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Co-infection with <jats:italic>Plasmodium<\/jats:italic> malaria (leading to cerebral malaria) and hepatitis E virus (HEV) is a rare phenomenon.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 33-year-old African American male with no past medical history developed altered mental status on his return from Ivory Coast. His blood tests were significant for renal and liver failure and a high <jats:italic>Plasmodium<\/jats:italic> parasite burden of 33% on the blood smear. Interestingly, he also had a positive result for hepatitis E IgM. The patient was effectively treated with aggressive hydration and intravenous (IV) artesunate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our report is the first to our knowledge in the cerebral malaria literature on a patient with hepatitis E co-infection. This exciting case emphasizes the importance of considering all kinds of endemic infectious diseases when evaluating sick returning travelers presenting to the emergency department.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13071-021-04723-4","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T10:03:50Z","timestamp":1618913030000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Co-infection of hepatitis E virus and Plasmodium falciparum malaria: A genuine risk in sub-Saharan Africa"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3329","authenticated-orcid":false,"given":"Syeda","family":"Sahra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Jahangir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qasim Zafar","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neville","family":"Mobarakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Jahangir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"4723_CR1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1203\/PDR.0b013e3181eee738","volume":"68","author":"R Idro","year":"2010","unstructured":"Idro R, Marsh K, John CC, Newton CR. 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No experimental intervention was performed, and it did not require any specification of guidelines, legislations, or permissions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient was contacted during the hospital stay and after discharge. Consent was obtained for the use of patient data, images, CSF studies, and blood work for the publication of the case for purely educational and research purposes, to which the patient and family agreed. No identifying information usage was explained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No competing financial or personal interests are involved for all the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"215"}}