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The study was approved by the local ethics committee of the Institute of Cytology and Genetics (protocol number 17, 16.12.2022) and the local ethics committee of the\u00a0Tomsk National Research Medical Center (protocol number 15, 28.02.2023). Informed Consent was obtained from all patients or their parents\/representatives included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publications was obtained from all patients or their parents\/representatives for all materials included in the study. 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