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The study was approved by Universidade Federal de Mato Grosso (23108.954157\/2018-91) and Universidade Federal do Maranhao Institutional (CIAEP: 01.0341.2014) Animal Care and Use Committees (IACUC) with the concurrence of Boehringer Ingelheim.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have reviewed this document and consent to publish the data.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A.C, L.P and E.T. are employees of Boehringer Ingelheim, manufacturer of the investigated products (NexGard\n                      \u00ae\n                      and NexGard Spectra\u00ae) and sponsor of this study.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"418"}}