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In addition, ticks resistant to multiple acaricides are present in this region. Recently, fluralaner (isoxazoline) was launched on the market. Thus, there is a need to evaluate the effects of fluralaner for the control of <jats:italic>R. microplus<\/jats:italic> on taurine cattle. In addition, occurrence of myiasis by <jats:italic>Cochliomyia hominivorax<\/jats:italic> larvae after tick parasitism and weight gain of cattle during the experimental period were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Thirty naturally infested cattle were divided into two experimental groups: T01, treated with fluralaner (2.5\u00a0mg\/kg) pour-on; T02, control. T01 received fluralaner on Days 0 (early summer in January), 42 and 84 (early autumn), whereas T02, a control group, received palliative treatment with a spray formulation when the group mean was\u2009\u2265\u200930 ticks. Counts of <jats:italic>R. microplus<\/jats:italic> females and calculation of the efficacy of fluralaner were performed on Days 3, 7, 14, 28, 35, 42, 56, 70, 84, 98, 112 and 126. The occurrence of myiasis was assessed throughout the study period. In addition, the weight, weight gain and daily weight gain of the animals were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the 12 evaluations performed, the parasitic load of T01 was near zero. Fluralaner showed 99.5% efficacy on the 3rd day after the first treatment and 100% efficacy from Day 7 to Day 126. <jats:italic>Cochliomyia hominivorax<\/jats:italic> larvae (<jats:italic>n<\/jats:italic>\u2009=\u20096; <jats:italic>p<\/jats:italic>\u2009=\u20090.0251) were found only in the control group (T02). At the end of the study, the animals subjected to treatments with fluralaner gained 32.8\u00a0kg more than the animals in the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Application of fluralaner in summer and autumn, with 42-day intervals between treatments, was effective to control <jats:italic>R. microplus<\/jats:italic> on taurine cattle, which also gained more weight than control cattle. Additionally, no cases of myasis were documented in animals treated with fluralaner.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-024-06200-0","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T14:02:09Z","timestamp":1709301729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Control of Rhipicephalus microplus on taurine cattle with fluralaner in a subtropical region"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-896X","authenticated-orcid":false,"given":"Tiago","family":"Gallina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1068-2775","authenticated-orcid":false,"given":"Camila","family":"dos Santos Lagranha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6170-3302","authenticated-orcid":false,"given":"Giancarlo","family":"Bilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4247-6113","authenticated-orcid":false,"given":"Cristiano","family":"Malavolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-3054","authenticated-orcid":false,"given":"Lorena Lopes","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-6269","authenticated-orcid":false,"given":"Fernando","family":"de Almeida Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-5744","authenticated-orcid":false,"given":"Daniel","family":"de Castro Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1490-5801","authenticated-orcid":false,"given":"Tom","family":"Strydom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-894X","authenticated-orcid":false,"given":"Siddartha","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-146X","authenticated-orcid":false,"given":"Emmanuel","family":"Arnhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-8436","authenticated-orcid":false,"given":"Welber Daniel Zanetti","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"6200_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3389\/fcimb.2017.00506","volume":"7","author":"AE Tabor","year":"2017","unstructured":"Tabor AE, Ali A, Rehman G, Rocha Garcia G, Zangirolamo AF, Malardo T, et al. 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