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Recent advances in -omic technologies and bioinformatic data analyses have led to a greater understanding of blowfly biology and should allow the identification of protein families involved in host-parasite interactions and disease. Current literature suggests that proteins of the SCP (Sperm-Coating Protein)\/TAPS (Tpx-1\/Ag5\/PR-1\/Sc7) (SCP\/TAPS) superfamily play key roles in immune modulation, cross-talk between parasite and host as well as developmental and reproductive processes in parasites.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Here, we employed a bioinformatics workflow to curate the SCP\/TAPS protein gene family in <jats:italic>L. cuprina<\/jats:italic>. Protein sequence, the presence and number of conserved CAP-domains and phylogeny were used to group identified SCP\/TAPS proteins; these were compared to those found in <jats:italic>Drosophila melanogaster<\/jats:italic> to make functional predictions<jats:italic>.<\/jats:italic> In addition, transcription levels of SCP\/TAPS protein-encoding genes were explored in different developmental stages.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 27 genes were identified as belonging to the SCP\/TAPS gene family: encoding 26 single-domain proteins each with a single CAP domain and a solitary double-domain protein containing two conserved cysteine-rich secretory protein\/antigen 5\/pathogenesis related-1 (CAP) domains. Surprisingly, 16 SCP\/TAPS predicted proteins formed an extended tandem array spanning a 53 kb region of one genomic region, which was confirmed by MinION long-read sequencing. RNA-seq data indicated that these 16 genes are highly transcribed in all developmental stages (excluding the embryo).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Future work should assess the potential of selected SCP\/TAPS proteins as novel targets for the control of <jats:italic>L. cuprina<\/jats:italic> and related parasitic flies of major socioeconomic importance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-020-04476-6","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T10:02:45Z","timestamp":1606471365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Major SCP\/TAPS protein expansion in Lucilia cuprina is associated with novel tandem array organisation and domain architecture"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4446-0733","authenticated-orcid":false,"given":"Yair D. 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