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Subjects were recruited under the University of Li\u00e8ge Ethics committee approved protocol B707201420418; or under the <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, National Institutes of Health protocol 97-CH-0076 (see ClinicalTrials.gov: NCT00001595 for details), or under Project code PGR00919 of the University of L\u2019Aquila Internal Review Board. The Institutional Review Boards of all Centers approved the study, and written informed consent was obtained from all the subjects\/guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent to publish patient-related details was obtained for all subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"AFD, FRF, AB, CAS, and GT hold a patent on GPR101 and its function (US Patent No. 10,350,273, Treatment of Hormonal Disorders of Growth). JRL has stock ownership in 23andMe and is a paid consultant for Genome International. CAS is co-founder and Director of ASTREA, a precision medicine company. The authors declare no other competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}