{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:02:08Z","timestamp":1787320928724,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["No. ZR2021QH039"],"award-info":[{"award-number":["No. ZR2021QH039"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81871680"],"award-info":[{"award-number":["No. 81871680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81672049"],"award-info":[{"award-number":["No. 81672049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Scholar Foundation of Shandong province","award":["No. ts201712066"],"award-info":[{"award-number":["No. ts201712066"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Toxoplasma gondii<\/jats:italic>\n                      is an obligate intracellular parasite that can lead to adverse pregnancy outcomes, particularly in early pregnancy. Previous studies have illustrated the landscape of decidual immune cells. However, the landscape of decidual immune cells in the maternal\u2013fetal microenvironment during\n                      <jats:italic>T.\u00a0gondii<\/jats:italic>\n                      infection remains unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we employed single-cell RNA sequencing to analyze the changes in human decidual immune cells following\n                      <jats:italic>T.\u00a0gondii<\/jats:italic>\n                      infection. The results of scRNA-seq were further validated with flow cytometry, reverse transcription-polymerase chain reaction, western blot, and immunofluorescence staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results showed that the proportion of 17 decidual immune cell clusters and the expression levels of 21 genes were changed after\n                      <jats:italic>T.\u00a0gondii<\/jats:italic>\n                      infection. Differential gene analysis demonstrated that\n                      <jats:italic>T.\u00a0gondii<\/jats:italic>\n                      infection induced the differential expression of 279, 312, and 380 genes in decidual NK cells (dNK), decidual macrophages (dM\u03c6), and decidual T cells (dT), respectively. Our results revealed for the first time that several previously unknown molecules in decidual immune cells changed following infection. This result revealed that the function of maternal\u2013fetal immune tolerance declined, whereas the killing ability of decidual immune cells enhanced, eventually contributing to the occurrence of adverse pregnancy outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides valuable resource for uncovering several novel molecules that play an important role in the occurrence of abnormal pregnancy outcomes induced by\n                      <jats:italic>T.\u00a0gondii<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13071-024-06266-w","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T09:02:03Z","timestamp":1715331723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Single-cell transcriptomic analysis of decidual immune cell landscape in the occurrence of adverse pregnancy outcomes induced by Toxoplasma gondii infection"],"prefix":"10.1186","volume":"17","author":[{"given":"Tianyi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"6266_CR1","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.pt.2019.07.001","volume":"35","author":"S Lourido","year":"2019","unstructured":"Lourido S. Toxoplasma gondii. Trends Parasitol. 2019;35:944\u20135.","journal-title":"Trends Parasitol"},{"key":"6266_CR2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.pt.2020.10.013","volume":"37","author":"D Arranz-Solis","year":"2021","unstructured":"Arranz-Solis D, Mukhopadhyay D, Saeij J. Toxoplasma effectors that affect pregnancy outcome. Trends Parasitol. 2021;37:283\u201395.","journal-title":"Trends Parasitol"},{"key":"6266_CR3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jri.2017.10.045","volume":"124","author":"S Liu","year":"2017","unstructured":"Liu S, Diao L, Huang C, Li Y, Zeng Y, Kwak-Kim J. The role of decidual immune cells on human pregnancy. J Reprod Immunol. 2017;124:44\u201353.","journal-title":"J Reprod Immunol"},{"key":"6266_CR4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","volume":"31","author":"A Erlebacher","year":"2013","unstructured":"Erlebacher A. Immunology of the maternal-fetal interface. Annu Rev Immunol. 2013;31:387\u2013411.","journal-title":"Annu Rev Immunol"},{"key":"6266_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/imr.13073","volume":"308","author":"SJ Zhao","year":"2022","unstructured":"Zhao SJ, Muyayalo KP, Luo J, Huang D, Mor G, Liao AH. Next generation of immune checkpoint molecules in maternal-fetal immunity. Immunol Rev. 2022;308:40\u201354.","journal-title":"Immunol Rev"},{"key":"6266_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-022-05455-9","volume":"15","author":"X Xu","year":"2022","unstructured":"Xu X, Zheng G, Ren Y, He X, Peng B, Hu X. A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-\u03b1 and IFN-\u03b3 production in dnk cells during Toxoplasma gondii infection. Parasit Vectors. 2022;15:1\u2013337.","journal-title":"Parasit Vectors"},{"key":"6266_CR7","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.3389\/fimmu.2019.01550","volume":"10","author":"D Zhang","year":"2019","unstructured":"Zhang D, Ren L, Zhao M, Yang C, Liu X, Zhang H. Role of Tim-3 in decidual macrophage functional polarization during abnormal pregnancy with toxoplasma gondii infection. Front Immunol. 2019;10:1550.","journal-title":"Front Immunol"},{"key":"6266_CR8","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s10753-019-01075-1","volume":"42","author":"H Zhang","year":"2019","unstructured":"Zhang H, Cui L, Ren L, Liu X, Jiang Y, Yang C. The role of decidual PD-1(+) treg cells in adverse pregnancy outcomes due to Toxoplasma gondii infection. Inflammation. 2019;42:2119\u201328.","journal-title":"Inflammation"},{"key":"6266_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s13071-023-05856-4","volume":"16","author":"Y Li","year":"2023","unstructured":"Li Y, Guo J, Zhang H, Li Z, Ren Y, Jiang Y. LILRB4 regulates the function of decidual MDSCs via the SHP-2\/STAT6 pathway during Toxoplasma gondii infection. Parasit Vectors. 2023;16:237.","journal-title":"Parasit Vectors"},{"key":"6266_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011329","volume":"19","author":"H Qi","year":"2023","unstructured":"Qi H, Li Y, Liu X, Jiang Y, Li Z, Xu X. Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C\/EBP\u03b2 pathway during Toxoplasma gondii infection. Plos Pathog. 2023;19:e1011329.","journal-title":"Plos Pathog"},{"key":"6266_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13071-022-05263-1","volume":"15","author":"X Sun","year":"2022","unstructured":"Sun X, Xie H, Zhang H, Li Z, Qi H, Yang C. B7\u2013H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2\/STAT3 pathway. Parasit Vectors. 2022;15:157.","journal-title":"Parasit Vectors"},{"key":"6266_CR12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13045-021-01105-2","volume":"14","author":"Y Lei","year":"2021","unstructured":"Lei Y, Tang R, Xu J, Wang W, Zhang B, Liu J. Applications of single-cell sequencing in cancer research: progress and perspectives. J Hematol Oncol. 2021;14:91.","journal-title":"J Hematol Oncol"},{"key":"6266_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13059-020-1926-6","volume":"21","author":"D Lahnemann","year":"2020","unstructured":"Lahnemann D, Koster J, Szczurek E, Mccarthy DJ, Hicks SC, Robinson MD. Eleven grand challenges in single-cell data science. Genome Biol. 2020;21:31.","journal-title":"Genome Biol"},{"key":"6266_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","volume":"563","author":"R Vento-Tormo","year":"2018","unstructured":"Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018;563:347\u201353.","journal-title":"Nature"},{"key":"6266_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41421-020-00236-z","volume":"7","author":"C Guo","year":"2021","unstructured":"Guo C, Cai P, Jin L, Sha Q, Yu Q, Zhang W. Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss. Cell Discov. 2021;7:1.","journal-title":"Cell Discov"},{"key":"6266_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.14348\/molcells.2021.0211","volume":"45","author":"W Zhou","year":"2022","unstructured":"Zhou W, Wang H, Yang Y, Guo F, Yu B, Su Z. Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell rna sequencing. Mol Cells. 2022;45:317\u201328.","journal-title":"Mol Cells"},{"key":"6266_CR17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS Mcginnis","year":"2019","unstructured":"Mcginnis CS, Murrow LM, Gartner ZJ. Doubletfinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell Syst. 2019;8:329\u201337.","journal-title":"Cell Syst"},{"key":"6266_CR18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36:411\u201320.","journal-title":"Nat Biotechnol"},{"key":"6266_CR19","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","volume":"14","author":"S Aibar","year":"2017","unstructured":"Aibar S, Gonzalez-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G. Scenic: single-cell regulatory network inference and clustering. Nat Methods. 2017;14:1083\u20136.","journal-title":"Nat Methods"},{"key":"6266_CR20","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH. Inference and analysis of cell-cell communication using cellchat. Nat Commun. 2021;12:1088.","journal-title":"Nat Commun"},{"key":"6266_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.imlet.2015.04.004","volume":"165","author":"K Jung","year":"2015","unstructured":"Jung K, Seo SK, Choi I. Endogenous vsig4 negatively regulates the helper t cell-mediated antibody response. Immunol Lett. 2015;165:78\u201383.","journal-title":"Immunol Lett"},{"key":"6266_CR22","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/labinvest.2014.73","volume":"94","author":"Y Liao","year":"2014","unstructured":"Liao Y, Guo S, Chen Y, Cao D, Xu H, Yang C. Vsig4 expression on macrophages facilitates lung cancer development. Lab Invest. 2014;94:706\u201315.","journal-title":"Lab Invest"},{"key":"6266_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.728291","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang X, Wei H. Role of decidual natural killer cells in human pregnancy and related pregnancy complications. Front Immunol. 2021;12:728291.","journal-title":"Front Immunol"},{"key":"6266_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.587150","volume":"11","author":"T Li","year":"2021","unstructured":"Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L. The role of Tim-3 on dnk cells dysfunction during abnormal pregnancy with Toxoplasma gondii infection. Front Cell Infect Microbiol. 2021;11:587150.","journal-title":"Front Cell Infect Microbiol"},{"key":"6266_CR25","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1093\/humupd\/dmab028","volume":"27","author":"A Bishop","year":"2021","unstructured":"Bishop A, Cartwright JE, Whitley GS. Stanniocalcin-1 in the female reproductive system and pregnancy. Hum Reprod Update. 2021;27:1098\u2013114.","journal-title":"Hum Reprod Update"},{"key":"6266_CR26","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/aji.12205","volume":"71","author":"R Ma","year":"2014","unstructured":"Ma R, Gu B, Gu Y, Groome LJ, Wang Y. Down-regulation of TIMP3 leads to increase in TACE expression and TNF\u03b1 production by placental trophoblast cells. Am J Reprod Immunol. 2014;71:427\u201333.","journal-title":"Am J Reprod Immunol"},{"key":"6266_CR27","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1530\/REP-08-0412","volume":"137","author":"Y Lin","year":"2009","unstructured":"Lin Y, Wang H, Wang W, Zeng S, Zhong Y, Li DJ. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2 (+) ISG20 (+) natural killer-cell transfer. Reproduction. 2009;137:943\u201355.","journal-title":"Reproduction"},{"key":"6266_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ajog.2014.07.021","volume":"212","author":"R Lim","year":"2015","unstructured":"Lim R, Acharya R, Delpachitra P, Hobson S, Sobey CG, Drummond GR. Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies. Am J Obstet Gynecol. 2015;212:86.","journal-title":"Am J Obstet Gynecol"},{"key":"6266_CR29","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(96)09264-1","volume":"349","author":"S Muttukrishna","year":"1997","unstructured":"Muttukrishna S, Knight PG, Groome NP, Redman CW, Ledger WL. Activin A and inhibin A as possible endocrine markers for pre-eclampsia. Lancet. 1997;349:1285\u20138.","journal-title":"Lancet"},{"key":"6266_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12958-017-0303-0","volume":"15","author":"N Ni","year":"2017","unstructured":"Ni N, Li Q. TGF-beta superfamily signaling and uterine decidualization. Reprod Biol Endocrinol. 2017;15:84.","journal-title":"Reprod Biol Endocrinol"},{"key":"6266_CR31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2120667119","volume":"119","author":"S Haider","year":"2022","unstructured":"Haider S, Lackner AI, Dietrich B, Kunihs V, Haslinger P, Meinhardt G. Transforming growth factor-beta signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta. Proc Natl Acad Sci U S A. 2022;119:e2120667119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6266_CR32","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.humimm.2021.01.014","volume":"82","author":"J Zhang","year":"2021","unstructured":"Zhang J, Lye SJ. The immune potential of decidua-resident CD16 (+) CD56 (+) NK cells in human pregnancy. Hum Immunol. 2021;82:332\u20139.","journal-title":"Hum Immunol"},{"key":"6266_CR33","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1084\/jem.20151764","volume":"213","author":"D Langlais","year":"2016","unstructured":"Langlais D, Barreiro LB, Gros P. The macrophage IRF8\/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med. 2016;213:585\u2013603.","journal-title":"J Exp Med"},{"key":"6266_CR34","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00439-020-02154-2","volume":"139","author":"S Salem","year":"2020","unstructured":"Salem S, Salem D, Gros P. Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases. Hum Genet. 2020;139:707\u201321.","journal-title":"Hum Genet"},{"key":"6266_CR35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/ng.137","volume":"40","author":"J Behmoaras","year":"2008","unstructured":"Behmoaras J, Bhangal G, Smith J, Mcdonald K, Mutch B, Lai PC. Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet. 2008;40:553\u20139.","journal-title":"Nat Genet"},{"key":"6266_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.717370","volume":"12","author":"J Wang","year":"2021","unstructured":"Wang J, Ding J, Zhang S, Chen X, Yan S, Zhang Y. Decreased USP2a expression inhibits trophoblast invasion and associates with recurrent miscarriage. Front Immunol. 2021;12:717370.","journal-title":"Front Immunol"},{"key":"6266_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.886261","volume":"13","author":"J Wang","year":"2022","unstructured":"Wang J, Zhou Q, Ding J, Yin T, Ye P, Zhang Y. The conceivable functions of protein ubiquitination and deubiquitination in reproduction. Front Physiol. 2022;13:886261.","journal-title":"Front Physiol"},{"key":"6266_CR38","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/aji.12477","volume":"75","author":"F Ning","year":"2016","unstructured":"Ning F, Liu H, Lash GE. The role of decidual macrophages during normal and pathological pregnancy. Am J Reprod Immunol. 2016;75:298\u2013309.","journal-title":"Am J Reprod Immunol"},{"key":"6266_CR39","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3389\/fimmu.2017.01013","volume":"8","author":"Z Li","year":"2017","unstructured":"Li Z, Zhao M, Li T, Zheng J, Liu X, Jiang Y. Decidual macrophage functional polarization during abnormal pregnancy due to Toxoplasma gondii: role for LILRB4. Front Immunol. 2017;8:1013.","journal-title":"Front Immunol"},{"key":"6266_CR40","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/s13071-022-05560-9","volume":"15","author":"L Cui","year":"2022","unstructured":"Cui L, Wang Y, Ren L, Li Z, Jiang Y, Wang C. Effect of B7\u2013H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes. Parasit Vectors. 2022;15:464.","journal-title":"Parasit Vectors"},{"key":"6266_CR41","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.bbrc.2019.11.077","volume":"522","author":"Q Lyu","year":"2020","unstructured":"Lyu Q, Pang X, Zhang Z, Wei Y, Hong J, Chen H. Microglial V-set and immunoglobulin domain-containing 4 protects against ischemic stroke in mice by suppressing TLR4-regulated inflammatory response. Biochem Biophys Res Commun. 2020;522:560\u20137.","journal-title":"Biochem Biophys Res Commun"},{"key":"6266_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.713757","volume":"12","author":"R Chen","year":"2021","unstructured":"Chen R, Wang X, Dai Z, Wang Z, Wu W, Hu Z. TNFSF13 is a novel onco-inflammatory marker and correlates with immune infiltration in gliomas. Front Immunol. 2021;12:713757.","journal-title":"Front Immunol"},{"key":"6266_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109554","volume":"115","author":"L Chen","year":"2023","unstructured":"Chen L, Dai M, Zuo W, Dai Y, Yang Q, Yu S. NF-\u03baB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7\/NLR-dependent macrophage M1 polarization. Int Immunopharmacol. 2023;115:109554.","journal-title":"Int Immunopharmacol"},{"key":"6266_CR44","doi-asserted-by":"publisher","first-page":"11097","DOI":"10.1038\/s41598-022-15482-2","volume":"12","author":"T Shi","year":"2022","unstructured":"Shi T, Huang L, Zhou Y, Tian J. Role of GBP1 in innate immunity and potential as a tuberculosis biomarker. Sci Rep. 2022;12:11097.","journal-title":"Sci Rep"},{"key":"6266_CR45","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1021\/acs.jproteome.7b00828","volume":"17","author":"C Huang","year":"2018","unstructured":"Huang C, Lewis C, Borg NA, Canals M, Diep H, Drummond GR. Proteomic identification of interferon-induced proteins with tetratricopeptide repeats as markers of m1 macrophage polarization. J Proteome Res. 2018;17:1485\u201399.","journal-title":"J Proteome Res"},{"key":"6266_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cellimm.2017.04.004","volume":"317","author":"X Xu","year":"2017","unstructured":"Xu X, Zhang J, Zhan S, Li Z, Liu X, Zhang H. TGF-\u03b21 improving abnormal pregnancy outcomes induced by Toxoplasma gondii infection: regulating NKG2D\/DAP10 and killer subset of decidual NK cells. Cell Immunol. 2017;317:9\u201317.","journal-title":"Cell Immunol"},{"key":"6266_CR47","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1600-0897.2011.01065.x","volume":"67","author":"H Zhang","year":"2012","unstructured":"Zhang H, Hu X, Liu X, Zhang R, Fu Q, Xu X. The Treg\/Th17 imbalance in Toxoplasma gondii-infected pregnant mice. Am J Reprod Immunol. 2012;67:112\u201321.","journal-title":"Am J Reprod Immunol"},{"key":"6266_CR48","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s10753-019-01075-1","volume":"42","author":"H Zhang","year":"2019","unstructured":"Zhang H, Cui L, Ren L, Liu X, Jiang Y, Yang C. The role of decidual PD-1+ Treg cells in adverse pregnancy outcomes due to Toxoplasma gondii infection. Inflammation. 2019;42:2119\u201328.","journal-title":"Inflammation"},{"key":"6266_CR49","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/08830185.2020.1777292","volume":"39","author":"X Li","year":"2020","unstructured":"Li X, Zhou J, Fang M, Yu B. Pregnancy immune tolerance at the maternal-fetal interface. Int Rev Immunol. 2020;39:247\u201363.","journal-title":"Int Rev Immunol"},{"key":"6266_CR50","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.biopha.2017.01.016","volume":"88","author":"M Ghaebi","year":"2017","unstructured":"Ghaebi M, Nouri M, Ghasemzadeh A, Farzadi L, Jadidi-Niaragh F, Ahmadi M. Immune regulatory network in successful pregnancy and reproductive failures. Biomed Pharmacother. 2017;88:61\u201373.","journal-title":"Biomed Pharmacother"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-024-06266-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13071-024-06266-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-024-06266-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:05:34Z","timestamp":1715335534000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-024-06266-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6266"],"URL":"https:\/\/doi.org\/10.1186\/s13071-024-06266-w","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]},"assertion":[{"value":"13 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The sample collection for this study was approved by the Ethics Committee of Binzhou Medical University (approval no.: 2017-016-01), and all voluntary abortions were obtained from Yantai Affiliated Hospital of Binzhou Medical University, Maternal and Child Health Care Hospital of Yantai Zhifu District, and Yantai Hospital of Traditional Chinese Medicine. Written informed consent was obtained from all the participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"213"}}