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Kupffer cells (KCs) play important roles in liver inflammatory response. However, their role in hepatic alveolar echinococcosis has not yet been fully elucidated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, qRT-PCR was used to detect the expression level of miR-374b-5p in KCs. The target gene of miR-374b-5p was identified through luciferase reporter assays and loss of function and gains.\u00a0Critical genes involved in NF\u03baB signaling pathway were analyzed by qRT-PCR and western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study reported that miR-374b-5p was significantly upregulated in KCs during\n                      <jats:italic>E. multilocularis<\/jats:italic>\n                      infection and further showed that miR-374b-5p was able to bind to the 3'-UTR of the\n                      <jats:italic>C\/EBP \u03b2<\/jats:italic>\n                      gene and suppressed its expression. The expression levels of NF-\u03baBp65, p-NF-\u03baBp65\u00a0and pro-inflammatory factors including iNOS, TNF\u03b1 and IL6 were attenuated after overexpression of miR-374b-5p while enhanced after suppression\u00a0of miR-374b-5p. However, the Arg1 expression level was promoted after overexpression of miR-374b-5p while suppressed after downregulation\u00a0of miR-374b-5p. Additionally, increased protein levels of NF-\u03baBp65 and p-NF-\u03baBp65 were found in the C\/EBP \u03b2-overexpressed KCs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results demonstrated that miR-374b-5p probably regulated the expression of inflammatory factors via C\/EBP \u03b2\/NF-\u03baB signaling. This finding is helpful to explore the mechanism of inflammation regulation during\n                      <jats:italic>E. multilocularis<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13071-024-06238-0","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T12:03:08Z","timestamp":1711713788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["mmu-miR-374b-5p modulated inflammatory factors via downregulation of C\/EBP \u03b2\/NF-\u03baB signaling in Kupffer cells during Echinococcus multilocularis infection"],"prefix":"10.1186","volume":"17","author":[{"given":"Guiting","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanling","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharheer Oluwashola","family":"Amuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaola","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"6238_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","volume":"17","author":"J Eckert","year":"2004","unstructured":"Eckert J, Deplazes P. 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