaks in China: molecular and morphological evidence. J Parasitol. 2004;90:958\u201365.","journal-title":"J Parasitol"},{"key":"3475_CR9","first-page":"157","volume":"70","author":"K Saidani","year":"2011","unstructured":"Saidani K, Benakhla A, D\u00edez-Ba\u00f1os P, Panadero R. Chronobiology of Hypoderma spp. in north-central Algeria as a basis to establish a control program. Rev Ibero-Latinoam Parasitol. 2011;70:157\u201363.","journal-title":"Rev Ibero-Latinoam Parasitol"},{"key":"3475_CR10","unstructured":"Guardi\u00e1n Garc\u00eda DE. Case study: impact of Hypoderma lineatum upon live growth, carcass attributes, and hide value of fed beef cattle. MSc. (Agric.) Thesis, West Texas A&M Univ., Canyon, TX, USA; 2016."},{"key":"3475_CR11","first-page":"479","volume":"94","author":"A Fain","year":"1975","unstructured":"Fain A, Devos E, Depoortere G, Demuynck G, Vandepitte J. Sur un cas de myiase ambulatoire sous-cutan\u00e9e d\u00fb \u00e0 Hypoderma lineatum en Belgique. Louvain M\u00e9d. 1975;94:479\u201383.","journal-title":"Louvain M\u00e9d"},{"key":"3475_CR12","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S0025-6196(11)64625-9","volume":"75","author":"J Starr","year":"2000","unstructured":"Starr J, Pruett JH, Yunginger JW, Gleich GJ. Myiasis due to Hypoderma lineatum infection mimicking the hypereosinophilic syndrome. Mayo Clin Proc. 2000;75:755\u20139.","journal-title":"Mayo Clin Proc"},{"key":"3475_CR13","doi-asserted-by":"publisher","first-page":"618","DOI":"10.4269\/ajtmh.18-0100","volume":"99","author":"P Rappelli","year":"2018","unstructured":"Rappelli P, Varcasia A, Vargiu A, Scala A. Case report: autochthonus human cutaneous myiasis caused by Hypoderma lineatum in Europe. Am J Trop Med Hyg. 2018;99:618\u20139.","journal-title":"Am J Trop Med Hyg"},{"key":"3475_CR14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1136\/vr.103.16.348","volume":"103","author":"AH Andrews","year":"1978","unstructured":"Andrews AH. Warble fly: the life cycle, distribution, economic losses and control. Vet Rec. 1978;103:348\u201353.","journal-title":"Vet Rec"},{"key":"3475_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1146\/annurev.en.38.010193.000413","volume":"39","author":"PJ Scholl","year":"1993","unstructured":"Scholl PJ. Biology and control of cattle grubs. Ann Rev Entomol. 1993;39:53\u201370.","journal-title":"Ann Rev Entomol"},{"key":"3475_CR16","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/S0020-7519(96)00123-3","volume":"26","author":"WL Shoop","year":"1996","unstructured":"Shoop WL, Egerton JR, Eary CH, Haines HW, Michael BF, Mrozik H, et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. Int J Parasitol. 1996;26:1237\u201342.","journal-title":"Int J Parasitol"},{"key":"3475_CR17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2460\/ajvr.1998.59.01.56","volume":"59","author":"JE Holste","year":"1998","unstructured":"Holste JE, Colwell DD, Kumar R, Lloyd JE, Pinkall NPM, Sierra MA, et al. Efficacy of eprinomectin against Hypoderma spp. in cattle. Am J Vet Res. 1998;59:56\u20138.","journal-title":"Am J Vet Res"},{"key":"3475_CR18","first-page":"1","volume-title":"Macrocyclic lactones in antiparasitic therapy","author":"W Shoop","year":"2002","unstructured":"Shoop W, Soll M. Ivermectin, abamectin and eprinomectin. In: Vercruysse J, Rew R, editors. Macrocyclic lactones in antiparasitic therapy. Wallingford: CABI; 2002. p. 1\u201329."},{"key":"3475_CR19","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.vetpar.2012.11.036","volume":"192","author":"AB Forbes","year":"2013","unstructured":"Forbes AB. LongRangeTM (eprinomectin 5%) extended-release injection parasiticide and the utility of extended activity antiparasitics in cattle. Vet Parasitol. 2013;192:308\u201312.","journal-title":"Vet Parasitol"},{"key":"3475_CR20","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.vetpar.2012.11.041","volume":"192","author":"JS Hunter III","year":"2013","unstructured":"Hunter JS III, Yoon S, Yazwinski TA, Williams JC, Rehbein S. The efficacy of eprinomectin extended-release injection against naturally acquired nematode parasites of cattle, with special regard to inhibited fourth-stage Ostertagia larvae. Vet Parasitol. 2013;192:346\u201352.","journal-title":"Vet Parasitol"},{"key":"3475_CR21","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.vetpar.2012.11.040","volume":"192","author":"S Rehbein","year":"2013","unstructured":"Rehbein S, Baggott DG, Royer GC, Yoon S, Cramer LG, Soll MD. Therapeutic efficacy of eprinomectin extended-release injection against induced infections of developing (fourth-stage larvae) and adult nematode parasites of cattle. Vet Parasitol. 2013;192:338\u201345.","journal-title":"Vet Parasitol"},{"key":"3475_CR22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.vetpar.2012.11.043","volume":"192","author":"M Visser","year":"2013","unstructured":"Visser M, L\u00f6wenstein M, Yoon S, Rehbein S. The treatment of bovine sarcoptic mange (Sarcoptes scabiei var. bovis) using eprinomectin extended-release injection. Vet Parasitol. 2013;192:359\u201364.","journal-title":"Vet Parasitol"},{"key":"3475_CR23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.vetpar.2012.11.038","volume":"192","author":"S Rehbein","year":"2013","unstructured":"Rehbein S, Baggott DG, Johnson EG, Kunkle BN, Yazwinski TA, Yoon S, et al. Nematode burdens of pastured cattle treated once at turnout with eprinomectin extended-release injection. Vet Parasitol. 2013;192:321\u201331.","journal-title":"Vet Parasitol"},{"key":"3475_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.vetpar.2012.11.037","volume":"192","author":"MD Soll","year":"2013","unstructured":"Soll MD, Kunkle BN, Royer GC, Yazwinsky TA, Baggot DG, Wehner TA, et al. An eprinomectin extended-release injection formulation providing nematode control in cattle for up to 150 days. Vet Parasitol. 2013;192:313\u201320.","journal-title":"Vet Parasitol"},{"key":"3475_CR25","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.vetpar.2012.11.042","volume":"192","author":"S Rehbein","year":"2013","unstructured":"Rehbein S, Holste JE, Smith LL, Lloyd JL. The efficacy of eprinomectin extended-release injection against Hypoderma spp. (Diptera: Oestridae) in cattle. Vet Parasitol. 2013;192:353\u20138.","journal-title":"Vet Parasitol"},{"key":"3475_CR26","first-page":"56","volume-title":"Improvements in the control methods for warble fly in livestock European cooperation in the field of scientific and technical research. COST 811","author":"D Reina","year":"1998","unstructured":"Reina D, Martinez-Moreno F, Hern\u00e1ndez S, Navarette I. Chronobiology of bovine hypodermosis in Europe. In: Boulard C, Sol J, Pithan K, O\u2019Brien D, Webster K, Sampimom OC, editors. Improvements in the control methods for warble fly in livestock European cooperation in the field of scientific and technical research. COST 811. Brussels: European Commission; 1998. p. 56\u20139."},{"key":"3475_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1603\/0022-2585-37.1.27","volume":"37","author":"R Panadero","year":"2000","unstructured":"Panadero R, L\u00f3pez C, D\u00edez N, Paz A, D\u00edez P, Morrondo P. Influence of internal and environmental factors on the distribution and occurrence of Hypoderma (Diptera: Oestridae) in cattle in Galicia (northwest of Spain). J Med Entomol. 2000;37:27\u20139.","journal-title":"J Med Entomol"},{"key":"3475_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0034-5288(18)31891-5","volume":"37","author":"IJ Sinclair","year":"1984","unstructured":"Sinclair IJ, Tarry DW, Wassal DA. Persistence of antibody in calves after an infection with Hypoderma bovis. Res Vet Sci. 1984;37:383\u20134.","journal-title":"Res Vet Sci"},{"key":"3475_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1051\/vetres:2002032","volume":"33","author":"C Boulard","year":"2002","unstructured":"Boulard C. Durably controlling bovine hypodermosis. Vet Res. 2002;33:455\u201364.","journal-title":"Vet Res"},{"key":"3475_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1365-2915.1990.tb00257.x","volume":"4","author":"DD Colwell","year":"1990","unstructured":"Colwell DD, Baron RW. Early detection of cattle grub infestation (Hypoderma lineatum De Vill. and H. bovis L.) (Diperta: Oestridae) using ELISA. Med Vet Entomol. 1990;4:35\u201342.","journal-title":"Med Vet Entomol"},{"key":"3475_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-5852-7","volume-title":"Veterinary entomology","author":"R Wall","year":"1997","unstructured":"Wall R, Shearer D. Veterinary entomology. London: Chapman & Hall; 1997."},{"key":"3475_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.vetpar.2005.11.007","volume":"136","author":"PA Holdsworth","year":"2006","unstructured":"Holdsworth PA, Vercruysse J, Rehbein S, Peter RJ, De Bruin C, Letonja T, Green P. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of ectoparasiticides against myiasis causing parasites on ruminants. Vet Parasitol. 2006;136:15\u201328.","journal-title":"Vet Parasitol"},{"key":"3475_CR33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.prevetmed.2005.01.007","volume":"69","author":"D Otranto","year":"2005","unstructured":"Otranto D, Lia RP, Agostini A, Traversa D, Milillo P, Capelli G. Efficacy of moxidectin injectable and pour-on formulations in a pilot control program against bovine hypodermosis in southern Italy. Prev Vet Med. 2005;69:153\u20139.","journal-title":"Prev Vet Med"},{"key":"3475_CR34","doi-asserted-by":"crossref","unstructured":"James MT. The flies that cause myiasis in man. USDA Miscellaneous Publication No. 631. Washington, DC: USDA; 1947.","DOI":"10.5962\/bhl.title.65688"},{"key":"3475_CR35","volume-title":"Myiasis in man and animals in the old world","author":"F Zumpt","year":"1965","unstructured":"Zumpt F. Myiasis in man and animals in the old world. London: Butterworths; 1965."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-019-3475-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-019-3475-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-019-3475-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T01:05:45Z","timestamp":1721264745000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-019-3475-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3475"],"URL":"https:\/\/doi.org\/10.1186\/s13071-019-3475-y","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"17 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animals were handled with due regard to their welfare and in compliance with Merial Institutional Animal Care and Use Committee (IACUC) approvals, any applicable local regulations, and requirements of any local IACUC. All the procedures were authorized by the Ministero della Salute, Rome, Italy (Prot. 0021867-21\/09\/2016-DGSAF-MDS-P).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors were contractors of Merial\/Boehringer Ingelheim (RPL, AG, DO) or are current employees of Merial\/Boehringer Ingelheim (SR, BF) and assisted with the study design, conduct, data analysis and manuscript preparation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This document is provided for scientific purposes only. Any reference to a brand or trademark herein is for informational purposes only and is not intended for commercial purpose or to dilute the rights of the respective owner(s) of the brand(s) or trademark(s). LONGRANGE\u00ae is a registered trademark of Merial, now part of Boehringer Ingelheim. All other marks are the property of their respective owners.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}],"article-number":"231"}}