{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:25:09Z","timestamp":1774239909319,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sao Paulo Research Foundation - FAPESP","award":["2014\/25821-0"],"award-info":[{"award-number":["2014\/25821-0"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel - CAPES","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"National Council for Scientific and Technological Development \u2013 CNPq","award":["302287\/2015-9"],"award-info":[{"award-number":["302287\/2015-9"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13071-019-3663-9","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T10:02:31Z","timestamp":1565776951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Extreme-QTL mapping of monepantel resistance in Haemonchus contortus"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-0050","authenticated-orcid":false,"given":"Simone Cristina M\u00e9o","family":"Niciura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polyana Cristine","family":"Tizioto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Val\u00e9rio","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Gabrielle","family":"Cruvinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cl\u00e1udia Alexandre","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul Costa Mascarenhas","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina de Souza","family":"Chagas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Novita","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda Vieira","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Francisco Talamini","family":"do Amarante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"3663_CR1","doi-asserted-by":"publisher","unstructured":"OECD-FAO. Meat. In: OECD-FAO Agricultural Outlook 2018\u20132027. 2018. https:\/\/doi.org\/10.1787\/agr_outlook-2018-en . Accessed 14 June 2019.","DOI":"10.1787\/agr_outlook-2018-en"},{"key":"3663_CR2","unstructured":"FAO. Livestock in livelihoods and economic growth. In: Shaping the future of livestock. 2018. http:\/\/www.fao.org\/3\/i8384en\/I8384EN.pdf . Accessed 15 July 2019."},{"key":"3663_CR3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/bs.apar.2016.02.022","volume":"93","author":"RB Besier","year":"2016","unstructured":"Besier RB, Kahn LP, Sargison ND, Van Wyk JA. The pathophysiology, ecology and epidemiology of Haemonchus contortus infection in small ruminants. Adv Parasitol. 2016;93:95\u2013143.","journal-title":"Adv Parasitol."},{"key":"3663_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.vetpar.2011.11.063","volume":"186","author":"CM Miller","year":"2012","unstructured":"Miller CM, Waghorn TS, Leathwick DM, Candy PM, Oliver AM, Watson TG. The production cost of anthelmintic resistance in lambs. Vet Parasitol. 2012;186:376\u201381.","journal-title":"Vet Parasitol."},{"key":"3663_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","volume":"186","author":"RM Kaplan","year":"2012","unstructured":"Kaplan RM, Vidyashankar AN. An inconvenient truth: global warming and anthelmintic resistance. Vet Parasitol. 2012;186:70\u20138.","journal-title":"Vet Parasitol."},{"key":"3663_CR6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nature06722","volume":"452","author":"R Kaminsky","year":"2008","unstructured":"Kaminsky R, Ducray P, Jung M, Clover R, Rufener L, Bouvier J, et al. A new class of anthelmintics effective against drug-resistant nematodes. Nature. 2008;452:176\u201380.","journal-title":"Nature."},{"key":"3663_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.vetpar.2013.07.037","volume":"198","author":"I Scott","year":"2013","unstructured":"Scott I, Pomroy WE, Kenyon PR, Smith G, Adlington B, Moss A. Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis. Vet Parasitol. 2013;198:166\u201371.","journal-title":"Vet Parasitol."},{"key":"3663_CR8","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1186\/s13071-014-0598-z","volume":"7","author":"AE Mederos","year":"2014","unstructured":"Mederos AE, Ramos Z, Banchero GE. First report of monepantel Haemonchus contortus resistance on sheep farms in Uruguay. Parasites Vectors. 2014;7:598.","journal-title":"Parasites Vectors."},{"key":"3663_CR9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.vetpar.2015.02.026","volume":"209","author":"R Van den Brom","year":"2015","unstructured":"Van den Brom R, Moll L, Kappert C, Vellema P. Haemonchus contortus resistance to monepantel in sheep. Vet Parasitol. 2015;209:278\u201380.","journal-title":"Vet Parasitol."},{"key":"3663_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0169-4758(95)80117-0","volume":"11","author":"EH Barnes","year":"1995","unstructured":"Barnes EH, Dobson RJ, Barger IA. Worm control and anthelmintic resistance: adventures with a model. Parasitol Today. 1995;11:56\u201363.","journal-title":"Parasitol Today."},{"key":"3663_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.vetpar.2007.12.001","volume":"152","author":"WJ Blackhall","year":"2008","unstructured":"Blackhall WJ, Prichard RK, Beech RN. P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Vet Parasitol. 2008;152:101\u20137.","journal-title":"Vet Parasitol."},{"key":"3663_CR12","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.pt.2009.04.004","volume":"25","author":"CE James","year":"2009","unstructured":"James CE, Hudson AL, Davey MW. Drug resistance mechanisms in helminths: is it survival of the fittest? Trends Parasitol. 2009;25:328\u201335.","journal-title":"Trends Parasitol."},{"key":"3663_CR13","doi-asserted-by":"publisher","first-page":"e1000380","DOI":"10.1371\/journal.ppat.1000380","volume":"5","author":"L Rufener","year":"2009","unstructured":"Rufener L, M\u00e4ser P, Roditi I, Kaminsky R. Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS Pathog. 2009;5:e1000380.","journal-title":"PLoS Pathog."},{"key":"3663_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ijpddr.2017.05.001","volume":"7","author":"NH Bagnall","year":"2017","unstructured":"Bagnall NH, Ruffell A, Raza A, Elliott TP, Lamb J, Hunt PW, et al. Mutations in the Hco-mptl-1 gene in a field-derived monepantel-resistant isolate of Haemonchus contortus. Int J Parasitol Drugs Drug Resist. 2017;7:236\u201340.","journal-title":"Int J Parasitol Drugs Drug Resist."},{"key":"3663_CR15","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1017\/S0031182013001145","volume":"140","author":"JS Gilleard","year":"2013","unstructured":"Gilleard JS. Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance. Parasitology. 2013;140:1506\u201322.","journal-title":"Parasitology."},{"key":"3663_CR16","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.ijpara.2006.06.010","volume":"36","author":"JS Gilleard","year":"2006","unstructured":"Gilleard JS. Understanding anthelmintic resistance: the need for genomics and genetics. Int J Parasitol. 2006;36:1227\u201339.","journal-title":"Int J Parasitol."},{"key":"3663_CR17","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12864-019-5592-6","volume":"20","author":"SR Doyle","year":"2019","unstructured":"Doyle SR, Illingworth CJR, Laing R, Bartley DJ, Redman E, Martinelli A, et al. Population genomic and evolutionary modeling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. BMC Genom. 2019;20:218.","journal-title":"BMC Genom"},{"key":"3663_CR18","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.pt.2019.01.004","volume":"35","author":"SR Doyle","year":"2019","unstructured":"Doyle SR, Cotton JA. Genome-wide approaches to investigate anthelmintic resistance. Trends Parasitol. 2019;35:298\u2013301.","journal-title":"Trends Parasitol."},{"key":"3663_CR19","doi-asserted-by":"publisher","first-page":"R88","DOI":"10.1186\/gb-2013-14-8-r88","volume":"14","author":"R Laing","year":"2013","unstructured":"Laing R, Kikuchi T, Martinelli A, Tsai IJ, Beech RN, Redman E, et al. The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biol. 2013;14:R88.","journal-title":"Genome Biol."},{"key":"3663_CR20","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1186\/gb-2013-14-8-r89","volume":"14","author":"EM Schwarz","year":"2013","unstructured":"Schwarz EM, Korhonen PK, Campbell BE, Young ND, Jex AR, Jabbar A, et al. The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus. Genome Biol. 2013;14:R89.","journal-title":"Genome Biol."},{"key":"3663_CR21","doi-asserted-by":"publisher","first-page":"e1002534","DOI":"10.1371\/journal.ppat.1002534","volume":"8","author":"E Redman","year":"2012","unstructured":"Redman E, Sargison N, Whitelaw F, Jackson F, Morrison A, Bartley DJ, et al. Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing. PLoS Pathog. 2012;8:e1002534.","journal-title":"PLoS Pathog."},{"key":"3663_CR22","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.pt.2018.08.001","volume":"34","author":"TJC Anderson","year":"2018","unstructured":"Anderson TJC, LoVerde PT, Le Clec\u2019h W, Chevalier FD. Genetic crosses and linkage mapping in schistosome parasites. Trends Parasitol. 2018;34:982\u201396.","journal-title":"Trends Parasitol."},{"key":"3663_CR23","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nature08923","volume":"464","author":"IA Ehrenreich","year":"2010","unstructured":"Ehrenreich IA, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, et al. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. 2010;464:1039\u201342.","journal-title":"Nature."},{"key":"3663_CR24","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1186\/1471-2164-15-617","volume":"15","author":"FD Chevalier","year":"2014","unstructured":"Chevalier FD, Valentim CLL, LoVerde PT, Anderson TJC. Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites. BMC Genom. 2014;15:617.","journal-title":"BMC Genom"},{"key":"3663_CR25","doi-asserted-by":"publisher","first-page":"e1006857","DOI":"10.1371\/journal.pgen.1006857","volume":"13","author":"YJ Choi","year":"2017","unstructured":"Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J, Grant WN, et al. Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta. PLoS Genet. 2017;13:e1006857.","journal-title":"PLoS Genet."},{"key":"3663_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parint.2012.07.001","volume":"62","author":"ACS Chagas","year":"2013","unstructured":"Chagas ACS, Katiki LM, Silva IC, Giglioti R, Esteves SN, Oliveira MC, et al. Haemonchus contortus: a multiple-resistant Brazilian isolate and the costs for its characterization and maintenance for research use. Parasitol Int. 2013;62:1\u20136.","journal-title":"Parasitol Int."},{"key":"3663_CR27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.vetpar.2017.09.010","volume":"246","author":"ACA de Albuquerque","year":"2017","unstructured":"de Albuquerque ACA, Bassetto CC, Almeida FA, Amarante AFT. Development of Haemonchus contortus resistance in sheep under suppressive or target selective treatment with monepantel. Vet Parasitol. 2017;246:112\u20137.","journal-title":"Vet Parasitol."},{"key":"3663_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1017\/s0022149x19000221","volume":"56","author":"SCM Niciura","year":"2019","unstructured":"Niciura SCM, Cruvinel GG, Moraes CV, Chagas ACS, Esteves SN, Benavides MV, et al. In vivo selection for Haemonchus contortus resistance to monepantel. J Helminthol. 2019;56:67. https:\/\/doi.org\/10.1017\/s0022149x19000221 .","journal-title":"J Helminthol."},{"key":"3663_CR29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.vetpar.2005.11.019","volume":"136","author":"GC Coles","year":"2006","unstructured":"Coles GC, Jackson F, Pomroy WE, Prichard RK, Von Samson-Himmelstjerna G, Silvestre A, et al. The detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol. 2006;136:167\u201385.","journal-title":"Vet Parasitol."},{"key":"3663_CR30","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.vetpar.2012.07.016","volume":"190","author":"SCM Niciura","year":"2012","unstructured":"Niciura SCM, Ver\u00edssimo CJ, Gromboni JG, Rocha MI, de Mello SS, Barbosa CM, et al. F200Y polymorphism in the \u03b2-tubulin gene in field isolates of Haemonchus contortus and risk factors of sheep flock management practices related to anthelmintic resistance. Vet Parasitol. 2012;190:608\u201312.","journal-title":"Vet Parasitol."},{"key":"3663_CR31","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R. Fast and accurate short read alignment with Burrows\u2013Wheeler transform. Bioinformatics. 2009;25:1754\u201360.","journal-title":"Bioinformatics."},{"key":"3663_CR32","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The sequence alignment\/map format and SAMtools. Bioinformatics. 2009;25:2078\u20139.","journal-title":"Bioinformatics."},{"key":"3663_CR33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4161\/fly.19695","volume":"6","author":"P Cingolani","year":"2012","unstructured":"Cingolani P, Platts A, Wang LL, Coon M, Nguyen T, Wang L, et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly. 2012;6:80\u201392.","journal-title":"Fly."},{"key":"3663_CR34","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1093\/bioinformatics\/btr589","volume":"27","author":"R Kofler","year":"2011","unstructured":"Kofler R, Pandey RV, Schl\u00f6tterer C. PoPoolation2: identifying differentiation between populations using sequencing of pooled DNA samples (Pool-Seq). Bioinformatics. 2011;27:3435\u20136.","journal-title":"Bioinformatics."},{"key":"3663_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/0471249688","volume-title":"Categorical data analysis","author":"A Agresti","year":"2002","unstructured":"Agresti A. Categorical data analysis. 2nd ed. New Jersey: Wiley; 2002.","edition":"2"},{"key":"3663_CR36","doi-asserted-by":"publisher","first-page":"e1003534","DOI":"10.1371\/journal.pgen.1003534","volume":"9","author":"H Bastide","year":"2013","unstructured":"Bastide H, Betancourt A, Nolte V, Tobler R, St\u00f6be P, Futschik A, et al. A genome-wide, fine-scale map of natural pigmentation variation in Drosophila melanogaster. PLoS Genet. 2013;9:e1003534.","journal-title":"PLoS Genet."},{"key":"3663_CR37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57:289\u2013300.","journal-title":"J R Stat Soc B"},{"key":"3663_CR38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.vetpar.2016.02.031","volume":"220","author":"A Raza","year":"2016","unstructured":"Raza A, Lamb J, Chambers M, Hunt PW, Kotze AC. Larval development assays reveal the presence of sub-populations showing high- and low-level resistance in a monepantel (Zolvix\u00ae)-resistant isolate of Haemonchus contortus. Vet Parasitol. 2016;220:77\u201382.","journal-title":"Vet Parasitol."},{"key":"3663_CR39","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1017\/S0031182000049179","volume":"78","author":"LF Le Jambre","year":"1979","unstructured":"Le Jambre LF, Royal WM, Martin PJ. The inheritance of thiabendazole resistance in Haemonchus contortus. Parasitology. 1979;78:107\u201319.","journal-title":"Parasitology."},{"key":"3663_CR40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ijpara.2007.06.008","volume":"38","author":"E Redman","year":"2008","unstructured":"Redman E, Packard E, Grillo V, Smith J, Jackson F, Gilleard JS. Microsatellite analysis reveals marked genetic differentiation between Haemonchus contortus laboratory isolates and provides a rapid system of genetic fingerprinting. Int J Parasitol. 2008;38:111\u201322.","journal-title":"Int J Parasitol."},{"key":"3663_CR41","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1017\/S0031182007000066","volume":"134","author":"JS Gilleard","year":"2007","unstructured":"Gilleard JS, Beech RN. Population genetics of anthelmintic resistance in parasitic nematodes. Parasitology. 2007;134:1133\u201347.","journal-title":"Parasitology."},{"key":"3663_CR42","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1093\/zoolinnean\/zly007","volume":"184","author":"H Weigand","year":"2018","unstructured":"Weigand H, Leese F. Detecting signatures of positive selection in non-model species using genomic data. Zool J Linn Soc. 2018;184:528\u201383.","journal-title":"Zool J Linn Soc."},{"key":"3663_CR43","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1590\/S1415-47572014000300004","volume":"37","author":"JJ de Simoni Gouveia","year":"2014","unstructured":"de Simoni Gouveia JJ, da Silva MVGB, Paiva SR, de Oliveira SMP. Identification of selection signatures in livestock species. Genet Mol Biol. 2014;37:330\u201342.","journal-title":"Genet Mol Biol."},{"key":"3663_CR44","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev.pharmtox.40.1.431","volume":"40","author":"PJ Corringer","year":"2000","unstructured":"Corringer PJ, Le Nov\u00e8re N, Changeux JP. Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol. 2000;40:431\u201358.","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"3663_CR45","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1085\/jgp.115.5.637","volume":"115","author":"C Grosman","year":"2000","unstructured":"Grosman C, Auerbach A. Asymmetric and independent contribution of the second transmembrane segment 12\u2019 residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist. J Gen Physiol. 2000;115:637\u201351.","journal-title":"J Gen Physiol."},{"key":"3663_CR46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/bies.10377","volume":"26","author":"AK Jones","year":"2004","unstructured":"Jones AK, Sattelle DB. Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans. Bioessays. 2004;26:39\u201349.","journal-title":"Bioessays."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-019-3663-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-019-3663-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-019-3663-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:26:50Z","timestamp":1721608010000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-019-3663-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3663"],"URL":"https:\/\/doi.org\/10.1186\/s13071-019-3663-9","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,14]]},"assertion":[{"value":"9 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in strict accordance with relevant guidelines and regulations, and with approval from the Animal Ethics Committee of \u201cEmbrapa Pecu\u00e1ria Sudeste\u201d (Permit Numbers: 06\/2015 and 03\/2017).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"403"}}