{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:41:35Z","timestamp":1790912495150,"version":"4.1.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2013-1670"],"award-info":[{"award-number":["PICT 2013-1670"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP N\u00ba11220110101102"],"award-info":[{"award-number":["PIP N\u00ba11220110101102"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Triatomine control campaigns have traditionally consisted of spraying the inside of houses with pyrethroid insecticides. However, exposure to sublethal insecticide doses after the initial application is a common occurrence and may have phenotypic consequences for survivors. Here, using <jats:italic>Triatoma infestans<\/jats:italic> (the main vector of Chagas disease in the Southern Cone of South America) as a model species, we quantified the effects of exposure to a sublethal dose of pyrethroid insecticide on wing morphology. We tested if the treatment (i) induced a plastic effect (change in the character mean); (ii) altered environmental canalisation (higher individual variation within genotypes); (iii) altered genetic canalisation (higher variation among genotypes); and (iv) altered developmental stability (higher fluctuating asymmetry [FA]).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Each of 25 full-sib families known to be susceptible to pyrethroid insecticides were split in two groups: one to be treated with a sublethal dose of deltamethrin (insecticide-treated group) and the other to be treated with pure acetone (control group). Wings of the emerging adults were used in a landmark-based geometric morphometry analysis to extract size and shape measurements. Average differences among treatments were measured. Levels of variation among families, among individuals within families and among sides within individuals were computed and compared among treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Wing size and shape were affected by a sublethal dose of deltamethrin. The treated insects had larger wings and a more variable wing size and shape than control insects. For both wing size and shape, genetic variation was higher in treated individuals. Individual variations and variations in FA were also greater in deltamethrin-treated insects than in control ones for all full-sib families; however, the patterns of shape variation associated with genetic variation, individual variation and FA were different.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Insects exposed to a sublethal dose of deltamethrin presented larger, less symmetrical and less canalised wings. The insecticide treatment jointly impaired developmental stability and genetic and environmental canalisation. The divergent patterns of shape variation suggest that the related developmental buffering processes differed at least partially. The morphological modifications induced by a single sublethal exposure to pyrethroids early in life may impinge on subsequent flight performance and consequently affect the dynamics of house invasion and reinfestation, and the effectiveness of triatomine control operations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-021-04857-5","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:04:02Z","timestamp":1625562242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Phenotypic plasticity, canalisation and developmental stability of Triatoma infestans wings: effects of a sublethal application of a pyrethroid insecticide"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-8627","authenticated-orcid":false,"given":"Julieta","family":"Nattero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gast\u00f3n","family":"Mougabure-Cueto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Debat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E.","family":"G\u00fcrtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"4857_CR1","unstructured":"World Health Organisation. Chagas disease (American trypanosomiasis). Geneva: World Health Organization; 2017. http:\/\/www.who.int\/mediacentre\/factsheets\/fs340\/en\/. Accessed 3 Feb 2021."},{"issue":"Suppl I","key":"4857_CR2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1590\/S0074-02761999000700073","volume":"94","author":"CJ Schofield","year":"1999","unstructured":"Schofield CJ, Diotaiuti L, Dujardin JP. The process of domestication in Triatominae. Mem Inst Oswaldo Cruz. 1999;94:(Suppl I):375-8.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4857_CR3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1590\/0074-02760140409","volume":"110","author":"E Waleckx","year":"2015","unstructured":"Waleckx E, Gourbi\u00e8re S, Dumonteil E. Intrusive versus domiciliated triatomines and the challenge of adapting vector control practices against Chagas disease. Mem Inst Oswaldo Cruz. 2015;110:324\u201338.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4857_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1590\/S0074-02761999000700011","volume":"94","author":"JCP Dias","year":"1999","unstructured":"Dias JCP, Schofield CJ. The evolution of Chagas disease (American Trypanosomiasis) control after 90 years since Carlos Chagas discovery. Mem Inst Oswaldo Cruz. 1999;94:103\u201321.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4857_CR5","unstructured":"World Health Organisation. Chagas disease (also known as American trypanosomiasis). Geneva: World Health Organization; 2020. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chagas-disease-(american-trypanosomiasis). Accessed 3 Feb 2021."},{"key":"4857_CR6","volume-title":"Triatominae\u2014the biology of Chagas disease vectors","author":"RE G\u00fcrtler","year":"2021","unstructured":"G\u00fcrtler RE, Cecere MC. Chagas disease vector control. In: Guarneri AA, Lorenzo MG, editors. Triatominae\u2014the biology of Chagas disease vectors. Heidelberg: Springer International Publishing; 2021."},{"issue":"Suppl. I","key":"4857_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1590\/S0074-02762009000900009","volume":"104","author":"RE G\u00fcrtler","year":"2009","unstructured":"G\u00fcrtler RE. Sustainability of vector control strategies in the Gran Chaco region: current challenges and possible approaches. Mem Inst Oswaldo Cruz. 2009;104(Suppl. I):52\u20139.","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"4857_CR8","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1603\/ME12070","volume":"49","author":"MD Germano","year":"2012","unstructured":"Germano MD, Santo Orihuela P, Roca Acevedo G, Toloza AC, Vassena C, Picollo MI, et al. Scientific evidence of three different insecticide resistant profiles in Triatoma infestans (Hemiptera: Reduviidae) populations from Argentina and Bolivia. J Med Entomol. 2012;49:1355\u201360.","journal-title":"J Med Entomol"},{"key":"4857_CR9","doi-asserted-by":"publisher","first-page":"e2158","DOI":"10.1371\/journal.pntd.0002158","volume":"7","author":"JM Gurevitz","year":"2013","unstructured":"Gurevitz JM, Gaspe MS, Enr\u00edquez GF, Provecho YM, Kitron U, G\u00fcrtler RE. Intensified surveillance and insecticide-based control of the Chagas disease vector Triatoma infestans in the Argentinean Chaco. PLoS Negl Trop Dis. 2013;7:e2158.","journal-title":"PLoS Negl Trop Dis"},{"key":"4857_CR10","doi-asserted-by":"publisher","first-page":"16194","DOI":"10.1073\/pnas.0700863104","volume":"104","author":"RE G\u00fcrtler","year":"2007","unstructured":"G\u00fcrtler RE, Kitron U, Cecere MC, Segura EL, Cohen JE. Sustainable vector control and management of Chagas disease in the Gran Chaco. Argentina Proc Natl Acad Sci USA. 2007;104:16194\u20139.","journal-title":"Argentina Proc Natl Acad Sci USA"},{"key":"4857_CR11","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1093\/jmedent\/42.4.637","volume":"42","author":"MI Picollo","year":"2005","unstructured":"Picollo MI, Vassena C, Santo Orihuela PS, Barrios S, Zaidemberg M, Zerba E. High resistance to pyrethroid insecticides associated with ineffective field treatments in Triatoma infestans (Hemiptera: Reduviidae) from northern Argentina. J Med Entomol. 2005;42:637\u201342.","journal-title":"J Med Entomol"},{"key":"4857_CR12","doi-asserted-by":"publisher","first-page":"e1822","DOI":"10.1371\/journal.pntd.0001822","volume":"6","author":"A Rojas de Arias","year":"2012","unstructured":"Rojas de Arias A, Abad-Franch F, Acosta N, L\u00f3pez E, Gonz\u00e1lez N, Zerba E, et al. Post-control surveillance of Triatoma infestans and Triatoma sordida with chemically- baited sticky traps. PLoS Negl Trop Dis. 2012;6:e1822.","journal-title":"PLoS Negl Trop Dis."},{"key":"4857_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.actatropica.2015.05.014","volume":"149","author":"G Mougabure-Cueto","year":"2015","unstructured":"Mougabure-Cueto G, Picollo MI. Insecticide resistance in vector Chagas Disease: evolution, mechanisms and management. Acta Trop. 2015;149:70\u201385.","journal-title":"Acta Trop"},{"key":"4857_CR14","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1525-142X.2007.00176.x","volume":"9","author":"JL Hendrikse","year":"2007","unstructured":"Hendrikse JL, Parsons TE, Hallgr\u00edmsson B. Evolvability as the proper focus of evolutionary developmental biology. Evol Dev. 2007;9:393\u2013401.","journal-title":"Evol Dev"},{"key":"4857_CR15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0169-5347(01)02266-2","volume":"16","author":"V Debat","year":"2001","unstructured":"Debat V, David P. Mapping phenotypes: canalization, plasticity and developmental stability. Trends Ecol Evol. 2001;16:555\u201361.","journal-title":"Trends Ecol Evol"},{"key":"4857_CR16","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/sym7020843","volume":"7","author":"CP Klingenberg","year":"2015","unstructured":"Klingenberg CP. Analyzing fluctuating asymmetry with geometric morphometrics: concepts, methods, and applications. Symmetry. 2015;7:843\u2013934.","journal-title":"Symmetry"},{"key":"4857_CR17","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1371\/journal.pone.0000007","volume":"1","author":"CJ Breuker","year":"2006","unstructured":"Breuker CJ, Patterson JS, Klingenberg CP. A single basis for developmental buffering of Drosophila wing shape. PLoS ONE. 2006;1:e7.","journal-title":"PLoS ONE."},{"key":"4857_CR18","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1111\/j.0014-3820.2006.tb01887.x","volume":"60","author":"V Debat","year":"2006","unstructured":"Debat V, Milton CC, Rutherford SL, Klingenberg CP, Hoffmann AA. Hsp90 and the quantitative variation of the shape of Drosophila wing. Evolution. 2006;60:2529\u201338.","journal-title":"Evolution"},{"key":"4857_CR19","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1111\/j.1558-5646.2009.00774.x","volume":"63","author":"V Debat","year":"2009","unstructured":"Debat V, Debelle A, Dworkin I. Plasticity, canalization and developmental stability of the Drosophila wing: joint effects of mutations and developmental temperature. Evolution. 2009;63:2864\u201376.","journal-title":"Evolution"},{"key":"4857_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ajpa.10182","volume":"45","author":"B Hallgr\u00edmsson","year":"2002","unstructured":"Hallgr\u00edmsson B, Willmore K, Hall BK. Canalization, developmental stability, and morphological integration in primate limbs. Yearb Phys Anthropol. 2002;45:131\u201358.","journal-title":"Yearb Phys Anthropol"},{"key":"4857_CR21","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/150563a0","volume":"150","author":"CH Waddington","year":"1942","unstructured":"Waddington CH. Canalization of development and the inheritance of acquired characters. Nature. 1942;150:563\u20135.","journal-title":"Nature"},{"key":"4857_CR22","doi-asserted-by":"publisher","first-page":"391421","DOI":"10.1146\/annurev.es.17.110186.002135","volume":"17","author":"AR Palmer","year":"1986","unstructured":"Palmer AR, Strobeck C. Fluctuating asymmetry: measurement, analysis, pattern. Annu Rev Ecol Syst. 1986;17:391421.","journal-title":"Annu Rev Ecol Syst."},{"key":"4857_CR23","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.actatropica.2008.09.026","volume":"110","author":"JP Dujardin","year":"2009","unstructured":"Dujardin JP, Costa J, Bustamante D, Jaramillo N, Catal\u00e1 SS. Deciphering morphology in Triatominae: the evolutionary signals. Acta Trop. 2009;110:101\u201311.","journal-title":"Acta Trop"},{"key":"4857_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.meegid.2013.06.014","volume":"19","author":"J Nattero","year":"2013","unstructured":"Nattero J, Malerba R, Rodr\u00edguez C, Crocco L. Phenotypic plasticity in response to food source in Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae: Triatominae). Infect Gen Evol. 2013;19:38\u201344.","journal-title":"Infect Gen Evol"},{"key":"4857_CR25","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.actatropica.2015.09.022","volume":"152","author":"J Nattero","year":"2015","unstructured":"Nattero J, Leonhard G, G\u00fcrtler RE, Crocco LB. Evidence of selection on phenotypic plasticity and cost of plasticity in response to host-feeding sources in the major Chagas disease vector Triatoma infestans. Acta Trop. 2015;152:237\u201344.","journal-title":"Acta Trop"},{"key":"4857_CR26","doi-asserted-by":"publisher","first-page":"jeb166868","DOI":"10.1242\/jeb.166868","volume":"221","author":"A Fraimout","year":"2018","unstructured":"Fraimout A, Jacquemart P, Villarroel B, Aponte DJ, Decamps T, Herrel A, etal. Phenotypic plasticity of Drosophila suzukii wing to developmental temperature: implications for flight. J Exp Biol. 2018;221:jeb166868.","journal-title":"J Exp Biol."},{"key":"4857_CR27","doi-asserted-by":"publisher","first-page":"103925","DOI":"10.1016\/j.meegid.2019.103925","volume":"74","author":"J Nattero","year":"2019","unstructured":"Nattero J, Piccinali RV, Gaspe MS, G\u00fcrtler RE. Fluctuating asymmetry and exposure to pyrethroid insecticides in Triatoma infestans populations in northeastern Argentina. Infect Gen Evol. 2019;74:103925.","journal-title":"Infect Gen Evol."},{"key":"4857_CR28","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1002\/ps.3636","volume":"70","author":"E Tooming","year":"2014","unstructured":"Tooming E, Merivee E, Must A, Sibul I, Williams I. Sub-lethal effects of the neurotoxic pyrethroid insecticide Fastacs 50EC on the general motor and locomotor activities of the non-targeted beneficial carabid beetle Platynus assimilis (Coleoptera: Carabidae). Pest Manag Sci. 2014;70:959\u201366.","journal-title":"Pest Manag Sci"},{"key":"4857_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.biocontrol.2009.09.012","volume":"53","author":"A Bayram","year":"2010","unstructured":"Bayram A, Salerno G, Onofri A, Conti E. Sub-lethal effects of two pyrethroids on biological parameters and behavioral responses to host cues in the egg parasitoid Telenomus busseolae. Biol Control. 2010;53:153\u201360.","journal-title":"Biol Control"},{"key":"4857_CR30","doi-asserted-by":"publisher","first-page":"e0144879","DOI":"10.1371\/journal.pone.0144879","volume":"10","author":"M Charreton","year":"2015","unstructured":"Charreton M, Decourtye A, Henry M, Rodet G, Sandoz J-C, Charnet P, et al. A locomotor deficit induced by sublethal doses of pyrethroid and neonicotinoid insecticides in the Honeybee Apis mellifera. PLoS ONE. 2015;10:e0144879.","journal-title":"PLoS ONE."},{"key":"4857_CR31","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1146\/annurev.en.32.010187.002045","volume":"32","author":"RT Roush","year":"1987","unstructured":"Roush RT, McKenzie JA. Ecological genetics of insecticide and acaricide resistance. Annu Rev Entomol. 1987;32:361\u201380.","journal-title":"Annu Rev Entomol"},{"key":"4857_CR32","doi-asserted-by":"publisher","first-page":"e1001000","DOI":"10.1371\/journal.ppat.1001000","volume":"6","author":"A Rivero","year":"2010","unstructured":"Rivero A, V\u00e9zilier J, Weill M, Read AF, Gandon S. Insecticide control of vector-borne diseases: when is insecticide resistance a problem? PLoS Pathog. 2010;6:e1001000.","journal-title":"PLoS Pathog."},{"key":"4857_CR33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00244-006-0162-8","volume":"53","author":"B Ribeiro","year":"2007","unstructured":"Ribeiro B, Guedes RNC, Corr\u00eaa AS, Santo CT. Fluctuating asymmetry in insecticide-resistant and insecticide-susceptible strains of the maize weevil, Sitophilus zeamais (Coleoptera: Curculionidae). Arch Environ Contam Toxicol. 2007;53:77\u201383.","journal-title":"Arch Environ Contam Toxicol"},{"key":"4857_CR34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1093\/jmedent\/33.1.58","volume":"33","author":"RA Alzogaray","year":"1996","unstructured":"Alzogaray RA, Zerba EN. Comparative toxicity of deltamethrin and cis-permethrin on first instars of Triatoma infestans (Hemiptera: Reduviidae). J Med Entomol. 1996;33:58\u201362.","journal-title":"J Med Entomol"},{"key":"4857_CR35","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1590\/S0074-02761997000300023","volume":"92","author":"RA Alzogaray","year":"1997","unstructured":"Alzogaray RA, Zerba EN. Incoordination, paralysis and recovery after pyrethroid treatment on nymphs III of Triatoma infestans (Hemiptera: Reduviidae). Mem Inst Oswaldo Cruz. 1997;92:431\u20135.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"4857_CR36","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/(SICI)1520-6327(199705)35:3<323::AID-ARCH6>3.0.CO;2-U","volume":"35","author":"RA Alzogaray","year":"1998","unstructured":"Alzogaray RA, Font\u00e1n A, Zerba EN. Evaluation of hyperactivity produced by pyrethroid treatment on third instar nymphs of Triatoma infestans (Hemiptera: Reduviidae). Arch Inst Biochem Physiol. 1998;35:323\u201333.","journal-title":"Arch Inst Biochem Physiol"},{"key":"4857_CR37","doi-asserted-by":"crossref","unstructured":"de Fran\u00e7a SM, Breda MO, Barbosa DR, Araujo AM, Guedes CA. The sublethal effects of insecticides in insects. In: Shields VDC, editor. Biological control of pest and vector insects. London: IntechOpen; 2017. p. 23\u201339.","DOI":"10.5772\/66461"},{"key":"4857_CR38","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev.ento.52.110405.091440","volume":"52","author":"N Desneux","year":"2007","unstructured":"Desneux N, Decourtye A, Delpuech J-M. The sublethal effects of pesticides on beneficial arthropods. Annu Rev Entomol. 2007;52:81\u2013106.","journal-title":"Annu Rev Entomol"},{"key":"4857_CR39","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.en.33.010188.001053","volume":"33","author":"KF Haynes","year":"1988","unstructured":"Haynes KF. Sublethal effects of neurotoxic insecticides on insect behavior. Annu Rev Entomol. 1988;33:149\u201368.","journal-title":"Annu Rev Entomol"},{"key":"4857_CR40","first-page":"29","volume":"2","author":"World Health Organisation","year":"1994","unstructured":"World Health Organisation. Protocolo de evaluaci\u00f3n de efecto insecticida sobre triatominos. Acta Toxicol Argentina. 1994;2:29\u201332.","journal-title":"Acta Toxicol Argentina."},{"key":"4857_CR41","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1603\/0022-2585-41.4.643","volume":"41","author":"J Schachter-Broide","year":"2004","unstructured":"Schachter-Broide J, Dujardin J-P, Kitron U, G\u00fcrtler RE. Spatial structuring of Triatoma infestans (Hemiptera, Reduviidae) populations from Northwestern Argentina using wing geometric morphometry. J Med Entomol. 2004;41:643\u20139.","journal-title":"J Med Entomol"},{"key":"4857_CR42","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/978-94-011-0830-0_26","volume-title":"Developmental instability: its origins and evolutionary implications","author":"AR Palmer","year":"1994","unstructured":"Palmer AR. Fluctuating asymmetry analyses: a primer. In: Markow TA, editor. Developmental instability: its origins and evolutionary implications. Dordrecht: Kluwer Academic; 1994. p. 335\u201364."},{"key":"4857_CR43","volume-title":"Statistical shape analysis","author":"IL Dryden","year":"1998","unstructured":"Dryden IL, Mardia KV. Statistical shape analysis. Chichester: Wiley; 1998."},{"key":"4857_CR44","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1755-0998.2010.02924.x","volume":"11","author":"CP Klingenberg","year":"2011","unstructured":"Klingenberg CP. MorphoJ: an integrated software package for geometric morphometrics. Mol Ecol Resour. 2011;11:353\u20137.","journal-title":"Mol Ecol Resour"},{"key":"4857_CR45","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1111\/j.0014-3820.2003.tb01519.x","volume":"57","author":"V Debat","year":"2003","unstructured":"Debat V, Begin M, Legout H, David JR. Allometric and nonallometric components of Drosophila wing shape respond differently to developmental temperature. Evolution. 2003;57:2773\u201384.","journal-title":"Evolution"},{"key":"4857_CR46","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/j.1558-5646.1998.tb02018.x","volume":"52","author":"CP Klingenberg","year":"1998","unstructured":"Klingenberg CP, McIntyre GS. Geometric morphometrics of developmental instability: analyzing patterns of fluctuating asymmetry with Procrustes methods. Evolution. 1998;52:1363\u201375.","journal-title":"Evolution"},{"key":"4857_CR47","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2307\/2992282","volume":"38","author":"J Cheverud","year":"1989","unstructured":"Cheverud J, Wagner G, Dow MM. Methods for the comparative analysis of variation patterns. Syst Zool. 1989;38:201.","journal-title":"Syst Zool"},{"key":"4857_CR48","volume-title":"Multivariate analysis","author":"KV Mardia","year":"1979","unstructured":"Mardia KV, Kent JT, Bibby JM. Multivariate analysis. London: Academic Press; 1979."},{"key":"4857_CR49","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/j.1558-5646.2008.00587.x","volume":"63","author":"P Mitteroecker","year":"2009","unstructured":"Mitteroecker P, Bookstein F. The ontogenetic trajectory of the phenotypic covariance matrix, with examples from craniofacial shape in rats and humans. Evolution. 2009;63:727\u201337.","journal-title":"Evolution"},{"key":"4857_CR50","volume-title":"Principal component analysis","author":"IT Jolliffe","year":"2002","unstructured":"Jolliffe IT. Principal component analysis. New York: Springer; 2002."},{"key":"4857_CR51","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.toxlet.2016.03.001","volume":"248","author":"GA Mougabure-Cueto","year":"2016","unstructured":"Mougabure-Cueto GA, Sfara V. The analysis of dose\u2013response curve from bioassays with quantal response: deterministic or statistical approaches? Toxicol Lett. 2016;248:46\u201351.","journal-title":"Toxicol Lett"},{"key":"4857_CR52","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3390\/insects11050274","volume":"11","author":"C Vilaseca","year":"2020","unstructured":"Vilaseca C, M\u00e9ndez MA, Pinto CF, Ben\u00edtez HA. Assessment of shape variation patterns in Triatoma infestans (Klug 1834) (Hemiptera: Reduviidae: Triatominae): a first report in populations from Bolivia. Insects. 2020;11:274.","journal-title":"Insects"},{"key":"4857_CR53","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.meegid.2013.03.044","volume":"17","author":"MS Gaspe","year":"2013","unstructured":"Gaspe MS, Gurevitz JM, G\u00fcrtler RE, Dujardin J-P. Origins of house reinfestation with Triatoma infestans after insecticide spraying in the Argentine Chaco using wing geometric morphometry. Infect Genet Evol. 2013;17:93\u2013100.","journal-title":"Infect Genet Evol"},{"key":"4857_CR54","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1603\/ME11176","volume":"49","author":"MS Gaspe","year":"2012","unstructured":"Gaspe MS, Schachter-Broide J, Gurevitz JM, Kitron U, G\u00fcrtler RE, Dujardin J-P. Microgeographic spatial structuring of Triatoma infestans (Hemiptera: Reduviidae) populations using wing geometric morphometry in the Argentine Chaco. J Med Entomol. 2012;49:504\u201314.","journal-title":"J Med Entomol"},{"key":"4857_CR55","doi-asserted-by":"publisher","first-page":"e0006097","DOI":"10.1371\/journal.pntd.0006097","volume":"11","author":"RE G\u00fcrtler","year":"2017","unstructured":"G\u00fcrtler RE, Fern\u00e1ndez MP, Cecere MC, Cohen JE. Body size and hosts of Triatoma infestans populations affect the size of bloodmeal contents and female fecundity in rural northwestern Argentina. PLoS Negl Trop Dis. 2017;11:e0006097.","journal-title":"PLoS Negl Trop Dis."},{"key":"4857_CR56","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/ps.4731","volume":"74","author":"RR Rix","year":"2018","unstructured":"Rix RR, Cutler GC. Does multigenerational exposure to hormetic concentrations of imidacloprid precondition aphids for increased insecticide tolerance? Pest Manag Sci. 2018;74:314\u201322.","journal-title":"Pest Manag Sci"},{"key":"4857_CR57","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.aspen.2016.06.013","volume":"19","author":"L Xu","year":"2016","unstructured":"Xu L, Zhao CQ, Zhang YN, Liu Y, Gu ZY. Lethal and sublethal effects of sulfoxaflor on the small brown planthopper Laodelphax striatellus. J Asia-Pac Entomol. 2016;19:683\u20139.","journal-title":"J Asia-Pac Entomol"},{"key":"4857_CR58","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pestbp.2018.04.003","volume":"148","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Wang Q, Ding J, Wang Y, Zhang Z, Liu F, Mu W. Sublethal effects of chlorfenapyr on the life table parameters, nutritional physiology and enzymatic properties of Bradysia odoriphaga (Diptera: Sciaridae). Pestic Biochem Physiol. 2018;148:93\u2013102.","journal-title":"Pestic Biochem Physiol"},{"key":"4857_CR59","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10646-014-1189-7","volume":"23","author":"H Feltham","year":"2014","unstructured":"Feltham H, Park K, Goulson D. Field realistic doses of pesticide imidacloprid reduce bumblebee pollen foraging efficiency. Ecotoxicology. 2014;23:317\u201323.","journal-title":"Ecotoxicology"},{"key":"4857_CR60","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/S0169-5347(02)02596-X","volume":"17","author":"CD Meiklejohn","year":"2002","unstructured":"Meiklejohn CD, Hartl DL. A single mode of canalization. Trends Ecol Evol. 2002;17:468\u201373.","journal-title":"Trends Ecol Evol"},{"key":"4857_CR61","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/j.0014-3820.2005.tb01799.x","volume":"59","author":"I Dworkin","year":"2005","unstructured":"Dworkin I. A study of canalization and developmental stability in the sternopleural bristle system of Drosophila melanogaster. Evolution. 2005;59:1500\u20139.","journal-title":"Evolution"},{"key":"4857_CR62","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/mve.12298","volume":"32","author":"P Lobbia","year":"2018","unstructured":"Lobbia P, Calcagno J, Mougabure-Cueto G. Excretion\/defecation patterns in Triatoma infestans populations that are, respectively, susceptible and resistant to deltamethrin. Med Vet Entomol. 2018;32:311\u201322.","journal-title":"Med Vet Entomol"},{"key":"4857_CR63","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/325345a0","volume":"325","author":"GM Clarke","year":"1987","unstructured":"Clarke GM, McKenzie JA. Developmental stability of insecticide resistant phenotypes in blowfly; a result of canalizing natural selection. Nature. 1987;325:345\u20136.","journal-title":"Nature"},{"key":"4857_CR64","doi-asserted-by":"publisher","first-page":"803","DOI":"10.4269\/ajtmh.2004.71.803","volume":"71","author":"MC Cecere","year":"2004","unstructured":"Cecere MC, Vazquez-Prokopec GM, G\u00fcrtler RE, Kitron U. Spatio-temporal analysis of reinfestation by Triatoma infestans (Hemiptera: Reduviidae) following insecticide spraying in a rural community in northwestern Argentina. Am J Trop Med Hyg. 2004;71:803\u201310.","journal-title":"Am J Trop Med Hyg"},{"key":"4857_CR65","first-page":"196","volume":"82","author":"RE G\u00fcrtler","year":"2004","unstructured":"G\u00fcrtler RE, Canale DM, Spillman C, Stariolo R, Salomon OD, Blanco S, Segura EL. Effectiveness of residual spraying with deltamethrin and permethrin on peridomestic populations of Triatoma infestans in rural western Argentina: a district-wide randomized trial. Bull World Health Organ. 2004;82:196\u2013205.","journal-title":"Bull World Health Organ"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04857-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-021-04857-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04857-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T12:44:56Z","timestamp":1633610696000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-021-04857-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4857"],"URL":"https:\/\/doi.org\/10.1186\/s13071-021-04857-5","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"23 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"355"}}