{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:12:22Z","timestamp":1785510742834,"version":"3.56.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072890"],"award-info":[{"award-number":["32072890"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Open Funds of the State Key Laboratory of Veterinary Aetiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","award":["SKLVEB2020KFKT015"],"award-info":[{"award-number":["SKLVEB2020KFKT015"]}]},{"name":"National Key Research and Development Program of China","award":["2017YFD0501305"],"award-info":[{"award-number":["2017YFD0501305"]}]},{"name":"The Innovation Support Plan of Shaanxi Province","award":["2021TD-31"],"award-info":[{"award-number":["2021TD-31"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Cryptosporidium<\/jats:italic> is an important zoonotic pathogen responsible for severe enteric diseases in humans and animals. However, the molecular mechanisms underlying host and <jats:italic>Cryptosporidium<\/jats:italic> interactions are still not clear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>To study the roles of circRNAs in host cells during <jats:italic>Cryptosporidium<\/jats:italic> infection, the expression profiles of circRNAs in HCT-8 cells infected with <jats:italic>C. parvum<\/jats:italic> were investigated using a microarray assay, and the regulatory role of a significantly upregulated circRNA, ciRS-7, was investigated during <jats:italic>C. parvum<\/jats:italic> infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>C. parvum<\/jats:italic> infection caused notable alterations in the expression profiles of circRNAs in HCT-8 cells, and a total of 178 (including 128 up- and 50 downregulated) circRNAs were significantly differentially expressed following <jats:italic>C. parvum<\/jats:italic> infection. Among them, ciRS-7 was significantly upregulated and regulated the NF-\u03baB signaling pathway by sponging miR-1270 during <jats:italic>C. parvum<\/jats:italic> infection. Furthermore, the ciRS-7\/miR-1270\/<jats:italic>relA<\/jats:italic> axis markedly affected the propagation of <jats:italic>C. parvum<\/jats:italic> in HCT-8 cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results revealed that ciRS-7 would promote <jats:italic>C. parvum<\/jats:italic> propagation by regulating the miR-1270\/<jats:italic>relA<\/jats:italic> axis and affecting the NF-\u03baB pathway. To the best of our knowledge, this is the first study to investigate the role of circRNA during <jats:italic>Cryptosporidium<\/jats:italic> infection, and the findings provide a novel view for implementing control strategies against <jats:italic>Cryptosporidium<\/jats:italic> infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-021-04739-w","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T10:03:39Z","timestamp":1620295419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-\u03baB signaling pathway"],"prefix":"10.1186","volume":"14","author":[{"given":"Yan-Ling","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Mei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ke","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-6332","authenticated-orcid":false,"given":"Guang-Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"4739_CR1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","volume":"390","author":"GBD","year":"2017","unstructured":"GBD. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1151\u2013210.","journal-title":"Lancet"},{"key":"4739_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpara.2017.09.004","volume":"48","author":"U Ryan","year":"2018","unstructured":"Ryan U, Hijjawi N, Xiao L. Foodborne cryptosporidiosis. Int J Parasitol. 2018;48:1\u201312.","journal-title":"Int J Parasitol"},{"key":"4739_CR3","doi-asserted-by":"publisher","first-page":"e758","DOI":"10.1016\/S2214-109X(18)30283-3","volume":"6","author":"IA Khalil","year":"2018","unstructured":"Khalil IA, Troeger C, Rao PC, Blacker BF, Brown A, Brewer TG, et al. Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study. Lancet Glob Health. 2018;6:e758\u201368.","journal-title":"Lancet Glob Health"},{"key":"4739_CR4","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.rvsc.2020.08.002","volume":"132","author":"A Zahedi","year":"2020","unstructured":"Zahedi A, Ryan U. Cryptosporidium\u2014an update with an emphasis on foodborne and waterborne transmission. Res Vet Sci. 2020;132:500\u201312.","journal-title":"Res Vet Sci"},{"key":"4739_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.watres.2017.01.036","volume":"114","author":"A Efstratiou","year":"2017","unstructured":"Efstratiou A, Ongerth JE, Karanis P. Waterborne transmission of protozoan parasites: review of worldwide outbreaks\u2014an update 2011\u20132016. Water Res. 2017;114:14\u201322.","journal-title":"Water Res"},{"key":"4739_CR6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.fawpar.2017.09.002","volume":"8\u20139","author":"L Xiao","year":"2017","unstructured":"Xiao L, Feng Y. Molecular epidemiologic tools for waterborne pathogens Cryptosporidium spp. and Giardia duodenalis. Food Waterborne Parasitol. 2017;8\u20139:14\u201332.","journal-title":"Food Waterborne Parasitol."},{"key":"4739_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","volume":"15","author":"W Checkley","year":"2015","unstructured":"Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for Cryptosporidium. Lancet Infect Dis. 2015;15:85\u201394.","journal-title":"Lancet Infect Dis"},{"key":"4739_CR8","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.mib.2020.09.012","volume":"58","author":"RMB Relat","year":"2020","unstructured":"Relat RMB, O\u2019Connor RM. Cryptosporidium: host and parasite transcriptome in infection. Curr Opin Microbiol. 2020;58:138\u201345.","journal-title":"Curr Opin Microbiol"},{"key":"4739_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1479-7364-5-2-90","volume":"5","author":"MW Wright","year":"2011","unstructured":"Wright MW, Bruford EA. Naming \u201cjunk\u201d: human non-protein coding RNA (ncRNA) gene nomenclature. Hum Genomics. 2011;5:90\u20138.","journal-title":"Hum Genomics"},{"key":"4739_CR10","doi-asserted-by":"publisher","first-page":"E3264","DOI":"10.3390\/cancers12113264","volume":"12","author":"H Tabatabaeian","year":"2020","unstructured":"Tabatabaeian H, Peiling Yang S, Tay Y. Non-coding RNAs: uncharted mediators of thyroid cancer pathogenesis. Cancers (Basel). 2020;12:E3264.","journal-title":"Cancers (Basel)."},{"key":"4739_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrm.2015.32","volume":"17","author":"LL Chen","year":"2016","unstructured":"Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 2016;17:205\u201311.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4739_CR12","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12958-020-00653-5","volume":"18","author":"Y Ma","year":"2020","unstructured":"Ma Y, Xu Y, Zhang J, Zheng L. Biogenesis and functions of circular RNAs and their role in diseases of the female reproductive system. Reprod Biol Endocrinol. 2020;18:104.","journal-title":"Reprod Biol Endocrinol"},{"key":"4739_CR13","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1007\/s00284-018-1576-z","volume":"75","author":"R Guo","year":"2018","unstructured":"Guo R, Chen D, Chen H, Xiong C, Zheng Y, Hou C, et al. Genome-wide identification of circular RNAs in fungal parasite nosema ceranae. Curr Microbiol. 2018;75:1655\u201360.","journal-title":"Curr Microbiol"},{"key":"4739_CR14","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1186\/s12864-018-5128-5","volume":"19","author":"X Ma","year":"2018","unstructured":"Ma X, Zhao X, Zhang Z, Guo J, Guan L, Li J, et al. Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-\u03baB pathway in porcine intestinal epithelial cell line. BMC Genomics. 2018;19:747.","journal-title":"BMC Genomics"},{"key":"4739_CR15","doi-asserted-by":"publisher","first-page":"4076","DOI":"10.1111\/jcmm.13684","volume":"22","author":"Z Yi","year":"2018","unstructured":"Yi Z, Gao K, Li R, Fu Y. Dysregulated circRNAs in plasma from active tuberculosis patients. J Cell Mol Med. 2018;22:4076\u201384.","journal-title":"J Cell Mol Med"},{"key":"4739_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.virol.2018.11.014","volume":"527","author":"J Chen","year":"2019","unstructured":"Chen J, Wang H, Jin L, Wang L, Huang X, Chen W, et al. Profile analysis of circRNAs induced by porcine endemic diarrhoea virus infection in porcine intestinal epithelial cells. Virology. 2019;527:169\u201379.","journal-title":"Virology"},{"key":"4739_CR17","doi-asserted-by":"publisher","first-page":"ftz062","DOI":"10.1093\/femspd\/ftz062","volume":"77","author":"Y Liu","year":"2019","unstructured":"Liu Y, Hu C, Sun Y, Wu H, Chen X, Liu Q. Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis. Pathog Dis. 2019;77:ftz062.","journal-title":"Pathog Dis."},{"key":"4739_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13071-020-04047-9","volume":"13","author":"XC Fan","year":"2020","unstructured":"Fan XC, Liu TL, Wang Y, Wu XM, Wang YX, Lai P, et al. Genome-wide analysis of differentially expressed profiles of mRNAs, lncRNAs and circRNAs in chickens during Eimeria necatrix infection. Parasit Vectors. 2020;13:167.","journal-title":"Parasit Vectors"},{"key":"4739_CR19","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s12864-018-4754-2","volume":"19","author":"GJ Ren","year":"2018","unstructured":"Ren GJ, Fan XC, Liu TL, Wang SS, Zhao GH. Genome-wide analysis of differentially expressed profiles of mRNAs, lncRNAs and circRNAs during Cryptosporidium baileyi infection. BMC Genomics. 2018;19:356.","journal-title":"BMC Genomics"},{"key":"4739_CR20","doi-asserted-by":"publisher","first-page":"4208","DOI":"10.1038\/srep04208","volume":"4","author":"R Wang","year":"2014","unstructured":"Wang R, Zhang L, Ax\u00e9n C, Bjorkman C, Jian F, Amer S, et al. Cryptosporidium parvum IId family: clonal population and dispersal from Western Asia to other geographical regions. Sci Rep. 2014;4:4208.","journal-title":"Sci Rep"},{"key":"4739_CR21","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.3389\/fmicb.2018.01409","volume":"9","author":"TL Liu","year":"2018","unstructured":"Liu TL, Fan XC, Li YH, Yuan YJ, Yin YL, Wang XT, et al. Expression profiles of mRNA and lncRNA in HCT-8 cells infected with Cryptosporidium parvum IId subtype. Front Microbiol. 2018;9:1409.","journal-title":"Front Microbiol"},{"key":"4739_CR22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13287-018-0976-0","volume":"9","author":"X Li","year":"2018","unstructured":"Li X, Zheng Y, Zheng Y, Huang Y, Zhang Y, Jia L, et al. Circular RNA CDR1as regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7\/GDF5\/SMAD and p38 MAPK signaling pathway. Stem Cell Res Ther. 2018;9:232.","journal-title":"Stem Cell Res Ther"},{"key":"4739_CR23","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1159\/000489208","volume":"46","author":"P Li","year":"2018","unstructured":"Li P, Yang X, Yuan W, Yang C, Zhang X, Han J, et al. CircRNA-Cdr1as exerts anti-oncogenic functions in bladder cancer by sponging microRNA-135a. Cell Physiol Biochem. 2018;46:1606\u201316.","journal-title":"Cell Physiol Biochem"},{"key":"4739_CR24","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.2147\/OTT.S207938","volume":"12","author":"H Chen","year":"2019","unstructured":"Chen H, Mao M, Jiang J, Zhu D, Li P. Circular RNA CDR1as acts as a sponge of miR-135b-5p to suppress ovarian cancer progression. Onco Targets Ther. 2019;12:3869\u201379.","journal-title":"Onco Targets Ther"},{"key":"4739_CR25","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","volume":"42","author":"JH Li","year":"2014","unstructured":"Li JH, Liu S, Zhou H, Qu LH, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014;42:D92\u20137.","journal-title":"Nucleic Acids Res."},{"key":"4739_CR26","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504.","journal-title":"Genome Res"},{"key":"4739_CR27","first-page":"8182","volume":"11","author":"Y Su","year":"2019","unstructured":"Su Y, Lv X, Yin W, Zhou L, Hu Y, Zhou A, et al. CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. Aging (Albany NY). 2019;11:8182\u2013203.","journal-title":"Aging (Albany NY)"},{"key":"4739_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.omtn.2019.07.012","volume":"18","author":"Z Zhao","year":"2019","unstructured":"Zhao Z, Ji M, Wang Q, He N, Li Y. Circular RNA Cdr1as upregulates SCAI to suppress cisplatin resistance in ovarian cancer via miR-1270 suppression. Mol Ther Nucleic Acids. 2019;18:24\u201333.","journal-title":"Mol Ther Nucleic Acids"},{"key":"4739_CR29","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/1878-0261.12523","volume":"13","author":"W Yuan","year":"2019","unstructured":"Yuan W, Zhou R, Wang J, Han J, Yang X, Yu H, et al. Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR-1270 inhibition. Mol Oncol. 2019;13:1559\u201376.","journal-title":"Mol Oncol"},{"key":"4739_CR30","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","volume":"141","author":"TX Lu","year":"2018","unstructured":"Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141:1202\u20137.","journal-title":"J Allergy Clin Immunol"},{"key":"4739_CR31","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1053\/gast.2001.24850","volume":"120","author":"XM Chen","year":"2001","unstructured":"Chen XM, Levine SA, Splinter PL, Tietz PS, Ganong AL, Jobin C, et al. Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis. Gastroenterology. 2001;120:1774\u201383.","journal-title":"Gastroenterology"},{"key":"4739_CR32","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.7150\/ijms.35149","volume":"16","author":"M Cao","year":"2019","unstructured":"Cao M, Zhang L, Wang JH, Zeng H, Peng Y, Zou J, et al. Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice. Int J Med Sci. 2019;16:1356\u201365.","journal-title":"Int J Med Sci"},{"key":"4739_CR33","doi-asserted-by":"publisher","first-page":"3630","DOI":"10.4049\/jimmunol.1800566","volume":"201","author":"M Li","year":"2018","unstructured":"Li M, Gong AY, Zhang XT, Wang Y, Mathy NW, Martins GA, et al. Induction of a long noncoding RNA transcript, NR_045064, promotes defense gene transcription and facilitates intestinal epithelial cell responses against Cryptosporidium infection. J Immunol. 2018;201:3630\u20134.","journal-title":"J Immunol"},{"key":"4739_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40364-020-00204-5","volume":"8","author":"Z Li","year":"2020","unstructured":"Li Z, Cheng Y, Wu F, Wu L, Cao H, Wang Q, et al. The emerging landscape of circular RNAs in immunity: breakthroughs and challenges. Biomark Res. 2020;8:25.","journal-title":"Biomark Res"},{"key":"4739_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.coi.2020.10.010","volume":"68","author":"I Li","year":"2020","unstructured":"Li I, Chen YG. Emerging roles of circular RNAs in innate immunity. Curr Opin Immunol. 2020;68:107\u201315.","journal-title":"Curr Opin Immunol"},{"key":"4739_CR36","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3389\/fimmu.2020.00545","volume":"11","author":"R Xie","year":"2020","unstructured":"Xie R, Zhang Y, Zhang J, Li J, Zhou X. The role of circular RNAs in immune-related diseases. Front Immunol. 2020;11:545.","journal-title":"Front Immunol"},{"key":"4739_CR37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12864-020-6464-9","volume":"21","author":"CX Zhou","year":"2020","unstructured":"Zhou CX, Ai K, Huang CQ, Guo JJ, Cong H, He SY, et al. miRNA and circRNA expression patterns in mouse brain during toxoplasmosis development. BMC Genomics. 2020;21:46.","journal-title":"BMC Genomics"},{"key":"4739_CR38","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/jcp.29950","volume":"236","author":"H Azari","year":"2021","unstructured":"Azari H, Mousavi P, Karimi E, Sadri F, Zarei M, Rafat M, et al. The expanding role of CDR1-AS in the regulation and development of cancer and human diseases. J Cell Physiol. 2021;236:771\u201390.","journal-title":"J Cell Physiol"},{"key":"4739_CR39","doi-asserted-by":"publisher","first-page":"9507","DOI":"10.1111\/jcmm.15619","volume":"24","author":"Y Zou","year":"2020","unstructured":"Zou Y, Zheng S, Deng X, Yang A, Kong Y, Kohansal M, et al. Diagnostic and prognostic value of circular RNA CDR1as\/ciRS-7 for solid tumours: a systematic review and meta-analysis. J Cell Mol Med. 2020;24:9507\u201317.","journal-title":"J Cell Mol Med"},{"key":"4739_CR40","doi-asserted-by":"publisher","first-page":"7224","DOI":"10.1007\/s12035-016-0213-8","volume":"54","author":"L Kumar","year":"2017","unstructured":"Kumar L, Haque R, Baghel T, Nazir A. Circular RNAs: the emerging class of non-coding RNAs and their potential role in human neurodegenerative diseases. Mol Neurobiol. 2017;54:7224\u201334.","journal-title":"Mol Neurobiol."},{"key":"4739_CR41","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/978-981-13-1426-1_19","volume":"1087","author":"R Akhter","year":"2018","unstructured":"Akhter R. Circular RNA and Alzheimer\u2019s disease. Adv Exp Med Biol. 2018;1087:239\u201343.","journal-title":"Adv Exp Med Biol"},{"key":"4739_CR42","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"TB Hansen","year":"2013","unstructured":"Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495:384\u20138.","journal-title":"Nature"},{"key":"4739_CR43","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.ijpara.2017.08.001","volume":"47","author":"F Laurent","year":"2017","unstructured":"Laurent F, Lacroix-Lamand\u00e9 S. Innate immune responses play a key role in controlling infection of the intestinal epithelium by Cryptosporidium. Int J Parasitol. 2017;47:711\u201321.","journal-title":"Int J Parasitol"},{"key":"4739_CR44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/pim.12020","volume":"35","author":"V McDonald","year":"2013","unstructured":"McDonald V, Korbel DS, Barakat FM, Choudhry N, Petry F. Innate immune responses against Cryptosporidium parvum infection. Parasite Immunol. 2013;35:55\u201364.","journal-title":"Parasite Immunol"},{"key":"4739_CR45","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1017\/S0031182014000614","volume":"141","author":"R Zhou","year":"2014","unstructured":"Zhou R, Feng Y, Chen XM. Non-coding RNAs in epithelial immunity to Cryptosporidium infection. Parasitology. 2014;141:1233\u201343.","journal-title":"Parasitology"},{"key":"4739_CR46","doi-asserted-by":"publisher","first-page":"7447","DOI":"10.4049\/jimmunol.175.11.7447","volume":"175","author":"XM Chen","year":"2005","unstructured":"Chen XM, O\u2019Hara SP, Nelson JB, Splinter PL, Small AJ, Tietz PS, et al. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J Immunol. 2005;175:7447\u201356.","journal-title":"J Immunol"},{"key":"4739_CR47","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.exppara.2010.05.022","volume":"126","author":"F Petry","year":"2010","unstructured":"Petry F, Jakobi V, Tessema TS. Host immune response to Cryptosporidium parvum infection. Exp Parasitol. 2010;126:304\u20139.","journal-title":"Exp Parasitol"},{"issue":"1710\u20133","key":"4739_CR48","first-page":"49","volume":"68","author":"DF McCole","year":"2000","unstructured":"McCole DF, Eckmann L, Laurent F, Kagnoff MF. Intestinal epithelial cell apoptosis following Cryptosporidium parvum infection. Infect Immun. 2000;68(1710\u20133):49.","journal-title":"Infect Immun"},{"key":"4739_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.intimp.2019.03.037","volume":"71","author":"X Zhou","year":"2019","unstructured":"Zhou X, Jiang L, Fan G, Yang H, Wu L, Huang Y, et al. Role of the ciRS-7\/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1\u03b2. Int Immunopharmacol. 2019;71:233\u201340.","journal-title":"Int Immunopharmacol"},{"key":"4739_CR50","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1128\/IAI.00955-08","volume":"77","author":"J Liu","year":"2009","unstructured":"Liu J, Deng M, Lancto CA, Abrahamsen MS, Rutherford MS, Enomoto S. Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells. Infect Immun. 2009;77:837\u201349.","journal-title":"Infect Immun"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04739-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-021-04739-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04739-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T11:15:44Z","timestamp":1675250144000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-021-04739-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,6]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["4739"],"URL":"https:\/\/doi.org\/10.1186\/s13071-021-04739-w","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,6]]},"assertion":[{"value":"24 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures in the present research were conducted strictly in accordance with the Guide for the Care and Use of Laboratory Animals of the Ministry of Health, China, and all experimental procedures were reviewed and approved by the Research Ethics Committee of Northwest A&F University, Yangling, China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"238"}}