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The analysis of methylation profiles using previously stored DNA under these conditions was approved by the Ethics Committee for Research on Existing Data and\/or outside the Jard\u00e9 Law (CERDE) of Rouen University Hospital (approval no. E2023-13). The Necker Biological Resource Centre (BRC) received approval from the Ethics Committee for Research of AP-HP Centre (CERAPHP Centre). In accordance with data protection regulations, informed consent for the use of DNA in analyses complementary to sequencing was obtained from each patient by their attending physician. All samples were anonymised at the clinical site prior to their transfer to the laboratory, where they were used for downstream analyses.This study was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for the use of biological samples and, where applicable, for the publication of photographs was obtained by the treating physicians at their respective institutions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39"}}