{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:37:35Z","timestamp":1792643855704,"version":"4.5.0"},"reference-count":164,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Initiation Funds for High-level Talents Program of Xi'an International University","award":["XAIU202588"],"award-info":[{"award-number":["XAIU202588"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epigenetics & Chromatin"],"DOI":"10.1186\/s13072-026-00693-y","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:25:09Z","timestamp":1785036309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protein arginine methyltransferase crosstalk: decoding the synergistic-antagonistic axis in cancer therapy"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5691-8742","authenticated-orcid":false,"given":"Yu","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5239-9330","authenticated-orcid":false,"given":"Lie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiqu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"issue":"3","key":"693_CR1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser KE, Joyce JA. The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 2023;41(3):374\u2013403.","journal-title":"Cancer Cell"},{"issue":"6","key":"693_CR2","doi-asserted-by":"publisher","first-page":"a038000","DOI":"10.1101\/cshperspect.a038000","volume":"11","author":"YL Chao","year":"2021","unstructured":"Chao YL, Pecot CV. Targeting Epigenetics in Lung Cancer. Cold Spring Harb Perspect Med. 2021;11(6):a038000.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"20","key":"693_CR3","doi-asserted-by":"publisher","first-page":"4729","DOI":"10.1158\/1078-0432.CCR-24-0160","volume":"30","author":"S Oh","year":"2024","unstructured":"Oh S, Koh J, Kim TM, et al. Transcriptomic Heterogeneity of EGFR-Mutant Non-Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer. Clin Cancer Res. 2024;30(20):4729\u201342.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"693_CR4","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1101\/gad.1787609","volume":"23","author":"SL Berger","year":"2009","unstructured":"Berger SL, Kouzarides T, Shiekhattar R, et al. An operational definition of epigenetics. Genes Dev. 2009;23(7):781\u20133.","journal-title":"Genes Dev"},{"issue":"1","key":"693_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","volume":"150","author":"MA Dawson","year":"2012","unstructured":"Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150(1):12\u201327.","journal-title":"Cell"},{"issue":"7","key":"693_CR6","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41573-021-00159-8","volume":"20","author":"Q Wu","year":"2021","unstructured":"Wu Q, Schapira M, Arrowsmith CH, et al. Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nat Rev Drug Discov. 2021;20(7):509\u201330.","journal-title":"Nat Rev Drug Discov"},{"key":"693_CR7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jbior.2014.09.003","volume":"57","author":"S Jahan","year":"2015","unstructured":"Jahan S, Davie JR. Protein arginine methyltransferases (PRMTs): role in chromatin organization. Adv Biol Regul. 2015;57:173\u201384.","journal-title":"Adv Biol Regul"},{"key":"693_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115456","volume":"167","author":"J Ning","year":"2023","unstructured":"Ning J, Chen L, Xiao G, et al. The protein arginine methyltransferase family (PRMTs) regulates metastases in various tumors: from experimental study to clinical application. Biomed Pharmacother. 2023;167:115456.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"693_CR9","doi-asserted-by":"publisher","first-page":"R59","DOI":"10.1016\/S0960-9822(01)00674-1","volume":"12","author":"JK Davie","year":"2002","unstructured":"Davie JK, Dent SY. Transcriptional control: an activating role for arginine methylation. Curr Biol. 2002;12(2):R59\u201361.","journal-title":"Curr Biol"},{"issue":"1","key":"693_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molcel.2016.11.003","volume":"65","author":"RS Blanc","year":"2017","unstructured":"Blanc RS, Richard S. Arginine Methylation: The Coming of Age. Mol Cell. 2017;65(1):8\u201324.","journal-title":"Mol Cell"},{"issue":"1","key":"693_CR11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s40364-025-00860-5","volume":"13","author":"Y Xu","year":"2025","unstructured":"Xu Y, Wu Q, Zhang Y, et al. Arginine methylation in cancer: mechanisms and therapeutic implications. Biomark Res. 2025;13(1):143.","journal-title":"Biomark Res"},{"issue":"1","key":"693_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.molcel.2013.08.039","volume":"52","author":"S Zheng","year":"2013","unstructured":"Zheng S, Moehlenbrink J, Lu YC, et al. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell. 2013;52(1):37\u201351.","journal-title":"Mol Cell"},{"key":"693_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177350","volume":"992","author":"Y Wei","year":"2025","unstructured":"Wei Y, Lyu X, Wang J, et al. Targeting protein arginine methyltransferases in breast cancer: promising strategies. Eur J Pharmacol. 2025;992:177350.","journal-title":"Eur J Pharmacol"},{"key":"693_CR14","doi-asserted-by":"publisher","first-page":"101016","DOI":"10.1016\/j.drup.2023.101016","volume":"72","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Xia T, Chen DQ, et al. Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance. Drug Resist Updat. 2024;72:101016.","journal-title":"Drug Resist Updat"},{"issue":"5","key":"693_CR15","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/s12276-021-00613-y","volume":"53","author":"JW Hwang","year":"2021","unstructured":"Hwang JW, Cho Y, Bae GU, et al. Protein arginine methyltransferases: promising targets for cancer therapy. Exp Mol Med. 2021;53(5):788\u2013808.","journal-title":"Exp Mol Med"},{"key":"693_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.865964","volume":"13","author":"W Dai","year":"2022","unstructured":"Dai W, Zhang J, Li S, et al. Protein arginine methylation: an emerging modification in cancer immunity and immunotherapy. Front Immunol. 2022;13:865964.","journal-title":"Front Immunol"},{"issue":"3","key":"693_CR17","doi-asserted-by":"publisher","first-page":"R223","DOI":"10.1530\/JME-18-0224","volume":"62","author":"SM Wang","year":"2019","unstructured":"Wang SM, Dowhan DH, Muscat GEO. Epigenetic arginine methylation in breast cancer: emerging therapeutic strategies. J Mol Endocrinol. 2019;62(3):R223\u201337.","journal-title":"J Mol Endocrinol"},{"issue":"3","key":"693_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108201","volume":"301","author":"M Cao","year":"2025","unstructured":"Cao M, Nguyen T, Song J, et al. Biomedical effects of protein arginine methyltransferase inhibitors. J Biol Chem. 2025;301(3):108201.","journal-title":"J Biol Chem"},{"issue":"3","key":"693_CR19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.molcel.2005.04.003","volume":"18","author":"MT Bedford","year":"2005","unstructured":"Bedford MT, Richard S. Arginine methylation an emerging regulator of protein function. Mol Cell. 2005;18(3):263\u201372.","journal-title":"Mol Cell"},{"issue":"575","key":"693_CR20","doi-asserted-by":"publisher","first-page":"eaat8388","DOI":"10.1126\/scisignal.aat8388","volume":"12","author":"D Musiani","year":"2019","unstructured":"Musiani D, Bok J, Massignani E, et al. Proteomics profiling of arginine methylation defines PRMT5 substrate specificity. Sci Signal. 2019;12(575):eaat8388.","journal-title":"Sci Signal"},{"key":"693_CR21","doi-asserted-by":"crossref","unstructured":"Li WJ, He YH, Yang JJ, et al. Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth. Nat Commun. 2021;12(1):1946.","DOI":"10.1038\/s41467-021-21963-1"},{"issue":"12","key":"693_CR22","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/S0960-9822(01)00294-9","volume":"11","author":"BD Strahl","year":"2001","unstructured":"Strahl BD, Briggs SD, Brame CJ, et al. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr Biol. 2001;11(12):996\u20131000.","journal-title":"Curr Biol"},{"issue":"24","key":"693_CR23","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1038\/sj.onc.1204325","volume":"20","author":"MR Stallcup","year":"2001","unstructured":"Stallcup MR. Role of protein methylation in chromatin remodeling and transcriptional regulation. Oncogene. 2001;20(24):3014\u201320.","journal-title":"Oncogene"},{"issue":"3","key":"693_CR24","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.molcel.2014.01.011","volume":"53","author":"Y Yang","year":"2014","unstructured":"Yang Y, McBride KM, Hensley S, et al. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell. 2014;53(3):484\u201397.","journal-title":"Mol Cell"},{"issue":"6025","key":"693_CR25","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.1202663","volume":"332","author":"RJ Sims III","year":"2011","unstructured":"Sims RJ III, Rojas LA, Beck DB, et al. The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science. 2011;332(6025):99\u2013103.","journal-title":"Science"},{"issue":"5531","key":"693_CR26","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1126\/science.1060781","volume":"293","author":"H Wang","year":"2001","unstructured":"Wang H, Huang ZQ, Xia L, et al. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science. 2001;293(5531):853\u20137.","journal-title":"Science"},{"issue":"16","key":"693_CR27","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1101\/gad.1333905","volume":"19","author":"S Huang","year":"2005","unstructured":"Huang S, Litt M, Felsenfeld G. Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev. 2005;19(16):1885\u201393.","journal-title":"Genes Dev"},{"issue":"10","key":"693_CR28","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1182\/blood-2009-07-236059","volume":"115","author":"X Li","year":"2010","unstructured":"Li X, Hu X, Patel B, et al. H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation. Blood. 2010;115(10):2028\u201337.","journal-title":"Blood"},{"issue":"23","key":"693_CR29","doi-asserted-by":"publisher","first-page":"20323","DOI":"10.1074\/jbc.M110.207258","volume":"286","author":"Y Feng","year":"2011","unstructured":"Feng Y, Wang J, Asher S, et al. Histone H4 acetylation differentially modulates arginine methylation by an in Cis mechanism. J Biol Chem. 2011;286(23):20323\u201334.","journal-title":"J Biol Chem"},{"issue":"1","key":"693_CR30","doi-asserted-by":"publisher","first-page":"4552","DOI":"10.1038\/s41467-018-06968-7","volume":"9","author":"F Dong","year":"2018","unstructured":"Dong F, Li Q, Yang C, et al. PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma. Nat Commun. 2018;9(1):4552.","journal-title":"Nat Commun"},{"issue":"6","key":"693_CR31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1101\/gad.233239.113","volume":"28","author":"X Su","year":"2014","unstructured":"Su X, Zhu G, Ding X, et al. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin\/Ssty repeats of Spindlin1. Genes Dev. 2014;28(6):622\u201336.","journal-title":"Genes Dev"},{"issue":"1","key":"693_CR32","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s11427-025-2959-x","volume":"69","author":"F Dong","year":"2026","unstructured":"Dong F, Cheng X, Wan J, et al. Transcriptional condensates enrich phosphorylated PRMT2 to stimulate H3R8me2a deposition and hypoxic response in glioblastoma. Sci China Life Sci. 2026;69(1):224\u201338.","journal-title":"Sci China Life Sci"},{"issue":"11","key":"693_CR33","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1007\/s00018-015-1847-9","volume":"72","author":"N Stopa","year":"2015","unstructured":"Stopa N, Krebs JE, Shechter D. The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cell Mol Life Sci. 2015;72(11):2041\u201359.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"693_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molcel.2008.12.013","volume":"33","author":"MT Bedford","year":"2009","unstructured":"Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Mol Cell. 2009;33(1):1\u201313.","journal-title":"Mol Cell"},{"issue":"1","key":"693_CR35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrc3409","volume":"13","author":"Y Yang","year":"2013","unstructured":"Yang Y, Bedford MT. Protein arginine methyltransferases and cancer. Nat Rev Cancer. 2013;13(1):37\u201350.","journal-title":"Nat Rev Cancer"},{"issue":"37","key":"693_CR36","doi-asserted-by":"publisher","first-page":"14894","DOI":"10.1073\/pnas.1312925110","volume":"110","author":"F Casadio","year":"2013","unstructured":"Casadio F, Lu X, Pollock SB, et al. H3R42me2a is a histone modification with positive transcriptional effects. Proc Natl Acad Sci U S A. 2013;110(37):14894\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"693_CR37","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/embo-reports\/kvf013","volume":"3","author":"UM Bauer","year":"2002","unstructured":"Bauer UM, Daujat S, Nielsen SJ, et al. Methylation at arginine 17 of histone H3 is linked to gene activation. EMBO Rep. 2002;3(1):39\u201344.","journal-title":"EMBO Rep"},{"issue":"10","key":"693_CR38","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1038\/s12276-025-01561-7","volume":"57","author":"Y Cho","year":"2025","unstructured":"Cho Y, Kim YK. Multifaceted roles of CARM1 beyond histone arginine methylation. Exp Mol Med. 2025;57(10):2251\u201363.","journal-title":"Exp Mol Med"},{"issue":"6","key":"693_CR39","doi-asserted-by":"publisher","first-page":"e34692","DOI":"10.1371\/journal.pone.0034692","volume":"7","author":"J Wu","year":"2012","unstructured":"Wu J, Cui N, Wang R, et al. A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS ONE. 2012;7(6):e34692.","journal-title":"PLoS ONE"},{"issue":"5","key":"693_CR40","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1007\/s13402-024-00943-9","volume":"47","author":"Z Xie","year":"2024","unstructured":"Xie Z, Tian Y, Guo X, et al. The emerging role of CARM1 in cancer. Cell Oncol (Dordr). 2024;47(5):1503\u201322.","journal-title":"Cell Oncol (Dordr)"},{"issue":"6","key":"693_CR41","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.molcel.2010.11.024","volume":"40","author":"Y Yang","year":"2010","unstructured":"Yang Y, Lu Y, Espejo A, et al. TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell. 2010;40(6):1016\u201323.","journal-title":"Mol Cell"},{"issue":"45","key":"693_CR42","doi-asserted-by":"publisher","first-page":"17454","DOI":"10.1074\/jbc.RA118.004028","volume":"293","author":"M Nie","year":"2018","unstructured":"Nie M, Wang Y, Guo C, et al. CARM1-mediated methylation of protein arginine methyltransferase 5 represses human \u03b3-globin gene expression in erythroleukemia cells. J Biol Chem. 2018;293(45):17454\u201363.","journal-title":"J Biol Chem"},{"issue":"3","key":"693_CR43","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nsmb.1568","volume":"16","author":"Q Zhao","year":"2009","unstructured":"Zhao Q, Rank G, Tan YT, et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009;16(3):304\u201311.","journal-title":"Nat Struct Mol Biol"},{"issue":"48","key":"693_CR44","doi-asserted-by":"publisher","first-page":"40641","DOI":"10.1074\/jbc.M112.414284","volume":"287","author":"J Li","year":"2012","unstructured":"Li J, Zhou F, Zhan D, et al. A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72. J Biol Chem. 2012;287(48):40641\u201351.","journal-title":"J Biol Chem"},{"issue":"21","key":"693_CR45","doi-asserted-by":"publisher","first-page":"9630","DOI":"10.1128\/MCB.24.21.9630-9645.2004","volume":"24","author":"S Pal","year":"2004","unstructured":"Pal S, Vishwanath SN, Erdjument-Bromage H, et al. Human SWI\/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol. 2004;24(21):9630\u201345.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"693_CR46","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1128\/MCB.01528-06","volume":"27","author":"CS Dacwag","year":"2007","unstructured":"Dacwag CS, Ohkawa Y, Pal S, et al. The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling. Mol Cell Biol. 2007;27(1):384\u201394.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"693_CR47","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1038\/s41467-019-11696-7","volume":"10","author":"L Cao","year":"2019","unstructured":"Cao L, Wu G, Zhu J, et al. Genotoxic stress-triggered \u03b2-catenin\/JDP2\/PRMT5 complex facilitates reestablishing glutathione homeostasis. Nat Commun. 2019;10(1):3761.","journal-title":"Nat Commun"},{"issue":"2","key":"693_CR48","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nsmb.2209","volume":"19","author":"V Migliori","year":"2012","unstructured":"Migliori V, M\u00fcller J, Phalke S, et al. Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance. Nat Struct Mol Biol. 2012;19(2):136\u201344.","journal-title":"Nat Struct Mol Biol"},{"issue":"31","key":"693_CR49","doi-asserted-by":"publisher","first-page":"28476","DOI":"10.1074\/jbc.M414328200","volume":"280","author":"J C\u00f4t\u00e9","year":"2005","unstructured":"C\u00f4t\u00e9 J, Richard S. Tudor domains bind symmetrical dimethylated arginines. J Biol Chem. 2005;280(31):28476\u201383.","journal-title":"J Biol Chem"},{"issue":"43","key":"693_CR50","doi-asserted-by":"publisher","first-page":"18398","DOI":"10.1073\/pnas.1013106107","volume":"107","author":"K Liu","year":"2010","unstructured":"Liu K, Chen C, Guo Y, et al. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A. 2010;107(43):18398\u2013403.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"693_CR51","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nchembio.88","volume":"4","author":"P Rathert","year":"2008","unstructured":"Rathert P, Dhayalan A, Murakami M, et al. Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol. 2008;4(6):344\u20136.","journal-title":"Nat Chem Biol"},{"issue":"10","key":"693_CR52","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41580-019-0155-x","volume":"20","author":"E Guccione","year":"2019","unstructured":"Guccione E, Richard S. The regulation, functions and clinical relevance of arginine methylation. Nat Rev Mol Cell Biol. 2019;20(10):642\u201357.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"693_CR53","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1074\/jbc.C700192200","volume":"283","author":"AN Iberg","year":"2008","unstructured":"Iberg AN, Espejo A, Cheng D, et al. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem. 2008;283(6):3006\u201310.","journal-title":"J Biol Chem"},{"issue":"1","key":"693_CR54","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41467-020-14511-w","volume":"11","author":"S Kim","year":"2020","unstructured":"Kim S, Kim NH, Park JE, et al. PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation. Nat Commun. 2020;11(1):612.","journal-title":"Nat Commun"},{"key":"693_CR55","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1756-8935-4-11","volume":"4","author":"T Waldmann","year":"2011","unstructured":"Waldmann T, Izzo A, Kamieniarz K, et al. Methylation of H2AR29 is a novel repressive PRMT6 target. Epigenetics Chromatin. 2011;4:11.","journal-title":"Epigenetics Chromatin"},{"issue":"24","key":"693_CR56","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1101\/gad.203356.112","volume":"26","author":"SS Dhar","year":"2012","unstructured":"Dhar SS, Lee SH, Kan PY, et al. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev. 2012;26(24):2749\u201362.","journal-title":"Genes Dev"},{"issue":"4","key":"693_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101123","volume":"297","author":"MD Fulton","year":"2021","unstructured":"Fulton MD, Cao M, Ho MC, et al. The macromolecular complexes of histones affect protein arginine methyltransferase activities. J Biol Chem. 2021;297(4):101123.","journal-title":"J Biol Chem"},{"key":"693_CR58","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.abb.2019.02.014","volume":"665","author":"K Jain","year":"2019","unstructured":"Jain K, Clarke SG. PRMT7 as a unique member of the protein arginine methyltransferase family: A review. Arch Biochem Biophys. 2019;665:36\u201345.","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"693_CR59","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2174\/1389203721666200507091952","volume":"21","author":"AA Al-Hamashi","year":"2020","unstructured":"Al-Hamashi AA, Diaz K, Huang R. Non-Histone Arginine Methylation by Protein Arginine Methyltransferases. Curr Protein Pept Sci. 2020;21(7):699\u2013712.","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"693_CR60","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/cells10010124","volume":"10","author":"JP Bryant","year":"2021","unstructured":"Bryant JP, Heiss J, Banasavadi-Siddegowda YK. Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies. Cells. 2021;10(1):124.","journal-title":"Cells"},{"issue":"1","key":"693_CR61","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12964-024-01506-z","volume":"22","author":"S Shen","year":"2024","unstructured":"Shen S, Zhou H, Xiao Z, et al. PRMT1 in human neoplasm: cancer biology and potential therapeutic target. Cell Commun Signal. 2024;22(1):102.","journal-title":"Cell Commun Signal"},{"key":"693_CR62","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3390\/cancers14020306","volume":"14","author":"S Suresh","year":"2022","unstructured":"Suresh S, Huard S, Brisson A, et al. PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast Cancer. Cancers (Basel). 2022;14:306.","journal-title":"Cancers (Basel)"},{"key":"693_CR63","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1158\/0008-5472.CAN-18-3211","volume":"79","author":"LM Liu","year":"2019","unstructured":"Liu LM, Sun WZ, Fan XZ, et al. Methylation of C\/EBP\u03b1 by PRMT1 inhibits its tumor-suppressive function in breast cancer. Cancer Res. 2019;79:2865\u201377.","journal-title":"Cancer Res"},{"issue":"4","key":"693_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115487","volume":"44","author":"WJ Li","year":"2025","unstructured":"Li WJ, Chen YC, Lin YA, et al. Hypoxia-induced PRMT1 methylates HIF2\u03b2 to promote breast tumorigenesis via enhancing glycolytic gene transcription. Cell Rep. 2025;44(4):115487.","journal-title":"Cell Rep"},{"issue":"11","key":"693_CR65","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41419-021-04381-5","volume":"12","author":"Z Li","year":"2021","unstructured":"Li Z, Wang D, Chen X, et al. PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis. Cell Death Dis. 2021;12(11):1080.","journal-title":"Cell Death Dis"},{"issue":"7","key":"693_CR66","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1158\/0008-5472.CAN-23-2266","volume":"84","author":"T Yamamoto","year":"2024","unstructured":"Yamamoto T, Hayashida T, Masugi Y, et al. PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer. Cancer Res. 2024;84(7):1065\u201383.","journal-title":"Cancer Res"},{"key":"693_CR67","doi-asserted-by":"publisher","first-page":"102953","DOI":"10.1016\/j.dnarep.2020.102953","volume":"95","author":"L He","year":"2020","unstructured":"He L, Hu Z, Sun Y, et al. PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells. DNA Repair (Amst). 2020;95:102953.","journal-title":"DNA Repair (Amst)"},{"issue":"1","key":"693_CR68","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1158\/2767-9764.CRC-24-0389","volume":"5","author":"X Sun","year":"2025","unstructured":"Sun X, Kumbier K, Gayathri S, et al. Targeting PRMT1 reduces cancer persistence and tumor relapse in EGFR- and KRAS-mutant lung cancer. Cancer Res Commun. 2025;5(1):119\u201327.","journal-title":"Cancer Res Commun"},{"issue":"7","key":"693_CR69","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s41419-024-06898-x","volume":"15","author":"L Peng","year":"2024","unstructured":"Peng L, Zhao Y, Tan J, et al. PRMT1 promotes Warburg effect by regulating the PKM2\/PKM1 ratio in non-small cell lung cancer. Cell Death Dis. 2024;15(7):504.","journal-title":"Cell Death Dis"},{"key":"693_CR70","doi-asserted-by":"publisher","first-page":"216707","DOI":"10.1016\/j.canlet.2024.216707","volume":"586","author":"X Liu","year":"2024","unstructured":"Liu X, Zheng W, Zhang L, et al. Arginine methylation-dependent cGAS stability promotes non-small cell lung cancer cell proliferation. Cancer Lett. 2024;586:216707.","journal-title":"Cancer Lett"},{"key":"693_CR71","doi-asserted-by":"crossref","unstructured":"Luo L, Wu X, Fan J, et al. FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma. Nat Commun. 2024;15(1):4790.","DOI":"10.1038\/s41467-024-49087-2"},{"issue":"1","key":"693_CR72","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/s41467-023-36708-5","volume":"14","author":"K Wang","year":"2023","unstructured":"Wang K, Luo L, Fu S, et al. PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. Nat Commun. 2023;14(1):1011.","journal-title":"Nat Commun"},{"issue":"1","key":"693_CR73","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41419-025-07723-9","volume":"16","author":"S Jiang","year":"2025","unstructured":"Jiang S, Li G, Peng S, et al. PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer. Cell Death Dis. 2025;16(1):404.","journal-title":"Cell Death Dis"},{"issue":"5","key":"693_CR74","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41419-019-1595-0","volume":"10","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Lu Q, Li C, et al. PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation. Cell Death Dis. 2019;10(5):359.","journal-title":"Cell Death Dis"},{"issue":"6","key":"693_CR75","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/hep4.1488","volume":"4","author":"J Zhao","year":"2020","unstructured":"Zhao J, O\u2019Neil M, Schonfeld M, et al. Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase. Hepatol Commun. 2020;4(6):790\u2013808.","journal-title":"Hepatol Commun"},{"issue":"3","key":"693_CR76","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s10120-015-0551-7","volume":"19","author":"B Altan","year":"2016","unstructured":"Altan B, Yokobori T, Ide M, et al. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients. Gastric Cancer. 2016;19(3):789\u201397.","journal-title":"Gastric Cancer"},{"key":"693_CR77","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.yexcr.2017.10.035","volume":"362","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Wang D, Zhang M, et al. Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition\/proliferation dichotomy in gastric cancer cells. Exp Cell Res. 2018;362:43\u201350.","journal-title":"Exp Cell Res"},{"key":"693_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/srep01311","volume":"3","author":"S Dhar","year":"2013","unstructured":"Dhar S, Vemulapalli V, Patananan AN, et al. Loss of the major type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep. 2013;3:1311.","journal-title":"Sci Rep"},{"issue":"38","key":"693_CR79","doi-asserted-by":"publisher","first-page":"8226","DOI":"10.1021\/bi200644c","volume":"50","author":"ML Pak","year":"2011","unstructured":"Pak ML, Lakowski TM, Thomas D, et al. A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity. Biochemistry. 2011;50(38):8226\u201340.","journal-title":"Biochemistry"},{"issue":"11","key":"693_CR80","volume":"11","author":"V Cura","year":"2021","unstructured":"Cura V, Cavarelli J. Structure, activity and function of the PRMT2 protein arginine methyltransferase. Life (Basel). 2021;11(11):1263.","journal-title":"Life (Basel)"},{"issue":"5","key":"693_CR81","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41419-023-05837-6","volume":"14","author":"Z Li","year":"2023","unstructured":"Li Z, Chen C, Yong H, et al. PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression. Cell Death Dis. 2023;14(5):322.","journal-title":"Cell Death Dis"},{"key":"693_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217967","volume":"632","author":"H Zou","year":"2025","unstructured":"Zou H, Liu Y, Yang X, et al. PRMT2 promotes tumorigenic phenotypes through the Wnt signaling pathway and drives immune suppression in colorectal cancer. Cancer Lett. 2025;632:217967.","journal-title":"Cancer Lett"},{"issue":"2","key":"693_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112152","volume":"394","author":"G Hu","year":"2020","unstructured":"Hu G, Yan C, Xie P, et al. PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation. Exp Cell Res. 2020;394(2):112152.","journal-title":"Exp Cell Res"},{"issue":"1","key":"693_CR84","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s42003-024-06453-6","volume":"7","author":"C Sauter","year":"2024","unstructured":"Sauter C, Morin T, Guidez F, et al. Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia. Commun Biol. 2024;7(1):753.","journal-title":"Commun Biol"},{"issue":"12","key":"693_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105360","volume":"299","author":"MJ Rowley","year":"2023","unstructured":"Rowley MJ, Prout-Holm RA, Liu RW, et al. Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1. J Biol Chem. 2023;299(12):105360.","journal-title":"J Biol Chem"},{"issue":"49","key":"693_CR86","doi-asserted-by":"publisher","first-page":"eadd8928","DOI":"10.1126\/sciadv.add8928","volume":"8","author":"L Liu","year":"2022","unstructured":"Liu L, Lin B, Yin S, et al. Arginine methylation of BRD4 by PRMT2\/4 governs transcription and DNA repair. Sci Adv. 2022;8(49):eadd8928.","journal-title":"Sci Adv"},{"issue":"11","key":"693_CR87","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/s41419-021-04352-w","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang X, Wang K, Feng X, et al. PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1\u03b1 in colorectal cancer. Cell Death Dis. 2021;12(11):1066.","journal-title":"Cell Death Dis"},{"key":"693_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145718","volume":"791","author":"Y Hu","year":"2021","unstructured":"Hu Y, Su Y, He Y, et al. Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer. Gene. 2021;791:145718.","journal-title":"Gene"},{"issue":"1","key":"693_CR89","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13045-019-0769-7","volume":"12","author":"MC Hsu","year":"2019","unstructured":"Hsu MC, Tsai YL, Lin CH, et al. Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer. J Hematol Oncol. 2019;12(1):79.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"693_CR90","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/cancers11010008","volume":"11","author":"MC Hsu","year":"2018","unstructured":"Hsu MC, Pan MR, Chu PY, et al. Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression. Cancers (Basel). 2018;11(1):8.","journal-title":"Cancers (Basel)"},{"issue":"11","key":"693_CR91","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/s41419-022-05389-1","volume":"13","author":"Y Liao","year":"2022","unstructured":"Liao Y, Luo Z, Lin Y, et al. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death Dis. 2022;13(11):943.","journal-title":"Cell Death Dis"},{"issue":"1","key":"693_CR92","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41419-025-07482-7","volume":"16","author":"CH Ding","year":"2025","unstructured":"Ding CH, Yan FZ, Xu BN, et al. PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma. Cell Death Dis. 2025;16(1):158.","journal-title":"Cell Death Dis"},{"issue":"1","key":"693_CR93","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.686","volume":"12","author":"Y Lei","year":"2022","unstructured":"Lei Y, Han P, Chen Y, et al. Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A. Clin Transl Med. 2022;12(1):e686.","journal-title":"Clin Transl Med"},{"issue":"27","key":"693_CR94","doi-asserted-by":"publisher","first-page":"16935","DOI":"10.1074\/jbc.273.27.16935","volume":"273","author":"J Tang","year":"1998","unstructured":"Tang J, Gary JD, Clarke S, et al. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. J Biol Chem. 1998;273(27):16935\u201345.","journal-title":"J Biol Chem"},{"issue":"19","key":"693_CR95","doi-asserted-by":"publisher","first-page":"13229","DOI":"10.1074\/jbc.274.19.13229","volume":"274","author":"JJ Smith","year":"1999","unstructured":"Smith JJ, R\u00fccknagel KP, Schierhorn A, et al. Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3. J Biol Chem. 1999;274(19):13229\u201334.","journal-title":"J Biol Chem"},{"issue":"8","key":"693_CR96","doi-asserted-by":"publisher","first-page":"bqae068","DOI":"10.1210\/endocr\/bqae068","volume":"165","author":"M Bacabac","year":"2024","unstructured":"Bacabac M, Liu P, Xu W. Protein Arginine Methyltransferase CARM1 in Human Breast Cancer. Endocrinology. 2024;165(8):bqae068.","journal-title":"Endocrinology"},{"issue":"11","key":"693_CR97","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1021\/acs.biochem.5b01071","volume":"55","author":"SL Jacques","year":"2016","unstructured":"Jacques SL, Aquino KP, Gureasko J, et al. CARM1 preferentially methylates H3R17 over H3R26 through a random kinetic mechanism. Biochemistry. 2016;55(11):1635\u201344.","journal-title":"Biochemistry"},{"issue":"2","key":"693_CR98","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41388-021-02078-9","volume":"41","author":"F Wang","year":"2022","unstructured":"Wang F, Zhang J, Tang H, et al. Nup54-induced CARM1 nuclear importation promotes gastric cancer cell proliferation and tumorigenesis through transcriptional activation and methylation of Notch2. Oncogene. 2022;41(2):246\u201359.","journal-title":"Oncogene"},{"issue":"12","key":"693_CR99","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41419-024-07313-1","volume":"15","author":"L Lin","year":"2024","unstructured":"Lin L, Yuan Q, Gu J, et al. CARM1-mediated OGT arginine methylation promotes non-small cell lung cancer glycolysis by stabilizing OGT. Cell Death Dis. 2024;15(12):927.","journal-title":"Cell Death Dis"},{"issue":"2","key":"693_CR100","doi-asserted-by":"publisher","first-page":"e48597","DOI":"10.15252\/embr.201948597","volume":"21","author":"J Liu","year":"2020","unstructured":"Liu J, Feng J, Li L, et al. Arginine methylation-dependent LSD1 stability promotes invasion and metastasis of breast cancer. EMBO Rep. 2020;21(2):e48597.","journal-title":"EMBO Rep"},{"issue":"16","key":"693_CR101","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1158\/0008-5472.CAN-24-3476","volume":"85","author":"EJ Kim","year":"2025","unstructured":"Kim EJ, Wang Y, Chen YL, et al. CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer. Cancer Res. 2025;85(16):3072\u201388.","journal-title":"Cancer Res"},{"issue":"2","key":"693_CR102","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1074\/jbc.M004228200","volume":"276","author":"SS Koh","year":"2001","unstructured":"Koh SS, Chen D, Lee YH, et al. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. J Biol Chem. 2001;276(2):1089\u201398.","journal-title":"J Biol Chem"},{"issue":"10","key":"693_CR103","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1093\/nar\/gkn166","volume":"36","author":"MA Kleinschmidt","year":"2008","unstructured":"Kleinschmidt MA, Streubel G, Samans B, et al. The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation. Nucleic Acids Res. 2008;36(10):3202\u201313.","journal-title":"Nucleic Acids Res"},{"key":"693_CR104","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1128\/MCB.22.11.3621-3632.2002","volume":"22","author":"YH Lee","year":"2002","unstructured":"Lee YH, Koh SS, Zhang X, et al. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002;22:3621\u201332.","journal-title":"Mol Cell Biol"},{"key":"693_CR105","doi-asserted-by":"publisher","first-page":"27242","DOI":"10.1074\/jbc.M605172200","volume":"282","author":"S Wagner","year":"2006","unstructured":"Wagner S, Weber S, Kleinschmidt MA, et al. SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. J Biol Chem. 2006;282:27242\u201350.","journal-title":"J Biol Chem"},{"key":"693_CR106","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1016\/S0960-9822(02)01387-8","volume":"12","author":"S Daujat","year":"2002","unstructured":"Daujat S, Bauer UM, Shah V, et al. Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol. 2002;12:2090\u20137.","journal-title":"Curr Biol"},{"key":"693_CR107","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.cell.2004.05.009","volume":"117","author":"W An","year":"2004","unstructured":"An W, Kim J, Roeder RG. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004;117:735\u201348.","journal-title":"Cell"},{"key":"693_CR108","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.biochi.2013.10.021","volume":"97","author":"R Elakoum","year":"2014","unstructured":"Elakoum R, Gauchotte G, Oussalah A, et al. CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features. Biochimie. 2014;97:210\u20138.","journal-title":"Biochimie"},{"issue":"50","key":"693_CR109","doi-asserted-by":"publisher","first-page":"17060","DOI":"10.1074\/jbc.RA120.014704","volume":"295","author":"D Cheng","year":"2020","unstructured":"Cheng D, Gao G, Di Lorenzo A, et al. Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. J Biol Chem. 2020;295(50):17060\u201370.","journal-title":"J Biol Chem"},{"issue":"1","key":"693_CR110","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1136\/gutjnl-2024-332998","volume":"74","author":"J Elurbide","year":"2024","unstructured":"Elurbide J, Colyn L, Latasa MU, et al. Identification of PRMT5 as a therapeutic target in cholangiocarcinoma. Gut. 2024;74(1):116\u201327.","journal-title":"Gut"},{"issue":"18","key":"693_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810046","volume":"25","author":"L Liu","year":"2024","unstructured":"Liu L, Soler J, Reckamp KL, et al. Emerging targets in non-small cell lung cancer. Int J Mol Sci. 2024;25(18):10046.","journal-title":"Int J Mol Sci"},{"issue":"3\u20134","key":"693_CR112","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41417-021-00327-3","volume":"29","author":"E Beketova","year":"2022","unstructured":"Beketova E, Owens JL, Asberry AM, et al. PRMT5: a putative oncogene and therapeutic target in prostate cancer. Cancer Gene Ther. 2022;29(3\u20134):264\u201376.","journal-title":"Cancer Gene Ther"},{"issue":"18","key":"693_CR113","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175023","volume":"134","author":"W Yan","year":"2024","unstructured":"Yan W, Liu X, Qiu X, et al. PRMT5-mediated FUBP1 methylation accelerates prostate cancer progression. J Clin Invest. 2024;134(18):e175023.","journal-title":"J Clin Invest"},{"issue":"23","key":"693_CR114","doi-asserted-by":"publisher","first-page":"e114558","DOI":"10.15252\/embj.2023114558","volume":"42","author":"Y Sun","year":"2023","unstructured":"Sun Y, Jin X, Meng J, et al. MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression. EMBO J. 2023;42(23):e114558.","journal-title":"EMBO J"},{"issue":"5","key":"693_CR115","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17856","volume":"28","author":"H Zhou","year":"2024","unstructured":"Zhou H, Chang J, Zhang J, et al. PRMT5 activates KLF5 by methylation to facilitate lung cancer. J Cell Mol Med. 2024;28(5):e17856.","journal-title":"J Cell Mol Med"},{"issue":"19","key":"693_CR116","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1038\/s41388-023-02674-x","volume":"42","author":"A Liu","year":"2023","unstructured":"Liu A, Yu C, Qiu C, et al. PRMT5 methylating SMAD4 activates TGF-\u03b2 signaling and promotes colorectal cancer metastasis. Oncogene. 2023;42(19):1572\u201384.","journal-title":"Oncogene"},{"issue":"2","key":"693_CR117","doi-asserted-by":"publisher","first-page":"e245","DOI":"10.1002\/mco2.245","volume":"4","author":"F Xie","year":"2023","unstructured":"Xie F, Zhang H, Zhu K, et al. PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1. MedComm. 2023;4(2):e245.","journal-title":"MedComm"},{"issue":"4","key":"693_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115484","volume":"44","author":"Q Xia","year":"2025","unstructured":"Xia Q, Zhong R, Zheng J, et al. PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms. Cell Rep. 2025;44(4):115484.","journal-title":"Cell Rep"},{"issue":"1","key":"693_CR119","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/s41467-021-21204-5","volume":"12","author":"P Sachamitr","year":"2021","unstructured":"Sachamitr P, Ho JC, Ciamponi FE, et al. PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nat Commun. 2021;12(1):979.","journal-title":"Nat Commun"},{"issue":"13","key":"693_CR120","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.7150\/ijbs.115225","volume":"21","author":"Y Han","year":"2025","unstructured":"Han Y, Ma L, Zhang X, et al. PRMT1\/PRMT5-Mediated Differential Arginine Methylation of CRIP1 Promotes the Recurrence of Small Cell Lung Cancer after Chemotherapy. Int J Biol Sci. 2025;21(13):5956\u201374.","journal-title":"Int J Biol Sci"},{"issue":"2","key":"693_CR121","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s10549-017-4597-6","volume":"168","author":"Z Wang","year":"2018","unstructured":"Wang Z, Kong J, Wu Y, et al. PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancer. Breast Cancer Res Treat. 2018;168(2):531\u201342.","journal-title":"Breast Cancer Res Treat"},{"issue":"38","key":"693_CR122","doi-asserted-by":"publisher","first-page":"10101","DOI":"10.1073\/pnas.1706978114","volume":"114","author":"K Jain","year":"2017","unstructured":"Jain K, Jin CY, Clarke SG. Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases. Proc Natl Acad Sci U S A. 2017;114(38):10101\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"693_CR123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116857","volume":"279","author":"J Peng","year":"2024","unstructured":"Peng J, Ni B, Li D, et al. Overview of the PRMT6 modulators in cancer treatment: current progress and emerged opportunity. Eur J Med Chem. 2024;279:116857.","journal-title":"Eur J Med Chem"},{"key":"693_CR124","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.841381","volume":"12","author":"Z Chen","year":"2022","unstructured":"Chen Z, Gan J, Wei Z, et al. The emerging role of PRMT6 in cancer. Front Oncol. 2022;12:841381.","journal-title":"Front Oncol"},{"issue":"10","key":"693_CR125","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41419-023-06148-6","volume":"14","author":"Q Chen","year":"2023","unstructured":"Chen Q, Hu Q, Chen Y, et al. PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer. Cell Death Dis. 2023;14(10):655.","journal-title":"Cell Death Dis"},{"issue":"1","key":"693_CR126","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.apsb.2022.05.019","volume":"13","author":"M Peng","year":"2023","unstructured":"Peng M, Li L, Niu Y, et al. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD\/ENO1 mediated cell metabolism. Acta Pharm Sin B. 2023;13(1):157\u201373.","journal-title":"Acta Pharm Sin B"},{"issue":"5","key":"693_CR127","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1615\/CritRevEukaryotGeneExpr.2024052979","volume":"34","author":"L Xu","year":"2024","unstructured":"Xu L, Zhang F, Yu B, et al. PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating ANXA1. Crit Rev Eukaryot Gene Expr. 2024;34(5):69\u201379.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"3","key":"693_CR128","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.celrep.2018.09.053","volume":"25","author":"LH Chan","year":"2018","unstructured":"Chan LH, Zhou L, Ng KY, et al. PRMT6 Regulates RAS\/RAF Binding and MEK\/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. Cell Rep. 2018;25(3):690\u2013701.","journal-title":"Cell Rep"},{"issue":"1","key":"693_CR129","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bbrc.2013.01.085","volume":"432","author":"NH Kim","year":"2013","unstructured":"Kim NH, Kim SN, Seo DW, et al. PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion. Biochem Biophys Res Commun. 2013;432(1):60\u20135.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"693_CR130","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4331\/wjbc.v14.i5.84","volume":"14","author":"MT Cao","year":"2023","unstructured":"Cao MT, Feng Y, Zheng YG. Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1. World J Biol Chem. 2023;14(5):84\u201398.","journal-title":"World J Biol Chem"},{"issue":"6","key":"693_CR131","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1080\/15548627.2019.1569931","volume":"15","author":"S Choi","year":"2019","unstructured":"Choi S, Jeong HJ, Kim H, et al. Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. Autophagy. 2019;15(6):1069\u201381.","journal-title":"Autophagy"},{"issue":"1","key":"693_CR132","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113413","volume":"422","author":"Y Chen","year":"2023","unstructured":"Chen Y, Liang W, Du J, et al. PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1. Exp Cell Res. 2023;422(1):113413.","journal-title":"Exp Cell Res"},{"issue":"6","key":"693_CR133","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.cmet.2022.04.004","volume":"34","author":"C Liu","year":"2022","unstructured":"Liu C, Zou W, Nie D, et al. Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML. Cell Metab. 2022;34(6):818\u201335.","journal-title":"Cell Metab"},{"issue":"20","key":"693_CR134","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.1038\/s41388-021-01785-7","volume":"40","author":"L Liu","year":"2021","unstructured":"Liu L, Zhang X, Ding H, et al. Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS. Oncogene. 2021;40(20):3548\u201363.","journal-title":"Oncogene"},{"key":"693_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2024.102690","volume":"93","author":"W Lu","year":"2025","unstructured":"Lu W, Yang S. METTL3\/IGF2BP1 promotes the development of triple-negative breast cancer by mediating m6A methylation modification of PRMT7. Tissue Cell. 2025;93:102690.","journal-title":"Tissue Cell"},{"issue":"6","key":"693_CR136","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3892\/ol.2025.15295","volume":"30","author":"H Wan","year":"2025","unstructured":"Wan H, Zhou H, Gui J, et al. Protein arginine methyltransferase 7 regulates the cell cycle and promotes the progression of prostate cancer. Oncol Lett. 2025;30(6):549.","journal-title":"Oncol Lett"},{"key":"693_CR137","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105686","volume":"120","author":"F Liu","year":"2020","unstructured":"Liu F, Wan L, Zou H, et al. PRMT7 promotes the growth of renal cell carcinoma through modulating the \u03b2-catenin\/C-MYC axis. Int J Biochem Cell Biol. 2020;120:105686.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"693_CR138","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1021\/acs.biochem.2c00363","volume":"62","author":"M Mendoza","year":"2023","unstructured":"Mendoza M, Mendoza M, Lubrino T, et al. Arginine Methylation of the PGC-1\u03b1 C-Terminus Is Temperature-Dependent. Biochemistry. 2023;62(1):22\u201334.","journal-title":"Biochemistry"},{"key":"693_CR139","doi-asserted-by":"crossref","unstructured":"Hernandez SJ, Dolivo DM, Dominko T. PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer. Oncol Lett. 2017;13(3):1983\u20139.","DOI":"10.3892\/ol.2017.5671"},{"key":"693_CR140","doi-asserted-by":"crossref","unstructured":"Dong H, He X, Zhang L, et al. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nat Cancer. 2024;5(4):601\u201324.","DOI":"10.1038\/s43018-024-00736-x"},{"key":"693_CR141","doi-asserted-by":"crossref","unstructured":"Jiang H, Zhou Z, Jin S, et al. PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K\/Akt\/GSK-3\u03b2\/Snail signaling. Cancer Sci. 2018;109(5):1414\u201327.","DOI":"10.1111\/cas.13598"},{"key":"693_CR142","doi-asserted-by":"crossref","unstructured":"Chen J, Yang J, Chen Z, et al. m6A-Mediated stabilization of PRMT9 mRNA by IGF2BP1 drives proliferation and metastasis in lung adenocarcinoma. Anal Cell Pathol (Amst). 2025;2025:6050688.","DOI":"10.1155\/ancp\/6050688"},{"issue":"12","key":"693_CR143","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/ncb1802","volume":"10","author":"M Jansson","year":"2008","unstructured":"Jansson M, Durant ST, Cho EC, et al. Arginine methylation regulates the p53 response. Nat Cell Biol. 2008;10(12):1431\u20139.","journal-title":"Nat Cell Biol"},{"issue":"9","key":"693_CR144","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091973","volume":"9","author":"Y Abe","year":"2020","unstructured":"Abe Y, Tanaka N. Fine-tuning of GLI activity through arginine methylation: its mechanisms and function. Cells. 2020;9(9):1973.","journal-title":"Cells"},{"issue":"1","key":"693_CR145","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52291-6","volume":"9","author":"A Favia","year":"2019","unstructured":"Favia A, Salvatori L, Nanni S, et al. The protein arginine methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells. Sci Rep. 2019;9(1):15925.","journal-title":"Sci Rep"},{"issue":"5","key":"693_CR146","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1083\/jcb.200702147","volume":"178","author":"GB Gonsalvez","year":"2007","unstructured":"Gonsalvez GB, Tian L, Ospina JK, et al. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol. 2007;178(5):733\u201340.","journal-title":"J Cell Biol"},{"issue":"1","key":"693_CR147","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12929-026-01240-3","volume":"33","author":"Y Jeong","year":"2026","unstructured":"Jeong Y, Cho Y, Kim YK. Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities. J Biomed Sci. 2026;33(1):37.","journal-title":"J Biomed Sci"},{"key":"693_CR148","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.biopha.2017.07.035","volume":"93","author":"KM Sakthivel","year":"2017","unstructured":"Sakthivel KM, Hariharan S. Regulatory players of DNA damage repair mechanisms: role in cancer chemoresistance. Biomed Pharmacother. 2017;93:1238\u201345.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"693_CR149","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1101\/gad.1279805","volume":"19","author":"FM Boisvert","year":"2005","unstructured":"Boisvert FM, D\u00e9ry U, Masson JY, et al. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev. 2005;19(6):671\u20136.","journal-title":"Genes Dev"},{"key":"693_CR150","doi-asserted-by":"crossref","unstructured":"Montenegro MF, Gonz\u00e1lez-Guerrero R, S\u00e1nchez-Del-Campo L, et al. PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation. Sci Rep. 2020;10(1):13275.","DOI":"10.1038\/s41598-020-70289-3"},{"key":"693_CR151","doi-asserted-by":"crossref","unstructured":"Gurunathan G, Yu Z, Coulombe Y, et al. Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage. Sci Rep. 2015;5:10475.","DOI":"10.1038\/srep10475"},{"key":"693_CR152","doi-asserted-by":"crossref","unstructured":"Hu D, Gur M, Zhou Z, et al. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015;6:8419.","DOI":"10.1038\/ncomms9419"},{"key":"693_CR153","doi-asserted-by":"publisher","first-page":"102902","DOI":"10.1016\/j.dnarep.2020.102902","volume":"94","author":"C Checa-Rodriguez","year":"2020","unstructured":"Checa-Rodriguez C, Cepeda-Garcia C, Ramon J, et al. Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination. DNA Repair (Amst). 2020;94:102902.","journal-title":"DNA Repair (Amst)"},{"key":"693_CR154","doi-asserted-by":"crossref","unstructured":"Bunting SF, Callen E, Wong N, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 2010;141(2):243\u201354.","DOI":"10.1016\/j.cell.2010.03.012"},{"issue":"4","key":"693_CR155","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s42764-022-00095-w","volume":"4","author":"S Yin","year":"2023","unstructured":"Yin S, Liu L, Gan W. PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining. Genome Instab Dis. 2023;4(4):197\u2013209.","journal-title":"Genome Instab Dis"},{"issue":"10","key":"693_CR156","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1093\/nar\/gkz200","volume":"47","author":"G Gao","year":"2019","unstructured":"Gao G, Zhang L, Villarreal OD, et al. PRMT1 loss sensitizes cells to PRMT5 inhibition. Nucleic Acids Res. 2019;47(10):5038\u201348.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"693_CR157","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ccell.2019.05.014","volume":"36","author":"A Fedoriw","year":"2019","unstructured":"Fedoriw A, Rajapurkar SR, O\u2019Brien S, et al. Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss. Cancer Cell. 2019;36(1):100\u201314.","journal-title":"Cancer Cell"},{"issue":"1","key":"693_CR158","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1158\/0008-5472.CAN-18-3552","volume":"79","author":"ZL Watson","year":"2019","unstructured":"Watson ZL, Bitler BG. Type I Protein Arginine Methyltransferases Overexpression Promotes Transformation and Potentiates Her2\/Neu-Driven Tumorigenesis. Cancer Res. 2019;79(1):3\u20134.","journal-title":"Cancer Res"},{"issue":"1","key":"693_CR159","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13046-019-1064-8","volume":"38","author":"M Li","year":"2019","unstructured":"Li M, An W, Xu L, et al. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR in human lung cancer cells. J Exp Clin Cancer Res. 2019;38(1):64.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"693_CR160","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15592294.2020.1864170","volume":"17","author":"MD Fulton","year":"2022","unstructured":"Fulton MD, Dang T, Brown T, et al. Effects of substrate modifications on the arginine dimethylation activities of PRMT1 and PRMT5. Epigenetics. 2022;17(1):1\u201318.","journal-title":"Epigenetics"},{"issue":"7","key":"693_CR161","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073958","volume":"25","author":"K Bhandari","year":"2024","unstructured":"Bhandari K, Ding WQ. Protein arginine methyltransferases in pancreatic ductal adenocarcinoma: new molecular targets for therapy. Int J Mol Sci. 2024;25(7):3958.","journal-title":"Int J Mol Sci"},{"issue":"19","key":"693_CR162","doi-asserted-by":"publisher","first-page":"9124","DOI":"10.1021\/acs.jmedchem.6b01033","volume":"59","author":"Y Shen","year":"2016","unstructured":"Shen Y, Szewczyk MM, Eram MS, et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016;59(19):9124\u201339.","journal-title":"J Med Chem"},{"key":"693_CR163","doi-asserted-by":"publisher","first-page":"RP105318","DOI":"10.7554\/eLife.105318.3","volume":"14","author":"H Su","year":"2025","unstructured":"Su H, Sun Y, Guo H, et al. PRMT1-mediated metabolic reprogramming promotes leukemogenesis. Elife. 2025;14:RP105318.","journal-title":"Elife"},{"key":"693_CR164","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1093\/nar\/gkae973","volume":"53","author":"S Jiang","year":"2025","unstructured":"Jiang S, Li H, Zhang L, et al. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics. Nucleic Acids Res. 2025;53:1670\u20136.","journal-title":"Nucleic Acids Res"}],"container-title":["Epigenetics & Chromatin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13072-026-00693-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-026-00693-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13072-026-00693-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:38:21Z","timestamp":1792640301000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13072-026-00693-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":164,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["693"],"URL":"https:\/\/doi.org\/10.1186\/s13072-026-00693-y","relation":{},"ISSN":["1756-8935"],"issn-type":[{"value":"1756-8935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]},"assertion":[{"value":"13 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"45"}}