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Informed written consent was approved by the UK Human Tissue Authority (#18\/WA\/0238).All experimental procedures and animal care were approved by the Institutional Animal Care and Use Committee Animal Use Protocol (IACUC AUP #19113 and #25006) of NTU-LKCMedicine Animal Research Facility. All experiments were carried out in accordance with the approved guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}