{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:19:37Z","timestamp":1791983977180,"version":"4.4.0"},"reference-count":173,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["0229\/DIA\/2015\/44"],"award-info":[{"award-number":["0229\/DIA\/2015\/44"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2016\/23\/N\/NZ1\/01138"],"award-info":[{"award-number":["UMO-2016\/23\/N\/NZ1\/01138"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010408","name":"Polpharma Scientific Foundation","doi-asserted-by":"publisher","award":["5\/XVII\/18"],"award-info":[{"award-number":["5\/XVII\/18"]}],"id":[{"id":"10.13039\/501100010408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epigenetics &amp; Chromatin"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    BRM (BRAHMA) is a core, SWI2\/SNF2-type ATPase subunit of SWI\/SNF chromatin-remodelling complex (CRC) involved in various important regulatory processes including development. Mutations in\n                    <jats:italic>SMARCA2<\/jats:italic>\n                    , a BRM-encoding gene as well as overexpression or epigenetic silencing were found in various human diseases including cancer. Missense mutations in\n                    <jats:italic>SMARCA2<\/jats:italic>\n                    gene were recently connected with occurrence of Nicolaides\u2013Baraitser genetics syndrome. By contrast,\n                    <jats:italic>SMARCA2<\/jats:italic>\n                    duplication rather than mutations is characteristic for Coffin\u2013Siris syndrome. It is believed that BRM usually acts as a tumour suppressor or a tumour susceptibility gene. However, other studies provided evidence that BRM function may differ depending on the cancer type and the disease stage, where BRM may play a role in the disease progression. The existence of alternative splicing forms of\n                    <jats:italic>SMARCA2<\/jats:italic>\n                    gene, leading to appearance of truncated functional, loss of function or gain-of-function forms of BRM protein suggest a far more complicated mode of BRM-containing SWI\/SNF CRCs actions. Therefore, the summary of recent knowledge regarding BRM alteration in various types of cancer and highlighting of differences and commonalities between BRM and BRG1, another SWI2\/SNF2 type ATPase, will lead to better understanding of SWI\/SNF CRCs function in cancer development\/progression. BRM has been recently proposed as an attractive target for various anticancer therapies including the use of small molecule inhibitors, synthetic lethality induction or proteolysis-targeting chimera (PROTAC). However, such attempts have some limitations and may lead to severe side effects given the homology of BRM ATPase domain to other ATPases, as well as due to the tissue-specific appearance of BRM- and BRG1-containing SWI\/SNF CRC classes. Thus, a better insight into BRM-containing SWI\/SNF CRCs function in human tissues and cancers is clearly required to provide a solid basis for establishment of new safe anticancer therapies.\n                  <\/jats:p>","DOI":"10.1186\/s13072-019-0315-4","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T01:03:10Z","timestamp":1573606990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["BRM: the core ATPase subunit of SWI\/SNF chromatin-remodelling complex\u2014a tumour suppressor or tumour-promoting factor?"],"prefix":"10.1186","volume":"12","author":[{"given":"Iga","family":"Jancewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz A.","family":"Siedlecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-2039","authenticated-orcid":false,"given":"Tomasz J.","family":"Sarnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Sarnowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"315_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1006\/jmbi.1999.2999","volume":"293","author":"C Muchardt","year":"1999","unstructured":"Muchardt C, Yaniv M. ATP-dependent chromatin remodelling: SWI\/SNF and Co. are on the job. J Mol Biol. 1999;293:187\u201398.","journal-title":"J Mol Biol."},{"key":"315_CR2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/genetics\/87.1.33","volume":"87","author":"JE Haber","year":"1977","unstructured":"Haber JE, Garvik B. A new gene affecting the efficiency of mating-type interconversions in homothallic strains of Saccharomyces cerevisiae. Genetics. 1977;87:33\u201350.","journal-title":"Genetics."},{"key":"315_CR3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/genetics\/98.1.25","volume":"98","author":"M Carlson","year":"1981","unstructured":"Carlson M, Osmond BC, Botstein D. Mutants of yeast defective in sucrose utilization. Genetics. 1981;98:25\u201340.","journal-title":"Genetics"},{"key":"315_CR4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/genetics\/108.4.845","volume":"108","author":"L Neigeborn","year":"1984","unstructured":"Neigeborn L, Carlson M. Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics. 1984;108:845\u201358.","journal-title":"Genetics."},{"key":"315_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/0092-8674(92)90192-F","volume":"68","author":"CL Peterson","year":"1992","unstructured":"Peterson CL, Herskowitz I. Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell. 1992;68:573\u201383.","journal-title":"Cell"},{"key":"315_CR6","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1093\/nar\/22.10.1815","volume":"22","author":"H Chiba","year":"1994","unstructured":"Chiba H, Muramatsu M, Nomoto A, Kato H. Two human homologues of saccharomyces cerevisiae SWI2\/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Nucleic Acids Res. 1994;22:1815\u201320.","journal-title":"Nucleic Acids Res"},{"key":"315_CR7","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1038\/sj.onc.1204331","volume":"20","author":"C Muchardt","year":"2001","unstructured":"Muchardt C, Yaniv M. When the SWI\/SNF complex remodels the cell cycle. Oncogene. 2001;20:3067\u201375.","journal-title":"Oncogene."},{"key":"315_CR8","doi-asserted-by":"publisher","first-page":"3986","DOI":"10.1038\/sj.emboj.7601291","volume":"25","author":"JH Park","year":"2006","unstructured":"Park JH, Park EJ, Lee HS, Kim SJ, Hur SK, et al. Mammalian SWI\/SNF complexes facilitate DNA double-strand break repair by promoting \u03b3-H2AX induction. EMBO J. 2006;25:3986\u201397.","journal-title":"EMBO J"},{"key":"315_CR9","doi-asserted-by":"publisher","first-page":"e1002008","DOI":"10.1371\/journal.pgen.1002008","volume":"7","author":"GM Euskirchen","year":"2011","unstructured":"Euskirchen GM, Auerbach RK, Davidov E, Gianoulis TA, Zhong G, et al. Diverse roles and interactions of the SWI\/SNF chromatin remodeling complex revealed using global approaches. PLoS Genet. 2011;7:e1002008.","journal-title":"PLoS Genet."},{"key":"315_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13072-019-0264-y","volume":"12","author":"A Alfert","year":"2019","unstructured":"Alfert A, Moreno N, Kerl K. The BAF complex in development and disease. Epigenet Chromatin. 2019;12:19.","journal-title":"Epigenet Chromatin."},{"key":"315_CR11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.cell.2009.01.009","volume":"136","author":"JI Wu","year":"2009","unstructured":"Wu JI, Lessard J, Crabtree GR. Understanding the words of chromatin regulation. Cell. 2009;136:200\u20136.","journal-title":"Cell"},{"key":"315_CR12","doi-asserted-by":"publisher","first-page":"5370","DOI":"10.1002\/j.1460-2075.1996.tb00921.x","volume":"15","author":"W Wang","year":"1996","unstructured":"Wang W, C\u00f4t\u00e9 J, Xue Y, Zhou S, Khavari PA, et al. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996;15:5370\u201382.","journal-title":"EMBO J"},{"key":"315_CR13","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S1097-2765(00)80315-9","volume":"3","author":"ML Phelan","year":"1999","unstructured":"Phelan ML, Sif S, Narlikar GJ, Kingston RE. Reconstitution of a core chromatin remodeling complex from SWI\/SNF subunits. Mol Cell. 1999;3:247\u201353.","journal-title":"Mol Cell"},{"issue":"1272\u20131288","key":"315_CR14","first-page":"e20","volume":"175","author":"N Mashtalir","year":"2018","unstructured":"Mashtalir N, D\u2019Avino AR, Michel BC, Luo J, Pan J, et al. Modular organization and assembly of SWI\/SNF family chromatin remodeling complexes. Cell. 2018;175(1272\u20131288):e20.","journal-title":"Cell"},{"key":"315_CR15","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1074\/jbc.RA117.001065","volume":"293","author":"A Alpsoy","year":"2018","unstructured":"Alpsoy A, Dykhuizen EC. Glioma tumor suppressor candidate region gene 1 (GLTSCR15) and its paralog GLTSCR15-like form SWI\/SNF chromatin remodeling subcomplexes. J Biol Chem. 2018;293:3892\u2013903.","journal-title":"J Biol Chem"},{"key":"315_CR16","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1038\/s41467-018-07528-9","volume":"9","author":"J Gatchalian","year":"2018","unstructured":"Gatchalian J, Malik S, Ho J, Lee D-S, Kelso TWR, et al. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018;9:5139.","journal-title":"Nat Commun."},{"key":"315_CR17","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1073\/pnas.1000398107","volume":"107","author":"Y Lorch","year":"2010","unstructured":"Lorch Y, Maier-Davis B, Kornberg RD. Mechanism of chromatin remodeling. Proc Natl Acad Sci USA. 2010;107:3458\u201362.","journal-title":"Proc Natl Acad Sci USA."},{"key":"315_CR18","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.cell.2013.07.011","volume":"154","author":"GJ Narlikar","year":"2013","unstructured":"Narlikar GJ, Sundaramoorthy R, Owen-Hughes T. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes. Cell. 2013;154:490\u2013503.","journal-title":"Cell"},{"key":"315_CR19","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.tplants.2016.01.017","volume":"21","author":"EA Sarnowska","year":"2016","unstructured":"Sarnowska EA, Gratkowska DM, Sacharowski SP, Cwiek P, Tohge T, et al. The role of SWI\/SNF chromatin remodeling complexes in hormone crosstalk. Trends Plant Sci. 2016;21:594\u2013608.","journal-title":"Trends Plant Sci"},{"key":"315_CR20","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1093\/emboj\/cdg219","volume":"22","author":"Z Huang","year":"2003","unstructured":"Huang Z, Li J, Sachs LM, Cole PA, Wong J. A role for cofactor\u2013cofactor and cofactor\u2013histone interactions in targeting p300, SWI\/SNF and Mediator for transcription. EMBO J. 2003;22:2146\u201355.","journal-title":"EMBO J."},{"key":"315_CR21","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.bbagrm.2012.02.019","volume":"1819","author":"HA King","year":"2012","unstructured":"King HA, Trotter KW, Archer TK. Chromatin remodeling during glucocorticoid receptor regulated transactivation. Biochim Biophys Acta Gene Regul Mech. 2012;1819:716\u201326.","journal-title":"Biochim Biophys Acta Gene Regul Mech."},{"key":"315_CR22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1101\/gad.872801","volume":"15","author":"S Sif","year":"2001","unstructured":"Sif S, Saurin AJ, Imbalzano AN, Kingston RE. Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Genes Dev. 2001;15:603\u201318.","journal-title":"Genes Dev"},{"key":"315_CR23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S1097-2765(03)00034-0","volume":"11","author":"S Kadam","year":"2003","unstructured":"Kadam S, Emerson BM. Transcriptional specificity of human SWI\/SNF BRG1 and BRM chromatin remodeling complexes. Mol Cell. 2003;11:377\u201389.","journal-title":"Mol Cell"},{"key":"315_CR24","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/S1097-2765(00)00127-1","volume":"6","author":"S Bultman","year":"2000","unstructured":"Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, et al. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI\/SNF complexes. Mol Cell. 2000;6:1287\u201395.","journal-title":"Mol Cell"},{"key":"315_CR25","doi-asserted-by":"publisher","first-page":"6979","DOI":"10.1093\/emboj\/17.23.6979","volume":"17","author":"JC Reyes","year":"1998","unstructured":"Reyes JC, Barra J, Muchardt C, Camus A, Babinet C, et al. Altered control of cellular proliferation in the absence of mammalian brahma (SNF2\u03b1). EMBO J. 1998;17:6979\u201391.","journal-title":"EMBO J"},{"key":"315_CR26","doi-asserted-by":"publisher","first-page":"7058","DOI":"10.1038\/sj.onc.1210514","volume":"26","author":"S Glaros","year":"2007","unstructured":"Glaros S, Cirrincione GM, Muchardt C, Kleer CG, Michael CW, et al. The reversible epigenetic silencing of BRM: implications for clinical targeted therapy. Oncogene. 2007;26:7058\u201366.","journal-title":"Oncogene"},{"key":"315_CR27","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s11306-015-0786-7","volume":"11","author":"R Banerjee","year":"2015","unstructured":"Banerjee R, Bultman SJ, Holley D, Hillhouse C, Bain JR, et al. Non-targeted metabolomics of Brg1\/Brm double-mutant cardiomyocytes reveals a novel role for SWI\/SNF complexes in metabolic homeostasis. Metabolomics. 2015;11:1287\u2013301.","journal-title":"Metabolomics"},{"key":"315_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1089\/dna.2015.3155","volume":"35","author":"S Sinha","year":"2016","unstructured":"Sinha S, Verma S, Chaturvedi MM. Differential expression of SWI\/SNF chromatin remodeler subunits brahma and brahma-related gene during drug-induced liver injury and regeneration in mouse model. DNA Cell Biol. 2016;35:373\u201384.","journal-title":"DNA Cell Biol"},{"key":"315_CR29","doi-asserted-by":"publisher","first-page":"349","DOI":"10.18632\/oncoscience.153","volume":"2","author":"K Thompson","year":"2015","unstructured":"Thompson K, Marquez SB, Lu L, Reisman D. Induction of functional Brm protein from Brm knockout mice. Oncoscience. 2015;2:349.","journal-title":"Oncoscience."},{"key":"315_CR30","doi-asserted-by":"publisher","first-page":"386","DOI":"10.7150\/jca.2.386","volume":"2","author":"M Yang","year":"2011","unstructured":"Yang M, Sun Y, Ma L, Wang C, Wu J, et al. Complex alternative splicing of the Smarca2 gene suggests the importance of Smarca2-B variants. J Cancer. 2011;2:386\u2013400.","journal-title":"J Cancer."},{"key":"315_CR31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.18632\/oncoscience.323","volume":"3","author":"SB Marquez-Vilendrer","year":"2016","unstructured":"Marquez-Vilendrer SB, Rai SK, Gramling SJB, Lu L. Loss of the SWI\/SNF ATPase subunits BRM and BRG1 drives lung cancer development. Oncoscience. 2016;3:322\u201336.","journal-title":"Oncoscience."},{"key":"315_CR32","first-page":"112","volume":"9","author":"H Kobayashi","year":"2018","unstructured":"Kobayashi H, Kawahara N, Ogawa K, Yamada Y, Iwai K, et al. Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary. Biomed Rep. 2018;9:112\u20138.","journal-title":"Biomed Rep."},{"key":"315_CR33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/ajmg.c.31415","volume":"166","author":"T Kosho","year":"2014","unstructured":"Kosho T, Miyake N, Carey JC. Coffin\u2013Siris syndrome and related disorders involving components of the BAF (mSWI\/SNF) complex: historical review and recent advances using next generation sequencing. Am J Med Genet Part C Semin Med Genet. 2014;166:241\u201351.","journal-title":"Am J Med Genet Part C Semin Med Genet."},{"key":"315_CR34","first-page":"1","volume":"2","author":"F Sekiguchi","year":"2019","unstructured":"Sekiguchi F, Tsurusaki Y, Okamoto N, Teik KW, Mizuno S, et al. Genetic abnormalities in a large cohort of Coffin\u2013Siris syndrome patients. J Hum Genet. 2019;2:1\u201314.","journal-title":"J Hum Genet."},{"key":"315_CR35","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.1093\/hmg\/ddt366","volume":"22","author":"D Wieczorek","year":"2013","unstructured":"Wieczorek D, B\u00f6gershausen N, Beleggia F, Steiner-Haldenst\u00e4tt S, Pohl E, et al. A comprehensive molecular study on Coffin\u2013Siris and Nicolaides\u2013Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling. Hum Mol Genet. 2013;22:5121\u201335.","journal-title":"Hum Mol Genet"},{"key":"315_CR36","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/ng.2219","volume":"44","author":"Y Tsurusaki","year":"2012","unstructured":"Tsurusaki Y, Okamoto N, Ohashi H, Kosho T, Imai Y, et al. Mutations affecting components of the SWI\/SNF complex cause Coffin\u2013Siris syndrome. Nat Genet. 2012;44:376\u20138.","journal-title":"Nat Genet"},{"key":"315_CR37","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/cge.12225","volume":"85","author":"Y Tsurusaki","year":"2014","unstructured":"Tsurusaki Y, Okamoto N, Ohashi H, Mizuno S, Matsumoto N, et al. Coffin\u2013Siris syndrome is a SWI\/SNF complex disorder. Clin Genet. 2014;85:548\u201354.","journal-title":"Clin Genet"},{"key":"315_CR38","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1093\/carcin\/bgv111","volume":"36","author":"A Esp\u00edn-P\u00e9rez","year":"2015","unstructured":"Esp\u00edn-P\u00e9rez A, de Kok TMCM, Jennen DGJ, Hendrickx DM, De Coster S, et al. Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens. Carcinogenesis. 2015;36:1154\u201361.","journal-title":"Carcinogenesis"},{"key":"315_CR39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13072-017-0167-8","volume":"10","author":"JR Raab","year":"2017","unstructured":"Raab JR, Runge JS, Spear CC, Magnuson T. Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI\/SNF ATPase subunits. Epigenet Chromatin. 2017;10:62.","journal-title":"Epigenet Chromatin."},{"key":"315_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.gene.2018.11.032","volume":"687","author":"J Wu","year":"2019","unstructured":"Wu J, He K, Zhang Y, Song J, Shi Z, et al. Inactivation of SMARCA2 by promoter hypermethylation drives lung cancer development. Gene. 2019;687:193\u20139.","journal-title":"Gene"},{"key":"315_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(94)90405-7","volume":"79","author":"JL Dunaief","year":"1994","unstructured":"Dunaief JL, Strober BE, Guha S, Khavari PA, \u00c5lin K, et al. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell. 1994;79:119\u201330.","journal-title":"Cell"},{"key":"315_CR42","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1128\/MCB.16.4.1576","volume":"16","author":"BE Strober","year":"1996","unstructured":"Strober BE, Dunaief JL, Goff SP. Functional interactions between the hBRM\/hBRG1 transcriptional activators and the pRB family of proteins. Mol Cell Biol. 1996;16:1576\u201383.","journal-title":"Mol Cell Biol."},{"key":"315_CR43","doi-asserted-by":"publisher","first-page":"11268","DOI":"10.1073\/pnas.94.21.11268","volume":"94","author":"D Trouche","year":"1997","unstructured":"Trouche D, Le Chalony C, Muchardt C, Yaniv M, Kouzarides T. RB and hbrm cooperate to repress the activation functions of E2F1. Proc Natl Acad Sci USA. 1997;94:11268\u201373.","journal-title":"Proc Natl Acad Sci USA."},{"key":"315_CR44","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/sj.onc.1205188","volume":"21","author":"DN Reisman","year":"2002","unstructured":"Reisman DN, Strobeck MW, Betz BL, Sciariotta J, Funkhouser W Jr, et al. Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression. Oncogene. 2002;21:1196\u2013207.","journal-title":"Oncogene"},{"key":"315_CR45","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1080\/15384101.2018.1493414","volume":"17","author":"SNA Roesley","year":"2018","unstructured":"Roesley SNA, La Marca JE, Deans AJ, Mckenzie L, Suryadinata R, et al. Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation. Cell Cycle. 2018;17:1559\u201378.","journal-title":"Cell Cycle"},{"key":"315_CR46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0092-8674(00)80625-X","volume":"101","author":"HS Zhang","year":"2000","unstructured":"Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, et al. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI\/SNF and Rb-hSWI\/SNF. Cell. 2000;101:79\u201389.","journal-title":"Cell"},{"key":"315_CR47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.18632\/oncoscience.333","volume":"3","author":"SB Marquez-Vilendrer","year":"2016","unstructured":"Marquez-Vilendrer SB, Rai SK, Gramling SJB, Lu L, Reisman DN. BRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo. Oncoscience. 2016;3:337\u201350.","journal-title":"Oncoscience."},{"key":"315_CR48","doi-asserted-by":"publisher","first-page":"22330","DOI":"10.1074\/jbc.M111987200","volume":"277","author":"D Lee","year":"2002","unstructured":"Lee D, Kim JW, Seo T, Hwang SG, Choi E-J, et al. SWI\/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem. 2002;277:22330\u20137.","journal-title":"J Biol Chem"},{"key":"315_CR49","doi-asserted-by":"publisher","first-page":"37429","DOI":"10.1074\/jbc.M706039200","volume":"282","author":"Y Xu","year":"2007","unstructured":"Xu Y, Zhang J, Chen X. The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI\/SNF chromatin remodeling complexes. J Biol Chem. 2007;282:37429\u201335.","journal-title":"J Biol Chem"},{"key":"315_CR50","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.dnarep.2015.04.023","volume":"32","author":"PM Brownlee","year":"2015","unstructured":"Brownlee PM, Meisenberg C, Downs JA. The SWI\/SNF chromatin remodelling complex: its role in maintaining genome stability and preventing tumourigenesis. DNA Repair. 2015;32:127\u201333.","journal-title":"DNA Repair"},{"key":"315_CR51","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1038\/s41467-018-06402-y","volume":"9","author":"C Ribeiro-Silva","year":"2018","unstructured":"Ribeiro-Silva C, Aydin \u00d6Z, Mesquita-Ribeiro R, Slyskova J, Helfricht A, et al. DNA damage sensitivity of SWI\/SNF-deficient cells depends on TFIIH subunit p62\/GTF2H1. Nat Commun. 2018;9:4067.","journal-title":"Nat Commun."},{"key":"315_CR52","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(00)00030-1","volume":"102","author":"DA Bochar","year":"2000","unstructured":"Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, et al. BRCA1 is associated with a human SWI\/SNF-related complex. Cell. 2000;102:257\u201365.","journal-title":"Cell"},{"key":"315_CR53","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nsmb1030","volume":"13","author":"E Batsch\u00e9","year":"2006","unstructured":"Batsch\u00e9 E, Yaniv M, Muchardt C. The human SWI\/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol. 2006;13:22\u20139.","journal-title":"Nat Struct Mol Biol"},{"key":"315_CR54","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1158\/0008-5472.CAN-10-2345","volume":"71","author":"K Sakurai","year":"2011","unstructured":"Sakurai K, Furukawa C, Haraguchi T, Inada K-I, Shiogama K, et al. MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI\/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 2011;71:1680\u20139.","journal-title":"Cancer Res."},{"key":"315_CR55","doi-asserted-by":"publisher","first-page":"8428","DOI":"10.1038\/srep08428","volume":"5","author":"K Kobayashi","year":"2015","unstructured":"Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, et al. The miR-199a\/Brm\/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep. 2015;5:8428.","journal-title":"Sci Rep."},{"key":"315_CR56","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.canlet.2019.02.031","volume":"449","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Li J, Guo H, Wang F, Ma L, et al. BRM transcriptionally regulates miR-302a-3p to target SOCS5\/STAT3 signaling axis to potentiate pancreatic cancer metastasis. Cancer Lett. 2019;449:215\u201325.","journal-title":"Cancer Lett"},{"key":"315_CR57","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.canlet.2017.05.006","volume":"402","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Wang F, Du C, Guo H, Ma L, et al. BRM\/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2\/STAT3 signaling. Cancer Lett. 2017;402:213\u201324.","journal-title":"Cancer Lett"},{"key":"315_CR58","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1128\/MCB.25.6.2200-2215.2005","volume":"25","author":"KA Link","year":"2005","unstructured":"Link KA, Burd CJ, Williams E, Marshall T, Rosson G, et al. BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI\/SNF. Mol Cell Biol. 2005;25:2200\u201315.","journal-title":"Mol Cell Biol"},{"key":"315_CR59","doi-asserted-by":"publisher","first-page":"30605","DOI":"10.1074\/jbc.M304582200","volume":"278","author":"TW Marshall","year":"2003","unstructured":"Marshall TW, Link KA, Petre-Draviam CE, Knudsen KE. Differential requirement of SWI\/SNF for androgen receptor activity. J Biol Chem. 2003;278:30605\u201313.","journal-title":"J Biol Chem"},{"key":"315_CR60","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1038\/sj.emboj.7600231","volume":"23","author":"S Wang","year":"2004","unstructured":"Wang S, Zhang B, Faller DV. BRG1\/BRM and prohibitin are required for growth suppression by estrogen antagonists. EMBO J. 2004;23:2293\u2013303.","journal-title":"EMBO J"},{"key":"315_CR61","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.cancergen.2014.04.004","volume":"207","author":"KH Kim","year":"2014","unstructured":"Kim KH, Roberts CWM. Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth. Cancer Genet. 2014;207:365\u201372.","journal-title":"Cancer Genet."},{"key":"315_CR62","doi-asserted-by":"publisher","first-page":"412","DOI":"10.4161\/cbt.8.5.8019","volume":"8","author":"CWM Roberts","year":"2009","unstructured":"Roberts CWM, Biegel JA. The role of SMARCB1\/INI1 in development of rhabdoid tumor. Cancer Biol Ther. 2009;8:412\u20136.","journal-title":"Cancer Biol Ther"},{"key":"315_CR63","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.18632\/oncotarget.1945","volume":"5","author":"B Kahali","year":"2014","unstructured":"Kahali B, Yu J, Marquez SB, Thompson KW, Liang SY, et al. The silencing of the SWI\/SNF subunit and anticancer gene BRM in Rhabdoid tumors. Oncotarget. 2014;5:3316\u201332.","journal-title":"Oncotarget."},{"key":"315_CR64","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.anndiagpath.2016.10.006","volume":"26","author":"E Herpel","year":"2017","unstructured":"Herpel E, Rieker RJ, Dienemann H, Muley T, Meister M, et al. SMARCA4 and SMARCA2 deficiency in non\u2013small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. Ann Diagn Pathol. 2017;26:47\u201351.","journal-title":"Ann Diagn Pathol."},{"key":"315_CR65","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/cas.12065","volume":"104","author":"D Matsubara","year":"2013","unstructured":"Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, et al. Lung cancer with loss of BRG1\/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci. 2013;104:266\u201373.","journal-title":"Cancer Sci"},{"key":"315_CR66","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/pin.12350","volume":"65","author":"T Yoshimoto","year":"2015","unstructured":"Yoshimoto T, Matsubara D, Nakano T, Tamura T, Endo S, et al. Frequent loss of the expression of multiple subunits of the SWI\/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. Pathol Int. 2015;65:595\u2013602.","journal-title":"Pathol Int"},{"key":"315_CR67","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1158\/1078-0432.CCR-03-0489","volume":"10","author":"J Fukuoka","year":"2004","unstructured":"Fukuoka J, Fujii T, Shih JH, Dracheva T, Meerzaman D, et al. Chromatin remodeling factors and BRM\/BRG1 expression as prognostic indicators in non-small cell lung cancer. Clin Cancer Res. 2004;10:4314\u201324.","journal-title":"Clin Cancer Res"},{"key":"315_CR68","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1038\/onc.2011.81","volume":"30","author":"G Liu","year":"2011","unstructured":"Liu G, Gramling SJB, Munoz D, Cheng D, Azad AK, et al. Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk. Oncogene. 2011;30:3295\u2013304.","journal-title":"Oncogene"},{"key":"315_CR69","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1158\/1535-7163.MCT-18-0067","volume":"18","author":"E Zernickel","year":"2019","unstructured":"Zernickel E, Sak A, Riaz A, Klein D, Groneberg M, et al. Targeting of BRM sensitizes BRG1 -mutant lung cancer cell lines to radiotherapy. Mol Cancer Ther. 2019;18:656\u201366.","journal-title":"Mol Cancer Ther"},{"key":"315_CR70","first-page":"2275","volume":"7","author":"EA Sarnowska","year":"2017","unstructured":"Sarnowska EA, Szymanski M, Rusetska N, Ligaj M, Jancewicz I, et al. Evaluation of the role of downregulation of SNF5\/INI1 core subunit of SWI\/SNF complex in clear cell renal cell carcinoma development. Am J Cancer Res. 2017;7:2275.","journal-title":"Am J Cancer Res."},{"key":"315_CR71","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nature12222","volume":"499","author":"The Cancer Genome Atlas Network","year":"2013","unstructured":"The Cancer Genome Atlas Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013;499:43\u20139.","journal-title":"Nature"},{"key":"315_CR72","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/his.12334","volume":"64","author":"Q-Y Xia","year":"2014","unstructured":"Xia Q-Y, Rao Q, Cheng L, Shen Q, Shi S-S, et al. Loss of BRM expression is a frequently observed event in poorly differentiated clear cell renal cell carcinoma. Histopathology. 2014;64:847\u201362.","journal-title":"Histopathology"},{"key":"315_CR73","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.humpath.2018.04.004","volume":"77","author":"A Agaimy","year":"2018","unstructured":"Agaimy A, Amin MB, Gill AJ, Popp B, Reis A, et al. SWI\/SNF protein expression status in fumarate hydratase\u2013deficient renal cell carcinoma: immunohistochemical analysis of 32 tumors from 28 patients. Hum Pathol. 2018;77:139\u201346.","journal-title":"Hum Pathol"},{"key":"315_CR74","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1111\/his.13120","volume":"70","author":"Q-Y Xia","year":"2016","unstructured":"Xia Q-Y, Zhan X-M, Fan X-S, Ye S-B, Shi S-S, et al. BRM\/SMARCA2-negative clear cell renal cell carcinoma is associated with a high percentage of BRM somatic mutations, deletions and promoter methylation. Histopathology. 2016;70:711\u201321.","journal-title":"Histopathology."},{"key":"315_CR75","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/PAS.0000000000000554","volume":"40","author":"A Agaimy","year":"2016","unstructured":"Agaimy A, Daum O, Markl B, Lichtmannegger I, Michal M, et al. SWI\/SNF complex-deficient undifferentiated\/rhabdoid carcinomas of the gastrointestinal tract: a series of 13 cases highlighting mutually exclusive loss of SMARCA4 and SMARCA2 and frequent co-inactivation of SMARCB1 and SMARCA2. Am J Surg Pathol. 2016;40:544\u201353.","journal-title":"Am J Surg Pathol"},{"key":"315_CR76","first-page":"1","volume":"13","author":"Y Yu","year":"2018","unstructured":"Yu Y, Cheng D, Parfrey P, Liu G, Savas S. Two functional indel polymorphisms in the promoter region of the Brahma gene (BRM) and disease risk and progression-free survival in colorectal cancer. PLoS ONE. 2018;13:1\u201317.","journal-title":"PLoS ONE"},{"key":"315_CR77","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/cam4.201","volume":"3","author":"KM Wong","year":"2014","unstructured":"Wong KM, Qiu X, Cheng D, Azad AKALA, Habbous S, et al. Two BRM promoter insertion polymorphisms increase the risk of early-stage upper aerodigestive tract cancers. Cancer Med. 2014;3:426\u201333.","journal-title":"Cancer Med."},{"key":"315_CR78","doi-asserted-by":"publisher","first-page":"10727","DOI":"10.1158\/0008-5472.CAN-07-2601","volume":"67","author":"N Yamamichi","year":"2007","unstructured":"Yamamichi N, Inada KI, Ichinose M, Yamamichi-Nishina M, Mizutani T, et al. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. Cancer Res. 2007;67:10727\u201335.","journal-title":"Cancer Res"},{"key":"315_CR79","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.canlet.2014.11.038","volume":"357","author":"H Takeshima","year":"2015","unstructured":"Takeshima H, Niwa T, Takahashi T, Wakabayashi M, Yamashita S, et al. Frequent involvement of chromatin remodeler alterations in gastric field cancerization. Cancer Lett. 2015;357:328\u201338.","journal-title":"Cancer Lett"},{"key":"315_CR80","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3892\/ijo.2012.1723","volume":"42","author":"M Numata","year":"2013","unstructured":"Numata M, Morinaga S, Watanabe T, Tamagawa H, Yamamoto N, et al. The clinical significance of SWI\/SNF complex in pancreatic cancer. Int J Oncol. 2013;42:403\u201310.","journal-title":"Int J Oncol"},{"key":"315_CR81","doi-asserted-by":"publisher","first-page":"E252","DOI":"10.1073\/pnas.1114817109","volume":"109","author":"AH Shain","year":"2012","unstructured":"Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, et al. Convergent structural alterations define SWItch\/Sucrose Non-Fermentable (SWI\/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci. 2012;109:E252\u20139.","journal-title":"Proc Natl Acad Sci."},{"key":"315_CR82","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/liv.12005","volume":"33","author":"M Endo","year":"2013","unstructured":"Endo M, Yasui K, Zen Y, Gen Y, Zen K, et al. Alterations of the SWI\/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma. Liver Int. 2013;33:105\u201317.","journal-title":"Liver Int."},{"key":"315_CR83","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/mc.22736","volume":"57","author":"I Pasic","year":"2018","unstructured":"Pasic I, Wong KM, Lee JJ, Espin-Garcia O, Brhane Y, et al. Two BRM promoter polymorphisms predict poor survival in patients with hepatocellular carcinoma. Mol Carcinog. 2018;57:106\u201313.","journal-title":"Mol Carcinog"},{"key":"315_CR84","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1093\/carcin\/bgt008","volume":"34","author":"JR Wang","year":"2013","unstructured":"Wang JR, Gramling SJB, Goldstein DP, Cheng D, Chen D, et al. Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk. Carcinogenesis. 2013;34:1012\u20137.","journal-title":"Carcinogenesis"},{"key":"315_CR85","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/ng.2643","volume":"45","author":"AS Ho","year":"2013","unstructured":"Ho AS, Kannan K, Roy DM, Morris LGT, Ganly I, et al. The mutational landscape of adenoid cystic carcinoma. Nat Genet. 2013;45:791\u20138.","journal-title":"Nat Genet"},{"key":"315_CR86","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00432-018-2783-5","volume":"145","author":"B Jagielska","year":"2019","unstructured":"Jagielska B, Sarnowska E, Rusetska N, Jancewicz I, Durzynska M, et al. Advanced adenoid cystic carcinoma (ACC) is featured by SWI\/SNF chromatin remodeling complex aberrations. J Cancer Res Clin Oncol. 2019;145:201\u201311.","journal-title":"J Cancer Res Clin Oncol"},{"key":"315_CR87","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jcp.22072","volume":"223","author":"N Cohet","year":"2010","unstructured":"Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, et al. SWI\/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. J Cell Physiol. 2010;223:667\u201378.","journal-title":"J Cell Physiol"},{"key":"315_CR88","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1002\/jcp.24991","volume":"230","author":"Q Wu","year":"2015","unstructured":"Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, et al. The SWI\/SNF ATPases are required for triple negative breast cancer cell proliferation. J Cell Physiol. 2015;230:2683\u201394.","journal-title":"J Cell Physiol"},{"key":"315_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-20217-3","volume":"8","author":"JA Guerrero-Mart\u00ednez","year":"2018","unstructured":"Guerrero-Mart\u00ednez JA, Reyes JC. High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer. Sci Rep. 2018;8:1\u201317.","journal-title":"Sci Rep."},{"key":"315_CR90","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bbagrm.2019.03.002","volume":"1862","author":"Y Yang","year":"2019","unstructured":"Yang Y, Liu L, Fang M, Bai H, Xu Y. The chromatin remodeling protein BRM regulates the transcription of tight junction proteins: implication in breast cancer metastasis. Biochim Biophys Acta Gene Regul Mech. 2019;1862:547\u201356.","journal-title":"Biochim Biophys Acta Gene Regul Mech."},{"key":"315_CR91","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.humpath.2012.11.007","volume":"44","author":"H Cho","year":"2013","unstructured":"Cho H, Kim JS-Y, Chung H, Perry C, Lee H, et al. Loss of ARID1A\/BAF250a expression is linked to tumor progression and adverse prognosis in cervical cancer. Hum Pathol. 2013;44:1365\u201374.","journal-title":"Hum Pathol."},{"key":"315_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0031346","volume":"7","author":"DW Serber","year":"2012","unstructured":"Serber DW, Rogala A, Makarem M, Rosson GB, Simin K, et al. The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. PLoS ONE. 2012;7:1\u201310.","journal-title":"PLoS ONE"},{"key":"315_CR93","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1158\/0008-5472.CAN-11-1562","volume":"71","author":"B Guan","year":"2011","unstructured":"Guan B, Wang TL, Shih IM. ARID1A, a factor that promotes formation of SWI\/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer Res. 2011;71:6718\u201327.","journal-title":"Cancer Res"},{"key":"315_CR94","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1471-2164-9-64","volume":"9","author":"A Shadeo","year":"2008","unstructured":"Shadeo A, Chari R, Lonergan KM, Pusic A, Miller D, et al. Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia. BMC Genomics. 2008;9:64.","journal-title":"BMC Genomics."},{"key":"315_CR95","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ygyno.2017.09.031","volume":"147","author":"DI Lin","year":"2017","unstructured":"Lin DI, Chudnovsky Y, Duggan B, Zajchowski D, Greenbowe J, et al. Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type. Gynecol Oncol. 2017;147:626\u201333.","journal-title":"Gynecol Oncol"},{"key":"315_CR96","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/ng.2931","volume":"46","author":"L Witkowski","year":"2014","unstructured":"Witkowski L, Carrot-Zhang J, Albrecht S, Fahiminiya S, Hamel N, et al. Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. Nat Genet. 2014;46:438\u201343.","journal-title":"Nat Genet"},{"key":"315_CR97","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/ng.2928","volume":"46","author":"P Ramos","year":"2014","unstructured":"Ramos P, Karnezis AN, Craig DW, Sekulic A, Russell ML, et al. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat Genet. 2014;46:427\u20139.","journal-title":"Nat Genet"},{"key":"315_CR98","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/ng.2922","volume":"46","author":"P Jelinic","year":"2014","unstructured":"Jelinic P, Mueller JJ, Olvera N, Dao F, Scott SN, et al. Recurrent SMARCA4 mutations in small cell carcinoma of the ovary. Nat Genet. 2014;46:424\u20136.","journal-title":"Nat Genet"},{"key":"315_CR99","doi-asserted-by":"publisher","first-page":"238","DOI":"10.5114\/pjp.2013.39331","volume":"64","author":"J Kupryja\u0144czyk","year":"2013","unstructured":"Kupryja\u0144czyk J, Dansonka-Mieszkowska A, Moes-Sosnowska J, Plisiecka-Ha\u0142asa J, Szafron \u0141, et al. Ovarian small cell carcinoma of hypercalcemic type\u2014evidence of germline origin and smarca4 gene inactivation. A pilot study. Polish J Pathol. 2013;64:238\u201346.","journal-title":"Polish J Pathol."},{"key":"315_CR100","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/path.4633","volume":"238","author":"AN Karnezis","year":"2016","unstructured":"Karnezis AN, Wang Y, Ramos P, Hendricks WPD, Oliva E, et al. Dual loss of the SWI\/SNF complex ATPases SMARCA4\/BRG1 and SMARCA2\/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. J Pathol. 2016;238:389\u2013400.","journal-title":"J Pathol."},{"key":"315_CR101","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/modpathol.2015.129","volume":"29","author":"P Jelinic","year":"2016","unstructured":"Jelinic P, Schlappe BA, Conlon N, Tseng J, Olvera N, et al. Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type. Mod Pathol. 2016;29:60\u20136.","journal-title":"Mod Pathol"},{"key":"315_CR102","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/bjc.2017.228","volume":"117","author":"H Itamochi","year":"2017","unstructured":"Itamochi H, Oishi T, Oumi N, Takeuchi S, Yoshihara K, et al. Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma. Br J Cancer. 2017;117:717\u201324.","journal-title":"Br J Cancer"},{"key":"315_CR103","first-page":"3796","volume":"16","author":"X Xu","year":"2018","unstructured":"Xu X, Zheng Z, Jia L, Suo S, Liu B, et al. Overexpression of SMARCA2 or CAMK2D is associated with cisplatin resistance in human epithelial ovarian cancer. Oncol Lett. 2018;16:3796\u2013804.","journal-title":"Oncol Lett."},{"key":"315_CR104","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1016\/j.yexcr.2012.06.011","volume":"318","author":"A Kothandapani","year":"2012","unstructured":"Kothandapani A, Gopalakrishnan K, Kahali B, Reisman D, Patrick SM. Downregulation of SWI\/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity. Exp Cell Res. 2012;318:1973\u201386.","journal-title":"Exp Cell Res"},{"key":"315_CR105","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/his.13091","volume":"70","author":"P Ramalingam","year":"2017","unstructured":"Ramalingam P, Croce S, McCluggage WG. Loss of expression of SMARCA4 (BRG1), SMARCA2 (BRM) and SMARCB1 (INI1) in undifferentiated carcinoma of the endometrium is not uncommon and is not always associated with rhabdoid morphology. Histopathology. 2017;70:359\u201366.","journal-title":"Histopathology"},{"key":"315_CR106","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/pros.20672","volume":"68","author":"H Gustavsson","year":"2008","unstructured":"Gustavsson H, Jennbacken K, Wel\u00e9n K, Damber J-E. Altered expression of genes regulating angiogenesis in experimental androgen-independent prostate cancer. Prostate. 2008;68:161\u201370.","journal-title":"Prostate"},{"key":"315_CR107","doi-asserted-by":"publisher","first-page":"10154","DOI":"10.1158\/0008-5472.CAN-08-1794","volume":"68","author":"H Shen","year":"2008","unstructured":"Shen H, Powers N, Saini N, Comstock CESS, Sharma A, et al. The SWI\/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer. Cancer Res. 2008;68:10154\u201362.","journal-title":"Cancer Res"},{"key":"315_CR108","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/j.1365-2133.2011.10267.x","volume":"164","author":"VL Bock","year":"2011","unstructured":"Bock VL, Lyons JG, Huang XXJ, Jones AM, McDonald LA, et al. BRM and BRG1 subunits of the SWI\/SNF chromatin remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours. Br J Dermatol. 2011;164:1221\u20137.","journal-title":"Br J Dermatol"},{"key":"315_CR109","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/jid.2008.319","volume":"129","author":"FJ Moloney","year":"2009","unstructured":"Moloney FJ, Lyons JG, Bock VL, Huang XX, Bugeja MJ, et al. Hotspot mutation of Brahma in non-melanoma skin cancer. J Invest Dermatol. 2009;129:1012\u20135.","journal-title":"J Invest Dermatol."},{"key":"315_CR110","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jdermsci.2018.11.006","volume":"92","author":"AW Farrell","year":"2018","unstructured":"Farrell AW, Halliday GM, Lyons JG. Brahma deficiency in keratinocytes promotes UV carcinogenesis by accelerating the escape from cell cycle arrest and the formation of DNA photolesions. J Dermatol Sci. 2018;92:254\u201363.","journal-title":"J Dermatol Sci"},{"key":"315_CR111","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.bbrc.2010.01.048","volume":"392","author":"J Vachtenheim","year":"2010","unstructured":"Vachtenheim J, Ondru\u0161ov\u00e1 L, Borovansk\u00fd J. SWI\/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells. Biochem Biophys Res Commun. 2010;392:454\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"315_CR112","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1182\/blood-2013-02-483495","volume":"123","author":"M Buscarlet","year":"2014","unstructured":"Buscarlet M, Krasteva V, Ho L, Simon C, Hebert J, et al. Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. Blood. 2014;123:1720\u20138.","journal-title":"Blood"},{"key":"315_CR113","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1371\/journal.pone.0038158","volume":"7","author":"E Dom\u00e9nech","year":"2012","unstructured":"Dom\u00e9nech E, G\u00f3mez-L\u00f3pez G, Gzlez-Pe\u00f1a D, L\u00f3pez M, Herreros B, et al. New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing. PLoS ONE. 2012;7:2\u20137.","journal-title":"PLoS ONE"},{"key":"315_CR114","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1158\/0008-5472.CAN-16-1386","volume":"77","author":"A-K Eisfeld","year":"2017","unstructured":"Eisfeld A-K, Kohlschmidt J, Mr\u00f3zek K, Volinia S, Blachly JS, et al. mutational landscape and gene expression patterns in adult acute myeloid leukemias with monosomy 7 as a sole abnormality. Cancer Res. 2017;77:207\u201318.","journal-title":"Cancer Res"},{"key":"315_CR115","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1016\/j.humpath.2014.06.027","volume":"45","author":"L Li","year":"2014","unstructured":"Li L, Fan XS, Xia QY, Rao Q, Liu B, et al. Concurrent loss of INI1, PBRM1, and BRM expression in epithelioid sarcoma: implications for the cocontributions of multiple SWI\/SNF complex members to pathogenesis. Hum Pathol. 2014;45:2247\u201354.","journal-title":"Hum Pathol"},{"key":"315_CR116","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.canep.2012.12.001","volume":"37","author":"EK Amankwah","year":"2013","unstructured":"Amankwah EK, Thompson RC, Nabors LB, Olson JJ, Browning JE, et al. SWI\/SNF gene variants and glioma risk and outcome. Cancer Epidemiol. 2013;37:162\u20135.","journal-title":"Cancer Epidemiol"},{"key":"315_CR117","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/ng.2628","volume":"45","author":"C Kadoch","year":"2013","unstructured":"Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, et al. Proteomic and bioinformatic analysis of mammalian SWI\/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013;45:592\u2013601.","journal-title":"Nat Genet"},{"key":"315_CR118","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1038\/onc.2011.80","volume":"30","author":"S Gramling","year":"2011","unstructured":"Gramling S, Rogers C, Liu G, Reisman D. Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy. Oncogene. 2011;30:3289\u201394.","journal-title":"Oncogene"},{"key":"315_CR119","doi-asserted-by":"publisher","first-page":"12249","DOI":"10.1073\/pnas.1703966114","volume":"114","author":"T Januario","year":"2017","unstructured":"Januario T, Ye X, Bainer R, Alicke B, Smith T, et al. PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI\/SNF mutant tumors. Proc Natl Acad Sci. 2017;114:12249\u201354.","journal-title":"Proc Natl Acad Sci."},{"key":"315_CR120","doi-asserted-by":"publisher","first-page":"6505","DOI":"10.1093\/emboj\/cdg621","volume":"22","author":"B Bourachot","year":"2003","unstructured":"Bourachot B, Yaniv M, Muchardt C. Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation. EMBO J. 2003;22:6505\u201315.","journal-title":"EMBO J"},{"key":"315_CR121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2014.00372","volume":"4","author":"SB Marquez","year":"2015","unstructured":"Marquez SB, Thompson KW, Lu L, Reisman D. Beyond mutations: additional mechanisms and implications of SWI\/SNF complex inactivation. Front Oncol. 2015;4:1\u201320.","journal-title":"Front Oncol."},{"key":"315_CR122","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.gene.2017.05.047","volume":"626","author":"X Ouyang","year":"2017","unstructured":"Ouyang X, Ye XL, Wei HB. BRM promoter insertion polymorphisms increase the risk of cancer: a meta-analysis. Gene. 2017;626:420\u20135.","journal-title":"Gene."},{"key":"315_CR123","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1002\/ijc.30369","volume":"139","author":"M Segedi","year":"2016","unstructured":"Segedi M, Anderson LN, Espin-Garcia O, Borgida A, Bianco T, et al. BRM polymorphisms, pancreatic cancer risk and survival. Int J Cancer. 2016;139:2474\u201381.","journal-title":"Int J Cancer"},{"key":"315_CR124","doi-asserted-by":"publisher","first-page":"4696","DOI":"10.1002\/cncr.25279","volume":"116","author":"J La Rochelle","year":"2010","unstructured":"La Rochelle J, Klatte T, Dastane A, Rao N, Seligson D, et al. Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma. Cancer. 2010;116:4696\u2013702.","journal-title":"Cancer"},{"key":"315_CR125","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2174\/157018011793663840","volume":"8","author":"SJB Gramling","year":"2011","unstructured":"Gramling SJB, Reisman D. Discovery of BRM targeted therapies: novel reactivation of an anticancer gene. Lett Drug Des Discov. 2011;8:93\u20139.","journal-title":"Lett Drug Des Discov."},{"key":"315_CR126","doi-asserted-by":"publisher","first-page":"5508","DOI":"10.1158\/0008-5472.CAN-12-4593","volume":"73","author":"T Oike","year":"2013","unstructured":"Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, et al. A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1. Cancer Res. 2013;73:5508\u201318.","journal-title":"Cancer Res"},{"key":"315_CR127","doi-asserted-by":"publisher","first-page":"10155","DOI":"10.1021\/acs.jmedchem.8b01318","volume":"61","author":"JPN Papillon","year":"2018","unstructured":"Papillon JPN, Nakajima K, Adair CD, Hempel J, Jouk AO, et al. Discovery of orally active inhibitors of brahma homolog (BRM)\/SMARCA2 ATPase activity for the treatment of brahma related gene 1 (BRG1)\/SMARCA4-mutant cancers. J Med Chem. 2018;61:10155\u201372.","journal-title":"J Med Chem"},{"key":"315_CR128","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41589-019-0294-6","volume":"15","author":"W Farnaby","year":"2019","unstructured":"Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019;15:672\u201380.","journal-title":"Nat Chem Biol"},{"key":"315_CR129","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1038\/onc.2009.4","volume":"28","author":"DN Reisman","year":"2009","unstructured":"Reisman DN, Glaros S, Thompson EA. The SWI\/SNF complex and cancer. Oncogene. 2009;28:1653\u201368.","journal-title":"Oncogene."},{"key":"315_CR130","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1038\/sj.onc.1208716","volume":"24","author":"N Yamamichi","year":"2005","unstructured":"Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, et al. The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits antioncogenic potential. Oncogene. 2005;24:5471\u201381.","journal-title":"Oncogene"},{"key":"315_CR131","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/onc.2012.613","volume":"33","author":"B Kahali","year":"2014","unstructured":"Kahali B, Gramling SJB, Marquez SB, Thompson KW, Lu L, et al. Identifying targets for the restoration and reactivation of BRM. Oncogene. 2014;33:653\u201364.","journal-title":"Oncogene"},{"key":"315_CR132","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1158\/1535-7163.MCT-16-0678","volume":"16","author":"E Chan-Penebre","year":"2017","unstructured":"Chan-Penebre E, Armstrong K, Drew A, Grassian AR, Feldman I, et al. Selective killing of SMARCA2- and SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type cells by inhibition of EZH2: in vitro and in vivo preclinical models. Mol Cancer Ther. 2017;16:850\u201360.","journal-title":"Mol Cancer Ther."},{"key":"315_CR133","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1158\/1535-7163.MCT-18-0348","volume":"17","author":"Y Wang","year":"2018","unstructured":"Wang Y, Chen SY, Colborne S, Lambert G, Shin CY, et al. Histone deacetylase inhibitors synergize with catalytic inhibitors of EZH2 to exhibit antitumor activity in small cell carcinoma of the ovary, hypercalcemic type. Mol Cancer Ther. 2018;17:2767\u201379.","journal-title":"Mol Cancer Ther."},{"key":"315_CR134","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nrg.2017.47","volume":"18","author":"NJ O\u2019Neil","year":"2017","unstructured":"O\u2019Neil NJ, Bailey ML, Hieter P. Synthetic lethality and cancer. Nat Rev Genet. 2017;18:613\u201323.","journal-title":"Nat Rev Genet"},{"key":"315_CR135","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1073\/pnas.1316793111","volume":"111","author":"GR Hoffman","year":"2014","unstructured":"Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, et al. Functional epigenetics approach identifies BRM\/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proc Natl Acad Sci. 2014;111:3128\u201333.","journal-title":"Proc Natl Acad Sci"},{"key":"315_CR136","doi-asserted-by":"publisher","first-page":"103739","DOI":"10.1016\/j.ejmg.2019.103739","volume":"14","author":"G Pascolini","year":"2019","unstructured":"Pascolini G, Valiante M, Bottillo I, Laino L, Fleischer N, et al. Striking phenotypic overlap between Nicolaides\u2013Baraitser and Coffin\u2013Siris syndromes in monozygotic twins with ARID1B intragenic deletion. Eur J Med Genet. 2019;14:103739.","journal-title":"Eur J Med Genet."},{"key":"315_CR137","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1093\/carcin\/bgn117","volume":"29","author":"Y Dai","year":"2008","unstructured":"Dai Y, Ngo D, Jacob J, Forman LW, Faller DV. Prohibitin and the SWI\/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes. Carcinogenesis. 2008;29:1725\u201333.","journal-title":"Carcinogenesis"},{"key":"315_CR138","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1074\/mcp.M117.067488","volume":"16","author":"JK Lempi\u00e4inen","year":"2017","unstructured":"Lempi\u00e4inen JK, Niskanen EA, Vuoti K-M, Lampinen RE, G\u00f6\u00f6s H, et al. Agonist-specific protein interactomes of glucocorticoid and androgen receptor as revealed by proximity mapping. Mol Cell Proteomics. 2017;16:1462\u201374.","journal-title":"Mol Cell Proteomics"},{"key":"315_CR139","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1210\/me.2008-0280","volume":"23","author":"DJ van de Wijngaart","year":"2009","unstructured":"van de Wijngaart DJ, Dubbink HJ, Molier M, de Vos C, Trapman J, et al. Functional screening of FxxLF-like peptide motifs identifies SMARCD1\/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. Mol Endocrinol. 2009;23:1776\u201386.","journal-title":"Mol Endocrinol"},{"key":"315_CR140","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/jcb.20003","volume":"91","author":"DA Hill","year":"2004","unstructured":"Hill DA, de la Serna IL, Veal TM, Imbalzano AN. BRCA1 interacts with dominant negative SWI\/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2. J Cell Biochem. 2004;91:987\u201398.","journal-title":"J Cell Biochem"},{"key":"315_CR141","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1093\/nar\/gkw780","volume":"45","author":"GA Fontana","year":"2017","unstructured":"Fontana GA, Rigamonti A, Lenzken SC, Filosa G, Alvarez R, et al. Oxidative stress controls the choice of alternative last exons via a Brahma-BRCA1-CstF pathway. Nucleic Acids Res. 2017;45:902\u201314.","journal-title":"Nucleic Acids Res"},{"key":"315_CR142","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1101\/gad.309404","volume":"18","author":"T Kondo","year":"2004","unstructured":"Kondo T, Raff M. Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev. 2004;18:2963\u201372.","journal-title":"Genes Dev"},{"key":"315_CR143","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1101\/gad.1183304","volume":"18","author":"G-L Wang","year":"2004","unstructured":"Wang G-L, Iakova P, Wilde M, Awad S, Timchenko NA. Liver tumors escape negative control of proliferation via PI3\u00a0K\/Akt-mediated block of C\/EBP alpha growth inhibitory activity. Genes Dev. 2004;18:912\u201325.","journal-title":"Genes Dev"},{"key":"315_CR144","doi-asserted-by":"publisher","first-page":"e1000769","DOI":"10.1371\/journal.pgen.1000769","volume":"5","author":"M Lavigne","year":"2009","unstructured":"Lavigne M, Eskeland R, Azebi S, Saint-Andr\u00e9 V, Jang SM, et al. Interaction of HP1 and Brg1\/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet. 2009;5:e1000769.","journal-title":"PLoS Genet"},{"key":"315_CR145","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/ncb2075","volume":"12","author":"R-S Nozawa","year":"2010","unstructured":"Nozawa R-S, Nagao K, Masuda H-T, Iwasaki O, Hirota T, et al. Human POGZ modulates dissociation of HP1\u03b1 from mitotic chromosome arms through Aurora B activation. Nat Cell Biol. 2010;12:719.","journal-title":"Nat Cell Biol"},{"key":"315_CR146","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1074\/mcp.M112.020727","volume":"12","author":"A-L Steunou","year":"2013","unstructured":"Steunou A-L, Ducoux-Petit M, Lazar I, Monsarrat B, Erard M, et al. Identification of the hypoxia-inducible factor 2\u03b1 nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. Mol Cell Proteomics. 2013;12:736\u201348.","journal-title":"Mol Cell Proteomics"},{"key":"315_CR147","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/cr.2010.155","volume":"20","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Cheng M, Zhang Y, Zhong X, Dai H, et al. A switch from hBrm to Brg1 at IFN\u03b3-activated sequences mediates the activation of human genes. Cell Res. 2010;20:1345\u201360.","journal-title":"Cell Res"},{"key":"315_CR148","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0378-1119(96)00785-8","volume":"188","author":"H Ichinose","year":"1997","unstructured":"Ichinose H, Garnier J-M, Chambon P, Losson R. Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2\/SNF2. Gene. 1997;188:95\u2013100.","journal-title":"Gene"},{"key":"315_CR149","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.immuni.2011.11.010","volume":"35","author":"X-X Jiang","year":"2011","unstructured":"Jiang X-X, Nguyen Q, Chou Y, Wang T, Nandakumar V, et al. Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity. 2011;35:883\u201396.","journal-title":"Immunity"},{"key":"315_CR150","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/S1097-2765(02)00740-2","volume":"10","author":"T Nakamura","year":"2002","unstructured":"Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, et al. ALL-1 Is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell. 2002;10:1119\u201328.","journal-title":"Mol Cell"},{"key":"315_CR151","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1038\/onc.2016.453","volume":"36","author":"J Li","year":"2017","unstructured":"Li J, Xi Y, Li W, McCarthy RL, Stratton SA, et al. TRIM28 interacts with EZH2 and SWI\/SNF to activate genes that promote mammosphere formation. Oncogene. 2017;36:2991\u20133001.","journal-title":"Oncogene"},{"key":"315_CR152","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1016\/j.yexcr.2009.01.006","volume":"315","author":"N Yamamichi","year":"2009","unstructured":"Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, et al. Cdx2 and the Brm-type SWI\/SNF complex cooperatively regulate villin expression in gastrointestinal cells. Exp Cell Res. 2009;315:1779\u201389.","journal-title":"Exp Cell Res"},{"key":"315_CR153","doi-asserted-by":"publisher","first-page":"46733","DOI":"10.1074\/jbc.M409002200","volume":"279","author":"F Wang","year":"2004","unstructured":"Wang F, Zhang R, Beischlag TV, Muchardt C, Yaniv M, et al. Roles of Brahma and Brahma\/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem. 2004;279:46733\u201341.","journal-title":"J Biol Chem."},{"key":"315_CR154","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1101\/gad.1523007","volume":"21","author":"J Secombe","year":"2007","unstructured":"Secombe J, Li L, Carlos L, Eisenman RN. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 2007;21:537\u201351.","journal-title":"Genes Dev"},{"key":"315_CR155","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.cell.2012.08.011","volume":"150","author":"PC Havugimana","year":"2012","unstructured":"Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, et al. A census of human soluble protein complexes. Cell. 2012;150:1068\u201381.","journal-title":"Cell"},{"key":"315_CR156","doi-asserted-by":"publisher","first-page":"7475","DOI":"10.1128\/MCB.23.21.7475-7487.2003","volume":"23","author":"S Pal","year":"2003","unstructured":"Pal S, Yun R, Datta A, Lacomis L, Erdjument-Bromage H, et al. mSin3A\/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol. 2003;23:7475\u201387.","journal-title":"Mol Cell Biol"},{"key":"315_CR157","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1038\/ncomms4127","volume":"5","author":"Q Cao","year":"2014","unstructured":"Cao Q, Wang X, Zhao M, Yang R, Malik R, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127.","journal-title":"Nat Commun."},{"key":"315_CR158","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S1097-2765(00)80384-6","volume":"4","author":"E Kowenz-Leutz","year":"1999","unstructured":"Kowenz-Leutz E, Leutz A. A C\/EBP\u03b2 Isoform Recruits the SWI\/SNF Complex to Activate Myeloid Genes. Mol Cell. 1999;4:735\u201343.","journal-title":"Mol Cell"},{"key":"315_CR159","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1074\/jbc.M009633200","volume":"276","author":"T Ito","year":"2001","unstructured":"Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, et al. Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos\/Jun dimers. J Biol Chem. 2001;276:2852\u20137.","journal-title":"J Biol Chem."},{"key":"315_CR160","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1074\/mcp.M116.064451","volume":"16","author":"BR Kim","year":"2017","unstructured":"Kim BR, Coyaud E, Laurent EMN, St-Germain J, Van de Laar E, et al. Identification of the SOX2 interactome by BioID reveals EP300 as a mediator of SOX2-dependent squamous differentiation and lung squamous cell carcinoma growth. Mol Cell Proteomics. 2017;16:1864\u201388.","journal-title":"Mol Cell Proteomics"},{"key":"315_CR161","doi-asserted-by":"publisher","first-page":"e62857","DOI":"10.1371\/journal.pone.0062857","volume":"8","author":"JL Cox","year":"2013","unstructured":"Cox JL, Wilder PJ, Gilmore JM, Wuebben EL, Washburn MP, et al. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. PLoS ONE. 2013;8:e62857.","journal-title":"PLoS ONE"},{"key":"315_CR162","doi-asserted-by":"publisher","first-page":"5355","DOI":"10.1128\/MCB.18.9.5355","volume":"18","author":"H Cho","year":"1998","unstructured":"Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, et al. A human RNA polymerase II complex containing factors that modify chromatin structure. Mol Cell Biol. 1998;18:5355\u201363.","journal-title":"Mol Cell Biol"},{"key":"315_CR163","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1038\/modpathol.2017.61","volume":"30","author":"JL Sauter","year":"2017","unstructured":"Sauter JL, Graham RP, Larsen BT, Jenkins SM, Roden AC, et al. SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior. Mod Pathol. 2017;30:1422\u201332.","journal-title":"Mod Pathol"},{"key":"315_CR164","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/neup.12452","volume":"38","author":"C Bookhout","year":"2018","unstructured":"Bookhout C, Bouldin TW, Ellison DW. Atypical teratoid\/rhabdoid tumor with retained INI1 (SMARCB1) expression and loss of BRG1 (SMARCA4). Neuropathology. 2018;38:305\u20138.","journal-title":"Neuropathology."},{"key":"315_CR165","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1159\/000500684","volume":"63","author":"L Mei","year":"2019","unstructured":"Mei L, Alikhan M, Mujacic I, Parilla M, Antic T. Genomic alterations in undifferentiated malignant tumors with rhabdoid phenotype and loss of BRG1 immunoexpression identified by fine needle aspirates. Acta Cytol. 2019;63:438\u201344.","journal-title":"Acta Cytol"},{"key":"315_CR166","doi-asserted-by":"publisher","first-page":"6486","DOI":"10.1158\/0008-5472.CAN-14-0061","volume":"74","author":"T Orvis","year":"2014","unstructured":"Orvis T, Hepperla A, Walter V, Song S, Simon J, et al. BRG1\/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization. Cancer Res. 2014;74:6486\u201398.","journal-title":"Cancer Res"},{"key":"315_CR167","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/humu.20730","volume":"29","author":"PP Medina","year":"2008","unstructured":"Medina PP, Romero OA, Kohno T, Montuenga LM, Pio R, et al. Frequent BRG1\/SMARCA4-inactivating mutations in human lung cancer cell lines. Hum Mutat. 2008;29:617\u201322.","journal-title":"Hum Mutat"},{"key":"315_CR168","first-page":"1782","volume":"7","author":"Q Rao","year":"2014","unstructured":"Rao Q, Xia Q-Y, Shen Q, Shi S-S, Tu P, et al. Coexistent loss of INI1 and BRG1 expression in a rhabdoid renal cell carcinoma (RCC): implications for a possible role of SWI\/SNF complex in the pathogenesis of RCC. Int J Clin Exp Pathol. 2014;7:1782\u20137.","journal-title":"Int J Clin Exp Pathol."},{"key":"315_CR169","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1159\/000064638","volume":"69","author":"K Sentani","year":"2001","unstructured":"Sentani K, Oue N, Kondo H, Kuraoka K, Motoshita J, et al. Increased expression but not genetic alteration of\u2009<\u2009i>BRG1\u2009<\/i\u2009>\u2009a component of the SWI\/SNF complex, is associated with the advanced stage of human gastric carcinomas. Pathobiology. 2001;69:315\u201320.","journal-title":"Pathobiology"},{"key":"315_CR170","first-page":"201","volume":"26","author":"E Gunduz","year":"2005","unstructured":"Gunduz E, Gunduz M, Ouchida M, Nagatsuka H, Beder L, et al. Genetic and epigenetic alterations of BRG1 promote oral cancer development. Int J Oncol. 2005;26:201\u201310.","journal-title":"Int J Oncol"},{"key":"315_CR171","first-page":"1","volume":"8","author":"J Bai","year":"2013","unstructured":"Bai J, Mei P, Zhang C, Chen F, Li C, et al. BRG1 is a prognostic marker and potential therapeutic target in human breast cancer. PLoS ONE. 2013;8:1\u20139.","journal-title":"PLoS ONE"},{"key":"315_CR172","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/j.1365-2133.2010.09851.x","volume":"163","author":"H Lin","year":"2010","unstructured":"Lin H, Wong RPC, Martinka M, Li G. BRG1 expression is increased in human cutaneous melanoma. Br J Dermatol. 2010;163:502\u201310.","journal-title":"Br J Dermatol"},{"key":"315_CR173","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/1476-4598-9-280","volume":"9","author":"S Saladi","year":"2010","unstructured":"Saladi S, Keenen B, Marathe HG, Qi H, Chin K-V, et al. Modulation of extracellular matrix\/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer. 2010;9:280.","journal-title":"Mol Cancer."}],"container-title":["Epigenetics &amp; Chromatin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-019-0315-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13072-019-0315-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-019-0315-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T16:50:53Z","timestamp":1722012653000},"score":1,"resource":{"primary":{"URL":"https:\/\/epigeneticsandchromatin.biomedcentral.com\/articles\/10.1186\/s13072-019-0315-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":173,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["315"],"URL":"https:\/\/doi.org\/10.1186\/s13072-019-0315-4","relation":{},"ISSN":["1756-8935"],"issn-type":[{"value":"1756-8935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]},"assertion":[{"value":"11 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing of interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}