{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:32:29Z","timestamp":1789475549934,"version":"build-2803163510"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Region Occitanie","award":["EPIPARA"],"award-info":[{"award-number":["EPIPARA"]}]},{"DOI":"10.13039\/100017605","name":"LabEx CeMEB","doi-asserted-by":"crossref","award":["ANR-10-LABX-04-01"],"award-info":[{"award-number":["ANR-10-LABX-04-01"]}],"id":[{"id":"10.13039\/100017605","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017605","name":"LabEx CeMEB","doi-asserted-by":"crossref","award":["ANR-10-LABX-04-01"],"award-info":[{"award-number":["ANR-10-LABX-04-01"]}],"id":[{"id":"10.13039\/100017605","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017605","name":"LabEx CeMEB","doi-asserted-by":"crossref","award":["ANR-10-LABX-04-01"],"award-info":[{"award-number":["ANR-10-LABX-04-01"]}],"id":[{"id":"10.13039\/100017605","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017605","name":"LabEx CeMEB","doi-asserted-by":"crossref","award":["ANR-10-LABX-04-01"],"award-info":[{"award-number":["ANR-10-LABX-04-01"]}],"id":[{"id":"10.13039\/100017605","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017605","name":"LabEx CeMEB","doi-asserted-by":"crossref","award":["ANR-10-LABX-04-01"],"award-info":[{"award-number":["ANR-10-LABX-04-01"]}],"id":[{"id":"10.13039\/100017605","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107475\/Z\/15\/Z"],"award-info":[{"award-number":["107475\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epigenetics & Chromatin"],"DOI":"10.1186\/s13072-025-00607-4","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:36:44Z","timestamp":1752503804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Introduction of epigenetic variation contribute to resistance against the human parasite Schistosoma mansoni"],"prefix":"10.1186","volume":"18","author":[{"given":"Nelia","family":"Luviano-Aparicio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Haegeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierick","family":"Mouginot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Chaparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola B.","family":"Arimondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cosseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Grunau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"607_CR1","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.3389\/fgene.2019.01150","volume":"10","author":"WJ Locke","year":"2019","unstructured":"Locke WJ, Guanzon D, Ma C, Liew YJ, Duesing KR, Fung KY, et al. DNA methylation cancer biomarkers: translation to the clinic. Front Genet. 2019;10:1150.","journal-title":"Front Genet"},{"key":"607_CR2","doi-asserted-by":"publisher","first-page":"e13699","DOI":"10.1111\/eva.13699","volume":"17","author":"A Balard","year":"2024","unstructured":"Balard A, Baltazar-Soares M, Eizaguirre C, Heckwolf MJ. An epigenetic toolbox for conservation biologists. Evol Appl. 2024;17:e13699.","journal-title":"Evol Appl"},{"key":"607_CR3","doi-asserted-by":"crossref","unstructured":"Johannsen W. Elemente der Exakten erblichkeitslehre. Gustav Fischer; 1909.","DOI":"10.1007\/BF01975768"},{"key":"607_CR4","unstructured":"Waddington C. The epigenotype: Endeavour. 1942."},{"key":"607_CR5","doi-asserted-by":"crossref","unstructured":"Waddington CH. Genetic assimilation of an acquired character. Evolution. 1953;7:118\u201326.","DOI":"10.1111\/j.1558-5646.1953.tb00070.x"},{"key":"607_CR6","first-page":"73","volume":"66","author":"A Nicoglou","year":"2017","unstructured":"Nicoglou A, Merlin F. Epigenetics: a way to bridge the gap between biological fields. Stud History Philos Sci Part C: Stud History Philos Biol Biomedical Sci. 2017;66:73\u201382.","journal-title":"Stud History Philos Sci Part C: Stud History Philos Biol Biomedical Sci"},{"key":"607_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.pt.2016.12.002","volume":"33","author":"C Cosseau","year":"2016","unstructured":"Cosseau C, Wolkenhauer O, Padalino G, Geyer KK, Hoffmann KF, Grunau C. (Epi)genetic inheritance in Schistosoma mansoni: a systems approach. Trends Parasitol. 2016;33:285\u201394.","journal-title":"Trends Parasitol"},{"key":"607_CR8","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s12551-018-0403-x","volume":"10","author":"K Nishikawa","year":"2018","unstructured":"Nishikawa K, Kinjo AR. Mechanism of evolution by genetic assimilation: equivalence and independence of genetic mutation and epigenetic modulation in phenotypic expression. Biophys Rev. 2018;10:667\u201376.","journal-title":"Biophys Rev"},{"key":"607_CR9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/brv.12453","volume":"94","author":"E Danchin","year":"2019","unstructured":"Danchin E, Pocheville A, Rey O, Pujol B, Blanchet S. Epigenetically facilitated mutational assimilation: epigenetics as a hub within the inclusive evolutionary synthesis. Biol Rev. 2019;94:259\u201382.","journal-title":"Biol Rev"},{"key":"607_CR10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/epigenomes6040033","volume":"6","author":"HE Hanson","year":"2022","unstructured":"Hanson HE, Liebl AL. The mutagenic consequences of DNA methylation within and across generations. Epigenomes. 2022;6:33.","journal-title":"Epigenomes"},{"key":"607_CR11","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1534\/genetics.117.201079","volume":"206","author":"L Fanti","year":"2017","unstructured":"Fanti L, Piacentini L, Cappucci U, Casale AM, Pimpinelli S. Canalization by selection of de novo induced mutations. Genetics. 2017;206:1995\u20132006.","journal-title":"Genetics"},{"key":"607_CR12","doi-asserted-by":"publisher","first-page":"11206","DOI":"10.1073\/pnas.0900301106","volume":"106","author":"N Elango","year":"2009","unstructured":"Elango N, Hunt BG, Goodisman MA, Yi SV. DNA methylation is widespread and associated with differential gene expression in castes of the honeybee, Apis mellifera. Proc Natl Acad Sci. 2009;106:11206\u201311.","journal-title":"Proc Natl Acad Sci"},{"key":"607_CR13","doi-asserted-by":"publisher","first-page":"e1006807","DOI":"10.1371\/journal.pgen.1006807","volume":"13","author":"G Riviere","year":"2017","unstructured":"Riviere G, He Y, Tecchio S, Crowell E, Gras M, Sourdaine P, et al. Dynamics of DNA methylomes underlie oyster development. PLoS Genet. 2017;13:e1006807.","journal-title":"PLoS Genet"},{"key":"607_CR14","doi-asserted-by":"publisher","first-page":"20132502","DOI":"10.1098\/rspb.2013.2502","volume":"281","author":"HE Amarasinghe","year":"2014","unstructured":"Amarasinghe HE, Clayton CI, Mallon EB. Methylation and worker reproduction in the bumble-bee (Bombus terrestris). Proc Royal Soc B: Biol Sci. 2014;281:20132502.","journal-title":"Proc Royal Soc B: Biol Sci"},{"key":"607_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms7513","volume":"6","author":"S Alvarado","year":"2015","unstructured":"Alvarado S, Rajakumar R, Abouheif E, Szyf M. Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants. Nat Commun. 2015;6:1\u20139.","journal-title":"Nat Commun"},{"key":"607_CR16","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1186\/1471-2164-13-480","volume":"13","author":"K Flores","year":"2012","unstructured":"Flores K, Wolschin F, Corneveaux JJ, Allen AN, Huentelman MJ, Amdam GV. Genome-wide association between DNA methylation and alternative splicing in an invertebrate. BMC Genomics. 2012;13:480.","journal-title":"BMC Genomics"},{"key":"607_CR17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pbi.2017.01.005","volume":"36","author":"DK Seymour","year":"2017","unstructured":"Seymour DK, Becker C. The causes and consequences of DNA methylome variation in plants. Curr Opin Plant Biol. 2017;36:56\u201363.","journal-title":"Curr Opin Plant Biol"},{"key":"607_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.curtheres.2019.06.001","volume":"91","author":"ML Nelwan","year":"2019","unstructured":"Nelwan ML. Schistosomiasis: life cycle, diagnosis, and control. Curr Therapeutic Res. 2019;91:5\u20139.","journal-title":"Curr Therapeutic Res"},{"key":"607_CR19","doi-asserted-by":"publisher","first-page":"782","DOI":"10.4269\/ajtmh.1978.27.782","volume":"27","author":"E Michelson","year":"1978","unstructured":"Michelson E, DuBois L. Susceptibility of Bahian population of Biomphalaria glabrata to an allopatric strain of Schistosoma mansoni. Am J Trop Med Hyg. 1978;27:782\u20136.","journal-title":"Am J Trop Med Hyg"},{"key":"607_CR20","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/s42003-022-03844-5","volume":"5","author":"L Bu","year":"2022","unstructured":"Bu L, Zhong D, Lu L, Loker ES, Yan G, Zhang S-M. Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping. Commun Biology. 2022;5:940.","journal-title":"Commun Biology"},{"key":"607_CR21","doi-asserted-by":"publisher","first-page":"e59395","DOI":"10.7554\/eLife.59395","volume":"9","author":"JA Tennessen","year":"2020","unstructured":"Tennessen JA, Bollmann SR, Peremyslova E, Kronmiller BA, Sergi C, Hamali B, et al. Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors. Elife. 2020;9:e59395.","journal-title":"Elife"},{"key":"607_CR22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/genes11010038","volume":"11","author":"JR Hambrook","year":"2019","unstructured":"Hambrook JR, Gharamah AA, Pila EA, Hussein S, Hanington PC. Biomphalaria glabrata granulin increases resistance to Schistosoma mansoni infection in several Biomphalaria species and induces the production of reactive oxygen species by haemocytes. Genes. 2019;11:38.","journal-title":"Genes"},{"key":"607_CR23","doi-asserted-by":"publisher","first-page":"103557","DOI":"10.1016\/j.dci.2019.103557","volume":"104","author":"MG Castillo","year":"2020","unstructured":"Castillo MG, Humphries JE, Mour\u00e3o MM, Marquez J, Gonzalez A, Montelongo CE. Biomphalaria glabrata immunity: post-genome advances. Dev Comp Immunol. 2020;104:103557.","journal-title":"Dev Comp Immunol"},{"key":"607_CR24","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s41437-018-0114-x","volume":"121","author":"JA Banta","year":"2018","unstructured":"Banta JA, Richards CL. Quantitative epigenetics and evolution. Heredity. 2018;121:210\u201324.","journal-title":"Heredity"},{"key":"607_CR25","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1111\/jeb.13130","volume":"30","author":"J Hu","year":"2017","unstructured":"Hu J, Barrett R. Epigenetics in natural animal populations. J Evol Biol. 2017;30:1612\u201332.","journal-title":"J Evol Biol"},{"key":"607_CR26","doi-asserted-by":"crossref","unstructured":"Horsthemke B. Epimutations in human disease. DNA Methylation: Dev Genetic Disease cancer. 2006;310:45\u201359.","DOI":"10.1007\/3-540-31181-5_4"},{"key":"607_CR27","doi-asserted-by":"crossref","unstructured":"Zhang YY, Fischer M, Colot V, Bossdorf O. Epigenetic variation creates potential for evolution of plant phenotypic plasticity. New Phytol. 2013;197:314\u201322.","DOI":"10.1111\/nph.12010"},{"key":"607_CR28","doi-asserted-by":"publisher","unstructured":"Verhoeven KJF, vonHoldt BM, Sork VL. Epigenetics in ecology and evolution: what we know and what we need to know. Molecular Ecology. 2016:1631\u20138. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/abs\/https:\/\/doi.org\/10.1111\/mec.13617","DOI":"10.1111\/mec.13617"},{"key":"607_CR29","doi-asserted-by":"publisher","first-page":"e1000530","DOI":"10.1371\/journal.pgen.1000530","volume":"5","author":"F Johannes","year":"2009","unstructured":"Johannes F, Porcher E, Teixeira FK, Saliba-Colombani V, Simon M, Agier N, et al. Assessing the impact of transgenerational epigenetic variation on complex traits. PLoS Genet. 2009;5:e1000530.","journal-title":"PLoS Genet"},{"key":"607_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13072-016-0076-2","volume":"9","author":"S Fneich","year":"2016","unstructured":"Fneich S, Th\u00e9ron A, Cosseau C, Rognon A, Aliaga B, Buard J, et al. Epigenetic origin of adaptive phenotypic variants in the human blood fluke Schistosoma mansoni. Epigenetics Chromatin. 2016;9:27.","journal-title":"Epigenetics Chromatin"},{"key":"607_CR31","doi-asserted-by":"publisher","first-page":"15451","DOI":"10.1038\/ncomms15451","volume":"8","author":"CM Adema","year":"2017","unstructured":"Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, et al. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun. 2017;8:15451.","journal-title":"Nat Commun"},{"key":"607_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/1756-3305-6-167","volume":"6","author":"S Fneich","year":"2013","unstructured":"Fneich S, Dheilly N, Adema C, Rognon A, Reichelt M, Bulla J, et al. 5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni. Parasites Vectors. 2013;6:167.","journal-title":"Parasites Vectors"},{"key":"607_CR33","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ijpara.2016.03.003","volume":"46","author":"M Knight","year":"2016","unstructured":"Knight M, Ittiprasert W, Arican-Goktas HD, Bridger JM. Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection. Int J Parasitol. 2016;46:389\u201394.","journal-title":"Int J Parasitol"},{"key":"607_CR34","doi-asserted-by":"publisher","first-page":"e0005246","DOI":"10.1371\/journal.pntd.0005246","volume":"11","author":"KK Geyer","year":"2017","unstructured":"Geyer KK, Niazi UH, Duval D, Cosseau C, Tomlinson C, Chalmers IW, et al. The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni. PLoS Negl Trop Dis. 2017;11:e0005246.","journal-title":"PLoS Negl Trop Dis"},{"key":"607_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13072-021-00422-7","volume":"14","author":"N Luviano","year":"2021","unstructured":"Luviano N, Lopez M, Gawehns F, Chaparro C, Arimondo PB, Ivanovic S, et al. The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor. Epigenetics Chromatin. 2021;14:1\u201325.","journal-title":"Epigenetics Chromatin"},{"key":"607_CR36","doi-asserted-by":"crossref","unstructured":"Luviano N, Halby L, Jallet C, Arimondo P, Cosseau C, Grunau C. An epigenetic molluscicide. bioRxiv. 2023:2023\u201303.","DOI":"10.1101\/2023.03.21.533666"},{"key":"607_CR37","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/agronomy8090163","volume":"8","author":"M Schmidt","year":"2018","unstructured":"Schmidt M, Byzova M, Martens C, Peeters M, Raj Y, Shukla S, et al. Methylome and epialleles in rice epilines selected for energy use efficiency. Agronomy. 2018;8:163.","journal-title":"Agronomy"},{"key":"607_CR38","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/agronomy9020092","volume":"9","author":"S Klemme","year":"2019","unstructured":"Klemme S, De Smet Y, Cammue BP, De Block M. Selection of salicylic acid tolerant epilines in brassica napus. Agronomy. 2019;9:92.","journal-title":"Agronomy"},{"key":"607_CR39","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12711-017-0292-7","volume":"49","author":"S Leroux","year":"2017","unstructured":"Leroux S, Gourichon D, Leterrier C, Labrune Y, Coustham V, Rivi\u00e8re S, et al. Embryonic environment and transgenerational effects in quail. Genet Sel Evol. 2017;49:14.","journal-title":"Genet Sel Evol"},{"key":"607_CR40","doi-asserted-by":"crossref","unstructured":"Catoni M, Cortijo S. EpiRILs: lessons from arabidopsis. Advances in botanical research. Elsevier; 2018. pp. 87\u2013116.","DOI":"10.1016\/bs.abr.2018.08.002"},{"key":"607_CR41","doi-asserted-by":"publisher","first-page":"111829","DOI":"10.1016\/j.ejmech.2019.111829","volume":"186","author":"D Pechalrieu","year":"2020","unstructured":"Pechalrieu D, Dauzonne D, Arimondo PB, Lopez M. Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells. Eur J Med Chem. 2020;186:111829.","journal-title":"Eur J Med Chem"},{"key":"607_CR42","doi-asserted-by":"publisher","first-page":"4665","DOI":"10.1021\/acs.jmedchem.7b00176","volume":"60","author":"L Halby","year":"2017","unstructured":"Halby L, Menon Y, Rilova E, Pechalrieu D, Masson V, Faux C, et al. Rational design of bisubstrate-type analogues as inhibitors of DNA methyltransferases in cancer cells. J Med Chem. 2017;60:4665\u201379.","journal-title":"J Med Chem"},{"key":"607_CR43","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.4269\/ajtmh.20-1433","volume":"104","author":"SA Spencer","year":"2021","unstructured":"Spencer SA, Linder C, Penney JMS, Russell HJ, Hyde K, Sheehy C, et al. Five-year follow-up on the prevalence and intensity of infections of Schistosoma mansoni in a hard-to-reach district of Madagascar. Am J Trop Med Hyg. 2021;104:1841.","journal-title":"Am J Trop Med Hyg"},{"key":"607_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/mollus\/eyl028","volume":"73","author":"A Wethington","year":"2007","unstructured":"Wethington A, Zavodna M, Smith M, Oliveira G, Lewis F, Minchella D. Population genetic structure of Biomphalaria glabrata in a schistosomiasis-endemic region in Brazil. J Molluscan Stud. 2007;73:45\u201352.","journal-title":"J Molluscan Stud"},{"key":"607_CR45","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/sj.hdy.6800127","volume":"89","author":"J Mav\u00e1rez","year":"2002","unstructured":"Mav\u00e1rez J, Pointier J, David P, Delay B, Jarne P. Genetic differentiation, dispersal and mating system in the schistosome-transmitting freshwater snail Biomphalaria glabrata. Heredity. 2002;89:258\u201365.","journal-title":"Heredity"},{"issue":"1","key":"607_CR46","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/07352689.2014.847631","volume":"33","author":"D Stanley","year":"2014","unstructured":"Stanley D, Kim Y. Eicosanoid signaling in insects: from discovery to plant protection. CRC Crit Rev Plant Sci. 2014;33(1):20\u201363.","journal-title":"CRC Crit Rev Plant Sci"},{"key":"607_CR47","doi-asserted-by":"publisher","first-page":"108868","DOI":"10.1016\/j.fsi.2023.108868","volume":"138","author":"Y Wu","year":"2023","unstructured":"Wu Y, Si X, Qiu L, Chen X, Fu P, Buttino I, Guo B, Liao Z, Yan X, Qi P. Regulation of innate immunity in marine mussel Mytilus coruscus: MicroRNA Mc-novel_miR_196 targets McTLR-like1 molecule to inhibit inflammatory response and apoptosis. Fish Shellfish Immunol. 2023;138:108868.","journal-title":"Fish Shellfish Immunol"},{"issue":"1","key":"607_CR48","doi-asserted-by":"publisher","first-page":"6577","DOI":"10.1038\/s41598-020-63676-3","volume":"10","author":"F Mao","year":"2020","unstructured":"Mao F, Mu H, Wong NK, Liu K, Song J, Qiu J, Lin Y, Zhang X, Xu D, Xiang Z, Li J. Hemocyte phagosomal proteome is dynamically shaped by cytoskeleton remodeling and interorganellar communication with endoplasmic reticulum during phagocytosis in a marine invertebrate, Crassostrea gigas. Sci Rep. 2020;10(1):6577.","journal-title":"Sci Rep"},{"key":"607_CR49","doi-asserted-by":"publisher","first-page":"1018423","DOI":"10.3389\/fimmu.2022.1018423","volume":"13","author":"H Wu","year":"2022","unstructured":"Wu H, Yang C, Hao R, Liao Y, Wang Q, Deng Y. Lipidomic insights into the immune response and pearl formation in transplanted pearl oyster Pinctada fucata martensii. Front Immunol. 2022;13:1018423.","journal-title":"Front Immunol"},{"key":"607_CR50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1006\/jtbi.1999.0974","volume":"200","author":"C P\u00e1l","year":"1999","unstructured":"P\u00e1l C, Mikl\u00f3s I. Epigenetic inheritance, genetic assimilation and speciation. J Theor Biol. 1999;200:19\u201337.","journal-title":"J Theor Biol"},{"key":"607_CR51","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0014-4894(89)90114-8","volume":"68","author":"AE Crews","year":"1989","unstructured":"Crews AE, Yoshino TP. Schistosoma mansoni: effect of infection on reproduction and gonadal growth in Biomphalaria glabrata. Exp Parasitol. 1989;68:326\u201334.","journal-title":"Exp Parasitol"},{"issue":"1","key":"607_CR52","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13071-022-05178-x","volume":"15","author":"K Kura","year":"2022","unstructured":"Kura K, Ayabina D, Hollingsworth TD, Anderson RM. Determining the optimal strategies to achieve elimination of transmission for Schistosoma mansoni. Parasites Vectors. 2022;15(1):55.","journal-title":"Parasites Vectors"},{"key":"607_CR53","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s13071-020-04409-3","volume":"13","author":"K Kura","year":"2020","unstructured":"Kura K, Hardwick RJ, Truscott JE, et al. The impact of mass drug administration on Schistosoma haematobium infection: what is required to achieve morbidity control and elimination? Parasites Vectors. 2020;13:554.","journal-title":"Parasites Vectors"},{"key":"607_CR54","doi-asserted-by":"publisher","first-page":"e0011983","DOI":"10.1371\/journal.pntd.0011983","volume":"18","author":"D Zhong","year":"2024","unstructured":"Zhong D, Bu L, Habib MR, Lu L, Yan G, Zhang S-M. A haplotype-like, chromosome-level assembled and annotated genome of Biomphalaria glabrata, an important intermediate host of schistosomiasis and the best studied model of schistosomiasis vector snails. PLoS Negl Trop Dis. 2024;18:e0011983.","journal-title":"PLoS Negl Trop Dis"},{"key":"607_CR55","doi-asserted-by":"publisher","first-page":"107212","DOI":"10.1016\/j.actatropica.2024.107212","volume":"255","author":"E Simphor","year":"2024","unstructured":"Simphor E, Rognon A, Vignal E, Henry S, Allienne J-F, Turtoi A, et al. Combining a transcriptomic approach and a targeted metabolomics approach for deciphering the molecular bases of compatibility phenotype in the snail Biomphalaria glabrata toward Schistosoma mansoni. Acta Trop. 2024;255:107212.","journal-title":"Acta Trop"},{"key":"607_CR56","doi-asserted-by":"publisher","first-page":"e0009094","DOI":"10.1371\/journal.pntd.0009094","volume":"15","author":"M Smith","year":"2021","unstructured":"Smith M, Yadav S, Fagunloye OG, Pels NA, Horton DA, Alsultan N, et al. PIWI Silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata. PLoS Negl Trop Dis. 2021;15:e0009094.","journal-title":"PLoS Negl Trop Dis"},{"key":"607_CR57","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1111\/1755-0998.13597","volume":"22","author":"F Gawehns","year":"2022","unstructured":"Gawehns F, Postuma M, van Antro M, Nunn A, Sepers B, Fatma S, et al. epiGBS2: improvements and evaluation of highly multiplexed, epiGBS-based reduced representation bisulfite sequencing. Mol Ecol Resour. 2022;22:2087\u2013104.","journal-title":"Mol Ecol Resour"},{"key":"607_CR58","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nmeth.3763","volume":"13","author":"TP van Gurp","year":"2016","unstructured":"van Gurp TP, Wagemaker NC, Wouters B, Vergeer P, Ouborg JN, Verhoeven KJ. EpiGBS: reference-free reduced representation bisulfite sequencing. Nat Methods. 2016;13:322\u20134.","journal-title":"Nat Methods"},{"key":"607_CR59","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/978-1-4939-7774-1_18","volume":"1767","author":"M Kernaleguen","year":"2018","unstructured":"Kernaleguen M, Daviaud C, Shen Y, Bonnet E, Renault V, Deleuze JF, et al. Whole-genome bisulfite sequencing for the analysis of genome-wide DNA methylation and hydroxymethylation patterns at single-nucleotide resolution. Methods Mol Biol. 2018;1767:311\u201349.","journal-title":"Methods Mol Biol"},{"key":"607_CR60","doi-asserted-by":"crossref","unstructured":"Buenrostro JD, Wu B, Chang HY, Greenleaf WJ. ATAC-seq: a method for assaying chromatin accessibility genome-wide. Curr Protoc Mol Biol. 2015;109:21.29.1-21.29.9.","DOI":"10.1002\/0471142727.mb2129s109"},{"key":"607_CR61","doi-asserted-by":"crossref","unstructured":"Karunaratne LB, Lewis FA, Freitas TC, Liang YS, Tucker MS, Karunaratne LB et al. Schistosomiasis. Curr Protocols Immunol. 2013;103.","DOI":"10.1002\/0471142735.im1901s103"},{"key":"607_CR62","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1038\/s41467-018-06659-3","volume":"9","author":"J de Lorgeril","year":"2018","unstructured":"de Lorgeril J, Lucasson A, Petton B, Toulza E, Montagnani C, Clerissi C, et al. Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters. Nat Commun. 2018;9:4215.","journal-title":"Nat Commun"},{"key":"607_CR63","doi-asserted-by":"crossref","unstructured":"Luviano N, Diaz-Palma S, Cosseau C, Grunau C. A simple dot blot assay for population scale screening of DNA methylation. BioRxiv. 2018;454439.","DOI":"10.1101\/454439"},{"key":"607_CR64","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","volume":"17","author":"M Martin","year":"2011","unstructured":"Martin M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 2011;17:10\u20132.","journal-title":"EMBnet J"},{"key":"607_CR65","doi-asserted-by":"crossref","unstructured":"Afgan E, Baker D, Batut B, van den Beek M, Bouvier D, Cech M et al. The galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update. Nucleic Acids Res. 2018;46:W537\u201344.","DOI":"10.1093\/nar\/gky379"},{"key":"607_CR66","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/1471-2105-10-232","volume":"10","author":"Y Xi","year":"2009","unstructured":"Xi Y, Li W. BSMAP: whole genome bisulfite sequence mapping program. BMC Bioinformatics. 2009;10:232.","journal-title":"BMC Bioinformatics"},{"key":"607_CR67","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","volume":"13","author":"A Akalin","year":"2012","unstructured":"Akalin A, Kormaksson M, Li S, Garrett-Bakelman FE, Figueroa ME, Melnick A, et al. MethylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol. 2012;13:R87.","journal-title":"Genome Biol"},{"key":"607_CR68","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/genes9020075","volume":"9","author":"H Tran","year":"2018","unstructured":"Tran H, Zhu H, Wu X, Kim G, Clarke CR, Larose H, et al. Identification of differentially methylated sites with weak methylation effects. Genes. 2018;9:75.","journal-title":"Genes"},{"issue":"6","key":"607_CR69","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26(6):841\u20132.","journal-title":"Bioinformatics"},{"issue":"W1","key":"607_CR70","doi-asserted-by":"publisher","first-page":"W395","DOI":"10.1093\/nar\/gkaa434","volume":"48","author":"V Jalili","year":"2020","unstructured":"Jalili V, Afgan E, Gu Q, Clements D, Blankenberg D, Goecks J, Taylor J, Nekrutenko A. The galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2020 update. Nucleic Acids Res. 2020;48(W1):W395\u2013402.","journal-title":"Nucleic Acids Res"},{"key":"607_CR71","doi-asserted-by":"crossref","unstructured":"Pertea G, Pertea M. GFF utilities: GffRead and gffcompare. F1000Research. 2020;9:ISCB-Comm.","DOI":"10.12688\/f1000research.23297.2"},{"issue":"W1","key":"607_CR72","doi-asserted-by":"publisher","first-page":"W191","DOI":"10.1093\/nar\/gkz369","volume":"47","author":"U Raudvere","year":"2019","unstructured":"Raudvere U, Kolberg L, Kuzmin I, Arak T, Adler P, Peterson H, Vilo J. G: profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res. 2019;47(W1):W191\u20138.","journal-title":"Nucleic Acids Res"},{"key":"607_CR73","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/bioinformatics\/btx595","volume":"34","author":"W Guo","year":"2018","unstructured":"Guo W, Zhu P, Pellegrini M, Zhang MQ, Wang X, Ni Z. CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data. Bioinformatics. 2018;34:381\u20137.","journal-title":"Bioinformatics"},{"key":"607_CR74","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1471-8286.2004.00828.x","volume":"5","author":"J Goudet","year":"2005","unstructured":"Goudet J. Hierfstat, a package for R to compute and test hierarchical F-statistics. Mol Ecol Notes. 2005;5:184\u20136.","journal-title":"Mol Ecol Notes"},{"key":"607_CR75","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1093\/bioinformatics\/btn129","volume":"24","author":"T Jombart","year":"2008","unstructured":"Jombart T. Adegenet: a R package for the multivariate analysis of genetic markers. Bioinformatics. 2008;24:1403\u20135.","journal-title":"Bioinformatics"},{"key":"607_CR76","unstructured":"Falconer DS. Introduction to quantitative genetics. Pearson Education India; 1996."}],"container-title":["Epigenetics & Chromatin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-025-00607-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13072-025-00607-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-025-00607-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T12:26:48Z","timestamp":1757248008000},"score":1,"resource":{"primary":{"URL":"https:\/\/epigeneticsandchromatin.biomedcentral.com\/articles\/10.1186\/s13072-025-00607-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["607"],"URL":"https:\/\/doi.org\/10.1186\/s13072-025-00607-4","relation":{},"ISSN":["1756-8935"],"issn-type":[{"value":"1756-8935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"5 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experiments were done according to the national ethics standards. The IHPE animal facility holds agreement number F6613601 and has authorization APAFIS #39910-2022121915564694 v2 for the routine production and shared used of\n                      S. mansoni\n                      larvae.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}