{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:03:03Z","timestamp":1764997383246},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1186\/s13071-021-04774-7","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:26:26Z","timestamp":1622161586000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Credelio\u00ae Plus: a novel oral endectocide for dogs"],"prefix":"10.1186","volume":"14","author":[{"given":"Donato","family":"Traversa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"4774_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04760-z","author":"KL Riggs","year":"2021","unstructured":"Riggs KL, Wiseman S. Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio\u00ae Plus) in juvenile and adult dogs. Parasit Vectors. 2021. https:\/\/doi.org\/10.1186\/s13071-021-04760-z.","journal-title":"Parasit Vectors"},{"key":"4774_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04762-x","author":"LM Young","year":"2021","unstructured":"Young LM, Wiseman S, Crawley E, Bowman DD, Reinemeyer CR, Snyder DE. Effectiveness of Credelio\u00ae Plus, a novel chewable tablet containing milbemycin oxime and lotilaner for the treatment of larval and immature adult stages of Toxocara canis in experimentally infected dogs. Parasit Vectors. 2021. https:\/\/doi.org\/10.1186\/s13071-021-04762-x.","journal-title":"Parasit Vectors"},{"key":"4774_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04761-y","author":"DE Snyder","year":"2021","unstructured":"Snyder DE, Wiseman S, Crawley E, Wallace K, Bowman DD, Reinemeyer CR. Effectiveness of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio\u00ae Plus) for the treatment of larval and immature adult stages of Ancylostoma caninum in experimentally infected dogs. Parasit Vectors. 2021. https:\/\/doi.org\/10.1186\/s13071-021-04761-y.","journal-title":"Parasit Vectors"},{"key":"4774_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04766-7","author":"B Hayes","year":"2021","unstructured":"Hayes B, Wiseman S, Snyder DE. Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio\u00ae Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe. Parasit Vectors. 2021. https:\/\/doi.org\/10.1186\/s13071-021-04766-7.","journal-title":"Parasit Vectors"},{"key":"4774_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04767-6","author":"LM Young","year":"2021","unstructured":"Young LM, Wiseman S, Crawley E, Wallace K, Snyder DE. Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio\u00ae Plus) for the prevention of heartworm disease (Dirofilaria immitis) in client-owned dogs in the USA. Parasit Vectors. 2021. https:\/\/doi.org\/10.1186\/s13071-021-04767-6.","journal-title":"Parasit Vectors"},{"key":"4774_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04808-0","author":"S Forster","year":"2021","unstructured":"Forster S, Wiseman S, Snyder DE.\u00a0Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio\u00ae Plus) against natural flea and tick infestations on dogs presented as veterinary patients in Europe. Parasit Vectors. 2021. https:\/\/doi.org\/10.1186\/s13071-021-04808-0.","journal-title":"Parasit Vectors"},{"key":"4774_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1756-3305-5-91","volume":"5","author":"D Traversa","year":"2012","unstructured":"Traversa D. Pet roundworms and hookworms: a continuing need for global worming. Parasit Vectors. 2012;5:91.","journal-title":"Parasit Vectors"},{"key":"4774_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1756-3305-4-32","volume":"4","author":"D Traversa","year":"2011","unstructured":"Traversa D. Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? Parasit Vectors. 2011;4:32.","journal-title":"Parasit Vectors"},{"key":"4774_CR9","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/S0195-5616(87)50005-5","volume":"17","author":"UP Kalkofen","year":"1987","unstructured":"Kalkofen UP. Hookworms of dogs and cats. Vet Clin North Am Small Anim Pract. 1987;17:1341\u201354.","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"4774_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","volume":"66","author":"JW McCall","year":"2008","unstructured":"McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L. Heartworm disease in animals and humans. Adv Parasitol. 2008;66:193\u2013285.","journal-title":"Adv Parasitol"},{"key":"4774_CR11","volume-title":"Veterinary parasitology","author":"MA Taylor","year":"2007","unstructured":"Taylor MA, Coop RL, Wall RL. Veterinary parasitology. 3rd ed. Blackwell Publishing; 2007.","edition":"3"},{"key":"4774_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1756-3305-3-2","volume":"3","author":"D Otranto","year":"2010","unstructured":"Otranto D, Dantas-Torres F. Canine and feline vector-borne diseases in Italy: current situation and perspectives. Parasit Vectors. 2010;3:2.","journal-title":"Parasit Vectors"},{"key":"4774_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pt.2012.04.004","volume":"28","author":"F Beugnet","year":"2012","unstructured":"Beugnet F, Franc M. Insecticide and acaricide molecules and\/or combinations to prevent pet infestation by ectoparasites. Trends Parasitol. 2012;28:267\u201379.","journal-title":"Trends Parasitol"},{"key":"4774_CR14","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/j.ttbdis.2018.06.013","volume":"9","author":"T Geurden","year":"2018","unstructured":"Geurden T, Becskei C, Six RH, Maeder S, Latrofa MS, Otranto D, Farkas R. Detection of tick-borne pathogens in ticks from dogs and cats in different European countries. Ticks Tick Borne Dis. 2018;9:1431\u20136.","journal-title":"Ticks Tick Borne Dis"},{"key":"4774_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1756-3305-6-59","volume":"6","author":"D Traversa","year":"2013","unstructured":"Traversa D. Fleas infesting pets in the era of emerging extra-intestinal nematodes. Parasit Vectors. 2013;6:59.","journal-title":"Parasit Vectors"},{"key":"4774_CR16","first-page":"139","volume":"5","author":"MW Dryden","year":"2004","unstructured":"Dryden MW, Payne PA. Biology and control of ticks infesting dogs and cats in North America. Vet Ther. 2004;5:139\u201354.","journal-title":"Vet Ther"},{"key":"4774_CR17","doi-asserted-by":"publisher","first-page":"593232","DOI":"10.1155\/2009\/593232","volume":"2009","author":"JS Gray","year":"2009","unstructured":"Gray JS, Dautel H, Estrada-Pe\u00f1a A, Kahl O, Lindgren E. Effects of climate change on ticks and tick-borne diseases in Europe. Interdiscip Perspect Infect Dis. 2009;2009:593232.","journal-title":"Interdiscip Perspect Infect Dis."},{"key":"4774_CR18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.cimid.2013.07.003","volume":"36","author":"F Beugnet","year":"2013","unstructured":"Beugnet F, Chalvet-Monfray K. Impact of climate change in the epidemiology of vector-borne diseases in domestic carnivores. Comp Immunol Microbiol Infect Dis. 2013;36:559\u201366.","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"4774_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-3305-6-1","volume":"6","author":"JM Medlock","year":"2013","unstructured":"Medlock JM, Hansford KM, Bormane A, Derdakova M, Estrada-Pe\u00f1a A, George JC, Golovljova I, Jaenson TGT, Jensen JK, Jensen PM, Kazimirova M, Oteo JA, Papa A, Pfister K, Plantard O, Randolph SE, Rizzoli A, Santos-Silva MM, Sprong H, Vial L, Hendrickx G, Zeller H, Van Bortel W. Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe. Parasit Vectors. 2013;6:1.","journal-title":"Parasit Vectors"},{"key":"4774_CR20","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.ttbdis.2019.05.015","volume":"10","author":"S Becker","year":"2019","unstructured":"Becker S, Webster A, Doyle RL, Martins JR, Reck J, Klafke GM. Resistance to deltamethrin, fipronil and ivermectin in the brown dog tick, Rhipicephalus sanguineus sensu stricto, Latreille (Acari: Ixodidae). Ticks Tick Borne Dis. 2019;10:1046\u201350.","journal-title":"Ticks Tick Borne Dis."},{"key":"4774_CR21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1756-3305-7-8","volume":"7","author":"TB Coles","year":"2014","unstructured":"Coles TB, Dryden MW. Insecticide\/acaricide resistance in fleas and ticks infesting dogs and cats. Parasit Vectors. 2014;7:8.","journal-title":"Parasit Vectors"},{"key":"4774_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/insects7010010","volume":"7","author":"MK Rust","year":"2016","unstructured":"Rust MK. Insecticide resistance in fleas. Insects. 2016;7:10.","journal-title":"Insects"},{"key":"4774_CR23","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1186\/s13071-017-2479-8","volume":"10","author":"D Cavalleri","year":"2017","unstructured":"Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S. A randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (CredelioTM) in controlling fleas in client-owned dogs in European countries. Parasit Vectors. 2017;10:526.","journal-title":"Parasit Vectors"},{"key":"4774_CR24","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1186\/s13071-017-2469-x","volume":"10","author":"D Karadzovska","year":"2017","unstructured":"Karadzovska D, Chappell K, Coble S, Murphy M, Cavalleri D, Wiseman S, Drake J, Nanchen S. A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (CredelioTM) in eliminating fleas in client-owned dogs in the USA. Parasit Vectors. 2017;10:528.","journal-title":"Parasit Vectors"},{"key":"4774_CR25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1046\/j.1365-3164.2000.00204.x","volume":"11","author":"DN Carlotti","year":"2000","unstructured":"Carlotti DN, Jacobs DE. Therapy, control and prevention of flea allergy dermatitis in dogs and cats. Vet Dermatol. 2000;11:83\u201398.","journal-title":"Vet Dermatol"},{"issue":"5","key":"4774_CR26","doi-asserted-by":"publisher","first-page":"e0007003","DOI":"10.1371\/journal.pntd.0007003","volume":"13","author":"A Diakou","year":"2019","unstructured":"Diakou A, Di Cesare A, Morelli S, Colombo M, Halos L, Simonato G, Tamvakis A, Beugnet F, Paoletti B, Traversa D. Endoparasites and vector-borne pathogens in dogs from Greek islands: pathogen distribution and zoonotic implications. PLoS Negl Trop Dis. 2019;13(5):e0007003.","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"4774_CR27","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s00436-012-3037-0","volume":"111","author":"J Heukelbach","year":"2012","unstructured":"Heukelbach J, Frank R, Ariza L, et al. High prevalence of intestinal infections and ectoparasites in dogs, Minas Gerais State (southeast Brazil). Parasitol Res. 2012;111(5):1913\u20132192.","journal-title":"Parasitol Res"},{"key":"4774_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cimid.2017.04.003","volume":"51","author":"D Traversa","year":"2017","unstructured":"Traversa D, Di Cesare A, Simonato G, Cassini R, Merola C, Diakou A, Halos L, Beugnet F, Frangipane di Regalbono A. Zoonotic intestinal parasites and vector-borne pathogens in italian shelter and kennel dogs. Comp Immunol Microbiol Infect Dis. 2017;51:69\u201375.","journal-title":"Comp Immunol Microbiol Infect Dis"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04774-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-021-04774-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04774-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:38:25Z","timestamp":1622162305000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-021-04774-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4774"],"URL":"https:\/\/doi.org\/10.1186\/s13071-021-04774-7","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"assertion":[{"value":"5 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Paid external independent consultant to Elanco Animal Health.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"286"}}