{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:23:55Z","timestamp":1790659435508,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epigenetics & Chromatin"],"DOI":"10.1186\/s13072-026-00667-0","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:16:27Z","timestamp":1773713787000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of fulvestrant on estrogen receptor-driven chromatin dynamics in breast cancer cells"],"prefix":"10.1186","volume":"19","author":[{"given":"C\u00e9line","family":"Barlier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Simplicien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Hermoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Pourrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia","family":"Delherme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Daluege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet","family":"Bharaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Piras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Hoareau-Aveilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaylor","family":"Boulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"667_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav1898","volume":"362","author":"MR Corces","year":"2018","unstructured":"Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, et al. The chromatin accessibility landscape of primary human cancers. Science. 2018;362:eaav1898. https:\/\/doi.org\/10.1126\/science.aav1898.","journal-title":"Science"},{"key":"667_CR2","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2023.2293411","volume":"19","author":"Z Fu","year":"2024","unstructured":"Fu Z, Jiang S, Sun Y, Zheng S, Zong L, Li P. Cut&tag: a powerful epigenetic tool for chromatin profiling. Epigenetics. 2024;19:2293411. https:\/\/doi.org\/10.1080\/15592294.2023.2293411.","journal-title":"Epigenetics"},{"key":"667_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7\u201330. https:\/\/doi.org\/10.3322\/caac.21442.","journal-title":"CA Cancer J Clin"},{"key":"667_CR4","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2119\/2008-00026.Stice","volume":"14","author":"JP Stice","year":"2008","unstructured":"Stice JP, Knowlton AA. Estrogen, NF\u03baB, and the Heat Shock Response. Mol Med. 2008;14:517\u201327. https:\/\/doi.org\/10.2119\/2008-00026.Stice.","journal-title":"Mol Med"},{"key":"667_CR5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/rmb2.12006","volume":"16","author":"P Ya\u015far","year":"2017","unstructured":"Ya\u015far P, Ayaz G, User SD, G\u00fcp\u00fcr G, Muyan M. Molecular mechanism of estrogen\u2013estrogen receptor signaling. Reprod Med Biol. 2017;16:4\u201320. https:\/\/doi.org\/10.1002\/rmb2.12006.","journal-title":"Reprod Med Biol"},{"key":"667_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.599586","volume":"12","author":"EB Belachew","year":"2021","unstructured":"Belachew EB, Sewasew DT. Molecular mechanisms of endocrine resistance in estrogen-receptor-positive breast cancer. Front Endocrinol. 2021;12:599586. https:\/\/doi.org\/10.3389\/fendo.2021.599586.","journal-title":"Front Endocrinol"},{"key":"667_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076834","volume":"24","author":"L Clusan","year":"2023","unstructured":"Clusan L, Ferri\u00e8re F, Flouriot G, Pakdel F. A basic review on estrogen receptor signaling pathways in breast cancer. Int J Mol Sci. 2023;24:6834. https:\/\/doi.org\/10.3390\/ijms24076834.","journal-title":"Int J Mol Sci"},{"key":"667_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030552","volume":"16","author":"RK Rej","year":"2024","unstructured":"Rej RK, Roy J, Allu SR. Therapies for the treatment of advanced\/metastatic estrogen receptor-positive breast cancer: current situation and future directions. Cancers. 2024;16:552. https:\/\/doi.org\/10.3390\/cancers16030552.","journal-title":"Cancers"},{"key":"667_CR9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1634\/theoncologist.7-6-477","volume":"7","author":"PF Bross","year":"2002","unstructured":"Bross PF, Cohen MH, Williams GA, Pazdur R. FDA drug approval summaries: fulvestrant. Oncologist. 2002;7:477\u201380. https:\/\/doi.org\/10.1634\/theoncologist.7-6-477.","journal-title":"Oncologist"},{"key":"667_CR10","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1210\/endo-129-4-2000","volume":"129","author":"MK Gibson","year":"1991","unstructured":"Gibson MK, Nemmers LA, Beckman WC, Davis VL, Curtis SW, Korach KS. The mechanism of ICI 164,384 antiestrogenieity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology. 1991;129:2000\u201310. https:\/\/doi.org\/10.1210\/endo-129-4-2000.","journal-title":"Endocrinology"},{"key":"667_CR11","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.cell.2019.06.026","volume":"178","author":"J Guan","year":"2019","unstructured":"Guan J, Zhou W, Hafner M, Blake RA, Chalouni C, Chen IP, et al. Therapeutic ligands antagonize estrogen receptor function by impairing its mobility. Cell. 2019;178:949-963.e18. https:\/\/doi.org\/10.1016\/j.cell.2019.06.026.","journal-title":"Cell"},{"key":"667_CR12","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","volume":"10","author":"HS Kaya-Okur","year":"2019","unstructured":"Kaya-Okur HS, Wu SJ, Codomo CA, Pledger ES, Bryson TD, Henikoff JG, et al. CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat Commun. 2019;10:1930. https:\/\/doi.org\/10.1038\/s41467-019-09982-5.","journal-title":"Nat Commun"},{"key":"667_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45839-z","volume":"9","author":"HM Amemiya","year":"2019","unstructured":"Amemiya HM, Kundaje A, Boyle AP. The ENCODE blacklist: identification of problematic regions of the genome. Sci Rep. 2019;9:9354. https:\/\/doi.org\/10.1038\/s41598-019-45839-z.","journal-title":"Sci Rep"},{"key":"667_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-237","volume":"11","author":"LJ Zhu","year":"2010","unstructured":"Zhu LJ, Gazin C, Lawson ND, Pag\u00e8s H, Lin SM, Lapointe DS, et al. ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data. BMC Bioinformatics. 2010;11:237. https:\/\/doi.org\/10.1186\/1471-2105-11-237.","journal-title":"BMC Bioinformatics"},{"key":"667_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340. https:\/\/doi.org\/10.1093\/bioinformatics\/btp616.","journal-title":"Bioinformatics"},{"key":"667_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4625-x","volume":"19","author":"Z Gu","year":"2018","unstructured":"Gu Z, Eils R, Schlesner M, Ishaque N. EnrichedHeatmap: an R\/Bioconductor package for comprehensive visualization of genomic signal associations. BMC Genomics. 2018;19:234. https:\/\/doi.org\/10.1186\/s12864-018-4625-x.","journal-title":"BMC Genomics"},{"key":"667_CR17","doi-asserted-by":"publisher","unstructured":"Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics [Internet]. Springer Science and Business Media LLC; 2013 [cited 2025 July 23];14. https:\/\/doi.org\/10.1186\/1471-2105-14-128.","DOI":"10.1186\/1471-2105-14-128"},{"key":"667_CR18","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 2016;44:W90\u20137. https:\/\/doi.org\/10.1093\/nar\/gkw377.","journal-title":"Nucleic Acids Res"},{"key":"667_CR19","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38:576\u201389. https:\/\/doi.org\/10.1016\/j.molcel.2010.05.004.","journal-title":"Mol Cell"},{"key":"667_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cell.2005.05.008","volume":"122","author":"JS Carroll","year":"2005","unstructured":"Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005;122:33\u201343. https:\/\/doi.org\/10.1016\/j.cell.2005.05.008.","journal-title":"Cell"},{"key":"667_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06400-5","volume":"7","author":"S Tabe-Bordbar","year":"2024","unstructured":"Tabe-Bordbar S, Song YJ, Lunt BJ, Alavi Z, Prasanth KV, Sinha S. Mechanistic analysis of enhancer sequences in the estrogen receptor transcriptional program. Commun Biol. 2024;7:719. https:\/\/doi.org\/10.1038\/s42003-024-06400-5.","journal-title":"Commun Biol"},{"key":"667_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.59","volume":"7","author":"SL Kong","year":"2011","unstructured":"Kong SL, Li G, Loh SL, Sung W, Liu ET. Cellular reprogramming by the conjoint action of ER\u03b1, FOXA1, and GATA3 to a ligand\u2010inducible growth state. Mol Syst Biol. 2011;7:526. https:\/\/doi.org\/10.1038\/msb.2011.59.","journal-title":"Mol Syst Biol"},{"key":"667_CR23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jss.2008.07.015","volume":"157","author":"SH Fang","year":"2009","unstructured":"Fang SH, Chen Y, Weigel RJ. GATA-3 as a marker of hormone response in breast cancer. J Surg Res. 2009;157:290\u20135. https:\/\/doi.org\/10.1016\/j.jss.2008.07.015.","journal-title":"J Surg Res"},{"key":"667_CR24","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1093\/carcin\/bgs223","volume":"33","author":"K Dahlman-Wright","year":"2012","unstructured":"Dahlman-Wright K, Qiao Y, Jonsson P, Gustafsson J-\u00c5, Williams C, Zhao C. Interplay between AP-1 and estrogen receptor \u03b1 in regulating gene expression and proliferation networks in breast cancer cells. Carcinogenesis. 2012;33:1684\u201391. https:\/\/doi.org\/10.1093\/carcin\/bgs223.","journal-title":"Carcinogenesis"},{"key":"667_CR25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1101\/gr.278680.123","volume":"34","author":"SEP Joosten","year":"2024","unstructured":"Joosten SEP, Gregoricchio S, Stelloo S, Yap\u0131c\u0131 E, Huang C-CF, Yavuz K, et al. Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions. Genome Res. 2024;34:539\u201355. https:\/\/doi.org\/10.1101\/gr.278680.123.","journal-title":"Genome Res"},{"key":"667_CR26","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/ng1901","volume":"38","author":"JS Carroll","year":"2006","unstructured":"Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, et al. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006;38:1289\u201397. https:\/\/doi.org\/10.1038\/ng1901.","journal-title":"Nat Genet"},{"key":"667_CR27","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.cell.2011.03.042","volume":"145","author":"N Hah","year":"2011","unstructured":"Hah N, Danko CG, Core L, Waterfall JJ, Siepel A, Lis JT, et al. A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell. 2011;145:622\u201334. https:\/\/doi.org\/10.1016\/j.cell.2011.03.042.","journal-title":"Cell"},{"key":"667_CR28","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1101\/gr.152306.112","volume":"23","author":"N Hah","year":"2013","unstructured":"Hah N, Murakami S, Nagari A, Danko CG, Kraus WL. Enhancer transcripts mark active estrogen receptor binding sites. Genome Res. 2013;23:1210\u201323. https:\/\/doi.org\/10.1101\/gr.152306.112.","journal-title":"Genome Res"},{"key":"667_CR29","doi-asserted-by":"publisher","first-page":"8387","DOI":"10.1074\/jbc.RA120.013666","volume":"295","author":"SC Hewitt","year":"2020","unstructured":"Hewitt SC, Grimm SA, Wu S-P, DeMayo FJ, Korach KS. Estrogen receptor \u03b1 (ER\u03b1)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice. J Biol Chem. 2020;295:8387\u2013400. https:\/\/doi.org\/10.1074\/jbc.RA120.013666.","journal-title":"J Biol Chem"},{"key":"667_CR30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf5733","volume":"7","author":"R Lopes","year":"2021","unstructured":"Lopes R, Sprouffske K, Sheng C, Uijttewaal ECH, Wesdorp AE, Dahinden J, et al. Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens. Sci Adv. 2021;7:eabf5733. https:\/\/doi.org\/10.1126\/sciadv.abf5733.","journal-title":"Sci Adv"},{"key":"667_CR31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206878120","volume":"120","author":"C Guo","year":"2023","unstructured":"Guo C, Meza-Sosa KF, Valle-Garcia D, Zhao G, Gao K, Yu L, et al. The SET oncoprotein promotes estrogen-induced transcription by facilitating establishment of active chromatin. Proc Natl Acad Sci USA. 2023;120:e2206878120. https:\/\/doi.org\/10.1073\/pnas.2206878120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"667_CR32","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ng1966","volume":"39","author":"ND Heintzman","year":"2007","unstructured":"Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, Hawkins RD, et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet. 2007;39:311\u20138. https:\/\/doi.org\/10.1038\/ng1966.","journal-title":"Nat Genet"},{"key":"667_CR33","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/nature07730","volume":"457","author":"A Visel","year":"2009","unstructured":"Visel A, Blow MJ, Li Z, Zhang T, Akiyama JA, Holt A, et al. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature. 2009;457:854\u20138. https:\/\/doi.org\/10.1038\/nature07730.","journal-title":"Nature"},{"key":"667_CR34","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1073\/pnas.1016071107","volume":"107","author":"MP Creyghton","year":"2010","unstructured":"Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci USA. 2010;107:21931\u20136. https:\/\/doi.org\/10.1073\/pnas.1016071107.","journal-title":"Proc Natl Acad Sci USA"},{"key":"667_CR35","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1016\/j.molcel.2021.03.008","volume":"81","author":"T Narita","year":"2021","unstructured":"Narita T, Ito S, Higashijima Y, Chu WK, Neumann K, Walter J, et al. Enhancers are activated by p300\/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release. Mol Cell. 2021;81:2166-2182.e6. https:\/\/doi.org\/10.1016\/j.molcel.2021.03.008.","journal-title":"Mol Cell"},{"key":"667_CR36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mce.2014.06.020","volume":"394","author":"SQ To","year":"2014","unstructured":"To SQ, Cheung V, Lazarus KA, Knower KC, Clyne CD. Estradiol regulates tumor necrosis factor-\u03b1 expression and secretion in estrogen receptor positive breast cancer cells. Mol Cell Endocrinol. 2014;394:21\u20138. https:\/\/doi.org\/10.1016\/j.mce.2014.06.020.","journal-title":"Mol Cell Endocrinol"},{"key":"667_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13402-019-00489-1","volume":"43","author":"D Cruceriu","year":"2020","unstructured":"Cruceriu D, Baldasici O, Balacescu O, Berindan-Neagoe I. The dual role of tumor necrosis factor-alpha (TNF-\u03b1) in breast cancer: molecular insights and therapeutic approaches. Cell Oncol. 2020;43:1\u201318. https:\/\/doi.org\/10.1007\/s13402-019-00489-1.","journal-title":"Cell Oncol"},{"key":"667_CR38","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1128\/MCB.00907-09","volume":"30","author":"S Malik","year":"2010","unstructured":"Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O\u2019Malley BW, et al. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Mol Cell Biol. 2010;30:399\u2013412. https:\/\/doi.org\/10.1128\/MCB.00907-09.","journal-title":"Mol Cell Biol"},{"key":"667_CR39","doi-asserted-by":"publisher","first-page":"11339","DOI":"10.1093\/nar\/gku791","volume":"42","author":"M Jangal","year":"2014","unstructured":"Jangal M, Couture J-P, Bianco S, Magnani L, Mohammed H, G\u00e9vry N. The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor \u03b1 target genes. Nucleic Acids Res. 2014;42:11339\u201348. https:\/\/doi.org\/10.1093\/nar\/gku791.","journal-title":"Nucleic Acids Res"},{"key":"667_CR40","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.cell.2008.01.018","volume":"132","author":"M Lupien","year":"2008","unstructured":"Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, et al. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell. 2008;132:958\u201370. https:\/\/doi.org\/10.1016\/j.cell.2008.01.018.","journal-title":"Cell"},{"key":"667_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ng.730","volume":"43","author":"A Hurtado","year":"2011","unstructured":"Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet. 2011;43:27\u201333. https:\/\/doi.org\/10.1038\/ng.730.","journal-title":"Nat Genet"},{"key":"667_CR42","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.bcp.2011.03.031","volume":"82","author":"SE Wardell","year":"2011","unstructured":"Wardell SE, Marks JR, McDonnell DP. The turnover of estrogen receptor \u03b1 by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol. 2011;82:122\u201330. https:\/\/doi.org\/10.1016\/j.bcp.2011.03.031.","journal-title":"Biochem Pharmacol"},{"key":"667_CR43","doi-asserted-by":"publisher","first-page":"9607","DOI":"10.1074\/jbc.M510809200","volume":"281","author":"X Long","year":"2006","unstructured":"Long X, Nephew KP. Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-\u03b1. J Biol Chem. 2006;281:9607\u201315. https:\/\/doi.org\/10.1074\/jbc.M510809200.","journal-title":"J Biol Chem"},{"key":"667_CR44","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/j.molcel.2021.04.015","volume":"81","author":"SJ Hogg","year":"2021","unstructured":"Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, et al. Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300\/CBP inhibition. Mol Cell. 2021;81:2183-2200.e13. https:\/\/doi.org\/10.1016\/j.molcel.2021.04.015.","journal-title":"Mol Cell"},{"key":"667_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112799","volume":"13","author":"A Waddell","year":"2021","unstructured":"Waddell A, Mahmud I, Ding H, Huo Z, Liao D. Pharmacological inhibition of CBP\/p300 blocks estrogen receptor alpha (ER\u03b1) function through suppressing enhancer H3K27 acetylation in luminal breast cancer. Cancers. 2021;13:2799. https:\/\/doi.org\/10.3390\/cancers13112799.","journal-title":"Cancers"},{"key":"667_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262378","volume":"17","author":"A Bommi-Reddy","year":"2022","unstructured":"Bommi-Reddy A, Park-Chouinard S, Mayhew DN, Terzo E, Hingway A, Steinbaugh MJ, et al. CREBBP\/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells. PLoS ONE. 2022;17:e0262378. https:\/\/doi.org\/10.1371\/journal.pone.0262378.","journal-title":"PLoS ONE"},{"key":"667_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00635-0","volume":"14","author":"J Wang","year":"2023","unstructured":"Wang J, Zhou Z. Estrogen-dependent activation of NCOA3 couples with p300 and NF-\u03baB to mediate antiapoptotic genes in ER-positive breast cancer cells. Discov Onc. 2023;14:28. https:\/\/doi.org\/10.1007\/s12672-023-00635-0.","journal-title":"Discov Onc"}],"container-title":["Epigenetics & Chromatin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13072-026-00667-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-026-00667-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-026-00667-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:53:16Z","timestamp":1780390396000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13072-026-00667-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["667"],"URL":"https:\/\/doi.org\/10.1186\/s13072-026-00667-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6779056\/v1","asserted-by":"object"}]},"ISSN":["1756-8935"],"issn-type":[{"value":"1756-8935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22"}}