{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:45:51Z","timestamp":1784774751295,"version":"3.55.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The human botfly,\n                      <jats:italic>Dermatobia hominis<\/jats:italic>\n                      , is a common cause of furuncular myiasis in dogs in Latin America. Lesions can be single or multiple, each harboring an individual larva, presented as an erythematous nodule that causes pruritus and pain. Typical treatment consists of sedation for removal of larvae by surgical incision or manual pressure. Medications to kill the larva before its extraction can reduce inflammation and discomfort and provide a less traumatic larval removal. Isoxazolines are broad-spectrum ectoparasiticides with larvicidal activity previously reported in the treatment of screwworm myiasis in companion animals. The aim of this study was to evaluate the effectiveness of sarolaner as part of the clinical management of furuncular myiasis in dogs caused by\n                      <jats:italic>D. hominis<\/jats:italic>\n                      larvae.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten short-haired mixed breed dogs naturally infested with\n                      <jats:italic>D. hominis<\/jats:italic>\n                      were enrolled. Clinical diagnosis was achieved by observation of skin nodules and visualization of larval motility through the lesion orifice. Sarolaner was administered at manufacturer recommended dose for fleas and ticks. Lesions were reexamined 24\u00a0h post-treatment and assessed for viability of larvae. Larvae were removed by digital compression and identified as\n                      <jats:italic>D. hominis.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-five\n                      <jats:italic>D. hominis<\/jats:italic>\n                      larvae were retrieved from ten dogs. No live larvae were observed, demonstrating 100% larvicidal efficacy of sarolaner. Skin lesions were healed 30\u00a0days post-treatment and new lesions were not observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarolaner seems to be effective as larvicidal treatment for dogs with furuncular myiasis, reducing discomfort caused by the presence of the larva in the skin and facilitating its safe removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13071-021-04910-3","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:03:07Z","timestamp":1628838187000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)"],"prefix":"10.1186","volume":"14","author":[{"given":"Paula A.","family":"Andriotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa P.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-3176","authenticated-orcid":false,"given":"Priscila C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo C.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme G.","family":"Verocai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio I.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"4910_CR1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.jaad.2008.03.014","volume":"58","author":"TA McGraw","year":"2008","unstructured":"McGraw TA, Turiansky GW. Cutaneous myiasis. J Am Acad Dermatol. 2008;58:907\u201326.","journal-title":"J Am Acad Dermatol"},{"key":"4910_CR2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jfms.2009.12.019","volume":"12","author":"GG Verocai","year":"2010","unstructured":"Verocai GG, Fernandes JI, Correia TR, Souza CP, Melo RMPS, Scott FB. Furuncular myiasis caused by the human bot-fly Dermatobia hominis in a domestic cat from Brazil. J Feline Med Surg. 2010;12:491\u20133.","journal-title":"J Feline Med Surg"},{"key":"4910_CR3","first-page":"100402","volume":"20","author":"AAF Mu\u00f1oz","year":"2020","unstructured":"Mu\u00f1oz AAF, Marin JAM, Marcixgclia JAS, Leon JCP. First report of furuncular myiasis in a domestic dog caused by Dermatobia hominis (Linnaeus, 1781) in Colombia. Vet Parasitol Reg Stud Reports. 2020;20:100402.","journal-title":"Vet Parasitol Reg Stud Reports."},{"key":"4910_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12959","author":"X Zhou","year":"2021","unstructured":"Zhou X, Hohman AE, Hsu W. Current review of isoxazoline ectoparasiticides used in veterinary medicine. J Vet Pharmacol Ther. 2021. https:\/\/doi.org\/10.1111\/jvp.12959.","journal-title":"J Vet Pharmacol Ther"},{"key":"4910_CR5","doi-asserted-by":"publisher","first-page":"108966","DOI":"10.1016\/j.vetpar.2019.108966","volume":"276","author":"PC Oliveira","year":"2019","unstructured":"Oliveira PC, Almeida GPS, Cardoso JD, Tavares RB, Fernandes JI, Correia TR, et al. Efficacy of sarolaner on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Vet Parasitol. 2019;276:108966.","journal-title":"Vet Parasitol"},{"key":"4910_CR6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/vde.12855","volume":"31","author":"HS Han","year":"2020","unstructured":"Han HS, Yasmin L. Chrysomya bezziana (Diptera: Calliphoridae) infestation in two Malaysian cats treated with oral lotilaner. Vet Dermatol. 2020;31:335-e87.","journal-title":"Vet Dermatol"},{"key":"4910_CR7","first-page":"100569","volume":"24","author":"AA Cutolo","year":"2021","unstructured":"Cutolo AA, Perier N, Menz I, Thyssen P, Silva FO, Beugnet F. Efficacy of afoxolaner (NexGard\u00ae) on the treatment of myiasis caused by the New World screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs. Vet Parasitol Reg Stud Rep. 2021;24:100569.","journal-title":"Vet Parasitol Reg Stud Rep."},{"key":"4910_CR8","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1590\/S0101-81751982000400001","volume":"1","author":"JH Guimar\u00e3es","year":"1983","unstructured":"Guimar\u00e3es JH, Papavero N, Prado AP. As mi\u00edases da regi\u00e3o neotropical. Rev Bras Zool. 1983;1:239\u2013416.","journal-title":"Rev Bras Zool"},{"key":"4910_CR9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/j.1365-4632.2010.04577.x","volume":"49","author":"K Robbins","year":"2010","unstructured":"Robbins K, Khachemoune A. Cutaneous myiasis: a review of the common types of myiasis. Int J Dermatol. 2010;49:1092\u20138.","journal-title":"Int J Dermatol"},{"key":"4910_CR10","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1186\/s13071-020-04264-2","volume":"13","author":"G Deak","year":"2020","unstructured":"Deak G, Ionic\u0103 AM, N\u0103d\u0103\u0219an-Cozma G, Mihalca AD. Dermatobia hominis in a dog imported from Brazil to Romania. Parasit Vectors. 2020;13:386.","journal-title":"Parasit Vectors"},{"key":"4910_CR11","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/00000637-200102000-00011","volume":"46","author":"CE Sampson","year":"2001","unstructured":"Sampson CE, MaGuire J, Eriksson E. Botfly myiasis: case report and brief review. Ann Plast Surg. 2001;46:150\u20132.","journal-title":"Ann Plast Surg"},{"key":"4910_CR12","first-page":"176","volume":"39","author":"BC Cramer-Ribeiro","year":"2002","unstructured":"Cramer-Ribeiro BC, Sanavria A, Oliveira MQ, Souza FS, Rocco FS, Cardoso PG. Inqu\u00e9rito sobre os casos de mi\u00edase por Dermatobia hominis em c\u00e3es da zona sul do munic\u00edpio do Rio de Janeiro no ano de 2000. Braz J Vet Anim Sci. 2002;39:176\u201380.","journal-title":"Braz J Vet Anim Sci"},{"key":"4910_CR13","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jfms.2009.08.003","volume":"12","author":"CP Souza","year":"2010","unstructured":"Souza CP, Verocai GG, Ramadinha RHR. Myiasis caused by the new word screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae) in cats from Brazil: report of five cases. J feline Med surg. 2010;12:166\u20138.","journal-title":"J feline Med surg"},{"key":"4910_CR14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.vetpar.2018.06.006","volume":"258","author":"PC Oliveira","year":"2018","unstructured":"Oliveira PC, Moraes PA, Scott FB, Verocai GG, Correia TR, Fernandes JI. Efficacy of spinosad on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Vet Parasitol. 2018;258:53\u20136.","journal-title":"Vet Parasitol"},{"key":"4910_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12998","author":"DR Campos","year":"2021","unstructured":"Campos DR, Assis RCP, Chaves JKO, Almeida GPS, Lima EAS, Intrieri JM, et al. Furuncular myiasis caused by Dermatobia hominis in five cats and efficacy of topical fluralaner for its treatment. Vet Dermatol. 2021. https:\/\/doi.org\/10.1111\/vde.12998.","journal-title":"Vet Dermatol"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04910-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-021-04910-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-021-04910-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:03:34Z","timestamp":1628838214000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-021-04910-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4910"],"URL":"https:\/\/doi.org\/10.1186\/s13071-021-04910-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-628242\/v1","asserted-by":"object"}]},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"assertion":[{"value":"15 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved and conducted in accordance with the institutional animal care and use committee (number 2165240619 CEUA\/UFFRJ).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Zoetis Brazil is the manufacturer and distributor of Simparic\u2122, the product tested herein. Zoetis Brazil covered the publication fees, but the authors declare that the sponsor had no role on this study and its conclusions or on the decision to publish this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"401"}}