{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:21:01Z","timestamp":1793143261729,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>A randomised, blinded, positive controlled, multicentre, Good Clinical Practice-compliant, pivotal field study was conducted to evaluate the effectiveness and safety of a new combination of lotilaner + milbemycin oxime tablets (Credelio<jats:sup>\u00ae<\/jats:sup> Plus; Elanco Animal Health) administered orally to client-owned dogs naturally infected with intestinal nematodes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Client-owned dogs presenting to veterinary clinics from households in France, Hungary and Germany were screened for intestinal nematodes. Dogs with an initial positive faecal egg count that was subsequently confirmed with a follow-up faecal examination to demonstrate the presence of naturally occurring mixed or mono-infections with <jats:italic>Toxocara canis<\/jats:italic>,<jats:italic> Toxascaris leonina<\/jats:italic>,<jats:italic> Trichuris vulpis<\/jats:italic> or <jats:italic>Ancylostoma caninum<\/jats:italic> were enrolled on Day 0 into the study. Households were randomised in an approximately 2:1 ratio to receive either an investigational product (IP; Credelio Plus tablets) or control product (CP; Nexgard Spectra<jats:sup>\u00ae<\/jats:sup> tablets) as treatment. Dogs were administered the IP (<jats:italic>n<\/jats:italic>\u2009=\u2009278) or CP (<jats:italic>n<\/jats:italic>\u2009=\u2009117) once on Day 0 at a dose rate of 0.75\u20131.56\u00a0mg\/kg bodyweight milbemycin oxime and 20.0\u201341.5\u00a0mg\/kg bodyweight lotilaner (IP) or as recommended (CP). Effectiveness of the IP and CP treatments was based on the post-treatment reduction in geometric mean faecal egg counts on Day 8 (range Day 7\u201310) after treatment as compared to their pre-treatment nematode faecal egg counts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Geometric mean (GM) faecal egg counts for <jats:italic>T. canis<\/jats:italic>, <jats:italic>A caninum<\/jats:italic> and <jats:italic>T. vulpis<\/jats:italic> were reduced by \u2265 97.2% in the Credelio Plus group and\u2009  by \u2265\u200995.3% in the afoxolaner\u2009+\u2009milbemycin oxime group. There were insufficient data to calculate a percentage reduction in GM faecal egg counts between Day 0 and Day 8 for <jats:italic>T. leonina<\/jats:italic> due to low prevalence. Credelio Plus was well tolerated in this field study. Of the 355 total doses administered, 82.3% were accepted free choice in the IP group compared to 80.8% in the CP group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study demonstrated effectiveness (\u2265\u200997.2% reduction), safety and tablet acceptance of a combination of milbemycin oxime and lotilaner (Credelio Plus) administered orally to dogs with natural intestinal infections of <jats:italic>T. canis, A. caninum and T. vulpis.<\/jats:italic><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-021-04766-7","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T08:02:40Z","timestamp":1621238560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio\u00ae Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe"],"prefix":"10.1186","volume":"14","author":[{"given":"Brad","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Wiseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-6297","authenticated-orcid":false,"given":"Daniel E.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"4766_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.vetpar.2006.11.013","volume":"145","author":"E Grandemange","year":"2007","unstructured":"Grandemange E, Claerebout E, Genchi C, Franc M. Field evaluation of the efficacy and the safety of a combination of oxantel\/pyrantel\/praziquantel in the treatment of naturally acquired gastrointestinal nematode and\/or cestode infestations in dogs in Europe. Vet Parasitol. 2007;145:94.","journal-title":"Vet Parasitol"},{"key":"4766_CR2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1186\/s13071-019-3701-7","volume":"12","author":"J Drake","year":"2019","unstructured":"Drake J, Carey T. Prevalence of common canine gastrointestinal nematodes in the USA. Parasites Vectors. 2019;12:430.","journal-title":"Parasites Vectors"},{"key":"4766_CR3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.vetpar.2013.11.005","volume":"200","author":"D Neves","year":"2014","unstructured":"Neves D, Lobo L, Brilhante Simoes P, Cardoso L. Frequency of intestinal parasites in pet dogs from an urban area (Greater Oporto, northern Portugal). Vet Parasitol. 2014;200:295.","journal-title":"Vet Parasitol"},{"key":"4766_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.vetpar.2012.11.026","volume":"193","author":"F Riggio","year":"2013","unstructured":"Riggio F, Mannella R, Ariti G, Perrucci S. Intestinal and lung parasites in owned dogs and cats from central Italy. Vet Parasitol. 2013;193:78.","journal-title":"Vet Parasitol"},{"key":"4766_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.pt.2010.01.005","volume":"26","author":"DD Bowman","year":"2010","unstructured":"Bowman DD, Montgomery SP, Zajac AM, Eberhard ML, Kazacos KR. Hookworms of dogs and cats as agents of cutaneous larva migrans. Trends Parasitol. 2010;26:162.","journal-title":"Trends Parasitol"},{"key":"4766_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.vetpar.2010.10.027","volume":"175","author":"T Schnieder","year":"2011","unstructured":"Schnieder T, Laabs EM, Welz C. Larval development of Toxocara canis in dogs. Vet Parasitol. 2011;175:193.","journal-title":"Vet Parasitol"},{"key":"4766_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.pt.2010.01.002","volume":"26","author":"AC Lee","year":"2010","unstructured":"Lee AC, Schantz PM, Kazacos K, Montgomery SP, Bowman DD. Epidemiologic and zoonotic aspects of ascarid infections in dogs and cats. Trends Parasitol. 2010;26:155.","journal-title":"Trends Parasitol"},{"key":"4766_CR8","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.vetpar.2012.12.035","volume":"193","author":"PAM Overgaauw","year":"2013","unstructured":"Overgaauw PAM, van Knapen F. Veterinary and public health aspects of Toxocara spp. Vet Parasitol. 2013;193:398.","journal-title":"Vet Parasitol"},{"key":"4766_CR9","unstructured":"European Scientific Counsel Companion Animal Parasites (ESCCAP). Worm control 1 in dogs and cats. ESCCAP Guideline 01 Sixth Edition. 2020. https:\/\/www.esccap.org\/guidelines\/gl1\/. Accessed 08 May 2021."},{"key":"4766_CR10","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.vetpar.2011.11.012","volume":"184","author":"B Schnitzler","year":"2012","unstructured":"Schnitzler B, Hayes B, Wiseman S, Snyder DE. Confirmation of the efficacy of a combination tablet of spinosad and milbemycin oxime against naturally acquired infections of canine intestinal nematode parasites. Vet Parasitol. 2012;184:279.","journal-title":"Vet Parasitol."},{"key":"4766_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.vetpar.2014.07.023","volume":"205","author":"DD Bowman","year":"2014","unstructured":"Bowman DD, Reinemeyer CR, Wiseman S, Snyder DE. Efficacy of milbemycin oxime in combination with spinosad in the treatment of larval and immature adult stages of Ancylostoma caninum and Toxocara canis in experimentally infected dogs. Vet Parasitol. 2014;205:134.","journal-title":"Vet Parasitol"},{"key":"4766_CR12","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/s13071-017-2474-0","volume":"10","author":"D Cavalleri","year":"2017","unstructured":"Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S. Assessment of the onset of lotilaner (Credelio\u2122) speed of kill of fleas on dogs. Parasites Vectors. 2017;10:521.","journal-title":"Parasites Vectors"},{"key":"4766_CR13","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1186\/s13071-017-2467-z","volume":"10","author":"M Murphy","year":"2017","unstructured":"Murphy M, Cavalleri D, Seewald W, Drake J, Nanchen S. Laboratory evaluation of the speed of kill of lotilaner (C Credelio\u2122) against Ixodes ricinus ticks on dogs. Parasites Vectors. 2017;10:541.","journal-title":"Parasites Vectors"},{"key":"4766_CR14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1186\/s13071-017-2476-y","volume":"10","author":"M Murphy","year":"2017","unstructured":"Murphy M, Garcia R, Karadzovska D, Cavalleri D, Snyder D, Seewald W, et al. Laboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio\u2122) against four common species of ticks affecting dogs in North America. Parasites Vectors. 2017;10:523.","journal-title":"Parasites Vectors"},{"key":"4766_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1186\/s13071-017-2466-0","volume":"10","author":"D Cavalleri","year":"2017","unstructured":"Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S. Assessment of the speed of flea kill of lotilaner (Credelio\u2122) throughout the month following oral administration to dogs. Parasites Vectors. 2017;10:529.","journal-title":"Parasites Vectors"},{"key":"4766_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13071-019-3873-1","volume":"3","author":"L Young","year":"2020","unstructured":"Young L, Karadzovska D, Wiseman S, Helbig R. Effectiveness of lotilaner (Credelio\u2122) against the adult cat flea, Ctenocephalides felis and flea eggs following oral administration to dogs. Parasites Vectors. 2020;3:25.","journal-title":"Parasites Vectors"},{"key":"4766_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1186\/s13071-018-2970-x","volume":"11","author":"I Wright","year":"2018","unstructured":"Wright I. Lotilaner\u2014a novel formulation for cats provides systemic tick and flea control. Parasites Vectors. 2018;11:407.","journal-title":"Parasites Vectors"},{"key":"4766_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2477-x","author":"D Cavalleri","year":"2017","unstructured":"Cavalleri D, Murphy M, Lizundia Gorbea R, Seewald W, Drake J, Nanchen S. Laboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio\u2122) against three common species of ticks affecting dogs in Europe. Parasites Vectors. 2017. https:\/\/doi.org\/10.1186\/s13071-017-2477-x.","journal-title":"Parasites Vectors"},{"key":"4766_CR19","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1186\/s13071-017-2479-8","volume":"10","author":"D Cavalleri","year":"2017","unstructured":"Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S. A randomised, blinded, controlled field study to assess the effectiveness and safety of lotilaner tablets (Credelio\u2122) in controlling fleas in client-owned dogs in European countries. Parasites Vectors. 2017;10:526.","journal-title":"Parasites Vectors"},{"key":"4766_CR20","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1186\/s13071-017-2469-x","volume":"10","author":"D Karadzovska","year":"2017","unstructured":"Karadzovska D, Chappell K, Murphy M, Cavalleri D, Wiseman S, Drake J, et al. A randomized, controlled field study to assess the effectiveness and safety of lotilaner flavored chewable tablets (Credelio\u2122) in eliminating fleas in client-owned dogs in the USA. Parasit Vectors. 2017;10:528.","journal-title":"Parasit Vectors"},{"key":"4766_CR21","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/s13071-017-2478-9","volume":"10","author":"D Cavalleri","year":"2017","unstructured":"Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S. A randomized, controlled study to assess the effectiveness and safety of lotilaner (Credelio\u2122) in controlling ticks in client owned dogs in Europe. Parasites Vectors. 2017;10:531.","journal-title":"Parasites Vectors"},{"key":"4766_CR22","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1186\/s13071-018-3116-x","volume":"11","author":"P Lasmar","year":"2018","unstructured":"Lasmar P, Murphy M, Nanchen S, Drake J, Coumendouros K, Borges D, et al. Laboratory evaluation of the effectiveness of lotilaner (Credelio\u2122) against Amblyomma cajennense (sensu lato) infestations of dogs. Parasites Vectors. 2018;11:537.","journal-title":"Parasites Vectors"},{"key":"4766_CR23","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1186\/s13071-018-3061-8","volume":"11","author":"K Baker","year":"2018","unstructured":"Baker K, Ellenberger C, Murphy M, Cavalleri D, Seewald W, Drake J, et al. Laboratory evaluations of the 3-month effectiveness of oral lotilaner (Credelio\u2122) against experimental infestations of dogs with the Australian paralysis tick, Ixodes holocyclus. Parasites Vectors. 2018;11:487.","journal-title":"Parasites Vectors"},{"key":"4766_CR24","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s13071-018-3032-0","volume":"11","author":"H Otaki","year":"2018","unstructured":"Otaki H, Sonobe J, Murphy M, Cavalleri D, Seewald W, Drake J, et al. Laboratory evaluation of the effectiveness of lotilaner (Credelio\u2122) against Haemaphysalis longicornis infestations of dogs. Parasites Vectors. 2018;11:448.","journal-title":"Parasites Vectors"},{"key":"4766_CR25","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1186\/s13071-017-2472-2","volume":"10","author":"DE Snyder","year":"2017","unstructured":"Snyder DE, Wiseman S, Liebenberg JE. Effectiveness of lotilaner (Credelio\u2122), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites Vectors. 2017;10:532.","journal-title":"Parasites Vectors"},{"key":"4766_CR26","unstructured":"European Medicines Agency. Guideline on good clinical practice. VICH Topic GL9. European Medicines Agency. Guideline on good clinical practice. VICH Topic GL9. https:\/\/www.ema.europa.eu\/en\/vich-gl9-good-clinical-practices. Accessed 08 May 2021."},{"key":"4766_CR27","unstructured":"European Medicines Agency. VICH GL 7. The efficacy requirements for anthelmintics: overall guidelines. https:\/\/www.ema.europa.eu\/en\/vich-gl7-efficacy-anthelmintics-general-requirements. Accessed 08 May 2021."},{"key":"4766_CR28","unstructured":"European Medicines Agency. VICH GL19 Effectiveness of anthelmintic; overall guidelines: specific recommendations for canines. 2001. https:\/\/www.ema.europa.eu\/en\/vich-gl19-efficacy-anthelmintics-specific-recommendations-canines. Accessed 08 May 2021."},{"key":"4766_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0304-4017(94)90110-4","volume":"52","author":"DE Jacobs","year":"1994","unstructured":"Jacobs DE, Arakawa A, Courtney CH, Gemmell MA, McCall JW, Myers GH, et al. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of anthelmintics for dogs and cats. Vet Parasitol. 1994;52:179.","journal-title":"Vet Parasitol."},{"key":"4766_CR30","unstructured":"European Medicines Agency, Committee for Medicinal Products for Veterinary Use. Guideline on the demonstration of palatability of veterinary medicinal products. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2014\/07\/WC500170030.pdf. Accessed24 Aug 2020."},{"key":"4766_CR31","first-page":"40","volume-title":"Veterinary clinical parasitology","author":"AM Zajac","year":"2012","unstructured":"Zajac AM, Conboy GA. Veterinary clinical parasitology. Hoboken: Wiley-Blackwell; 2012. p. 40\u201387."},{"key":"4766_CR32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.vetpar.2011.07.014","volume":"182","author":"P Deplazes","year":"2011","unstructured":"Deplazes P, van Knapen F, Schweiger A, Overgaauw PA. Role of pet dogs and cats in the transmission of helminthic zoonoses in Europe, with a focus on echinococcosis and toxocarosis. Vet Parasitol. 2011;182:41.","journal-title":"Vet Parasitol"},{"key":"4766_CR33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00436-014-4218-9","volume":"114","author":"R Nijsse","year":"2015","unstructured":"Nijsse R, Ploeger HW, Wagenaar JA, Mughini-Gras L. Toxocara canis in household dogs: prevalence, risk factors and owners\u2019 attitude towards deworming. Parasitol Res. 2015;114:561.","journal-title":"Parasitol Res"},{"key":"4766_CR34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s13071-020-04147-6","volume":"13","author":"K Stafford","year":"2020","unstructured":"Stafford K, Kollasch TM, Duncan KT, Horr S, Goddu T, Heinz-Loomer C, et al. Detection of gastrointestinal parasitism at recreational canine sites in the USA: the DOGPARCS study. Parasites Vectors. 2020;13:275.","journal-title":"Parasites Vectors"},{"key":"4766_CR35","doi-asserted-by":"publisher","first-page":"6.7","DOI":"10.1186\/1756-3305-7-67","volume":"7","author":"D Traversa","year":"2014","unstructured":"Traversa D, Frangipane di Regalbono A, Di Cesare A, La Torre F, Drake J, Pietrobelli M. Environmental contamination by canine geohelminths. Parasites Vectors. 2014;7:6.7.","journal-title":"Parasites Vectors."},{"key":"4766_CR36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.vetpar.2012.03.011","volume":"88","author":"MP Manini","year":"2012","unstructured":"Manini MP, Marchioro AA, Colli CM, Nishi L, Falavigna-Guilherme AL. Association between contamination of public squares and seropositivity for Toxocara spp. in children. Vet Parasitol. 2012;88:48.","journal-title":"Vet Parasitol."},{"key":"4766_CR37","doi-asserted-by":"publisher","first-page":"552","DOI":"10.4269\/ajtmh.2008.79.552","volume":"79","author":"KY Won","year":"2008","unstructured":"Won KY, Kruszon-Moran D, Schantz PM, Jones JL. National seroprevalence and risk factors for zoonotic Toxocara spp. infection. Am J Trop Med Hyg. 2008;79:552.","journal-title":"Am J Trop Med Hyg."},{"key":"4766_CR38","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.ijpara.2013.07.004","volume":"43","author":"CNL Macpherson","year":"2013","unstructured":"Macpherson CNL. The epidemiology and public health importance of toxocariasis: a zoonosis of global importance. Int J Parasitol. 2013;43:999.","journal-title":"Int J Parasitol"},{"issue":"152","key":"4766_CR39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.vetpar.2007.11.022","volume":"2008","author":"AS Fahrion","year":"2008","unstructured":"Fahrion AS, Staebler SP, Deplazes P. Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs. Vet Parasitol. 2008;2008(152):108.","journal-title":"Vet Parasitol"},{"key":"4766_CR40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.vetpar.2014.11.011","volume":"207","author":"B Hayes","year":"2015","unstructured":"Hayes B, Schnitzler B, Wiseman S, Snyder DE. Field evaluation of the efficacy and safety of a combination of spinosad and milbemycin oxime in the treatment and prevention of naturally acquired flea infestations and treatment of intestinal nematode infections in dogs in Europe. Vet Parasitol. 2015;207:99.","journal-title":"Vet Parasitol"},{"key":"4766_CR41","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00436-016-5287-8","volume":"116","author":"S Rehbein","year":"2017","unstructured":"Rehbein S, Knaus M, Mallouk Y, Breiltgens T, Brianti E, Cap\u00e1ri B, et al. Efficacy against nematode infections and safety of afoxolaner plus milbemycin oxime chewable tablets in domestic dogs under field conditions in Europe. Parasitol Res. 2017;116:259.","journal-title":"Parasitol Res"},{"key":"4766_CR42","unstructured":"European Scientific Counsel Companion Animal Parasites (ESCCAP). Homepage ESCCAP. Accessed 08 May 2021."},{"key":"4766_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.vetpar.2006.08.004","volume":"143","author":"FJ Martinez-Moreno","year":"2007","unstructured":"Martinez-Moreno FJ, Hernandex S, Lopez-Cobos E, Becerra C, Acosta I, Martinez-Moreno A. Estimation of canine intestinal parasites in Cordoba (Spain) and their risk to public health. Vet Parasitol. 2007;143:7.","journal-title":"Vet Parasitol"},{"key":"4766_CR44","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13071-020-04086-2","volume":"13","author":"C Pennelegion","year":"2020","unstructured":"Pennelegion C, Drake J, Wiseman S, Wright I. Survey of UK pet owners quantifying internal parasite infection risk and deworming recommendation implications. Parasites Vectors. 2020;13:218.","journal-title":"Parasites Vectors"},{"key":"4766_CR45","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1186\/s13071-019-3712-4","volume":"12","author":"C Roussel","year":"2019","unstructured":"Roussel C, Drake J, Ariza JM. French national survey of dog and cat owners on the deworming behaviour and lifestyle of pets associated with the risk of endoparasites. Parasites Vectors. 2019;12:480.","journal-title":"Parasites Vectors"},{"key":"4766_CR46","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s13071-019-3410-2","volume":"12","author":"C Strube","year":"2019","unstructured":"Strube C, Neubert A, Springer A, von Samson-Himmelstjern G. Survey of German pet owners quantifying endoparasitic infection risk and implications for deworming recommendations. Parasites Vectors. 2019;12:203.","journal-title":"Parasites Vectors"},{"key":"4766_CR47","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1186\/s13071-018-3149-1","volume":"11","author":"J McNamara","year":"2018","unstructured":"McNamara J, Drake J, Wiseman S, Wright I. Survey of European pet owners quantifying endoparasitic infection risk and implications for deworming recommendations. Parasites Vectors. 2018;11:571.","journal-title":"Parasites Vectors"},{"key":"4766_CR48","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.vetpar.2014.05.003","volume":"204","author":"MC Gates","year":"2014","unstructured":"Gates MC, Nolan TJ. Declines in canine endoparasite prevalence associated with the introduction of commercial heartworm and flea preventatives from 1984 to 2007. Vet Parasitol. 2014;204:265.","journal-title":"Vet Parasitol"},{"key":"4766_CR49","unstructured":"The United States Pharmacopeial Convention, Inc. Macrocyclic lactones (Veterinary\u2014Systemic). MACROCYCLIC LACTONES Veterinary\u2014Systemic (ymaws.com). Accessed 08 May 2021."}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04766-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-021-04766-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04766-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T08:06:30Z","timestamp":1636704390000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-021-04766-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4766"],"URL":"https:\/\/doi.org\/10.1186\/s13071-021-04766-7","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,17]]},"assertion":[{"value":"3 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This clinical field study was conducted in compliance with local and national regulatory requirements in France, Germany and Hungary and is consistent with the principles of Good Clinical Practices (VICH guideline on good clinical practice [GCP; VICH GL 9]), cited VICH referenced anthelmintic guidelines as well as cited and referenced World Association for the Advancement of Veterinary Parasitology (WAAVP) anthelmintic guidelines. Participating dog owners were required to sign an informed consent form for their dog(s) to participate in the study after details of the study design and products under investigation had been explained.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"These studies were funded by Elanco Animal Health. All authors are current or former employees of Elanco Animal Health. The handling editors have been involved in consulting services (Filipe Dantas-Torres), research projects (Filipe Dantas-Torres, Adnan Hod\u017ei#) and meetings (Filipe Dantas-Torres) sponsored by different veterinary pharmaceutical companies in the past 10 years, including Elanco. They declare that each manuscript in this collection was handled impartially and peer reviewed rigorously by at least two independent external reviewers.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"258"}}