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All participants provided written informed consent to participate in the study. Families were counseled and provided consent for \u201cPID gene panel only\u201d or \u201cgene panel and exome-wide analysis\u201d as presented here. The research conforms to the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All individuals involved in this study provided consent for publication. We also obtained consent to publish the clinical information of all individuals presented in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38"}}