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Nanoparticles containing drugs have been widely utilized in various formulations for several purposes, including improving the bioavailability of drugs by increasing the solubility and dissolution rate of the nanoparticles. The purpose of this study was to evaluate the effects of solid lipid nanoparticles containing albendazole and conjugated to albumin (B-SLN\u2009+\u2009ABZ) as a novel treatment approach for hydatid cysts in vivo.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Albendazole-loaded solid lipid nanoparticles were prepared by emulsification and solvent evaporation method. The experimental mice were assessed for prophylactic and therapeutic effects of the drugs. Ultrastructural changes were observed by transmission electron microscopy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The variance analysis of the fitted model indicated that the Glyceryl monostearate (GMS)\/soy lecithin concentration ratio and the amount of albendazole had a significant effect on nanoparticle size. The GMS\/soy lecithin concentration ratio and the amount of albendazole had a notable effect on nanoparticle polydispersity index (PdI) and entrapment efficiency (EE%), respectively. During chemoprophylaxis, the B-SLN\u2009+\u2009ABZ group showed a lower number and weight of cysts (0.90\u2009\u00b1\u20090.73 and 15.01\u2009\u00b1\u200910.46, respectively) compared with the ABZ\u2009+\u2009SLN group (1.4\u2009\u00b1\u20090.51 and 26.73\u2009\u00b1\u20099.92, respectively). In addition, therapeutic efficacy analysis showed a significant reduction in wet weights of metacestodes in mice treated with both B-SLN\u2009+\u2009ABZ (29.37\u2009\u00b1\u200913.82\u00a0mg) and SLN\u2009+\u2009ABZ (35.88\u2009\u00b1\u20097.49\u00a0mg) compared with the control group (59.78\u2009\u00b1\u20093.80\u00a0mg).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The results showed that B-SLN\u2009+\u2009ABZ nanoparticles were more effective against <jats:italic>E.\u00a0granulosus<\/jats:italic> cysts compared with free ABZ. The cysts in the animals receiving B-SLN\u2009+\u2009ABZ every 24\u00a0h showed more ultrastructural changes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-024-06473-5","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T13:43:22Z","timestamp":1735307002000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cationized albumin conjugated solid lipid nanoparticles as vectors for delivery of albendazole against cystic echinococcosis"],"prefix":"10.1186","volume":"17","author":[{"given":"Fariba","family":"Faizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Mahjub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Torabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedmousa","family":"Motavallihaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Fallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"6473_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","volume":"17","author":"J Eckert","year":"2004","unstructured":"Eckert J, Deplazes P. 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