{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T14:56:29Z","timestamp":1794236189368,"version":"4.9.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["AP1141361"],"award-info":[{"award-number":["AP1141361"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1042677"],"award-info":[{"award-number":["APP1042677"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epigenetics &amp; Chromatin"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13072-018-0247-4","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T23:18:01Z","timestamp":1546471081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination"],"prefix":"10.1186","volume":"12","author":[{"given":"Dimitrios","family":"Cakouros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hemming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahlia","family":"Gronthos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Zannettino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-3084","authenticated-orcid":false,"given":"Stan","family":"Gronthos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"issue":"4","key":"247_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):13.","journal-title":"Cell"},{"issue":"5929","key":"247_CR2","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1126\/science.1170116","volume":"324","author":"M Tahiliani","year":"2009","unstructured":"Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324(5929):930\u20135.","journal-title":"Science"},{"issue":"19","key":"247_CR3","doi-asserted-by":"publisher","first-page":"e181","DOI":"10.1093\/nar\/gkq684","volume":"38","author":"A Szwagierczak","year":"2010","unstructured":"Szwagierczak A, Bultmann S, Schmidt CS, Spada F, Leonhardt H. Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res. 2010;38(19):e181.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"247_CR4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1365-2443.2007.01058.x","volume":"12","author":"N Hattori","year":"2007","unstructured":"Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, Yagi S, Tanaka S, Shiota K. Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes Cells. 2007;12(3):387\u201396.","journal-title":"Genes Cells"},{"issue":"7310","key":"247_CR5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/nature09303","volume":"466","author":"S Ito","year":"2010","unstructured":"Ito S, D\u2019Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010;466(7310):1129\u201333.","journal-title":"Nature"},{"issue":"8","key":"247_CR6","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1016\/j.celrep.2015.10.037","volume":"13","author":"Z Zhao","year":"2015","unstructured":"Zhao Z, Chen L, Dawlaty MM, Pan F, Weeks O, Zhou Y, Cao Z, Shi H, Wang J, Lin L, et al. Combined loss of Tet1 and Tet2 promotes B cell, but not myeloid malignancies, in mice. Cell Rep. 2015;13(8):1692\u2013704.","journal-title":"Cell Rep"},{"issue":"22","key":"247_CR7","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","volume":"360","author":"F Delhommeau","year":"2009","unstructured":"Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, Kosmider O, Le Couedic JP, Robert F, Alberdi A, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289\u2013301.","journal-title":"N Engl J Med"},{"issue":"3","key":"247_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3960\/jslrt.55.145","volume":"55","author":"K Shimoda","year":"2015","unstructured":"Shimoda K, Shide K, Kameda T, Hidaka T, Kubuki Y, Kamiunten A, Sekine M, Akizuki K, Shimoda H, Yamaji T, et al. TET2 mutation in adult T-cell leukemia\/lymphoma. J Clin Exp Hematop. 2015;55(3):145\u20139.","journal-title":"J Clin Exp Hematop"},{"issue":"1","key":"247_CR9","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1038\/s41467-018-04464-6","volume":"9","author":"R Yang","year":"2018","unstructured":"Yang R, Yu T, Kou X, Gao X, Chen C, Liu D, Zhou Y, Shi S. Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter. Nat Commun. 2018;9(1):2143.","journal-title":"Nat Commun"},{"issue":"18","key":"247_CR10","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.113.002887","volume":"128","author":"R Liu","year":"2013","unstructured":"Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation. 2013;128(18):2047\u201357.","journal-title":"Circulation"},{"issue":"2","key":"247_CR11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.immuni.2015.07.017","volume":"43","author":"R Yang","year":"2015","unstructured":"Yang R, Qu C, Zhou Y, Konkel JE, Shi S, Liu Y, Chen C, Liu S, Liu D, Chen Y, et al. Hydrogen sulfide promotes Tet1- and Tet2-mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis. Immunity. 2015;43(2):251\u201363.","journal-title":"Immunity"},{"issue":"3","key":"247_CR12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.devcel.2012.12.015","volume":"24","author":"MM Dawlaty","year":"2013","unstructured":"Dawlaty MM, Breiling A, Le T, Raddatz G, Barrasa MI, Cheng AW, Gao Q, Powell BE, Li Z, Xu M, et al. Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell. 2013;24(3):310\u201323.","journal-title":"Dev Cell"},{"issue":"1","key":"247_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.devcel.2014.03.003","volume":"29","author":"MM Dawlaty","year":"2014","unstructured":"Dawlaty MM, Breiling A, Le T, Barrasa MI, Raddatz G, Gao Q, Powell BE, Cheng AW, Faull KF, Lyko F, et al. Loss of Tet enzymes compromises proper differentiation of embryonic stem cells. Dev Cell. 2014;29(1):102\u201311.","journal-title":"Dev Cell"},{"issue":"4","key":"247_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.stem.2013.02.005","volume":"12","author":"Y Gao","year":"2013","unstructured":"Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell. 2013;12(4):453\u201369.","journal-title":"Cell Stem Cell"},{"key":"247_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-3-642-67319-1_3","volume-title":"Immunology of bone marrow transplantation","author":"A Friedenstein","year":"1980","unstructured":"Friedenstein A. Stromal mechanocytes of bone marrow: cloning in vitro and retransplantation in vivo. In: Thiernfelder S, editor. Immunology of bone marrow transplantation. Berlin: Springer; 1980. p. 19."},{"issue":"5411","key":"247_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143\u20137.","journal-title":"Science"},{"key":"247_CR17","first-page":"42","volume":"136","author":"M Owen","year":"1988","unstructured":"Owen M, Friedenstein A. Marrow-derived osteogenic precursors. CIba Found Symp. 1988;136:42\u201360.","journal-title":"CIba Found Symp"},{"key":"247_CR18","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1242\/jcs.00369","volume":"116","author":"S Gronthos","year":"2003","unstructured":"Gronthos S, Zannettino A, Hay S. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003;116:1827\u201335.","journal-title":"J Cell Sci"},{"issue":"2","key":"247_CR19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","volume":"131","author":"B Sacchetti","year":"2007","unstructured":"Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007;131(2):324\u201336.","journal-title":"Cell"},{"issue":"7","key":"247_CR20","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s13059-014-0422-2","volume":"15","author":"A Nayak","year":"2014","unstructured":"Nayak A, Muller S. SUMO-specific proteases\/isopeptidases: SENPs and beyond. Genome Biol. 2014;15(7):422.","journal-title":"Genome Biol"},{"key":"247_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1573","author":"S Hemming","year":"2013","unstructured":"Hemming S, Cakouros D, Isenmann S, Cooper L, Menicanin D, Zannettino AC, Gronthos S. EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification. Stem Cells. 2013. \n                    https:\/\/doi.org\/10.1002\/stem.1573\n                    \n                  .","journal-title":"Stem Cells"},{"issue":"1","key":"247_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.stem.2012.04.009","volume":"11","author":"L Ye","year":"2012","unstructured":"Ye L, Fan Z, Yu B, Chang J, Al Hezaimi K, Zhou X, Park N, Wang C. Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell. 2012;11(1):11.","journal-title":"Cell Stem Cell"},{"key":"247_CR23","doi-asserted-by":"publisher","first-page":"13418","DOI":"10.1038\/srep13418","volume":"5","author":"F Zhang","year":"2015","unstructured":"Zhang F, Xu L, Xu L, Xu Q, Karsenty G, Chen CD. Histone demethylase JMJD3 is required for osteoblast differentiation in mice. Sci Rep. 2015;5:13418.","journal-title":"Sci Rep"},{"issue":"1","key":"247_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/jmcb\/mjv003","volume":"7","author":"F Zhang","year":"2015","unstructured":"Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen CD. JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol. 2015;7(1):23\u201334.","journal-title":"J Mol Cell Biol"},{"key":"247_CR25","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","volume":"89","author":"T Komori","year":"1997","unstructured":"Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson R, Gao Y, Inada M, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89:755\u201364.","journal-title":"Cell"},{"issue":"5","key":"247_CR26","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","volume":"89","author":"P Ducy","year":"1997","unstructured":"Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89(5):747\u201354.","journal-title":"Cell"},{"issue":"7","key":"247_CR27","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","volume":"79","author":"P Tontonoz","year":"1994","unstructured":"Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79(7):1147\u201356.","journal-title":"Cell"},{"issue":"5\u20136","key":"247_CR28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/1947601913489020","volume":"4","author":"PF Cartron","year":"2013","unstructured":"Cartron PF, Nadaradjane A, Lepape F, Lalier L, Gardie B, Vallette FM. Identification of TET1 partners that control its DNA-demethylating function. Genes Cancer. 2013;4(5\u20136):235\u201341.","journal-title":"Genes Cancer"},{"issue":"10","key":"247_CR29","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1002\/stem.181","volume":"27","author":"S Isenmann","year":"2009","unstructured":"Isenmann S, Arthur A, Zannettino A, Turner J, Shi S, Glackin C, Gronthos S. Twist family of basic-helix\u2013loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem Cells. 2009;27(10):2457\u201368.","journal-title":"Stem Cells"},{"issue":"3","key":"247_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1530\/JME-12-0003","volume":"48","author":"S Fitter","year":"2012","unstructured":"Fitter S, Vandyke K, Gronthos S, Zannettino AC. Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion. J Mol Endocrinol. 2012;48(3):229\u201340.","journal-title":"J Mol Endocrinol"},{"issue":"3","key":"247_CR31","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/stem.1573","volume":"32","author":"S Hemming","year":"2014","unstructured":"Hemming S, Cakouros D, Isenmann S, Cooper L, Menicanin D, Zannettino A, Gronthos S. EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification. Stem Cells. 2014;32(3):802\u201315.","journal-title":"Stem Cells"},{"key":"247_CR32","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1089\/scd.2014.0471","volume":"24","author":"D Cakouros","year":"2015","unstructured":"Cakouros D, Isenmann S, Hemming SE, Menicanin D, Camp E, Zannettino AC, Gronthos S. Novel basic helix loop helix transcription factor Hes4 antagonizes the function of twist-1 to regulate lineage commitment of bone marrow stromal\/stem cells. Stem Cells Dev. 2015;24:1297\u2013308.","journal-title":"Stem Cells Dev"},{"issue":"8","key":"247_CR33","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1128\/MCB.06315-11","volume":"32","author":"D Cakouros","year":"2012","unstructured":"Cakouros D, Isenmann S, Cooper L, Zannettino A, Anderson P, Glackin C, Gronthos S. Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A\/Arf locus in mesenchymal stem cells. Mol Cell Biol. 2012;32(8):8.","journal-title":"Mol Cell Biol"},{"issue":"7","key":"247_CR34","doi-asserted-by":"publisher","first-page":"e2615","DOI":"10.1371\/journal.pone.0002615","volume":"3","author":"T Yamaza","year":"2008","unstructured":"Yamaza T, Miura Y, Bi Y, Liu Y, Akiyama K, Sonoyama W, Patel V, Gutkind Young M, Gronthos S, et al. Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. Plos One. 2008;3(7):e2615.","journal-title":"Plos One"},{"issue":"3","key":"247_CR35","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1096\/fj.201600748R","volume":"31","author":"S Hemming","year":"2017","unstructured":"Hemming S, Cakouros D, Codrington J, Vandyke K, Arthur A, Zannettino A, Gronthos S. EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture and structural integrity and accelerates remodeling. FASEB J. 2017;31(3):1011\u201327.","journal-title":"FASEB J"},{"issue":"9","key":"247_CR36","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1002\/stem.2069","volume":"33","author":"TM Nguyen","year":"2015","unstructured":"Nguyen TM, Arthur A, Panagopoulos R, Paton S, Hayball JD, Zannettino AC, Purton LE, Matsuo K, Gronthos S. EphB4 expressing stromal cells exhibit an enhanced capacity for hematopoietic stem cell maintenance. Stem Cells. 2015;33(9):2838\u201349.","journal-title":"Stem Cells"},{"issue":"7","key":"247_CR37","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1359\/jbmr.1999.14.7.1115","volume":"14","author":"G D\u2019Ippolito","year":"1999","unstructured":"D\u2019Ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA. Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res. 1999;14(7):1115\u201322.","journal-title":"J Bone Miner Res"},{"issue":"8","key":"247_CR38","doi-asserted-by":"publisher","first-page":"R91","DOI":"10.1186\/gb-2013-14-8-r91","volume":"14","author":"F Neri","year":"2013","unstructured":"Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S. Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol. 2013;14(8):R91.","journal-title":"Genome Biol"},{"issue":"5","key":"247_CR39","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/emboj.2012.357","volume":"32","author":"R Deplus","year":"2013","unstructured":"Deplus R, Delatte B, Schwinn MK, Defrance M, Mendez J, Murphy N, Dawson MA, Volkmar M, Putmans P, Calonne E, et al. TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1\/COMPASS. EMBO J. 2013;32(5):645\u201355.","journal-title":"EMBO J"},{"issue":"7347","key":"247_CR40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature10066","volume":"473","author":"K Williams","year":"2011","unstructured":"Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA, Rappsilber J, Helin K. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011;473(7347):343\u20138.","journal-title":"Nature"},{"issue":"4","key":"247_CR41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.molcel.2011.04.005","volume":"42","author":"Y Xu","year":"2011","unstructured":"Xu Y, Wu F, Tan L, Kong L, Xiong L, Deng J, Barbera AJ, Zheng L, Zhang H, Huang S, et al. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell. 2011;42(4):451\u201364.","journal-title":"Mol Cell"},{"issue":"6","key":"247_CR42","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.molcel.2008.05.007","volume":"30","author":"F Mohn","year":"2008","unstructured":"Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, Stadler MB, Bibel M, Schubeler D. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell. 2008;30(6):755\u201366.","journal-title":"Mol Cell"},{"issue":"7","key":"247_CR43","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1101\/gad.2036011","volume":"25","author":"H Wu","year":"2011","unstructured":"Wu H, D\u2019Alessio AC, Ito S, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 2011;25(7):679\u201384.","journal-title":"Genes Dev"},{"issue":"2","key":"247_CR44","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.stem.2011.01.008","volume":"8","author":"KP Koh","year":"2011","unstructured":"Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, et al. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011;8(2):200\u201313.","journal-title":"Cell Stem Cell"},{"issue":"5","key":"247_CR45","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s13238-016-0267-4","volume":"7","author":"J Gao","year":"2016","unstructured":"Gao J, Ma Y, Fu HL, Luo Q, Wang Z, Xiao YH, Yang H, Cui DX, Jin WL. Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells. Protein Cell. 2016;7(5):351\u201361.","journal-title":"Protein Cell"},{"issue":"2","key":"247_CR46","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.stem.2011.07.010","volume":"9","author":"MM Dawlaty","year":"2011","unstructured":"Dawlaty MM, Ganz K, Powell BE, Hu YC, Markoulaki S, Cheng AW, Gao Q, Kim J, Choi SW, Page DC, et al. Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell. 2011;9(2):166\u201375.","journal-title":"Cell Stem Cell"},{"issue":"51","key":"247_CR47","doi-asserted-by":"publisher","first-page":"E8267","DOI":"10.1073\/pnas.1617802113","volume":"113","author":"X Li","year":"2016","unstructured":"Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans SM, Rao A. Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proc Natl Acad Sci USA. 2016;113(51):E8267\u201376.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"247_CR48","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/ijo.2017.8","volume":"41","author":"Y Yoo","year":"2017","unstructured":"Yoo Y, Park JH, Weigel C, Liesenfeld DB, Weichenhan D, Plass C, Seo DG, Lindroth AM, Park YJ. TET-mediated hydroxymethylcytosine at the Ppargamma locus is required for initiation of adipogenic differentiation. Int J Obes. 2017;41(4):652\u20139.","journal-title":"Int J Obes"},{"issue":"20","key":"247_CR49","doi-asserted-by":"publisher","first-page":"e00177","DOI":"10.1128\/MCB.00177-17","volume":"37","author":"H Sepulveda","year":"2017","unstructured":"Sepulveda H, Villagra A, Montecino M. Tet-mediated DNA demethylation is required for SWI\/SNF-dependent chromatin remodeling and histone-modifying activities that trigger expression of the Sp7 osteoblast master gene during mesenchymal lineage commitment. Mol Cell Biol. 2017;37(20):e00177.","journal-title":"Mol Cell Biol"},{"key":"247_CR50","doi-asserted-by":"publisher","first-page":"15903","DOI":"10.1038\/ncomms15903","volume":"8","author":"X Li","year":"2017","unstructured":"Li X, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, et al. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nat Commun. 2017;8:15903.","journal-title":"Nat Commun"},{"issue":"2","key":"247_CR51","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1093\/nar\/gkw919","volume":"45","author":"J Zhong","year":"2017","unstructured":"Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, Zhang J, Wu N, Li Y, Mao F, et al. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Res. 2017;45(2):672\u201384.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"247_CR52","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.molcel.2014.08.026","volume":"56","author":"GC Hon","year":"2014","unstructured":"Hon GC, Song CX, Du T, Jin F, Selvaraj S, Lee AY, Yen CA, Ye Z, Mao SQ, Wang BA, et al. 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation. Mol Cell. 2014;56(2):286\u201397.","journal-title":"Mol Cell"},{"issue":"3","key":"247_CR53","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/jbmr.2711","volume":"31","author":"SE Taylor","year":"2016","unstructured":"Taylor SE, Li YH, Smeriglio P, Rath M, Wong WH, Bhutani N. Stable 5-hydroxymethylcytosine (5hmC) acquisition marks gene activation during chondrogenic differentiation. J Bone Miner Res Off J Am Soc Bone Miner Res. 2016;31(3):524\u201334.","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"2","key":"247_CR54","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/ijos.2016.4","volume":"8","author":"LJ Rao","year":"2016","unstructured":"Rao LJ, Yi BC, Li QM, Xu Q. TET1 knockdown inhibits the odontogenic differentiation potential of human dental pulp cells. Int J Oral Sci. 2016;8(2):110\u20136.","journal-title":"Int J Oral Sci"},{"issue":"7347","key":"247_CR55","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature09934","volume":"473","author":"H Wu","year":"2011","unstructured":"Wu H, D\u2019Alessio AC, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011;473(7347):389\u201393.","journal-title":"Nature"},{"issue":"17","key":"247_CR56","doi-asserted-by":"publisher","first-page":"8255","DOI":"10.1093\/nar\/gks595","volume":"40","author":"AA Serandour","year":"2012","unstructured":"Serandour AA, Avner S, Oger F, Bizot M, Percevault F, Lucchetti-Miganeh C, Palierne G, Gheeraert C, Barloy-Hubler F, Peron CL, et al. Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic Acids Res. 2012;40(17):8255\u201365.","journal-title":"Nucleic Acids Res"},{"issue":"7347","key":"247_CR57","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature10102","volume":"473","author":"WA Pastor","year":"2011","unstructured":"Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 2011;473(7347):394\u20137.","journal-title":"Nature"},{"issue":"1","key":"247_CR58","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.stem.2014.03.005","volume":"15","author":"Y Liu","year":"2014","unstructured":"Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, Wang S, Zandi E, Du J, Ambudkar IS, et al. Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2\u2009+) channel sulfhydration. Cell Stem Cell. 2014;15(1):66\u201378.","journal-title":"Cell Stem Cell"}],"container-title":["Epigenetics &amp; Chromatin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-018-0247-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13072-018-0247-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-018-0247-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T19:08:46Z","timestamp":1577992126000},"score":1,"resource":{"primary":{"URL":"https:\/\/epigeneticsandchromatin.biomedcentral.com\/articles\/10.1186\/s13072-018-0247-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["247"],"URL":"https:\/\/doi.org\/10.1186\/s13072-018-0247-4","relation":{},"ISSN":["1756-8935"],"issn-type":[{"value":"1756-8935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,3]]},"assertion":[{"value":"8 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}