{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:17:27Z","timestamp":1790806647929,"version":"4.1.0"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"labex IBEID","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Louping ill virus (LIV) and tick-borne encephalitis virus (TBEV) are tick-borne flaviviruses that are both transmitted by the major European tick,\n                      <jats:italic>Ixodes ricinus<\/jats:italic>\n                      . Despite the importance of\n                      <jats:italic>I. ricinus<\/jats:italic>\n                      as an arthropod vector, its capacity to acquire and subsequently transmit viruses, known as vector competence, is poorly understood. At the molecular scale, vector competence is governed in part by binary interactions established between viral and cellular proteins within infected tick cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To investigate virus-vector protein\u2013protein interactions (PPIs), the entire set of open reading frames for LIV and TBEV was screened against an\n                      <jats:italic>I. ricinus<\/jats:italic>\n                      cDNA library established from three embryonic tick cell lines using yeast two-hybrid methodology (Y2H). PPIs revealed for each viral bait were retested in yeast by applying a gap repair (GR) strategy, and notably against the cognate protein of both viruses, to determine whether the PPIs were specific for a single virus or common to both. The interacting tick proteins were identified by automatic BLASTX, and in silico analyses were performed to expose the biological processes targeted by LIV and TBEV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For each virus, we identified 24 different PPIs involving six viral proteins and 22 unique tick proteins, with all PPIs being common to both viruses. According to our data, several viral proteins (pM, M, NS2A, NS4A, 2K and NS5) target multiple tick protein modules implicated in critical biological pathways. Of note, the NS5 and pM viral proteins establish PPI with several tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins, which are essential adaptor proteins at the nexus of multiple signal transduction pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We provide the first description of the TBEV\/LIV-\n                      <jats:italic>I. ricinus<\/jats:italic>\n                      PPI network, and indeed of any PPI network involving a tick-borne virus and its tick vector. While further investigation will be needed to elucidate the role of each tick protein in the replication cycle of tick-borne flaviviruses, our study provides a foundation for understanding the vector competence of\n                      <jats:italic>I. ricinus<\/jats:italic>\n                      at the molecular level. Indeed, certain PPIs may represent molecular determinants of vector competence of\n                      <jats:italic>I. ricinus<\/jats:italic>\n                      for TBEV and LIV, and potentially for other tick-borne flaviviruses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13071-021-04651-3","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T13:03:05Z","timestamp":1615035785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exploration of binary protein\u2013protein interactions between tick-borne flaviviruses and Ixodes ricinus"],"prefix":"10.1186","volume":"14","author":[{"given":"Manon","family":"Lemasson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Caignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Unterfinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houssam","family":"Attoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Bell-Sakyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Hirchaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Moutailler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Vitour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-0398","authenticated-orcid":false,"given":"Sandrine A.","family":"Lacour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"issue":"Suppl","key":"4651_CR1","doi-asserted-by":"publisher","first-page":"S221","DOI":"10.1017\/s0031182004005220","volume":"129","author":"M Labuda","year":"2004","unstructured":"Labuda M, Nuttall PA. Tick-borne viruses. Parasitology. 2004;129(Suppl):S221\u201345. https:\/\/doi.org\/10.1017\/s0031182004005220.","journal-title":"Parasitology"},{"key":"4651_CR2","first-page":"469","volume":"32","author":"CH Calisher","year":"1988","unstructured":"Calisher CH. Antigenic classification and taxonomy of flaviviruses (family Flaviviridae) emphasizing a universal system for the taxonomy of viruses causing tick-borne encephalitis. Acta Virol. 1988;32:469\u201378.","journal-title":"Acta Virol"},{"key":"4651_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0065-3527(03)61008-0","volume":"61","author":"TS Gritsun","year":"2003","unstructured":"Gritsun TS, Nuttall PA, Gould EA. Tick-borne flaviviruses. Adv Virus Res. 2003;61:317\u201371. https:\/\/doi.org\/10.1016\/S0065-3527(03)61008-0.","journal-title":"Adv Virus Res"},{"key":"4651_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ttbdis.2010.10.007","volume":"2","author":"J S\u00fcss","year":"2011","unstructured":"S\u00fcss J. Tick-borne encephalitis 2010: epidemiology, risk areas, and virus strains in Europe and Asia\u2014an overview. Ticks Tick Borne Dis. 2011;2:2\u201315. https:\/\/doi.org\/10.1016\/j.ttbdis.2010.10.007.","journal-title":"Ticks Tick Borne Dis"},{"key":"4651_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0166-3542(02)00206-1","volume":"57","author":"TS Gritsun","year":"2003","unstructured":"Gritsun TS, Lashkevich VA, Gould EA. Tick-borne encephalitis. Antiviral Res. 2003;57:129\u201346.","journal-title":"Antiviral Res"},{"key":"4651_CR6","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/S0140-6736(08)60800-4","volume":"371","author":"L Lindquist","year":"2008","unstructured":"Lindquist L, Vapalahti O. Tick-borne encephalitis. Lancet. 2008;371:1861\u201371.","journal-title":"Lancet"},{"key":"4651_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0368-1742(30)80026-2","volume":"43","author":"WA Pool","year":"1930","unstructured":"Pool WA, Brownlee A, Wilson DR. The etiology of \u201clouping-ill.\u201d J Comp Pathol Ther. 1930;43:253\u201390. https:\/\/doi.org\/10.1016\/S0368-1742(30)80026-2.","journal-title":"J Comp Pathol Ther"},{"issue":"5","key":"4651_CR8","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1099\/vir.0.062356-0","volume":"95","author":"CL Jeffries","year":"2014","unstructured":"Jeffries CL, Mansfield KL, Phipps LP, Wakeley PR, Mearns R, Schock A, et al. Louping ill virus: an endemic tick-borne disease of Great Britain. J Gen Virol. 2014;95(5):1005\u201314.","journal-title":"J Gen Virol"},{"key":"4651_CR9","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s10493-015-9952-x","volume":"68","author":"L Gilbert","year":"2016","unstructured":"Gilbert L. Louping ill virus in the UK: a review of the hosts, transmission and ecological consequences of control. Exp Appl Acarol. 2016;68:363\u201374.","journal-title":"Exp Appl Acarol"},{"key":"4651_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0163-4453(91)92756-U","volume":"23","author":"MM Davidson","year":"1991","unstructured":"Davidson MM, Williams H, Macleod JA. Louping ill in man: a forgotten disease. J Infect. 1991;23:241\u20139.","journal-title":"J Infect"},{"key":"4651_CR11","doi-asserted-by":"publisher","first-page":"12123","DOI":"10.1073\/pnas.2032324100","volume":"100","author":"V Spirin","year":"2003","unstructured":"Spirin V, Mirny LA. Protein complexes and functional modules in molecular networks. Proc Natl Acad Sci USA. 2003;100:12123\u20138. https:\/\/doi.org\/10.1073\/pnas.2032324100.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4651_CR12","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1021\/acs.jproteome.9b00318","volume":"18","author":"D Kovanich","year":"2019","unstructured":"Kovanich D, Saisawang C, Sittipaisankul P, Ramphan S, Kalpongnukul N, Somparn P, et al. Analysis of the Zika and Japanese Encephalitis virus NS5 interactomes. J Proteome Res. 2019;18:3203\u201318. https:\/\/doi.org\/10.1021\/acs.jproteome.9b00318.","journal-title":"J Proteome Res"},{"key":"4651_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00114","author":"J de la Fuente","year":"2017","unstructured":"de la Fuente J, Antunes S, Bonnet S, Cabezas-Cruz A, Domingos AG, Estrada-Pe\u00f1a A, et al. Tick\u2013pathogen interactions and vector competence: identification of molecular drivers for tick-borne diseases. Front Cell Infect Microbiol. 2017. https:\/\/doi.org\/10.3389\/fcimb.2017.00114.","journal-title":"Front Cell Infect Microbiol"},{"key":"4651_CR14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3389\/fcimb.2017.00519","volume":"7","author":"JM Grabowski","year":"2017","unstructured":"Grabowski JM, Hill CA. A roadmap for tick-borne flavivirus research in the \u201cOmics\u201d era. Front Cell Infect Microbiol. 2017;7:519. https:\/\/doi.org\/10.3389\/fcimb.2017.00519.","journal-title":"Front Cell Infect Microbiol"},{"key":"4651_CR15","first-page":"1101","volume-title":"Fields virology","author":"BD Lindenbach","year":"2007","unstructured":"Lindenbach BD, Thiel H-J, Rice CM. Flaviviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fields virology. 5th ed. Lippincott-Raven Publishers: Philadelphia; 2007. p. 1101\u201352.","edition":"5"},{"key":"4651_CR16","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1128\/AEM.68.9.4559-4566.2002","volume":"68","author":"JA Simser","year":"2002","unstructured":"Simser JA, Palmer AT, Fingerle V, Wilske B, Kurtti TJ, Munderloh UG. Rickettsia monacensis sp. nov., a spotted fever group rickettsia, from ticks (Ixodes ricinus) collected in a European city park. Appl Environ Microbiol. 2002;68:4559\u201366. https:\/\/doi.org\/10.1128\/AEM.68.9.4559-4566.2002.","journal-title":"Appl Environ Microbiol"},{"key":"4651_CR17","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.pt.2007.07.009","volume":"23","author":"L Bell-Sakyi","year":"2007","unstructured":"Bell-Sakyi L, Zweygarth E, Blouin EF, Gould EA, Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 2007;23:450\u20137.","journal-title":"Trends Parasitol"},{"key":"4651_CR18","first-page":"388","volume":"9","author":"L Posp\u00ed\u0161il","year":"1954","unstructured":"Posp\u00ed\u0161il L, Jand\u00e1sek L, Pe\u0161ek J. Isolation of new strains of meningoencephalitis virus in the Brno region during the summer of 1953. Lek List. 1954;9:388\u20139.","journal-title":"Lek List"},{"key":"4651_CR19","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1099\/vir.0.000096","volume":"96","author":"KL Mansfield","year":"2015","unstructured":"Mansfield KL, Morales AB, Johnson N, Ayll\u00f3n N, H\u00f6fle U, Alberdi P, et al. Identification and characterization of a novel tick-borne flavivirus subtype in goats (Capra hircus) in Spain. J Gen Virol. 2015;96:1676\u201381.","journal-title":"J Gen Virol"},{"key":"4651_CR20","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1093\/nar\/gkj493","volume":"34","author":"B Titz","year":"2006","unstructured":"Titz B, Thomas S, Rajagopala SV, Chiba T, Ito T, Uetz P. Transcriptional activators in yeast. Nucleic Acids Res. 2006;34:955\u201367. https:\/\/doi.org\/10.1093\/nar\/gkj493.","journal-title":"Nucleic Acids Res"},{"key":"4651_CR21","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ymeth.2003.10.001","volume":"32","author":"PO Vidalain","year":"2004","unstructured":"Vidalain PO, Boxem M, Ge H, Li S, Vidal M. Increasing specificity in high-throughput yeast two-hybrid experiments. Methods. 2004;32:363\u201370.","journal-title":"Methods"},{"key":"4651_CR22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1006\/METH.2001.1190","volume":"24","author":"AJM Walhout","year":"2001","unstructured":"Walhout AJM, Vidal M. High-throughput yeast two-hybrid assays for large-scale protein interaction mapping. Methods. 2001;24:297\u2013306. https:\/\/doi.org\/10.1006\/METH.2001.1190.","journal-title":"Methods"},{"key":"4651_CR23","doi-asserted-by":"publisher","first-page":"10507","DOI":"10.1038\/ncomms10507","volume":"7","author":"M Gulia-Nuss","year":"2016","unstructured":"Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, et al. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat Commun. 2016;7:10507. https:\/\/doi.org\/10.1038\/ncomms10507.","journal-title":"Nat Commun"},{"key":"4651_CR24","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504. https:\/\/doi.org\/10.1101\/gr.1239303.","journal-title":"Genome Res"},{"key":"4651_CR25","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/bioinformatics\/btm554","volume":"24","author":"Y Assenov","year":"2008","unstructured":"Assenov Y, Ram\u00edrez F, Schelhorn SESE, Lengauer T, Albrecht M. Computing topological parameters of biological networks. Bioinformatics. 2008;24:282\u20134. https:\/\/doi.org\/10.1093\/bioinformatics\/btm554.","journal-title":"Bioinformatics"},{"key":"4651_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-015-1210-x","volume":"8","author":"S Weisheit","year":"2015","unstructured":"Weisheit S, Villar M, Tykalov\u00e1 H, Popara M, Loecherbach J, Watson M, et al. Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis. Parasites Vectors. 2015;8:1\u201326.","journal-title":"Parasites Vectors"},{"key":"4651_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-017-2011-1","volume":"10","author":"KL Mansfield","year":"2017","unstructured":"Mansfield KL, Cook C, Ellis RJ, Bell-Sakyi L, Johnson N, Alberdi P, et al. Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells. Parasites Vectors. 2017;10:1\u201312.","journal-title":"Parasites Vectors"},{"key":"4651_CR28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.virusres.2008.05.013","volume":"137","author":"D R\u016f\u017eek","year":"2008","unstructured":"R\u016f\u017eek D, Bell-Sakyi L, Kopeck\u00fd J, Grubhoffer L. Growth of tick-borne encephalitis virus (European subtype) in cell lines from vector and non-vector ticks. Virus Res. 2008;137:142\u20136. https:\/\/doi.org\/10.1016\/j.virusres.2008.05.013.","journal-title":"Virus Res"},{"key":"4651_CR29","doi-asserted-by":"publisher","first-page":"D377","DOI":"10.1038\/nprot.2013.092","volume":"41","author":"H Mi","year":"2013","unstructured":"Mi H, Muruganujan A, Thomas PD. PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees. Nucleic Acids Res. 2013;41:D377\u201386. https:\/\/doi.org\/10.1038\/nprot.2013.092.","journal-title":"Nucleic Acids Res"},{"key":"4651_CR30","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1093\/nar\/gkg115","volume":"31","author":"PD Thomas","year":"2003","unstructured":"Thomas PD, Kejariwal A, Campbell MJ, Mi H, Diemer K, Guo N, et al. PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification | Nucleic Acids Research | Oxford Academic. Nucleic Acids Res. 2003;31:334\u201341. https:\/\/doi.org\/10.1093\/nar\/gkg115.","journal-title":"Nucleic Acids Res"},{"key":"4651_CR31","doi-asserted-by":"publisher","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","volume":"6","author":"F Supek","year":"2011","unstructured":"Supek F, Bo\u0161njak M, \u0160kunca N, \u0160muc T. Revigo summarizes and visualizes long lists of gene ontology terms. PLoS ONE. 2011;6:e21800.","journal-title":"PLoS ONE"},{"key":"4651_CR32","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1101\/gad.11.13.1717","volume":"11","author":"JR Riesgo-Escovar","year":"1997","unstructured":"Riesgo-Escovar JR, Hafen E. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 1997;11:1717\u201327. https:\/\/doi.org\/10.1101\/gad.11.13.1717.","journal-title":"Genes Dev"},{"key":"4651_CR33","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1101\/gad.11.13.1748","volume":"11","author":"L Kockel","year":"1997","unstructured":"Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D. Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 1997;11:1748\u201358. https:\/\/doi.org\/10.1101\/gad.11.13.1748.","journal-title":"Genes Dev"},{"key":"4651_CR34","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1534\/genetics.107.085555","volume":"180","author":"AL Franciscovich","year":"2008","unstructured":"Franciscovich AL, Vrailas Mortimer AD, Freeman AA, Gu J, Sanyal S. Overexpression screen in drosophila identifies neuronal roles of GSK-3\u03b2\/shaggy as a regulator of AP-1-dependent developmental plasticity. Genetics. 2008;180:2057\u201371. https:\/\/doi.org\/10.1534\/genetics.107.085555.","journal-title":"Genetics"},{"key":"4651_CR35","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fimmu.2019.00326","volume":"10","author":"GA Bishop","year":"2019","unstructured":"Bishop GA, Abdul-Sater AA, Watts TH. Editorial: TRAF proteins in health and disease. Front Immunol. 2019;10:326. https:\/\/doi.org\/10.3389\/fimmu.2019.00326.","journal-title":"Front Immunol"},{"key":"4651_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/1750-2187-8-7","author":"P Xie","year":"2013","unstructured":"Xie P. TRAF molecules in cell signaling and in human diseases. J Mol Signal. 2013. https:\/\/doi.org\/10.1186\/1750-2187-8-7.","journal-title":"J Mol Signal"},{"key":"4651_CR37","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/cmi.2012.30","volume":"9","author":"H Yin","year":"2012","unstructured":"Yin H, Shi Z, Jiao S, Chen C, Wang W, Greene MI, et al. Germinal center kinases in immune regulation. Cell Mol Immunol. 2012;9:439\u201345. https:\/\/doi.org\/10.1038\/cmi.2012.30.","journal-title":"Cell Mol Immunol"},{"key":"4651_CR38","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1083\/jcb.200310061","volume":"164","author":"C Preisinger","year":"2004","unstructured":"Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, et al. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14\u20133-3\u03b6. J Cell Biol. 2004;164:1009\u201320. https:\/\/doi.org\/10.1083\/jcb.200310061.","journal-title":"J Cell Biol"},{"key":"4651_CR39","doi-asserted-by":"publisher","first-page":"6559","DOI":"10.1038\/sj.onc.1204818","volume":"20","author":"JL Lin","year":"2001","unstructured":"Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. 2001;20:6559\u201369. https:\/\/doi.org\/10.1038\/sj.onc.1204818.","journal-title":"Oncogene"},{"key":"4651_CR40","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0092-8674(00)80830-2","volume":"101","author":"C Scheufler","year":"2000","unstructured":"Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, Bartunik H, et al. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell. 2000;101:199\u2013210. https:\/\/doi.org\/10.1016\/S0092-8674(00)80830-2.","journal-title":"Cell"},{"key":"4651_CR41","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.neuron.2015.10.012","volume":"88","author":"V Uytterhoeven","year":"2015","unstructured":"Uytterhoeven V, Lauwers E, Maes I, Miskiewicz K, Melo MN, Swerts J, et al. Hsc70-4 deforms membranes to promote synaptic protein turnover by endosomal microautophagy. Neuron. 2015;88:735\u201348.","journal-title":"Neuron"},{"key":"4651_CR42","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0896-6273(01)00427-5","volume":"31","author":"S Tobaben","year":"2001","unstructured":"Tobaben S, Thakur P, Fern\u00e1ndez-Chac\u00f3n R, S\u00fcdhof TC, Rettig J, Stahl B. A trimeric protein complex functions as a synaptic chaperone machine. Neuron. 2001;31:987\u201399.","journal-title":"Neuron"},{"key":"4651_CR43","doi-asserted-by":"publisher","first-page":"19214","DOI":"10.1073\/pnas.1209997109","volume":"109","author":"P Leznicki","year":"2012","unstructured":"Leznicki P, High S. SGTA antagonizes BAG6-mediated protein triage. Proc Natl Acad Sci USA. 2012;109:19214\u20139. https:\/\/doi.org\/10.1073\/pnas.1209997109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4651_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/srep26433","author":"EM Krysztofinska","year":"2016","unstructured":"Krysztofinska EM, Mart\u00ednez-Lumbreras S, Thapaliya A, Evans NJ, High S, Isaacson RL. Structural and functional insights into the E3 ligase, RNF126. Sci Rep. 2016. https:\/\/doi.org\/10.1038\/srep26433.","journal-title":"Sci Rep"},{"key":"4651_CR45","doi-asserted-by":"publisher","first-page":"4774","DOI":"10.1242\/jcs.159038","volume":"127","author":"D Asante","year":"2014","unstructured":"Asante D, Stevenson NL, Stephens DJ. Subunit composition of the human cytoplasmic dynein-2 complex. J Cell Sci. 2014;127:4774\u201387. https:\/\/doi.org\/10.1242\/jcs.159038.","journal-title":"J Cell Sci"},{"key":"4651_CR46","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nrm3667","volume":"14","author":"AJ Roberts","year":"2013","unstructured":"Roberts AJ, Kon T, Knight PJ, Sutoh K, Burgess SA. Functions and mechanics of dynein motor proteins. Nat Rev Mol Cell Biol. 2013;14:713\u201326. https:\/\/doi.org\/10.1038\/nrm3667.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4651_CR47","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1242\/jcs.207027","volume":"130","author":"T Kreko-Pierce","year":"2017","unstructured":"Kreko-Pierce T, Eaton BA. The Drosophila LC8 homolog cut up specifies the axonal transport of proteasomes. J Cell Sci. 2017;130:3388\u201398. https:\/\/doi.org\/10.1242\/jcs.207027.","journal-title":"J Cell Sci"},{"key":"4651_CR48","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0968-0004(00)01730-8","volume":"26","author":"I Callebaut","year":"2001","unstructured":"Callebaut I, De Gunzburg J, Goud B, Mornon JP. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Trends Biochem Sci. 2001;26:79\u201383. https:\/\/doi.org\/10.1016\/S0968-0004(00)01730-8.","journal-title":"Trends Biochem Sci"},{"key":"4651_CR49","doi-asserted-by":"publisher","first-page":"42501","DOI":"10.1074\/jbc.M104885200","volume":"276","author":"M Mari","year":"2001","unstructured":"Mari M, Macia E, Le Marchand-Brustel Y, Cormont M. Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4. J Biol Chem. 2001;276:42501\u20138. https:\/\/doi.org\/10.1074\/jbc.M104885200.","journal-title":"J Biol Chem"},{"key":"4651_CR50","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1017\/S0031182004005967","volume":"129","author":"F Jongejan","year":"2004","unstructured":"Jongejan F, Uilenberg G. The global importance of ticks. Parasitology. 2004;129:S3-14. https:\/\/doi.org\/10.1017\/S0031182004005967.","journal-title":"Parasitology"},{"key":"4651_CR51","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/1471-2180-11-234","volume":"11","author":"M Le Breton","year":"2011","unstructured":"Le Breton M, Meyniel-Schicklin L, Deloire A, Coutard B, Canard B, de Lamballerie X, et al. Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen. BMC Microbiol. 2011;11:234. https:\/\/doi.org\/10.1186\/1471-2180-11-234.","journal-title":"BMC Microbiol"},{"key":"4651_CR52","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.3855\/jidc.6422","volume":"9","author":"HW Tham","year":"2015","unstructured":"Tham HW, Balasubramaniam VRMT, Chew MF, Ahmad H, Hassan SS. Protein\u2013protein interactions between A. aegypti midgut and dengue virus 2: two-hybrid screens using the midgut cDNA library. J Infect Dev Ctries. 2015;9:1338\u201349. https:\/\/doi.org\/10.3855\/jidc.6422.","journal-title":"J Infect Dev Ctries"},{"key":"4651_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-380","author":"X Guo","year":"2010","unstructured":"Guo X, Xu Y, Bian G, Pike AD, Xie Y, Xi Z. Response of the mosquito protein interaction network to dengue infection. BMC Genom. 2010. https:\/\/doi.org\/10.1186\/1471-2164-11-380.","journal-title":"BMC Genom"},{"key":"4651_CR54","doi-asserted-by":"publisher","first-page":"e53535","DOI":"10.1371\/journal.pone.0053535","volume":"8","author":"D Mairiang","year":"2013","unstructured":"Mairiang D, Zhang H, Sodja A, Murali T, Suriyaphol P, Malasit P, et al. Identification of new protein interactions between dengue fever virus and its hosts, human and mosquito. PLoS ONE. 2013;8:e53535. https:\/\/doi.org\/10.1371\/journal.pone.0053535.","journal-title":"PLoS ONE"},{"key":"4651_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00298","author":"KL Mansfield","year":"2017","unstructured":"Mansfield KL, Jizhou L, Phipps LP, Johnson N. Emerging tick-borne viruses in the twenty-first century. Front Cell Infect Microbiol. 2017. https:\/\/doi.org\/10.3389\/fcimb.2017.00298.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1328\u20131340","key":"4651_CR56","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.cell.2020.07.023","volume":"182","author":"N Jia","year":"2020","unstructured":"Jia N, Wang J, Shi W, Du L, Sun Y, Zhan W, et al. Large-scale comparative analyses of tick genomes elucidate their genetic diversity and vector capacities. Cell. 2020;182(1328\u20131340):e13. https:\/\/doi.org\/10.1016\/j.cell.2020.07.023.","journal-title":"Cell"},{"key":"4651_CR57","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1186\/s12864-015-1981-7","volume":"16","author":"WJ Cramaro","year":"2015","unstructured":"Cramaro WJ, Revets D, Hunewald OE, Sinner R, Reye AL, Muller CP. Integration of Ixodes ricinus genome sequencing with transcriptome and proteome annotation of the na\u00efve midgut. BMC Genom. 2015;16:871. https:\/\/doi.org\/10.1186\/s12864-015-1981-7.","journal-title":"BMC Genom"},{"key":"4651_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2008-9","author":"WJ Cramaro","year":"2017","unstructured":"Cramaro WJ, Hunewald OE, Bell-Sakyi L, Muller CP. Genome scaffolding and annotation for the pathogen vector Ixodes ricinus by ultra-long single molecule sequencing. Parasites Vectors. 2017. https:\/\/doi.org\/10.1186\/s13071-017-2008-9.","journal-title":"Parasites Vectors"},{"key":"4651_CR59","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1126\/science.1091403","volume":"303","author":"S Li","year":"2004","unstructured":"Li S, Armstrong CM, Bertin N, Ge H, Milstein S, Boxem M, et al. A map of the interactome network of the metazoan C. elegans. Science. 2004;303:540\u20133. https:\/\/doi.org\/10.1126\/science.1091403.","journal-title":"Science"},{"key":"4651_CR60","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.dci.2008.03.003","volume":"32","author":"WY Chen","year":"2008","unstructured":"Chen WY, Ho KC, Leu JH, Liu KF, Wang HC, Kou GH, et al. WSSV infection activates STAT in shrimp. Dev Comp Immunol. 2008;32:1142\u201350. https:\/\/doi.org\/10.1016\/j.dci.2008.03.003.","journal-title":"Dev Comp Immunol"},{"key":"4651_CR61","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nmeth.1281","volume":"6","author":"P Braun","year":"2009","unstructured":"Braun P, Tasan M, Dreze M, Barrios-Rodiles M, Lemmens I, Yu H, et al. An experimentally derived confidence score for binary protein\u2013protein interactions. Nat Methods. 2009;6:91\u20137. https:\/\/doi.org\/10.1038\/nmeth.1281.","journal-title":"Nat Methods"},{"key":"4651_CR62","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature13302","volume":"509","author":"MS Kim","year":"2014","unstructured":"Kim MS, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, et al. A draft map of the human proteome. Nature. 2014;509:575\u201381. https:\/\/doi.org\/10.1038\/nature13302.","journal-title":"Nature"},{"key":"4651_CR63","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nature13319","volume":"509","author":"M Wilhelm","year":"2014","unstructured":"Wilhelm M, Schlegl J, Hahne H, Gholami AM, Lieberenz M, Savitski MM, et al. Mass-spectrometry-based draft of the human proteome. Nature. 2014;509:582\u20137. https:\/\/doi.org\/10.1038\/nature13319.","journal-title":"Nature"},{"key":"4651_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.1164801","volume":"322","author":"LJ Jensen","year":"2008","unstructured":"Jensen LJ, Bork P. Biochemistry: not comparable, but complementary. Science. 2008;322:56\u20137. https:\/\/doi.org\/10.1126\/science.1164801.","journal-title":"Science"},{"key":"4651_CR65","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.012187","author":"S Khadka","year":"2011","unstructured":"Khadka S, Vangeloff AD, Zhang C, Siddavatam P, Heaton NS, Wang L, et al. A physical interaction network of dengue virus and human proteins. Mol Cell Proteom. 2011. https:\/\/doi.org\/10.1074\/mcp.M111.012187.","journal-title":"Mol Cell Proteom"},{"issue":"7","key":"4651_CR66","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.cell.2018.11.028","volume":"175","author":"PS Shah","year":"2018","unstructured":"Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, et al. Comparative flavivirus-host protein interaction mapping reveals mechanisms of dengue and Zika virus pathogenesis. Cell. 2018;175(7):1931\u201345.","journal-title":"Cell"},{"key":"4651_CR67","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/J.CELREP.2018.01.038","volume":"22","author":"ML Hafirassou","year":"2018","unstructured":"Hafirassou ML, Meertens L, Uma\u00f1a-Diaz C, Labeau A, Dejarnac O, Bonnet-Madin L, et al. A global interactome map of the dengue virus NS1 identifies virus restriction and dependency host factors. Cell Rep. 2018;22:1364. https:\/\/doi.org\/10.1016\/J.CELREP.2018.01.038.","journal-title":"Cell Rep"},{"key":"4651_CR68","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1038\/ni.1664","volume":"9","author":"S Deddouche","year":"2008","unstructured":"Deddouche S, Matt N, Budd A, Mueller S, Kemp C, Galiana-Arnoux D, et al. The DExD\/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nat Immunol. 2008;9:1425\u201332. https:\/\/doi.org\/10.1038\/ni.1664.","journal-title":"Nat Immunol"},{"key":"4651_CR69","doi-asserted-by":"publisher","first-page":"18915","DOI":"10.1073\/pnas.1205231109","volume":"109","author":"PN Paradkar","year":"2012","unstructured":"Paradkar PN, Trinidad L, Voysey R, Duchemin JB, Walker PJ. Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway. Proc Natl Acad Sci USA. 2012;109:18915\u201320.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4651_CR70","doi-asserted-by":"publisher","first-page":"e2823","DOI":"10.1371\/journal.pntd.0002823","volume":"8","author":"PN Paradkar","year":"2014","unstructured":"Paradkar PN, Duchemin J-B, Voysey R, Walker PJ. Dicer-2-dependent activation of Culex Vago occurs via the TRAF-Rel2 signaling pathway. PLoS Negl Trop Dis. 2014;8:e2823. https:\/\/doi.org\/10.1371\/journal.pntd.0002823.","journal-title":"PLoS Negl Trop Dis"},{"key":"4651_CR71","doi-asserted-by":"publisher","first-page":"17841","DOI":"10.1073\/pnas.0905006106","volume":"106","author":"JA Souza-Neto","year":"2009","unstructured":"Souza-Neto JA, Sim S, Dimopoulos G. An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense. Proc Natl Acad Sci USA. 2009;106:17841\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4651_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02050","author":"YI Angler\u00f3-Rodr\u00edguez","year":"2017","unstructured":"Angler\u00f3-Rodr\u00edguez YI, MacLeod HJ, Kang S, Carlson JS, Jupatanakul N, Dimopoulos G. Aedes aegypti molecular responses to Zika Virus: modulation of infection by the toll and Jak\/Stat immune pathways and virus host factors. Front Microbiol. 2017. https:\/\/doi.org\/10.3389\/fmicb.2017.02050.","journal-title":"Front Microbiol"},{"key":"4651_CR73","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nrc1209","volume":"3","author":"R Eferl","year":"2003","unstructured":"Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer. 2003;3:859\u201368. https:\/\/doi.org\/10.1038\/nrc1209.","journal-title":"Nat Rev Cancer"},{"key":"4651_CR74","doi-asserted-by":"publisher","first-page":"4757","DOI":"10.1038\/onc.2008.120","volume":"27","author":"JM Hernandez","year":"2008","unstructured":"Hernandez JM, Floyd DH, Weilbaecher KN, Green PL, Boris-Lawrie K. Multiple facets of junD gene expression are atypical among AP-1 family members. Oncogene. 2008;27:4757\u201367. https:\/\/doi.org\/10.1038\/onc.2008.120.","journal-title":"Oncogene"},{"key":"4651_CR75","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0014-5793(04)00225-X","volume":"562","author":"S Th\u00e9bault","year":"2004","unstructured":"Th\u00e9bault S, Basbous J, Hivin P, Devaux C, Mesnard JM. HBZ interacts with JunD and stimulates its transcriptional activity. FEBS Lett. 2004;562:165\u201370. https:\/\/doi.org\/10.1016\/S0014-5793(04)00225-X.","journal-title":"FEBS Lett"},{"key":"4651_CR76","doi-asserted-by":"publisher","first-page":"8956","DOI":"10.1128\/jvi.01094-14","volume":"88","author":"E Larocque","year":"2014","unstructured":"Larocque E, Andre-Arpin C, Borowiak M, Lemay G, Switzer WM, Duc Dodon M, et al. Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motif. J Virol. 2014;88:8956\u201370. https:\/\/doi.org\/10.1128\/jvi.01094-14.","journal-title":"J Virol"},{"key":"4651_CR77","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-4-92","author":"AS Kuhlmann","year":"2007","unstructured":"Kuhlmann AS, Villaudy J, Gazzolo L, Castellazzi M, Mesnard JM, Dodon MD. HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology. 2007. https:\/\/doi.org\/10.1186\/1742-4690-4-92.","journal-title":"Retrovirology"},{"key":"4651_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers12061586","volume":"12","author":"S Jantrapirom","year":"2020","unstructured":"Jantrapirom S, Piccolo LL, Pruksakorn D, Potikanond S, Nimlamool W. Ubiquilin networking in cancers. Cancers. 2020;12:1\u201317. https:\/\/doi.org\/10.3390\/cancers12061586.","journal-title":"Cancers"},{"key":"4651_CR79","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1128\/jvi.77.7.4149-4159.2003","volume":"77","author":"L Gao","year":"2003","unstructured":"Gao L, Tu H, Shi ST, Lee K-J, Asanaka M, Hwang SB, et al. Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. J Virol. 2003;77:4149\u201359. https:\/\/doi.org\/10.1128\/jvi.77.7.4149-4159.2003.","journal-title":"J Virol"},{"key":"4651_CR80","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/s41564-019-0375-z","volume":"4","author":"M Li","year":"2019","unstructured":"Li M, Johnson JR, Truong B, Kim G, Weinbren N, Dittmar M, et al. Identification of antiviral roles for the exon\u2013junction complex and nonsense-mediated decay in flaviviral infection. Nat Microbiol. 2019;4:985\u201395. https:\/\/doi.org\/10.1038\/s41564-019-0375-z.","journal-title":"Nat Microbiol"},{"key":"4651_CR81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021153","author":"N Biswas","year":"2011","unstructured":"Biswas N, Liu S, Ronni T, Aussenberg SE, Liu W, Fujita T, et al. The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling. PLoS ONE. 2011. https:\/\/doi.org\/10.1371\/journal.pone.0021153.","journal-title":"PLoS ONE"},{"key":"4651_CR82","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1111\/j.1742-4658.2011.08254.x","volume":"278","author":"P Rapali","year":"2011","unstructured":"Rapali P, Szenes \u00c1, Radnai L, Bakos A, P\u00e1l G, Nyitray L. DYNLL\/LC8: a light chain subunit of the dynein motor complex and beyond. FEBS J. 2011;278:2980\u201396. https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08254.x.","journal-title":"FEBS J"},{"key":"4651_CR83","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1038\/emboj.2011.283","volume":"30","author":"MP Dodding","year":"2011","unstructured":"Dodding MP, Way M. Coupling viruses to dynein and kinesin-1. EMBO J. 2011;30:3527\u201339. https:\/\/doi.org\/10.1038\/emboj.2011.283.","journal-title":"EMBO J"},{"key":"4651_CR84","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.45","author":"TC Izidoro-Toledo","year":"2013","unstructured":"Izidoro-Toledo TC, Borges AC, Araujo DD, Leit\u00e3o Mazzi DPS, Junior FON, Sousa JF, et al. A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells. Cell Death Dis. 2013. https:\/\/doi.org\/10.1038\/cddis.2013.45.","journal-title":"Cell Death Dis"},{"key":"4651_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010067","author":"N Fili","year":"2020","unstructured":"Fili N, Toseland CP. Unconventional myosins: how regulation meets function. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21010067.","journal-title":"Int J Mol Sci"},{"key":"4651_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17501-z","author":"A Real-Hohn","year":"2017","unstructured":"Real-Hohn A, Provance DW, Gon\u00e7alves RB, Denani CB, de Oliveira AC, Salerno VP, et al. Impairing the function of MLCK, myosin Va or myosin Vb disrupts Rhinovirus B14 replication. Sci Rep. 2017. https:\/\/doi.org\/10.1038\/s41598-017-17501-z.","journal-title":"Sci Rep"},{"key":"4651_CR87","doi-asserted-by":"publisher","first-page":"9889","DOI":"10.1128\/jvi.00732-10","volume":"84","author":"KL Roberts","year":"2010","unstructured":"Roberts KL, Baines JD. Myosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteins. J Virol. 2010;84:9889\u201396. https:\/\/doi.org\/10.1128\/jvi.00732-10.","journal-title":"J Virol"},{"key":"4651_CR88","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01849-17","author":"AR Wilkie","year":"2018","unstructured":"Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM. A role for myosin Va in human cytomegalovirus nuclear egress. J Virol. 2018. https:\/\/doi.org\/10.1128\/jvi.01849-17.","journal-title":"J Virol"},{"key":"4651_CR89","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000230669","volume":"52","author":"XF Xu","year":"2009","unstructured":"Xu XF, Chen ZT, Gao N, Zhang JL, An J. Myosin Vc, a member of the actin motor family associated with Rab8, is involved in the release of DV2 from HepG2 cells. Intervirology. 2009;52:258\u201365. https:\/\/doi.org\/10.1159\/000230669.","journal-title":"Intervirology"},{"key":"4651_CR90","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.bbrc.2009.11.114","volume":"391","author":"H Zhang","year":"2010","unstructured":"Zhang H, Ma X, Shi T, Song Q, Zhao H, Ma D. NSA2, a novel nucleolus protein regulates cell proliferation and cell cycle. Biochem Biophys Res Commun. 2010;391:651\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2009.11.114.","journal-title":"Biochem Biophys Res Commun"},{"key":"4651_CR91","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bbrc.2018.09.041","volume":"505","author":"J Xing","year":"2018","unstructured":"Xing J, Nan X, Cui Q, Ma W, Zhao H. Nop-7-associated 2 (NSA2) is required for ribosome biogenesis and protein synthesis. Biochem Biophys Res Commun. 2018;505:249\u201354. https:\/\/doi.org\/10.1016\/j.bbrc.2018.09.041.","journal-title":"Biochem Biophys Res Commun"},{"key":"4651_CR92","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9010042","author":"S Sotcheff","year":"2020","unstructured":"Sotcheff S, Routh A. Understanding flavivirus capsid protein functions: the tip of the iceberg. Pathogens. 2020. https:\/\/doi.org\/10.3390\/pathogens9010042.","journal-title":"Pathogens"},{"key":"4651_CR93","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1348-0421.2006.tb03789.x","volume":"50","author":"Y Tsuda","year":"2006","unstructured":"Tsuda Y, Mori Y, Abe T, Yamashita T, Okamoto T, Ichimura T, et al. Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication. Microbiol Immunol. 2006;50:225\u201334. https:\/\/doi.org\/10.1111\/j.1348-0421.2006.tb03789.x.","journal-title":"Microbiol Immunol"},{"key":"4651_CR94","doi-asserted-by":"publisher","first-page":"13094","DOI":"10.1128\/jvi.00704-13","volume":"87","author":"CA Balinsky","year":"2013","unstructured":"Balinsky CA, Schmeisser H, Ganesan S, Singh K, Pierson TC, Zoon KC. Nucleolin Interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles. J Virol. 2013;87:13094\u2013106. https:\/\/doi.org\/10.1128\/jvi.00704-13.","journal-title":"J Virol"},{"key":"4651_CR95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006498","author":"ML Taracena","year":"2018","unstructured":"Taracena ML, Bottino-Rojas V, Talyuli OAC, Walter-Nuno AB, Oliveira JHM, Angler\u00f3-Rodriguez YI, et al. Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus. PLoS Negl Trop Dis. 2018. https:\/\/doi.org\/10.1371\/journal.pntd.0006498.","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"4651_CR96","doi-asserted-by":"publisher","first-page":"101414","DOI":"10.1016\/j.ttbdis.2020.101414","volume":"11","author":"M Li\u010dkov\u00e1","year":"2020","unstructured":"Li\u010dkov\u00e1 M, Fuma\u010dov\u00e1 Havl\u00edkov\u00e1 S, Sl\u00e1vikov\u00e1 M, Slov\u00e1k M, Drexler JF, Klempa B. Dermacentor reticulatus is a vector of tick-borne encephalitis virus. Ticks Tick Borne Dis. 2020;11(4):101414.","journal-title":"Ticks Tick Borne Dis"},{"key":"4651_CR97","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ttbdis.2017.07.008","volume":"8","author":"OA Belova","year":"2017","unstructured":"Belova OA, Litov AG, Kholodilov IS, Kozlovskaya LI, Bell-Sakyi L, Romanova LI, et al. Properties of the tick-borne encephalitis virus population during persistent infection of ixodid ticks and tick cell lines. Ticks Tick Borne Dis. 2017;8:895\u2013906. https:\/\/doi.org\/10.1016\/j.ttbdis.2017.07.008.","journal-title":"Ticks Tick Borne Dis"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04651-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-021-04651-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04651-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T08:04:33Z","timestamp":1635753873000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-021-04651-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,6]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4651"],"URL":"https:\/\/doi.org\/10.1186\/s13071-021-04651-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-127284\/v1","asserted-by":"object"}]},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,6]]},"assertion":[{"value":"11 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"144"}}