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Scabies seriously affects the commercial rabbit breeding, causing severe economic losses. Host resistance to\n                      <jats:italic>S. scabiei<\/jats:italic>\n                      is an important factor in further development of the rabbit industry. In the present study, we compared the host resistance to\n                      <jats:italic>S. scabiei<\/jats:italic>\n                      var.\n                      <jats:italic>cuniculi<\/jats:italic>\n                      of a new breed of domestic rabbit propagated by the Sichuan Animal Sciences Academy (QiXing rabbit, QX) compared with that of a traditional rabbit breed in the domestic rabbit industry (IRA rabbit, IRA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Both QX and IRA rabbits were experimentally infested with live\n                      <jats:italic>S. scabiei<\/jats:italic>\n                      var.\n                      <jats:italic>cuniculi<\/jats:italic>\n                      mites for 48 h. Then, during the course of four-week experimental infestation period, the body weight of rabbits was recorded every two weeks for calculating body-weight variations in comparison to the non-infested control rabbits. Skin lesions in the foot area were assessed on weekly basis and serum samples were tested weekly for the estimation of changes in the total antibody levels (IgG, IgE and IgM). Moreover, DNA extracted from the blood samples was amplified for analysis of the genetic diversity in the major histocompatibility complex, class II, DQ Alpha (\n                      <jats:italic>MHC-DQA<\/jats:italic>\n                      ) gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the IRA rabbits, the QX rabbits showed a significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) relative body weight gain compared to the non-infested control rabbits and significantly lower (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) scores for foot skin lesions and higher levels of IgG, IgE and IgM at weeks 1 to 4, week 2 and week 1 post-infestation, respectively. Furthermore, a polymorphism site at position 103 bp of exon two of\n                      <jats:italic>MHC-DQA<\/jats:italic>\n                      gene and a different gene frequency were found between two rabbit breeds, suggesting the genetic basis for the differential host resistance to the\n                      <jats:italic>S. scabiei<\/jats:italic>\n                      var.\n                      <jats:italic>cuniculi<\/jats:italic>\n                      between two rabbit breeds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The QX rabbits showed higher host resistance to\n                      <jats:italic>S. scabiei<\/jats:italic>\n                      var.\n                      <jats:italic>cuniculi<\/jats:italic>\n                      compared to the IRA rabbits at the clinical, immunological and genetic levels. These results provide a reference for the breeding of rabbits with adequately improved and sustained host resistance to scabies in the domestic rabbit industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13071-019-3764-5","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T10:21:02Z","timestamp":1573208462000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds"],"prefix":"10.1186","volume":"12","author":[{"given":"Wenrui","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengxing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Angel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangde","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"3764_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1136\/pgmj.2003.014563","volume":"80","author":"JS Mccarthy","year":"2004","unstructured":"Mccarthy JS, Kemp DJ, Walton SF, Currie BJ. 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All procedures were implemented in strict accordance with the Guide for the Care and Use of Laboratory Animals of the Animal Ethics Committee of Sichuan Agricultural University (Ya\u2019an, China; Approval No. 2015\u2013028). All methods were carried out in accordance with relevant guidelines and regulations.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"530"}}