{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:29Z","timestamp":1790704889587,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["316758"],"award-info":[{"award-number":["316758"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["250157"],"award-info":[{"award-number":["250157"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["437015"],"award-info":[{"award-number":["437015"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["607358"],"award-info":[{"award-number":["607358"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008016","name":"Financial Markets Foundation for Children","doi-asserted-by":"publisher","award":["032-2007"],"award-info":[{"award-number":["032-2007"]}],"id":[{"id":"10.13039\/100008016","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Victorian Government's Operational Infrastructure"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genome Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13073-017-0413-5","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:32:14Z","timestamp":1490337134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation"],"prefix":"10.1186","volume":"9","author":[{"given":"Juan E.","family":"Castillo-Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk Jing","family":"Loke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bass-Stringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D.","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana T.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"413_CR1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/dms018","volume":"18","author":"S Pandey","year":"2012","unstructured":"Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF\/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012;18:485\u2013503.","journal-title":"Hum Reprod Update."},{"key":"413_CR2","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1093\/humrep\/del153","volume":"21","author":"LB Romundstad","year":"2006","unstructured":"Romundstad LB, Romundstad PR, Sunde A, von D\u00fcring V, Skjaerven R, Vatten LJ. Increased risk of placenta previa in pregnancies following IVF\/ICSI; a comparison of ART and non-ART pregnancies in the same mother. Hum Reprod. 2006;21:2353\u20138.","journal-title":"Hum Reprod."},{"key":"413_CR3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1086\/341096","volume":"71","author":"GF Cox","year":"2002","unstructured":"Cox GF, B\u00fcrger J, Lip V, Mau UA, Sperling K, Wu B-L, Horsthemke B. Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet. 2002;71:162\u20134.","journal-title":"Am J Hum Genet."},{"key":"413_CR4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/jmg.40.1.62","volume":"40","author":"ER Maher","year":"2003","unstructured":"Maher ER, Brueton LA, Bowdin SC, Luharia A, Cooper W, Cole TR, Macdonald F, Sampson JR, Barratt CL, Reik W, Hawkins MM. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet. 2003;40:62\u20134.","journal-title":"J Med Genet."},{"key":"413_CR5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/01443610802091792","volume":"28","author":"O Apantaku","year":"2008","unstructured":"Apantaku O, Chandrasekaran I, Bentick B. Obstetric outcome of singleton pregnancies achieved with in vitro fertilisation and intracytoplasmic sperm injection: experience from a district general hospital. J Obstet Gynaecol. 2008;28:398\u2013402.","journal-title":"J Obstet Gynaecol."},{"key":"413_CR6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/humrep\/dei424","volume":"21","author":"D Neubourg De","year":"2006","unstructured":"De Neubourg D, Gerris J, Mangelschots K, Van Royen E, Vercruyssen M, Steylemans A, Elseviers M. The obstetrical and neonatal outcome of babies born after single-embryo transfer in IVF\/ICSI compares favourably to spontaneously conceived babies. Hum Reprod. 2006;21:1041\u20136.","journal-title":"Hum Reprod."},{"key":"413_CR7","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1101\/gr.136598.111","volume":"22","author":"L Gordon","year":"2012","unstructured":"Gordon L, Joo JE, Powell JE, Ollikainen M, Novakovic B, Li X, Andronikos R, Cruickshank MN, Conneely KN, Smith AK, Alisch RS, Morley R, Visscher PM, Craig JM, Saffery R. Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res. 2012;22:1395\u2013406.","journal-title":"Genome Res."},{"key":"413_CR8","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/hmg\/11.11.1317","volume":"11","author":"R Weksberg","year":"2002","unstructured":"Weksberg R. Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome. Hum Mol Genet. 2002;11:1317\u201325.","journal-title":"Hum Mol Genet."},{"key":"413_CR9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000365020","volume":"64","author":"R Saffery","year":"2014","unstructured":"Saffery R. Epigenetic change as the major mediator of fetal programming in humans: are we there yet? Ann Nutr Metab. 2014;64:203\u20137.","journal-title":"Ann Nutr Metab."},{"key":"413_CR10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nature13581","volume":"511","author":"ZD Smith","year":"2014","unstructured":"Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, Meissner A. DNA methylation dynamics of the human preimplantation embryo. Nature. 2014;511:611\u20135.","journal-title":"Nature."},{"key":"413_CR11","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fertnstert.2012.12.047","volume":"99","author":"P Fauque","year":"2013","unstructured":"Fauque P. Ovulation induction and epigenetic anomalies. Fertil Steril. 2013;99:616\u201323.","journal-title":"Fertil Steril."},{"key":"413_CR12","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1095\/biolreprod62.6.1526","volume":"62","author":"AS Doherty","year":"2000","unstructured":"Doherty AS, Mann MR, Tremblay KD, Bartolomei MS, Schultz RM. Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol Reprod. 2000;62:1526\u201335.","journal-title":"Biol Reprod."},{"key":"413_CR13","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.fertnstert.2010.03.025","volume":"93","author":"Z Wang","year":"2010","unstructured":"Wang Z, Xu L, He F. Embryo vitrification affects the methylation of the H19\/Igf2 differentially methylated domain and the expression of H19 and Igf2. Fertil Steril. 2010;93:2729\u201333.","journal-title":"Fertil Steril."},{"key":"413_CR14","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.fertnstert.2011.01.173","volume":"95","author":"L Li","year":"2011","unstructured":"Li L, Wang L, Le F, Liu X, Yu P, Sheng J, Huang H, Jin F. Evaluation of DNA methylation status at differentially methylated regions in IVF-conceived newborn twins. Fertil Steril. 2011;95:1975\u20139.","journal-title":"Fertil Steril."},{"key":"413_CR15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/humrep\/des459","volume":"28","author":"ECM Nelissen","year":"2013","unstructured":"Nelissen ECM, Dumoulin JCM, Daunay A, Evers JLH, Tost J, van Montfoort APA. Placentas from pregnancies conceived by IVF\/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions. Hum Reprod. 2013;28:1117\u201326.","journal-title":"Hum Reprod."},{"key":"413_CR16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1017\/S2040174415000161","volume":"6","author":"YJ Loke","year":"2015","unstructured":"Loke YJ, Galati JC, Saffery R, Craig JM. Association of in vitro fertilization with global and IGF2\/H19 methylation variation in newborn twins. J Dev Orig Health Dis. 2015;6:115\u201324.","journal-title":"J Dev Orig Health Dis."},{"key":"413_CR17","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1093\/hmg\/ddp319","volume":"18","author":"S Katari","year":"2009","unstructured":"Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, Gaughan JP, Coutifaris C, Sapienza C. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet. 2009;18:3769\u201378.","journal-title":"Hum Mol Genet."},{"key":"413_CR18","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4161\/15592294.2014.988041","volume":"10","author":"N Melamed","year":"2015","unstructured":"Melamed N, Choufani S, Wilkins-Haug LE, Koren G, Weksberg R. Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies. Epigenetics. 2015;10:474\u201383.","journal-title":"Epigenetics."},{"key":"413_CR19","doi-asserted-by":"crossref","unstructured":"Estill MS, Bolnick JM, Waterland RA, Bolnick AD, Diamond MP, Krawetz SA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants. Fertil Steril. 2016;106:629\u201339.e10.","DOI":"10.1016\/j.fertnstert.2016.05.006"},{"key":"413_CR20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ygeno.2011.07.007","volume":"98","author":"M Bibikova","year":"2011","unstructured":"Bibikova M, Barnes B, Tsan C, Ho V, Klotzle B, Le JM, Delano D, Zhang L, Schroth GP, Gunderson KL, Fan J-B, Shen R. High density DNA methylation array with single CpG site resolution. Genomics. 2011;98:288\u201395.","journal-title":"Genomics."},{"key":"413_CR21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrg3000","volume":"12","author":"VK Rakyan","year":"2011","unstructured":"Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat Rev Genet. 2011;12:529\u201341.","journal-title":"Nat Rev Genet."},{"key":"413_CR22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/ng1598","volume":"37","author":"M Weber","year":"2005","unstructured":"Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, Sch\u00fcbeler D. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet. 2005;37:853\u201362.","journal-title":"Nat Genet."},{"key":"413_CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/ije\/dyr140","volume":"41","author":"R Saffery","year":"2012","unstructured":"Saffery R, Morley R, Carlin JB, Joo J-HE, Ollikainen M, Novakovic B, Andronikos R, Li X, Loke YJ, Carson N, Wallace EM, Umstad MP, Permezel M, Galati JC, Craig JM. Cohort profile: The peri\/post-natal epigenetic twins study. Int J Epidemiol. 2012;41:55\u201361.","journal-title":"Int J Epidemiol."},{"key":"413_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/thg.2012.114","volume":"16","author":"YJ Loke","year":"2013","unstructured":"Loke YJ, Novakovic B, Ollikainen M, Wallace EM, Umstad MP, Permezel M, Morley R, Ponsonby A-L, Gordon L, Galati JC, Saffery R, Craig JM. The Peri\/postnatal Epigenetic Twins Study (PETS). Twin Res Hum Genet. 2013;16:13\u201320.","journal-title":"Twin Res Hum Genet."},{"key":"413_CR25","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1093\/hmg\/ddq336","volume":"19","author":"M Ollikainen","year":"2010","unstructured":"Ollikainen M, Smith KR, Joo EJ-H, Ng HK, Andronikos R, Novakovic B, Abdul Aziz NK, Carlin JB, Morley R, Saffery R, Craig JM. DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum Mol Genet. 2010;19:4176\u201388.","journal-title":"Hum Mol Genet."},{"key":"413_CR26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1101\/gr.110114.110","volume":"20","author":"L Chavez","year":"2010","unstructured":"Chavez L, Jozefczuk J, Grimm C, Dietrich J, Timmermann B, Lehrach H, Herwig R, Adjaye J. Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res. 2010;20:1441\u201350.","journal-title":"Genome Res."},{"key":"413_CR27","doi-asserted-by":"crossref","unstructured":"Bates D, M\u00e4chler M, Bolker B, Walker S. Fitting Linear Mixed-Effects Models Using lme4. J Stat Softw. 2015;67:1\u201348.","DOI":"10.18637\/jss.v067.i01"},{"key":"413_CR28","unstructured":"R Core Team: R: a Language and Environment for Statistical Computing. 2014. http:\/\/www.R-project.org\/ ."},{"key":"413_CR29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/bib\/3.2.119","volume":"3","author":"FV Rijsdijk","year":"2002","unstructured":"Rijsdijk FV, Sham PC. Analytic approaches to twin data using structural equation models. Brief Bioinform. 2002;3:119\u201333.","journal-title":"Brief Bioinform."},{"key":"413_CR30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s11336-010-9200-6","volume":"76","author":"S Boker","year":"2011","unstructured":"Boker S, Neale M, Maes H, Wilde M, Spiegel M, Brick T, Spies J, Estabrook R, Kenny S, Bates T, Mehta P, Fox J. OpenMx: an open source extended structural equation modeling framework. Psychometrika. 2011;76:306\u201317.","journal-title":"Psychometrika."},{"key":"413_CR31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng.286","volume":"41","author":"ZA Kaminsky","year":"2009","unstructured":"Kaminsky ZA, Tang T, Wang S-C, Ptak C, Oh GHT, Wong AHC, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, McRae AF, Visscher PM, Montgomery GW, Gottesman II, Martin NG, Petronis A. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 2009;41:240\u20135.","journal-title":"Nat Genet."},{"key":"413_CR32","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2164\/jandrol.05069","volume":"26","author":"Y Miyagawa","year":"2005","unstructured":"Miyagawa Y, Nishimura H, Tsujimura A, Matsuoka Y, Matsumiya K, Okuyama A, Nishimune Y, Tanaka H. Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. J Androl. 2005;26:779\u201386.","journal-title":"J Androl."},{"key":"413_CR33","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1128\/MCB.10.4.1828","volume":"10","author":"JM Trasler","year":"1990","unstructured":"Trasler JM, Hake LE, Johnson PA, Alcivar AA, Millette CF, Hecht NB. DNA methylation and demethylation events during meiotic prophase in the mouse testis. Mol Cell Biol. 1990;10:1828\u201334.","journal-title":"Mol Cell Biol."},{"key":"413_CR34","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","volume":"44","author":"Y Shi","year":"2012","unstructured":"Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012;44:1020\u20135.","journal-title":"Nat Genet."},{"key":"413_CR35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.ijrobp.2010.07.036","volume":"78","author":"SL Kerns","year":"2010","unstructured":"Kerns SL, Ostrer H, Stock R, Li W, Moore J, Pearlman A, Campbell C, Shao Y, Stone N, Kusnetz L, Rosenstein BS. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010;78:1292\u2013300.","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"413_CR36","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/molehr\/gaq064","volume":"16","author":"MH Fenstad","year":"2010","unstructured":"Fenstad MH, Johnson MP, L\u00f8set M, Mundal SB, Roten LT, Eide IP, Bj\u00f8rge L, Sande RK, Johansson AK, Dyer TD, Forsmo S, Blangero J, Moses EK, Austgulen R. STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study. Mol Hum Reprod. 2010;16:960\u20138.","journal-title":"Mol Hum Reprod."},{"key":"413_CR37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature12433","volume":"500","author":"MJ Ziller","year":"2013","unstructured":"Ziller MJ, Gu H, M\u00fcller F, Donaghey J, Tsai LT-Y, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A. Charting a dynamic DNA methylation landscape of the human genome. Nature. 2013;500:477\u201381.","journal-title":"Nature."},{"key":"413_CR38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature11232","volume":"489","author":"RE Thurman","year":"2012","unstructured":"Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, Canfield TK, Diegel M, Dunn D, Ebersol AK, Frum T, Giste E, Johnson AK, Johnson EM, Kutyavin T, Lajoie B, Lee B-K, Lee K, London D, Lotakis D, Neph S, et al. The accessible chromatin landscape of the human genome. Nature. 2012;489:75\u201382.","journal-title":"Nature."},{"key":"413_CR39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-2836(87)90689-9","volume":"196","author":"M Gardiner-Garden","year":"1987","unstructured":"Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol. 1987;196:261\u201382.","journal-title":"J Mol Biol."},{"key":"413_CR40","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13059-015-0660-y","volume":"16","author":"MJ Silver","year":"2015","unstructured":"Silver MJ, Kessler NJ, Hennig BJ, Dominguez-Salas P, Laritsky E, Baker MS, Coarfa C, Hernandez-Vargas H, Castelino JM, Routledge MN, Gong YY, Herceg Z, Lee YS, Lee K, Moore SE, Fulford AJ, Prentice AM, Waterland RA. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. Genome Biol. 2015;16:118.","journal-title":"Genome Biol."},{"key":"413_CR41","doi-asserted-by":"crossref","unstructured":"Schulz R, Woodfine K, Menheniott TR, Bourc\u2019his D, Bestor T, Oakey RJ. WAMIDEX: a web atlas of murine genomic imprinting and differential expression. Epigenetics. 2008;3:89\u201396.","DOI":"10.4161\/epi.3.2.5900"},{"key":"413_CR42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","volume":"340","author":"G Palermo","year":"1992","unstructured":"Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340:17\u20138.","journal-title":"Lancet."},{"key":"413_CR43","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/978-1-4939-0659-8_26","volume":"1154","author":"GD Palermo","year":"2014","unstructured":"Palermo GD, Neri QV, Rosenwaks Z. Safety of intracytoplasmic sperm injection. Methods Mol Biol. 2014;1154:549\u201362.","journal-title":"Methods Mol Biol."},{"key":"413_CR44","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhlen","year":"2015","unstructured":"Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson A, Kampf C, Sjostedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA-K, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist P-H, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, et al. Tissue-based map of the human proteome. Science. 2015;347:1260419.","journal-title":"Science."},{"key":"413_CR45","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0168-9525(02)02709-9","volume":"18","author":"VK Rakyan","year":"2002","unstructured":"Rakyan VK, Blewitt ME, Druker R, Preis JI, Whitelaw E. Metastable epialleles in mammals. Trends Genet. 2002;18:348\u201351.","journal-title":"Trends Genet."},{"key":"413_CR46","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1038\/ncomms4746","volume":"5","author":"P Dominguez-Salas","year":"2014","unstructured":"Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, Fulford AJ, Guan Y, Laritsky E, Silver MJ, Swan GE, Zeisel SH, Innis SM, Waterland RA, Prentice AM, Hennig BJ. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun. 2014;5:3746.","journal-title":"Nat Commun."},{"key":"413_CR47","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fertnstert.2011.10.027","volume":"97","author":"VF Oliver","year":"2012","unstructured":"Oliver VF, Miles HL, Cutfield WS, Hofman PL, Ludgate JL, Morison IM. Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population. Fertil Steril. 2012;97:147\u201353. e7.","journal-title":"Fertil Steril"},{"key":"413_CR48","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jmg.2009.073189","volume":"47","author":"S Tierling","year":"2010","unstructured":"Tierling S, Souren NY, Gries J, Loporto C, Groth M, Lutsik P, Neitzel H, Utz-Billing I, Gillessen-Kaesbach G, Kentenich H, Griesinger G, Sperling K, Schwinger E, Walter J. Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human. J Med Genet. 2010;47:371\u20136.","journal-title":"J Med Genet."},{"key":"413_CR49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ejhg.2009.117","volume":"18","author":"CC Boissonnas","year":"2010","unstructured":"Boissonnas CC, El Abdalaoui H, Haelewyn V, Fauque P, Dupont JM, Gut I, Vaiman D, Jouannet P, Tost J, Jammes H. Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. Eur J Hum Genet. 2010;18:73\u201380.","journal-title":"Eur J Hum Genet."},{"key":"413_CR50","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/humrep\/deu094","volume":"29","author":"N Whitelaw","year":"2014","unstructured":"Whitelaw N, Bhattacharya S, Hoad G, Horgan GW, Hamilton M, Haggarty P. Epigenetic status in the offspring of spontaneous and assisted conception. Hum Reprod. 2014;29:1452\u20138.","journal-title":"Hum Reprod."},{"key":"413_CR51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/jmg.2004.026930","volume":"42","author":"M Ludwig","year":"2005","unstructured":"Ludwig M, Katalinic A, Gross S, Sutcliffe A, Varon R, Horsthemke B. Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J Med Genet. 2005;42:289\u201391.","journal-title":"J Med Genet."},{"key":"413_CR52","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/humrep\/dem172","volume":"22","author":"ME Doornbos","year":"2007","unstructured":"Doornbos ME, Maas SM, McDonnell J, Vermeiden JPW, Hennekam RCM. Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study. Hum Reprod. 2007;22:2476\u201380.","journal-title":"Hum Reprod."},{"key":"413_CR53","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1016\/j.fertnstert.2010.02.043","volume":"94","author":"AM Jaques","year":"2010","unstructured":"Jaques AM, Amor DJ, Baker HWG, Healy DL, Ukoumunne OC, Breheny S, Garrett C, Halliday JL. Adverse obstetric and perinatal outcomes in subfertile women conceiving without assisted reproductive technologies. Fertil Steril. 2010;94:2674\u20139.","journal-title":"Fertil Steril."},{"key":"413_CR54","doi-asserted-by":"crossref","unstructured":"Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, S\u00f6derstr\u00f6m-Anttila V, Nygren KG, Hazekamp J, Bergh C. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2013;19:87\u2013104.","DOI":"10.1093\/humupd\/dms044"},{"key":"413_CR55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13148-015-0071-7","volume":"7","author":"S Song","year":"2015","unstructured":"Song S, Ghosh J, Mainigi M, Turan N, Weinerman R, Truongcao M, Coutifaris C, Sapienza C. DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility. Clin Epigenetics. 2015;7:41.","journal-title":"Clin Epigenetics."},{"key":"413_CR56","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/gb-2014-15-2-r31","volume":"15","author":"AE Jaffe","year":"2014","unstructured":"Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biol. 2014;15:R31.","journal-title":"Genome Biol."},{"key":"413_CR57","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/ng1909","volume":"38","author":"F Eckhardt","year":"2006","unstructured":"Eckhardt F, Lewin J, Cortese R, Rakyan VK, Attwood J, Burger M, Burton J, Cox TV, Davies R, Down TA, Haefliger C, Horton R, Howe K, Jackson DK, Kunde J, Koenig C, Liddle J, Niblett D, Otto T, Pettett R, Seemann S, Thompson C, West T, Rogers J, Olek A, Berlin K, Beck S. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet. 2006;38:1378\u201385.","journal-title":"Nat Genet."},{"key":"413_CR58","doi-asserted-by":"crossref","unstructured":"Tsai P-C, Bell JT. Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation. Int J Epidemiol. 2015;44:1429.","DOI":"10.1093\/ije\/dyv041"}],"container-title":["Genome Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-017-0413-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T11:14:16Z","timestamp":1526642056000},"score":1,"resource":{"primary":{"URL":"http:\/\/genomemedicine.biomedcentral.com\/articles\/10.1186\/s13073-017-0413-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["413"],"URL":"https:\/\/doi.org\/10.1186\/s13073-017-0413-5","relation":{},"ISSN":["1756-994X"],"issn-type":[{"value":"1756-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,24]]},"article-number":"28"}}