{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:32:36Z","timestamp":1777984356826,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ourofino Sa\u00fade Animal LTDA"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      One of the most relevant parasitic mites is\n                      <jats:italic>Sarcoptes scabiei<\/jats:italic>\n                      , which causes sarcoptic mange, commonly known as scabies. This condition is highly contagious and leads to intense itching and skin lesions in dogs.\n                      <jats:italic>Otodectes cynotis<\/jats:italic>\n                      , the \u201cear mite,\u201d is immensely relevant as well, being the primary cause of external otitis in domestic carnivores, causing severe ear itching. The treatment and control of both these forms of mange rely on the use of antiparasitic compounds, such as fluralaner, which acts by paralyzing and killing arthropods. This study aimed to determine the acaricidal efficacy of WellPet\u2122 (Ourofino Sa\u00fade Animal Ltda.), a new commercial palatable tablet based on fluralaner, at a dose range of 10\u201322.5\u00a0mg\/kg, against\n                      <jats:italic>S.\u00a0scabiei<\/jats:italic>\n                      and\n                      <jats:italic>O.\u00a0cynotis<\/jats:italic>\n                      mites parasitizing naturally infested domestic dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two clinical studies evaluate the acaricide efficacy against each mite species in naturally infested animals. Each study utilizes 14 animals each, divided into a Control Group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), treated with a reference product on the basis of sarolaner (a palatable tablet based on sarolaner, 2.0\u20134.0\u00a0mg\/kg\u2014Zoetis Ind\u00fastria de Produtos Veterin\u00e1rios Ltda.), and a treated group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) treated with WellPet\u2122 (a palatable tablet based on fluralaner, 10\u201322.5\u00a0mg\/kg\u2014Ourofino Sa\u00fade Animal Ltda.). Acaricidal efficacy is assessed in both trials through mite counts and evaluation of lesions resulting from the diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Against\n                      <jats:italic>Sarcoptes scabiei<\/jats:italic>\n                      , WellPet\u2122 provided a significant reduction in mite counts from day 14 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) onward, reaching 100% efficacy by day 28 without need for retreatment. The control group showed significant reduction from day 7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) onward, but required retreatment to reach 100% efficacy by day 44. In the\n                      <jats:italic>Otodectes cynotis<\/jats:italic>\n                      trial, the WellPet\u2122 group showed significant reduction starting from day 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036), with 94.1% efficacy by day 14 and 100% from day 21 onward. The control group showed significant reduction starting from day 7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) and reached 100% efficacy by day 14.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The WellPet\u2122 product, a novel ectoparasiticide based on fluralaner, proved to be highly effective in the treatment of both sarcoptic and otodectic mange, with results similar to those of sarolaner, the only isoxazoline, at the time of these trials, registered in Brazil for controlling these mites. The main advantage observed for WellPet\u2122 is the ability to achieve complete cure of sarcoptic mange with a single dose, thereby simplifying disease management. For otodectic mange, both products were highly effective. Further trials must still be conducted to corroborate these initial findings, but in summary, data presented here indicates that WellPet\u2122 is an effective and practical treatment option for sarcoptic and otodectic mange in dogs with a single administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13071-026-07279-3","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T11:04:03Z","timestamp":1771758243000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of a fluralaner-based ectoparasiticide for the control of otodectic and sarcoptic mange in naturally infested dogs, evaluated in randomized, double-blind clinical studies"],"prefix":"10.1186","volume":"19","author":[{"given":"Breno Cayeiro","family":"Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Belucci","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gessica Ariane","family":"de Melo Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Aparecida","family":"do Carmo Emidio Moreira da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milenni Garcia","family":"Michels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Della Nina","family":"Pistoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Antonio Martins","family":"Buso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando Nielsen","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Renan Honorato","family":"Gatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"7279_CR1","volume-title":"Dermatologia de pequenos animais: atlas colorido e guia terap\u00eautico","author":"KA Hnilica","year":"2018","unstructured":"Hnilica KA, Patterson AP. 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The sarcoptic mange study was approved under protocol number 011.20\/23 and the otodectic mange study under protocol number 010.20\/23, both approved by the Animal Use Ethics Committee (CEUA) of CTA during the meeting held on 5 December 2023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"BCC, MBT, GAMC, JACEMS, MGMM, CDNP, MAMB, FNA, AND IRHG are employees of Ourofino Sa\u00fade Animal Ltda.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"107"}}