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This protein has been shown to play an important role in modulating host immune response. In this study we expressed <jats:italic>Eg<\/jats:italic>AgB as soluble recombinant protein in <jats:italic>E.\u00a0coli<\/jats:italic> (r<jats:italic>Eg<\/jats:italic>AgB) and explored its protective effect on sepsis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The sepsis model was established by cecal ligation and puncture (CLP) procedure in BALB\/c mice. The therapeutic effect of r<jats:italic>Eg<\/jats:italic>AgB on sepsis was performed by interperitoneally injecting 5\u00a0\u00b5g r<jats:italic>Eg<\/jats:italic>AgB in mice with CLP-induced sepsis and observing the 72\u00a0h survival rate after onset of sepsis. The proinflammatory cytokines [tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-6] and regulatory cytokines [IL-10, transforming growth factor beta\u00a0(TGF-\u03b2)] were measured in sera, and the histopathological change was observed in livers, kidneys, and lungs of septic mice treated with r<jats:italic>Eg<\/jats:italic>AgB compared with untreated mice. The effect of r<jats:italic>Eg<\/jats:italic>AgB on the macrophage polarization was performed in vitro by incubating r<jats:italic>Eg<\/jats:italic>AgB with peritoneal macrophages. The levels of TLR2 and MyD88 were measured in these tissues to determine the involvement of TLR-2\/MyD88 in the sepsis-induced inflammatory signaling pathway.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In vivo, we observed that treatment with r<jats:italic>Eg<\/jats:italic>AgB significantly increased the survival rate of mice with CLP-induced sepsis up to 72\u00a0h while all mice without treatment died within the same period. The increased survival was associated with reduced pathological damage in key organs such as liver, lung, and kidneys. It was supported by the reduced proinflammatory cytokine levels and increased regulatory cytokine expression in peripheral blood and key organ tissues. Further study identified that treatment with r<jats:italic>Eg<\/jats:italic>AgB promoted macrophage polarization from classically activated macrophage (M1) to regulatory M2-like macrophage via inhibiting TLR2\/MyD88 signal pathway.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The therapeutic effects of r<jats:italic>Eg<\/jats:italic>AgB on mice with sepsis was observed in a mice model that was associated with reduced inflammatory responses and increased regulatory responses, possibly through inducing polarization of macrophages from proinflammatory M1 to regulatory M2 phenotype through inhibiting TLR2\/MyD88 inflammatory pathway.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13071-024-06540-x","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:17:00Z","timestamp":1731665820000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic effect of recombinant Echinococcus granulosus antigen B subunit 2 protein on sepsis in a mouse model"],"prefix":"10.1186","volume":"17","author":[{"given":"Ya-Yun","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Fei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Di","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"6540_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4161\/viru.27372","volume":"5","author":"F Mayr","year":"2014","unstructured":"Mayr F, Yende S, Angus D. 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