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Chemical analyses of schistosome-molluscan interactions indicate that host identification involves chemosensation, including na\u00efve host preference. Proteomic technique advances enable sophisticated comparative analyses between infected and na\u00efve snail host proteins. This study aimed to compare resistant, susceptible and na\u00efve<jats:italic>Biomphalaria glabrata<\/jats:italic>snail-conditioned water (SCW) to identify potential attractants and deterrents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Behavioural bioassays were performed on<jats:italic>S. mansoni<\/jats:italic>miracidia to compare the effects of susceptible, F1 resistant and na\u00efve<jats:italic>B. glabrata<\/jats:italic>SCW. The F1 resistant and susceptible<jats:italic>B. glabrata<\/jats:italic>SCW excretory\u2013secretory proteins (ESPs) were fractionated using SDS-PAGE, identified with LC-MS\/MS and compared to na\u00efve snail ESPs. Protein-protein interaction (PPI) analyses based on published studies (including experiments, co-expression, text-mining and gene fusion) identified<jats:italic>S. mansoni<\/jats:italic>and<jats:italic>B. glabrata<\/jats:italic>protein interaction. Data are available<jats:italic>via<\/jats:italic>ProteomeXchange with identifier PXD015129.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 291, 410 and 597 ESPs were detected in the susceptible, F1 resistant and na\u00efve SCW, respectively. Less overlap in ESPs was identified between susceptible and na\u00efve snails than F1 resistant and na\u00efve snails. F1 resistant<jats:italic>B. glabrata<\/jats:italic>ESPs were predominately associated with anti-pathogen activity and detoxification, such as leukocyte elastase and peroxiredoxin. Susceptible<jats:italic>B. glabrata<\/jats:italic>several proteins correlated with immunity and anti-inflammation, such as glutathione S-transferase and zinc metalloproteinase, and<jats:italic>S. mansoni<\/jats:italic>sporocyst presence. PPI analyses found that uncharacterised<jats:italic>S. mansoni<\/jats:italic>protein Smp_142140.1 potentially interacts with numerous<jats:italic>B. glabrata<\/jats:italic>proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified ESPs released by F1 resistant, susceptible and na\u00efve<jats:italic>B. glabrata<\/jats:italic>to explain<jats:italic>S. mansoni<\/jats:italic>miracidia interplay. Susceptible<jats:italic>B. glabrata<\/jats:italic>ESPs shed light on potential<jats:italic>S. mansoni<\/jats:italic>miracidia deterrents. Further targeted research on specific ESPs identified in this study could help inhibit<jats:italic>B. glabrata<\/jats:italic>and<jats:italic>S. mansoni<\/jats:italic>interactions and stop human schistosomiasis.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13071-019-3708-0","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T04:23:57Z","timestamp":1568435037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparative study of excretory\u2013secretory proteins released by Schistosoma mansoni-resistant, susceptible and na\u00efve Biomphalaria glabrata"],"prefix":"10.1186","volume":"12","author":[{"given":"Conor E.","family":"Fogarty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary G.","family":"Duke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott F.","family":"Cummins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-7767","authenticated-orcid":false,"given":"Tianfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,14]]},"reference":[{"key":"3708_CR1","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1016\/j.bmc.2017.04.031","volume":"25","author":"VBR da Silva","year":"2017","unstructured":"da Silva VBR, Campos BRKL, de Oliveira JF, Decout JL, de Lima M. 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This study was performed in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The Swiss mice used in this study were subject to Biosecurity Quarantine Control and hence held in a quarantine containment area within a Specific Pathogen Free Animal Facility. <i>S. mansoni<\/i> were maintained with an Australian Department Agriculture, Fisheries and Forestry Biosecurity permit. This study was performed in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"452"}}